Hepabrex L 140mg/525mg Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain, especially in the upper right side
- Blood in vomit or black, tarry stools
- Swelling of face, lips, or throat, or difficulty breathing
- Severe skin rash with blistering or peeling
- Confusion, drowsiness, or extreme fatigue
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is hepabrex l 140mg/525mg tablet used for?
This medicine is a combination of Silymarin and Lecithin used to support liver health in conditions like fatty liver disease and chronic hepatitis. It works by protecting liver cells from damage and helping in fat metabolism.
- Generic Name: Silymarin (140mg) + Lecithin (525mg)
- Manufacturer: Ikon Remedies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 hepabrex l 140mg/525mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सिलीमारिन और लेसिथिन का संयोजन है, जिसका उपयोग लिवर से जुड़ी समस्याओं जैसे फैटी लिवर, क्रोनिक हेपेटाइटिस और लिवर सिरोसिस में सहायक उपचार के रूप में किया जाता है। यह लिवर कोशिकाओं को नुकसान से बचाती है और लिवर में वसा के जमाव को कम करने में मदद करती है। यह दवा लिवर के कार्य को बेहतर बनाने और पित्त के प्रवाह को सुधारने में सहायक होती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, पेट में असुविधा, दस्त, सिरदर्द और त्वचा पर दाने शामिल हो सकते हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर त्वचा प्रतिक्रिया होती है, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को गर्भावस्था, स्तनपान, या किसी अन्य दवा के सेवन के बारे में बताएं। शराब का सेवन बिल्कुल न करें क्योंकि इससे लिवर को और नुकसान हो सकता है। दवा को डॉक्टर के बताए अनुसार ही लें, अधिक मात्रा में न लें। यदि आपको कोई एलर्जी है तो डॉक्टर को बताएं। दवा को बच्चों की पहुंच से दूर रखें।
💊 hepabrex l 140mg/525mg tablet Uses & Benefits
[{"condition":"Fatty liver disease (hepatic steatosis)","description":"This medicine is used as a supportive treatment to improve liver function and reduce fat accumulation in the liver.","evidence":"Moderate"},{"condition":"Chronic hepatitis","description":"It may be prescribed as an adjunct to standard antiviral therapy to help protect liver cells and improve liver enzyme levels.","evidence":"Limited"},{"condition":"Liver cirrhosis","description":"Used as a supportive measure to potentially slow progression and improve quality of life, but does not reverse cirrhosis.","evidence":"Limited"},{"condition":"Drug-induced liver injury","description":"May be used to support liver recovery after damage caused by certain medications or toxins.","evidence":"Limited"},{"condition":"Alcoholic liver disease","description":"Can be prescribed as part of a comprehensive treatment plan, but alcohol abstinence is essential.","evidence":"Limited"}]
Off-label uses: [{"condition":"Hypercholesterolemia","description":"Lecithin may help in lowering cholesterol levels, but this combination is not primarily indicated for this purpose.","evidence":"Limited"},{"condition":"Gallbladder disorders","description":"Lecithin may help in emulsifying bile, but evidence is insufficient for routine use.","evidence":"Insufficient"}]
Primary treatment for: Liver disorders
Also treats: Fatty liver disease, Chronic hepatitis, Liver cirrhosis, Drug-induced liver injury, Alcoholic liver disease
📋 Drug Information
| Generic Name(s) | Silymarin (140mg) + Lecithin (525mg) |
| Brand Name | hepabrex l 140mg/525mg tablet |
| Manufacturer | Ikon Remedies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place. Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Silymarin, a flavonolignan complex from milk thistle, works by multiple mechanisms: it acts as a potent antioxidant, scavenging free radicals and reducing oxidative stress in liver cells. It inhibits lipid peroxidation, thereby stabilizing hepatocyte cell membranes and preventing toxin entry. Silymarin also stimulates protein synthesis and promotes the regeneration of damaged liver cells by increasing ribosomal RNA synthesis. It has anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines. Lecithin, a mixture of phospholipids, particularly phosphatidylcholine, helps in the emulsification and transport of fats. It supports the breakdown of fats in the liver, preventing fat accumulation (steatosis). Lecithin also provides choline, which is essential for the synthesis of very-low-density lipoproteins (VLDL), aiding in the export of triglycerides from the liver. Together, they protect the liver from damage and improve its function.
Mechanism Steps
💡 How to Take hepabrex l 140mg/525mg tablet
Strength: Silymarin 140 mg + Lecithin 525 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily, or as directed by your physician. The dose may be adjusted based on the severity of the liver condition and your response to treatment. It is best taken with meals to enhance absorption and reduce stomach upset. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients, but they should be monitored for any side effects. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is established for patients with renal impairment. Use with caution and consult your doctor. |
| Hepatic Impairment | No dose adjustment is established for patients with hepatic impairment. Use with caution and consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is not established from available information. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of hepabrex l 140mg/525mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Metronidazole | Major | |
| Phenytoin | Major | |
| Simvastatin | Moderate | |
| Diazepam | Moderate | |
| Ketoconazole | Moderate | |
| Oral contraceptives | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Metronidazole
- Phenytoin
⚡ Moderate Interactions
- Simvastatin
- Diazepam
- Ketoconazole
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Alcohol can worsen liver damage and counteract the beneficial effects of Silymarin and Lecithin. Additionally, both alcohol and this medicine are processed by the liver, and combining them may increase the risk of liver toxicity. If you have a history of alcohol abuse, consult your doctor before taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Silymarin, Lecithin, or any component of the formulation","Acute liver failure","Pregnancy and breastfeeding (unless advised by doctor)","Children under 12 years of age (unless prescribed)"]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose.","Avoid alcohol consumption.","Use with caution in patients with kidney disease.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you have a history of allergies to plants in the Asteraceae family.","Not a substitute for definitive treatment of underlying liver disease.","Consult doctor before use if you are pregnant or breastfeeding."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
There is no specific antidote for overdose. In case of overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Gastric lavage may be considered if ingestion is recent. Monitor liver function and vital signs.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine without a prescription. Take it exactly as directed by your doctor. Do not exceed the recommended dose. Avoid alcohol consumption while taking this medicine, as alcohol can worsen liver damage and may reduce the effectiveness of the treatment. If you have a history of allergies to plants in the daisy family (like ragweed, marigold, chrysanthemum), tell your doctor, as Silymarin may cause allergic reactions. This medicine may interact with certain drugs, including some diabetes medications, cholesterol-lowering drugs, and drugs that affect the liver. Always provide a complete list of all medicines you are taking to your doctor. Do not stop taking this medicine abruptly without consulting your doctor. Keep this medicine out of reach of children. Store it in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects. Use with caution and monitor liver and kidney function regularly.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It is not recommended during pregnancy unless clearly needed.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may affect liver function and interact with other medications.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It is unlikely to cause issues, but your dentist should be aware.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine. However, if you experience dizziness or fatigue, avoid strenuous activities until you know how the medicine affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to work or drive. However, if you experience dizziness or drowsiness, avoid driving or operating heavy machinery until you know how it affects you.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or allergic reactions, stop immediately and seek medical help. Your doctor will advise when to stop based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine is generally considered safe when taken as prescribed. However, regular monitoring of liver function is advised. There is limited information on its effects beyond 12 months of use. It should not be used as a substitute for definitive treatment of underlying liver disease.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise can improve liver health and complement medicine.
Evidence: Well-establishedOther herbs like turmeric may have liver-protective effects, but evidence is limited.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking your doses at regular intervals as prescribed. Keep enough supply for your trip. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take several weeks to months to see improvement in liver function tests. Continue taking it as prescribed.
A: Consult your doctor before combining with other liver medicines to avoid interactions.
A: Consult your doctor. It is not recommended unless prescribed.
🤔 Common Patient Concerns
🔄 Substitutes for hepabrex l 140mg/525mg tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Hepabrex L can cure all liver diseases.
Fact: This medicine is a supportive treatment and does not cure underlying liver diseases. It should be used along with other treatments as prescribed. - Myth: Hepabrex L is a steroid.
Fact: This medicine contains Silymarin and Lecithin, which are natural substances and not steroids. - Myth: You can drink alcohol while taking Hepabrex L.
Fact: Alcohol should be strictly avoided as it can worsen liver damage and reduce the effectiveness of this medicine.
🔄 Alternative Options
Generic Alternatives
- Silymarin + Lecithin combination generics available
Brand Alternatives
- Hepabrex L 140mg/525mg tablet