antigrain tablet
What is antigrain tablet used for?
This medicine contains Caffeine (100mg) + Ergotamine (1mg) and is used to treat NEURO CNS. Ergotamine is a serotonin (5-HT1B/1D) receptor agonist causing vasoconstriction of cranial blood ves. Always consult your doctor before use.
- Generic Name: Caffeine + Ergotamine
- Manufacturer: Ikon Remedies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Category A
- Prescription Required: Yes
💊 antigrain tablet Uses & Benefits
Acute treatment of migraine headaches with or without aura.
Off-label uses: Cluster headaches, orthostatic hypotension (ergotamine alone).
📋 Drug Information
| Generic Name(s) | Caffeine + Ergotamine |
| Brand Name | Antigrain Tablet |
| Manufacturer | Ikon Remedies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Antimigraine Agent |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25°C), protect from light and moisture. |
| Shelf Life | As per manufacturer |
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ergotamine is a serotonin (5-HT1B/1D) receptor agonist causing vasoconstriction of cranial blood vessels; also inhibits neurogenic inflammation. Caffeine is a CNS stimulant and vasoconstrictor; enhances ergotamine absorption and efficacy.
Mechanism Steps
💡 How to Take antigrain tablet
Follow your doctor's prescription exactly.
⚠️ Side Effects of antigrain tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Sumatriptan | Major | Additive vasoconstriction, risk of ischemia |
| Ketoconazole | Major | Increased ergotamine levels, risk of ergotism |
| Propranolol | Major | Increased vasoconstriction, peripheral ischemia |
| Ciprofloxacin | Major | Increased caffeine levels, toxicity |
| Oral Contraceptives | Moderate | Increased ergotamine levels |
| Grapefruit Juice | Moderate | Increased ergotamine bioavailability |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine)
- Other vasoconstrictors (e.g., triptans, ergot alkaloids)
- Beta-blockers (e.g., propranolol)
- Macrolide antibiotics
⚡ Moderate Interactions
- Oral contraceptives
- Antifungals (azole)
- Grapefruit juice
- Cimetidine
- Disulfiram
🍷 Alcohol Interaction
Alcohol may increase risk of ergotism and worsen side effects; avoid concurrent use.
🛡️ Safety & Warnings
🚫 Contraindications
Pregnancy, lactation, coronary artery disease, peripheral vascular disease, hypertension, sepsis, hepatic or renal impairment, hypersensitivity to ergot alkaloids or caffeine.
🤱 Lactation Safety
Contraindicated; ergotamine can cause ergotism in infants and reduce milk production.
💊 Overdose Management
Symptoms: nausea, vomiting, paresthesia, muscle pain, ischemia, gangrene. Treatment: symptomatic and supportive; vasodilators (e.g., nitroprusside) for vasospasm; activated charcoal if recent ingestion.
⏰ Missed Dose
Take as soon as remembered if within 1 hour; otherwise skip. Do not double dose.
🔄 Substitutes for antigrain tablet
View AllAlternative brands with exact same active ingredient:
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neuromol plus tabletBilcare Ltd ₹26.25 56.6% CHEAPER
-
nt grain tabletIntas Pharmaceuticals Ltd ₹37.97 37.2% CHEAPER
-
e grain tabletElixir Life Care Pvt Ltd ₹42.19 30.2% CHEAPER
-
livigrain tabletLividus Pharmaceuticals Pvt Ltd ₹46.88 22.5% CHEAPER
-
migrarest tabletInnovative Pharmaceuticals ₹55.78 7.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.