Diabend-Mex 30 Tablet ER: Complete Guide to Uses, Side Effects, and Dosage
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Muscle pain, trouble breathing, stomach pain, or extreme weakness (possible lactic acidosis)
- Severe hypoglycemia symptoms: confusion, seizures, loss of consciousness
- Severe abdominal pain radiating to the back (possible pancreatitis)
- Skin rash with blisters or peeling (possible serious skin reaction)
- Yellowing of skin or eyes, dark urine (possible liver problem)
- Decreased urine output or swelling in legs (possible kidney problem)
- Persistent nausea, vomiting, or diarrhea leading to dehydration
If experiencing severe symptoms, call emergency services immediately.
What is gliclastar-m 30 tablet used for?
This medicine is a combination of gliclazide and metformin used to treat type 2 diabetes. It helps lower blood sugar by increasing insulin release and improving insulin sensitivity. It is taken once daily with a meal.
- Generic Name: Gliclazide (30mg) + Metformin (500mg)
- Manufacturer: Zinnia Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 gliclastar-m 30 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए इस्तेमाल की जाती है। इसमें ग्लिक्लाजाइड और मेटफॉर्मिन दो दवाएं होती हैं। ग्लिक्लाजाइड शरीर में इंसुलिन बनाने में मदद करती है, जबकि मेटफॉर्मिन शरीर में शुगर के स्तर को कम करती है और इंसुलिन के प्रति संवेदनशीलता बढ़ाती है। यह दवा उन लोगों के लिए है जिनका ब्लड शुगर सिर्फ डाइट और एक दवा से कंट्रोल नहीं हो पाता। इसे हमेशा खाने के साथ लेना चाहिए। इस दवा को डॉक्टर की सलाह के बिना बंद न करें।
साइड इफेक्ट्स: इस दवा के आम साइड इफेक्ट्स में जी मिचलाना, दस्त, पेट में गड़बड़ी, मुंह में धातु जैसा स्वाद और सिरदर्द शामिल हैं। कभी-कभी ब्लड शुगर बहुत कम हो सकता है, जिससे कंपकंपी, पसीना, घबराहट और भूख लग सकती है। दुर्लभ मामलों में लैक्टिक एसिडोसिस हो सकता है, जिसमें मांसपेशियों में दर्द, सांस लेने में तकलीफ और बहुत थकान होती है। अगर ऐसे लक्षण दिखें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा खाने के साथ लें। खाना न छोड़ें। शराब बिल्कुल न पिएं क्योंकि इससे ब्लड शुगर बहुत कम हो सकता है और लैक्टिक एसिडोसिस का खतरा बढ़ सकता है। अपने ब्लड शुगर की नियमित जांच करें। अगर आपको किडनी या लिवर की बीमारी है तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के दवा बंद न करें।
💊 gliclastar-m 30 tablet Uses & Benefits
- [{"condition":"Type 2 diabetes mellitus (add-on therapy)","description":"Used when diet, exercise, and a single oral antidiabetic drug do not provide adequate glycemic control.
- This fixed-dose combination targets both insulin secretion and insulin resistance.","evidence":"Well-established"},{"condition":"Type 2 diabetes mellitus (initial combination therapy)","description":"May be prescribed as initial therapy in patients with significantly elevated HbA1c who are unlikely to reach target with a single agent.","evidence":"Established"}]
Off-label uses: [{"condition":"Polycystic ovary syndrome (PCOS)","description":"Metformin component is sometimes used off-label to improve insulin sensitivity and menstrual regularity in PCOS, but the gliclazide component is not standard for this use.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Insulin resistance, Metabolic syndrome
📋 Drug Information
| Generic Name(s) | Gliclazide (30mg) + Metformin (500mg) |
| Brand Name | gliclastar-m 30 tablet |
| Manufacturer | Zinnia Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. Guidelines generally recommend metformin as first-line therapy for type 2 diabetes, with sulfonylureas as add-on options. Fixed-dose combinations may be used to improve adherence. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for type 2 diabetes recommend individualized therapy based on patient factors. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two oral antidiabetic agents with complementary mechanisms. Gliclazide, a second-generation sulfonylurea, binds to ATP-sensitive potassium channels on pancreatic beta cells, causing depolarization and calcium influx that triggers insulin release. Metformin, a biguanide, decreases hepatic glucose production, reduces intestinal glucose absorption, and improves peripheral insulin sensitivity by activating AMP-activated protein kinase. The extended-release formulation of metformin provides slower absorption, improving gastrointestinal tolerability and allowing once-daily dosing.
Mechanism Steps
💡 How to Take gliclastar-m 30 tablet
Strength: Extended-release tablet containing gliclazide 30 mg and metformin hydrochloride 500 mg.
Dosage Information
| Adult Dosage | The usual starting dose is one tablet of gliclazide 30 mg and metformin 500 mg extended-release once daily with breakfast. The dose may be increased gradually based on blood glucose levels, up to a maximum of gliclazide 120 mg and metformin 2000 mg per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concurrent medications. Never adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of gliclazide and metformin. Start with a low dose and titrate slowly. Monitor kidney function closely, as renal impairment is common in the elderly. The risk of hypoglycemia and lactic acidosis is higher. |
| Renal Impairment | This medicine is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). In mild to moderate renal impairment, dose reduction or alternative therapy may be needed. Monitor kidney function regularly. Metformin should be temporarily discontinued before procedures involving iodinated contrast media. |
| Hepatic Impairment | Use with caution in mild to moderate hepatic impairment. Contraindicated in severe hepatic impairment due to increased risk of lactic acidosis and hypoglycemia. Monitor liver function tests. |
| Maximum Daily Dose | The maximum recommended daily dose is gliclazide 120 mg and metformin 2000 mg, but the exact maximum for this fixed-dose combination depends on the specific product and clinical judgment. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of gliclastar-m 30 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Contrast media | Major | |
| Diuretics | Major | |
| Cimetidine | Major | |
| Beta-blockers | Moderate | |
| Corticosteroids | Moderate | |
| ACE inhibitors | Moderate | |
| Fluconazole | Moderate | |
| Rifampicin | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Alcohol
- Contrast media (iodinated)
- Diuretics (e.g., furosemide)
- Cationic drugs (e.g., cimetidine, amiloride)
⚡ Moderate Interactions
- Beta-blockers
- Corticosteroids
- ACE inhibitors
- Fluconazole
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. It can cause severe hypoglycemia by inhibiting glucose production in the liver, and it increases the risk of lactic acidosis, a rare but life-threatening complication of metformin. Even moderate social drinking can be dangerous.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Risk of lactic acidosis with metformin, especially in renal impairment, liver disease, dehydration, or excessive alcohol use.","Hypoglycemia risk with gliclazide, particularly if meals are skipped or alcohol is consumed.","Temporarily discontinue before surgery or contrast imaging.","Monitor kidney function regularly; dose adjustment may be needed.","May cause vitamin B12 deficiency with long-term use; monitor levels.","Avoid in pregnancy and breastfeeding unless clearly needed.","Elderly patients are at higher risk of hypoglycemia and lactic acidosis.","Do not use in patients with severe infections, trauma, or shock."]
🤱 Lactation Safety
Gliclazide is not recommended during breastfeeding due to potential risk of hypoglycemia in the infant. Metformin is excreted in breast milk in small amounts and is generally considered compatible with breastfeeding, but the combination should be used only if the benefit outweighs the risk. Consult your doctor.
💊 Overdose Management
Overdose can cause severe hypoglycemia due to gliclazide and lactic acidosis due to metformin. Symptoms include shakiness, sweating, confusion, rapid heartbeat, and in severe cases, unconsciousness. If overdose is suspected, seek emergency medical help immediately. Treatment includes intravenous glucose for hypoglycemia and supportive care. Hemodialysis may be considered for metformin removal in severe lactic acidosis.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember with a meal. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you miss multiple doses, contact your doctor for advice.
Additional Safety Advice
Always take this medicine with a meal to reduce stomach upset and the risk of low blood sugar. Do not skip meals while on this medicine. Avoid alcohol completely because it can cause dangerous hypoglycemia and increase the risk of lactic acidosis. Check your blood sugar regularly as advised by your doctor. Inform your doctor if you have kidney or liver problems, as the dose may need adjustment or this medicine may not be suitable for you. Stop this medicine and seek immediate medical help if you experience symptoms of lactic acidosis such as muscle pain, trouble breathing, stomach pain, or extreme weakness. Do not take this medicine if you are dehydrated, have a severe infection, or are scheduled for surgery or contrast imaging; your doctor may advise temporary discontinuation. Keep this medicine out of reach of children. Do not share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of hypoglycemia and lactic acidosis. Start with a low dose and titrate slowly. Monitor kidney function closely. Avoid alcohol. Ensure adequate nutrition and hydration.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before conception. This medicine is generally not recommended during pregnancy. Insulin is the preferred treatment for diabetes during pregnancy. Your doctor will adjust your treatment plan.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily stopped before surgery due to the risk of lactic acidosis and hypoglycemia. Your doctor will advise when to restart. Monitor blood sugar closely during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. If you are unable to eat after a dental procedure, contact your doctor as your dose may need adjustment to prevent hypoglycemia.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar. If you exercise vigorously, check your blood sugar before and after. Carry a fast-acting sugar source in case of hypoglycemia. Stay hydrated. Consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause low blood sugar, which can affect your ability to drive or operate machinery. Be cautious until you know how this medicine affects you. Keep a fast-acting sugar source with you at work. Inform your employer about your diabetes and treatment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects like lactic acidosis or severe hypoglycemia, seek immediate medical help. Your doctor may stop the medicine temporarily before surgery or contrast imaging. Long-term discontinuation should be decided by your doctor based on your overall health and blood sugar control.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring of blood sugar, kidney function, and vitamin B12 levels. Metformin can cause vitamin B12 deficiency over time, which may lead to anemia or nerve damage. Gliclazide can lose effectiveness over time as diabetes progresses. Weight gain and hypoglycemia are possible with long-term sulfonylurea use. Regular follow-up with your doctor is essential to adjust therapy as needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the foundation of diabetes management and can reduce the need for medication.
Evidence: Well-establishedDPP-4 inhibitors, SGLT2 inhibitors, or GLP-1 receptor agonists may be alternatives based on patient factors.
Evidence: Well-establishedMay be needed if oral agents fail to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
People with diabetes are at higher risk of infections. Ensure you are up to date with influenza, pneumococcal, and hepatitis B vaccines. Consult your doctor about vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid temperature extremes. If traveling across time zones, consult your doctor about adjusting the timing of your dose. Store at room temperature and protect from moisture. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within a few hours, but it may take several weeks to see the full effect on your overall blood sugar control. Your doctor will monitor your HbA1c every 3 to 6 months.
A: It depends on the severity of your kidney disease. This medicine is contraindicated in severe kidney impairment. Your doctor will check your kidney function and may adjust the dose or choose a different medicine.
A: If you feel shaky, sweaty, or confused, check your blood sugar if possible. If it is low, eat or drink something sugary like glucose tablets, candy, or fruit juice. If you become unconscious, seek emergency help immediately.
🤔 Common Patient Concerns
🔄 Substitutes for gliclastar-m 30 tablet
View AllAlternative brands with exact same active ingredient:
-
zilmet 30mg/500mg tabletFDC Ltd ₹26.90 11.7% CHEAPER
-
glyciday m 30mg/500mg tabletBeats Pharmaceuticals ₹46.88 53.9% COSTLIER
-
exermet gz 30mg/500mg tabletCipla Ltd ₹47.08 54.5% COSTLIER
-
walformin od 30 tablet erWallace Pharmaceuticals Pvt Ltd ₹47.77 56.8% COSTLIER
-
bytey m 30mg/500mg tablet srArrient Healthcare Pvt Ltd ₹54.19 77.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. It must be continued along with diet and exercise. - Myth: You can stop this medicine once your sugar levels are normal.
Fact: Blood sugar levels may be normal because of the medicine. Stopping it without medical advice can cause sugar levels to rise again. - Myth: This medicine causes kidney damage.
Fact: Metformin is excreted by the kidneys but does not directly damage them. However, it should be used with caution in kidney disease. - Myth: Taking this medicine means you can eat anything.
Fact: Diet and exercise are essential for managing diabetes. This medicine works best when combined with a healthy lifestyle.
🔄 Alternative Options
Generic Alternatives
- Gliclazide 30 mg + Metformin 500 mg extended-release tablet (various manufacturers)
Brand Alternatives
- Diabend-Mex 30 Tablet ER