Bytey M 60mg/500mg Tablet SR: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe hypoglycemia: confusion, seizures, or loss of consciousness.
- Symptoms of lactic acidosis: muscle pain, difficulty breathing, stomach pain, extreme tiredness.
- Allergic reactions: rash, swelling of face, lips, or throat, difficulty breathing.
- Signs of liver problems: yellowing of skin or eyes, dark urine, severe abdominal pain.
- Persistent vomiting or diarrhea leading to dehydration.
- Unusual bleeding or bruising.
- Decreased urine output or swelling in legs.
If experiencing severe symptoms, call emergency services immediately.
What is gliclastar-m 60 tablet used for?
This medicine is a combination of Gliclazide and Metformin used to treat type 2 diabetes. It helps control blood sugar levels by increasing insulin release and improving insulin sensitivity. It is taken orally with meals, usually once daily, as prescribed by a doctor.
- Generic Name: Gliclazide (60mg) + Metformin (500mg)
- Manufacturer: Zinnia Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 gliclastar-m 60 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए इस्तेमाल की जाती है। इसमें ग्लिक्लाजाइड और मेटफॉर्मिन दो सक्रिय तत्व होते हैं जो रक्त शर्करा को नियंत्रित करने में मदद करते हैं। ग्लिक्लाजाइड अग्न्याशय से इंसुलिन निकालने में मदद करता है, जबकि मेटफॉर्मिन शरीर में शर्करा के उत्पादन को कम करता है और इंसुलिन के प्रति संवेदनशीलता बढ़ाता है। यह दवा उन वयस्कों के लिए है जिनका मधुमेह केवल मेटफॉर्मिन या ग्लिक्लाजाइड से ठीक से नियंत्रित नहीं हो रहा है। इसे डॉक्टर के परामर्श के बिना न लें और न ही बंद करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में कम रक्त शर्करा (हाइपोग्लाइसीमिया), जी मिचलाना, दस्त, पेट दर्द, और मुंह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभावों में लैक्टिक एसिडोसिस (रक्त में लैक्टिक एसिड का बढ़ना) और गंभीर हाइपोग्लाइसीमिया शामिल हैं। यदि आपको मांसपेशियों में दर्द, सांस लेने में कठिनाई, पेट में परेशानी, या अत्यधिक थकान महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी और हाइपोग्लाइसीमिया का खतरा कम हो। अपने रक्त शर्करा की नियमित जांच करें। कम रक्त शर्करा के लक्षणों के लिए हमेशा ग्लूकोज की गोलियां या मिठाई साथ रखें। शराब का सेवन न करें क्योंकि इससे लैक्टिक एसिडोसिस और हाइपोग्लाइसीमिया का खतरा बढ़ सकता है। गर्भावस्था या स्तनपान के दौरान इस दवा का उपयोग न करें। नियमित जांच के लिए डॉक्टर के पास जाएं।
💊 gliclastar-m 60 tablet Uses & Benefits
[{"condition":"Type 2 Diabetes Mellitus","description":"Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes who are not adequately controlled on Metformin or Gliclazide alone.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Type 2 Diabetes Mellitus
📋 Drug Information
| Generic Name(s) | Gliclazide (60mg) + Metformin (500mg) |
| Brand Name | gliclastar-m 60 tablet |
| Manufacturer | Zinnia Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two oral antihyperglycemic agents with complementary mechanisms. Gliclazide, a sulfonylurea, binds to ATP-sensitive potassium channels on pancreatic beta cells, leading to membrane depolarization, calcium influx, and increased insulin secretion. Metformin, a biguanide, decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Together, they effectively lower blood glucose levels.
Mechanism Steps
💡 How to Take gliclastar-m 60 tablet
Strength: Tablet containing Gliclazide 60 mg and Metformin 500 mg.
Dosage Information
| Adult Dosage | The usual starting dose is one tablet taken once daily with breakfast. The dose may be adjusted by your doctor based on your blood sugar levels and response to treatment. The maximum recommended daily dose is one tablet of 60 mg/500 mg, but your doctor may prescribe additional Metformin if needed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially hypoglycemia and lactic acidosis. Dose should be adjusted based on renal function and overall health. Regular monitoring is essential. |
| Renal Impairment | This medicine is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). In mild to moderate renal impairment, dose adjustments may be necessary. Consult your doctor for personalized dosing. |
| Hepatic Impairment | This medicine should be used with caution in patients with hepatic impairment. In severe hepatic impairment, it is contraindicated. Dose adjustment may be required based on liver function tests. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet of 60 mg/500 mg. However, additional Metformin may be prescribed separately. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of gliclastar-m 60 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Contrast media | Major | |
| Diuretics | Major | |
| Beta-blockers | Moderate | |
| Corticosteroids | Moderate | |
| ACE inhibitors | Moderate | |
| Antacids | Minor | |
| Cimetidine | Minor |
🚨 Major Interactions
- Alcohol
- Contrast media (iodinated)
- Diuretics
⚡ Moderate Interactions
- Beta-blockers
- Corticosteroids
- ACE inhibitors
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It can increase the risk of lactic acidosis, a rare but serious complication, and can also cause severe hypoglycemia. If you consume alcohol, do so only in moderation and with food, and inform your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Risk of lactic acidosis: rare but serious; seek immediate medical help if symptoms occur.","Risk of hypoglycemia: especially with skipped meals, alcohol, or intense exercise.","Renal function should be assessed before and during treatment.","Avoid alcohol consumption.","Temporarily discontinue before surgery or contrast procedures as advised.","Elderly patients are at higher risk of hypoglycemia and lactic acidosis.","May cause vitamin B12 deficiency with long-term use.","Not for use in type 1 diabetes or diabetic ketoacidosis."]
🤱 Lactation Safety
This medicine is not recommended during breastfeeding as it may pass into breast milk and affect the baby. Consult your doctor for alternative treatments.
💊 Overdose Management
Overdose can cause severe hypoglycemia and lactic acidosis. Symptoms may include shakiness, sweating, confusion, rapid heartbeat, muscle pain, difficulty breathing, and stomach pain. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and may include glucose administration for hypoglycemia and hemodialysis for lactic acidosis.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not adjust the dose on your own. Take it with meals to reduce stomach upset and lower the risk of hypoglycemia. Regularly monitor your blood sugar levels as advised. Carry a fast-acting source of sugar, such as glucose tablets or candy, to treat low blood sugar episodes. Avoid alcohol, as it can increase the risk of lactic acidosis and hypoglycemia. Stay well hydrated, especially during hot weather or exercise. Inform your doctor if you have kidney or liver problems, as dose adjustments may be needed. Do not use this medicine if you are pregnant, planning to become pregnant, or breastfeeding without consulting your doctor. Keep all appointments for blood tests and check-ups. Store this medicine in its original container at room temperature, away from moisture and heat. Do not share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of hypoglycemia and lactic acidosis. Dose should be adjusted based on renal function, and blood sugar should be monitored more frequently. Avoid skipping meals and stay hydrated.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative, such as insulin. Good blood sugar control before and during pregnancy is crucial for the health of both mother and baby.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily discontinued before surgery, especially if you will be fasting or if iodinated contrast media will be used. Follow your doctor's instructions carefully. Blood sugar levels should be monitored closely during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. If you are scheduled for a dental procedure that requires fasting or sedation, your doctor may need to adjust your dose. Maintain good oral hygiene to prevent infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar levels and increase the risk of hypoglycemia, especially if you take this medicine. Check your blood sugar before and after exercise, and carry a fast-acting sugar source. Avoid intense exercise if your blood sugar is very low or very high. Stay hydrated and consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause hypoglycemia, which can affect your ability to drive or operate machinery. Avoid driving if you feel shaky, dizzy, or confused. Inform your employer about your condition and the medicine you take, especially if your job involves operating heavy machinery. Take your medicine with meals and keep a sugar source at work.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as lactic acidosis or severe hypoglycemia, seek immediate medical attention. Your doctor may adjust the dose or switch to a different medicine if needed. Stopping suddenly can cause blood sugar levels to rise and lead to complications.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency, which can cause anemia and nerve problems. Regular monitoring of vitamin B12 levels is advised. Kidney function should also be monitored, as Metformin can accumulate in renal impairment. Prolonged use may increase the risk of hypoglycemia, especially in elderly patients. Regular follow-up with your doctor is essential to adjust the dose and monitor for complications.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the cornerstone of diabetes management and can complement medicine.
Evidence: Well-establishedDPP-4 inhibitors, SGLT2 inhibitors, or GLP-1 receptor agonists may be alternatives based on individual needs.
Evidence: Well-establishedMay be required if oral agents are not sufficient to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
People with diabetes are at higher risk of infections. Ensure you are up to date with vaccinations, including influenza, pneumococcal, and hepatitis B vaccines. Consult your doctor about the best timing for vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the timing of your dose. Store at room temperature and avoid leaving it in a hot car. Check customs regulations for carrying prescription medicines to your destination. Always carry a fast-acting source of sugar in case of hypoglycemia.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within a few hours, but it may take several weeks to see the full effect on your HbA1c levels.
A: It depends on the severity of your kidney disease. Your doctor will check your kidney function and may adjust the dose or choose a different medicine.
A: Treat it immediately with a fast-acting source of sugar, such as glucose tablets, candy, or fruit juice. If symptoms persist, seek medical help.
🤔 Common Patient Concerns
🔄 Substitutes for gliclastar-m 60 tablet
View AllAlternative brands with exact same active ingredient:
-
zilmet 60 mg/500 mg tabletFDC Ltd ₹38.34 11.1% CHEAPER
-
glychek-m 60mg/500mg tabletIndoco Remedies Ltd ₹50.25 16.5% COSTLIER
-
stayhappi gliclazide+metformin 60mg/500mg tabletSarvagunaushdhi Pvt Ltd ₹51.56 19.5% COSTLIER
-
glycigon m od 60mg/500mg tabletAristo Pharmaceuticals Pvt Ltd ₹53.43 23.9% COSTLIER
-
exermet gz 60mg/500mg tabletCipla Ltd ₹59.18 37.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps manage blood sugar levels but does not cure diabetes. Lifestyle changes and ongoing medical care are essential. - Myth: You can stop taking this medicine once your sugar levels are normal.
Fact: Diabetes is a chronic condition. Stopping medicine without medical advice can cause blood sugar to rise again and lead to complications. - Myth: This medicine causes kidney damage.
Fact: Metformin is excreted by the kidneys and can accumulate if kidney function is poor, but it does not directly damage the kidneys. Regular monitoring is important.
🔄 Alternative Options
Generic Alternatives
- Gliclazide 60 mg + Metformin 500 mg tablet