Nexpro RD 40 Capsule SR: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe chest pain or irregular heartbeat
- Difficulty breathing or swelling of face, lips, or throat
- Blood in vomit or black, tarry stools
- Severe abdominal pain or persistent vomiting
- Yellowing of skin or eyes (jaundice)
- Decreased urine output or swelling in legs
- Uncontrollable muscle spasms or tremors
- Severe diarrhea with fever or abdominal cramps
If experiencing severe symptoms, call emergency services immediately.
What is gasgocid d 30mg/40mg capsule sr used for?
This medicine is a combination of Domperidone and Esomeprazole used to treat acid reflux with nausea. It works by reducing stomach acid and improving gastric emptying. It is usually taken once daily before breakfast.
- Generic Name: Domperidone (30mg) + Esomeprazole (40mg)
- Manufacturer: Aroma Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 gasgocid d 30mg/40mg capsule sr के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन और एसोमेप्राजोल का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, गैस्ट्रोएसोफेगल रिफ्लक्स रोग (GERD), अपच, और मतली व उल्टी के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पेट खाली होने की प्रक्रिया को तेज करती है। यह दवा आमतौर पर नाश्ते से पहले खाली पेट ली जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, दस्त, मतली, पेट दर्द, गैस, मुंह सूखना और चक्कर आना शामिल हैं। कुछ गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, स्तन में दर्द या सूजन, और मांसपेशियों में अकड़न हो सकती है। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। कैप्सूल को चबाएं या तोड़ें नहीं, पूरा निगलें। इसे खाली पेट, भोजन से 30-60 मिनट पहले लें। शराब का सेवन न करें। यदि आपको चक्कर आते हैं तो वाहन न चलाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बिना डॉक्टर की सलाह के लंबे समय तक इसका सेवन न करें।
💊 gasgocid d 30mg/40mg capsule sr Uses & Benefits
[{"condition":"Gastroesophageal reflux disease (GERD) with nausea","description":"This medicine helps reduce acid reflux and associated nausea by combining acid suppression with improved gastric emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"It relieves symptoms of upper abdominal discomfort, early satiety, and postprandial fullness by enhancing gastric motility and reducing acid.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with acid-related disorders","description":"Domperidone component helps control nausea and vomiting, while esomeprazole treats the underlying acid condition.","evidence":"Moderate"},{"condition":"Gastroparesis with acid reflux","description":"May be used to improve gastric emptying and reduce acid exposure in patients with delayed stomach emptying.","evidence":"Limited"}]
Off-label uses: [{"condition":"Refractory nausea in palliative care","description":"Sometimes prescribed off-label for nausea not responding to other treatments, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Gastroesophageal reflux disease (GERD) with nausea
Also treats: Functional dyspepsia, Gastroparesis, Nausea and vomiting associated with acid-related disorders
📋 Drug Information
| Generic Name(s) | Domperidone (30mg) + Esomeprazole (40mg) |
| Brand Name | gasgocid d 30mg/40mg capsule sr |
| Manufacturer | Aroma Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and the gastrointestinal tract, thereby enhancing gastric motility and accelerating gastric emptying without significant central nervous system effects. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme in gastric parietal cells, blocking the final step of acid production. Together, they reduce acid-related symptoms and improve upper gastrointestinal motility.
Mechanism Steps
💡 How to Take gasgocid d 30mg/40mg capsule sr
Strength: Sustained-release capsule containing Domperidone 30 mg and Esomeprazole 40 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one capsule of this medicine taken orally once daily on an empty stomach, at least 30 to 60 minutes before breakfast, or as directed by your doctor. The dose may be adjusted based on your condition and response to treatment. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially cardiac effects and electrolyte disturbances. Dose adjustment may be necessary based on renal and hepatic function. Regular monitoring is advised. |
| Renal Impairment | Dose adjustment may be required in patients with severe renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Dose adjustment may be required in patients with hepatic impairment. This medicine is contraindicated in severe hepatic impairment. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is one capsule (Domperidone 30 mg + Esomeprazole 40 mg) per day. Do not exceed this dose unless directed by a doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of gasgocid d 30mg/40mg capsule sr
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Warfarin | Major | |
| Methotrexate | Major | |
| Rifampicin | Major | |
| Atazanavir | Major | |
| Diazepam | Moderate | |
| Phenytoin | Moderate | |
| Citalopram | Moderate | |
| Furosemide | Moderate | |
| Clopidogrel | Moderate |
🚨 Major Interactions
- Ketoconazole, itraconazole, clarithromycin
- Warfarin
- Methotrexate
- Rifampicin
- Atazanavir, nelfinavir
⚡ Moderate Interactions
- Diazepam
- Phenytoin
- Citalopram, escitalopram
- Diuretics (e.g., furosemide)
- Clopidogrel
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding, worsen acid reflux, and may exacerbate side effects such as dizziness and drowsiness. It can also interfere with the effectiveness of esomeprazole.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to domperidone, esomeprazole, or any component of the formulation","Severe heart failure, known QT prolongation, or congenital long QT syndrome","Concurrent use with QT-prolonging drugs or potent CYP3A4 inhibitors","Gastrointestinal bleeding, mechanical obstruction, or perforation","Severe hepatic impairment","Moderate to severe renal impairment (for domperidone component)","Prolactin-releasing pituitary tumor (prolactinoma)","Breastfeeding"]
⚠️ Warnings & Precautions
["Use with caution in patients with cardiovascular disease or electrolyte imbalances.","May cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Long-term use may lead to low magnesium and vitamin B12 levels; periodic monitoring is advised.","May increase the risk of bone fractures with prolonged use.","Not recommended for children unless prescribed by a pediatrician.","Elderly patients may be more sensitive to side effects; dose adjustment may be needed.","Inform your doctor if you have kidney or liver disease before taking this medicine.","Do not use for longer than prescribed without medical supervision."]
🤱 Lactation Safety
Domperidone is excreted in breast milk and may cause side effects in the infant. Esomeprazole is also excreted in breast milk. This medicine is not recommended during breastfeeding unless clearly needed and advised by a doctor.
💊 Overdose Management
Overdose of this medicine may cause severe drowsiness, extrapyramidal symptoms, hypotension, and cardiac arrhythmias. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be considered if ingestion is recent. Monitor vital signs and ECG closely.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the sustained-release capsules; swallow them whole with water. It is best taken on an empty stomach, at least 30 to 60 minutes before a meal, unless your doctor advises otherwise. Avoid alcohol while taking this medicine, as it may increase the risk of stomach bleeding and worsen side effects. Do not drive or operate heavy machinery if you feel dizzy or drowsy after taking this medicine. Inform your doctor about all other medications you are taking, especially blood thinners, antifungals, HIV medications, and antidepressants. Do not use this medicine for longer than recommended without medical supervision. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of the reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of electrolyte imbalances, cardiac arrhythmias, and falls due to dizziness. Dose adjustment and regular monitoring of renal function, electrolytes, and magnesium levels are recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established, and alternative treatments may be considered.
🏥 Post-Surgery Considerations
After surgery, use this medicine only if prescribed by your doctor. It may affect gastric motility and acid secretion, which could impact postoperative recovery. Inform your surgeon about all medications you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may increase the risk of bleeding during dental procedures. Your dentist may recommend temporary discontinuation or additional precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid vigorous activities immediately after meals as they may worsen reflux. If you experience dizziness or palpitations, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually taken once daily before breakfast, so it should not interfere with work if taken as prescribed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms resolve, your doctor may advise tapering or stopping. Abrupt discontinuation of esomeprazole can cause rebound acid hypersecretion.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to low magnesium levels, vitamin B12 deficiency, and an increased risk of bone fractures. It may also mask symptoms of stomach cancer. Periodic monitoring of magnesium, vitamin B12, and bone health is advised. Use the lowest effective dose for the shortest duration necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Avoiding trigger foods, eating smaller meals, and elevating the head of the bed can help manage GERD symptoms.
Evidence: Well-establishedH2 blockers or other proton pump inhibitors may be alternatives if this combination is not suitable.
Evidence: Well-establishedIf acid suppression is not needed, domperidone alone may be used for nausea and gastroparesis.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medication.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the dosing schedule. Keep it in your carry-on luggage to avoid loss. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Domperidone starts relieving nausea within 30-60 minutes, while esomeprazole begins suppressing acid within 1 hour. Full effects may take 1-4 days.
A: It is best taken on an empty stomach, at least 30-60 minutes before a meal, to maximize absorption.
A: Consult your doctor. The safety of this combination during pregnancy is not well established.
A: Common side effects include headache, diarrhea, nausea, abdominal pain, and dizziness.
A: Do not stop without consulting your doctor, as abrupt discontinuation may cause rebound acid hypersecretion.
🤔 Common Patient Concerns
🔄 Substitutes for gasgocid d 30mg/40mg capsule sr
View AllAlternative brands with exact same active ingredient:
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eszone d 30mg/40mg capsule srZeelab Pharmacy Pvt Ltd ₹24.00 84.5% CHEAPER
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davaindia domperidone+esomeprazole 30mg/40mg capsule srDavaindia Generic Pharmacy ₹28.00 81.9% CHEAPER
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StayHappi Domperidone+Esomeprazole 30mg/40mg CapsuleSarvagunaushdhi Pvt Ltd ₹33.75 78.2% CHEAPER
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ranidom o nf 30 mg/40 mg tabletMankind Pharma Ltd ₹41.18 73.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken anytime.
Fact: It should be taken on an empty stomach before a meal for best effect. - Myth: It is safe to take indefinitely.
Fact: Long-term use requires medical supervision due to potential side effects. - Myth: It can be crushed for easier swallowing.
Fact: Capsules should be swallowed whole; crushing may affect release and efficacy.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Esomeprazole generic capsules
Brand Alternatives
- Nexpro RD 40 Capsule SR