gasgocid d 30mg/40mg capsule sr - Domperidone (30mg) + Esomeprazole (40mg) medicine

Nexpro RD 40 Capsule SR: Complete Medicine Guide

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🏭 Aroma Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 24, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Moderate
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe chest pain or irregular heartbeat
  • Difficulty breathing or swelling of face, lips, or throat
  • Blood in vomit or black, tarry stools
  • Severe abdominal pain or persistent vomiting
  • Yellowing of skin or eyes (jaundice)
  • Decreased urine output or swelling in legs
  • Uncontrollable muscle spasms or tremors
  • Severe diarrhea with fever or abdominal cramps

If experiencing severe symptoms, call emergency services immediately.

What is gasgocid d 30mg/40mg capsule sr used for?

This medicine is a combination of Domperidone and Esomeprazole used to treat acid reflux with nausea. It works by reducing stomach acid and improving gastric emptying. It is usually taken once daily before breakfast.

  • Generic Name: Domperidone (30mg) + Esomeprazole (40mg)
  • Manufacturer: Aroma Healthcare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 gasgocid d 30mg/40mg capsule sr के बारे में (Hindi Summary)

उपयोग: यह दवा डोम्पेरिडोन और एसोमेप्राजोल का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, गैस्ट्रोएसोफेगल रिफ्लक्स रोग (GERD), अपच, और मतली व उल्टी के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पेट खाली होने की प्रक्रिया को तेज करती है। यह दवा आमतौर पर नाश्ते से पहले खाली पेट ली जाती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, दस्त, मतली, पेट दर्द, गैस, मुंह सूखना और चक्कर आना शामिल हैं। कुछ गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, स्तन में दर्द या सूजन, और मांसपेशियों में अकड़न हो सकती है। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। कैप्सूल को चबाएं या तोड़ें नहीं, पूरा निगलें। इसे खाली पेट, भोजन से 30-60 मिनट पहले लें। शराब का सेवन न करें। यदि आपको चक्कर आते हैं तो वाहन न चलाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बिना डॉक्टर की सलाह के लंबे समय तक इसका सेवन न करें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 gasgocid d 30mg/40mg capsule sr Uses & Benefits

[{"condition":"Gastroesophageal reflux disease (GERD) with nausea","description":"This medicine helps reduce acid reflux and associated nausea by combining acid suppression with improved gastric emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"It relieves symptoms of upper abdominal discomfort, early satiety, and postprandial fullness by enhancing gastric motility and reducing acid.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with acid-related disorders","description":"Domperidone component helps control nausea and vomiting, while esomeprazole treats the underlying acid condition.","evidence":"Moderate"},{"condition":"Gastroparesis with acid reflux","description":"May be used to improve gastric emptying and reduce acid exposure in patients with delayed stomach emptying.","evidence":"Limited"}]

Off-label uses: [{"condition":"Refractory nausea in palliative care","description":"Sometimes prescribed off-label for nausea not responding to other treatments, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Gastroesophageal reflux disease (GERD) with nausea

Also treats: Functional dyspepsia, Gastroparesis, Nausea and vomiting associated with acid-related disorders

📋 Drug Information

Generic Name(s)Domperidone (30mg) + Esomeprazole (40mg)
Brand Namegasgocid d 30mg/40mg capsule sr
ManufacturerAroma Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine on an empty stomach, at least 30 minutes before breakfast, for maximum effectiveness.
2
Swallow the capsule whole; do not crush or chew it, as this can affect the sustained-release properties.
3
Avoid alcohol while taking this medicine to reduce the risk of stomach bleeding and other side effects.
4
Do not use this medicine for longer than prescribed without consulting your doctor, as long-term use may cause nutrient deficiencies.
5
Inform your doctor if you have heart rhythm problems, kidney or liver disease, or are taking other medications.
6
Report any unusual symptoms such as palpitations, muscle stiffness, or severe diarrhea immediately.
7
If you miss a dose, take it as soon as you remember, but skip it if it's almost time for the next dose.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Heartburn
This medicine is commonly prescribed for this.
Likely Use
Nausea
Domperidone component helps relieve nausea.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary
Headache
This medicine is not indicated for headache.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDomperidone is rapidly absorbed after oral administration, with peak plasma levels occurring within 30 to 60 minutes. Esomeprazole is also rapidly absorbed, with peak plasma concentrations achieved within 1 to 2 hours. The sustained-release formulation may alter the absorption profile to provide prolonged effect.
DistributionDomperidone is widely distributed in body tissues but does not readily cross the blood-brain barrier. Esomeprazole is distributed extensively into tissues, with a volume of distribution of approximately 0.22 L/kg.
Protein BindingDomperidone is approximately 91-93% bound to plasma proteins. Esomeprazole is about 97% bound to plasma proteins.
MetabolismDomperidone undergoes extensive first-pass metabolism in the liver via CYP3A4 and CYP1A2 enzymes. Esomeprazole is metabolized in the liver by CYP2C19 and CYP3A4 enzymes.
Half-LifeDomperidone has an elimination half-life of approximately 7 hours. Esomeprazole has a plasma elimination half-life of about 1 to 1.5 hours.
ExcretionDomperidone is excreted mainly in the feces (about 66%) and urine (about 33%). Esomeprazole is excreted primarily as metabolites in urine (about 80%) and feces (about 20%).
BioavailabilityDomperidone has a bioavailability of approximately 13-17% due to first-pass metabolism. Esomeprazole has a bioavailability of about 64% after a single dose and increases to about 89% with repeated dosing.
Onset of ActionDomperidone begins to relieve nausea within 30 to 60 minutes. Esomeprazole starts suppressing acid within 1 hour, but maximum effect may take 1 to 4 days of regular use.
Peak Plasma TimeDomperidone: 30-60 minutes; Esomeprazole: 1-2 hours.
Duration of ActionDomperidone: approximately 6-8 hours; Esomeprazole: acid suppression lasts up to 24 hours.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and the gastrointestinal tract, thereby enhancing gastric motility and accelerating gastric emptying without significant central nervous system effects. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme in gastric parietal cells, blocking the final step of acid production. Together, they reduce acid-related symptoms and improve upper gastrointestinal motility.

Mechanism Steps

1
Domperidone blocks dopamine D2 receptors: Domperidone antagonizes dopamine D2 receptors in the chemoreceptor trigger zone and the gastrointestinal tract, which reduces nausea and vomiting and enhances gastric motility.
2
Enhanced gastric emptying: By blocking D2 receptors, domperidone increases the tone of the lower esophageal sphincter and promotes coordinated gastric contractions, leading to faster stomach emptying.
3
Esomeprazole inhibits proton pumps: Esomeprazole accumulates in the acidic environment of gastric parietal cells and irreversibly binds to the H+/K+ ATPase enzyme, blocking the final step of acid secretion.
4
Reduced gastric acid secretion: The inhibition of proton pumps leads to a significant reduction in both basal and stimulated acid production, alleviating acid-related symptoms.
5
Combined symptomatic relief: The dual action of improved motility and acid suppression provides comprehensive relief from nausea, vomiting, heartburn, and dyspepsia.

💡 How to Take gasgocid d 30mg/40mg capsule sr

Strength: Sustained-release capsule containing Domperidone 30 mg and Esomeprazole 40 mg.

1Take this medicine at least 30 to 60 minutes before a meal, preferably breakfast.
2Swallow the capsule whole with a glass of water. Do not crush, chew, or break it.
3Do not take with food unless your doctor advises otherwise.
4Take it at the same time each day to maintain consistent levels.
5If you miss a dose, follow the missed dose instructions.
6Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose is one capsule of this medicine taken orally once daily on an empty stomach, at least 30 to 60 minutes before breakfast, or as directed by your doctor. The dose may be adjusted based on your condition and response to treatment. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially cardiac effects and electrolyte disturbances. Dose adjustment may be necessary based on renal and hepatic function. Regular monitoring is advised.
Renal ImpairmentDose adjustment may be required in patients with severe renal impairment. Consult your doctor for individualized dosing.
Hepatic ImpairmentDose adjustment may be required in patients with hepatic impairment. This medicine is contraindicated in severe hepatic impairment. Consult your doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is one capsule (Domperidone 30 mg + Esomeprazole 40 mg) per day. Do not exceed this dose unless directed by a doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take on an empty stomach
Food may reduce absorption of esomeprazole.
Grapefruit
Avoid
May increase domperidone levels and side effects.
Alcohol
Avoid
Increases risk of stomach bleeding and worsens side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of gasgocid d 30mg/40mg capsule sr

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent or severe.
Diarrhea (Common (5-10%))
Stay hydrated. Consult doctor if diarrhea persists beyond 2 days.
Nausea (Common (5-10%))
Take with food if advised. Consult doctor if it worsens.
Abdominal pain (Common (5-10%))
Usually transient. Consult doctor if severe or persistent.
Flatulence (Common (5-10%))
May reduce with dietary adjustments. Consult doctor if bothersome.
Dry mouth (Common (5-10%))
Sip water frequently. Consult doctor if it interferes with eating.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.

🚨 Serious Side Effects

Irregular heartbeat (QT prolongation) (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations, fainting, or shortness of breath.
Extrapyramidal symptoms (Rare (<0.1%))
Report muscle stiffness, tremor, or difficulty speaking to your doctor immediately.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Call emergency services if you develop rash, swelling of face/lips/throat, or difficulty breathing.
Clostridium difficile-associated diarrhea (Rare (<0.1%))
Seek medical attention if you have persistent watery diarrhea, fever, or abdominal cramps.
Hypomagnesemia (Uncommon (0.1-1%))
Report muscle cramps, tremors, or seizures to your doctor. Periodic monitoring may be needed.

⚠️ Rare Side Effects

Breast enlargement or tenderness (gynecomastia)
Consult your doctor; dose adjustment or alternative may be needed.
Galactorrhea (unusual milk secretion)
Report to your doctor for evaluation.
Liver enzyme elevation
Periodic liver function tests may be advised. Report jaundice or dark urine.
Interstitial nephritis
Seek medical attention if you experience decreased urine output or swelling.
Severe skin reactions (Stevens-Johnson syndrome)
Stop the medicine and seek emergency care if you develop rash, blisters, or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Warfarin Major
Methotrexate Major
Rifampicin Major
Atazanavir Major
Diazepam Moderate
Phenytoin Moderate
Citalopram Moderate
Furosemide Moderate
Clopidogrel Moderate

🚨 Major Interactions

  • Ketoconazole, itraconazole, clarithromycin
  • Warfarin
  • Methotrexate
  • Rifampicin
  • Atazanavir, nelfinavir

⚡ Moderate Interactions

  • Diazepam
  • Phenytoin
  • Citalopram, escitalopram
  • Diuretics (e.g., furosemide)
  • Clopidogrel

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding, worsen acid reflux, and may exacerbate side effects such as dizziness and drowsiness. It can also interfere with the effectiveness of esomeprazole.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to domperidone, esomeprazole, or any component of the formulation","Severe heart failure, known QT prolongation, or congenital long QT syndrome","Concurrent use with QT-prolonging drugs or potent CYP3A4 inhibitors","Gastrointestinal bleeding, mechanical obstruction, or perforation","Severe hepatic impairment","Moderate to severe renal impairment (for domperidone component)","Prolactin-releasing pituitary tumor (prolactinoma)","Breastfeeding"]

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular disease or electrolyte imbalances.","May cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Long-term use may lead to low magnesium and vitamin B12 levels; periodic monitoring is advised.","May increase the risk of bone fractures with prolonged use.","Not recommended for children unless prescribed by a pediatrician.","Elderly patients may be more sensitive to side effects; dose adjustment may be needed.","Inform your doctor if you have kidney or liver disease before taking this medicine.","Do not use for longer than prescribed without medical supervision."]

🤱 Lactation Safety

Domperidone is excreted in breast milk and may cause side effects in the infant. Esomeprazole is also excreted in breast milk. This medicine is not recommended during breastfeeding unless clearly needed and advised by a doctor.

💊 Overdose Management

Overdose of this medicine may cause severe drowsiness, extrapyramidal symptoms, hypotension, and cardiac arrhythmias. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be considered if ingestion is recent. Monitor vital signs and ECG closely.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the sustained-release capsules; swallow them whole with water. It is best taken on an empty stomach, at least 30 to 60 minutes before a meal, unless your doctor advises otherwise. Avoid alcohol while taking this medicine, as it may increase the risk of stomach bleeding and worsen side effects. Do not drive or operate heavy machinery if you feel dizzy or drowsy after taking this medicine. Inform your doctor about all other medications you are taking, especially blood thinners, antifungals, HIV medications, and antidepressants. Do not use this medicine for longer than recommended without medical supervision. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of the reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of electrolyte imbalances, cardiac arrhythmias, and falls due to dizziness. Dose adjustment and regular monitoring of renal function, electrolytes, and magnesium levels are recommended.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established, and alternative treatments may be considered.

🏥 Post-Surgery Considerations

After surgery, use this medicine only if prescribed by your doctor. It may affect gastric motility and acid secretion, which could impact postoperative recovery. Inform your surgeon about all medications you are taking.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may increase the risk of bleeding during dental procedures. Your dentist may recommend temporary discontinuation or additional precautions.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce pressure on the stomach.
🥗
Avoid lying down immediately after meals; wait at least 2-3 hours.
😴
Elevate the head of your bed by 6-8 inches to reduce nighttime reflux.
💧
Eat smaller, more frequent meals instead of large ones.
🧘
Avoid trigger foods such as spicy, fatty, or acidic foods.
🌞
Quit smoking and limit alcohol consumption.
🚭
Practice stress-reducing techniques like yoga or meditation.

🏋️ Exercise Considerations

Moderate exercise is generally safe, but avoid vigorous activities immediately after meals as they may worsen reflux. If you experience dizziness or palpitations, stop exercising and consult your doctor.

🥗 Diet Recommendations

Include high-fiber foods like fruits, vegetables, and whole grains.
Choose lean proteins such as chicken, fish, and tofu.
Avoid spicy, fatty, and fried foods.
Limit caffeine and carbonated beverages.
Stay well hydrated with water throughout the day.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually taken once daily before breakfast, so it should not interfere with work if taken as prescribed.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms resolve, your doctor may advise tapering or stopping. Abrupt discontinuation of esomeprazole can cause rebound acid hypersecretion.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to low magnesium levels, vitamin B12 deficiency, and an increased risk of bone fractures. It may also mask symptoms of stomach cancer. Periodic monitoring of magnesium, vitamin B12, and bone health is advised. Use the lowest effective dose for the shortest duration necessary.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Dietary and lifestyle modifications

Avoiding trigger foods, eating smaller meals, and elevating the head of the bed can help manage GERD symptoms.

Evidence: Well-established
Other acid-suppressing medications

H2 blockers or other proton pump inhibitors may be alternatives if this combination is not suitable.

Evidence: Well-established
Prokinetic agents alone

If acid suppression is not needed, domperidone alone may be used for nausea and gastroparesis.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medication.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the dosing schedule. Keep it in your carry-on luggage to avoid loss. Check local customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old man with chronic acid reflux and nausea
He was prescribed this medicine once daily before breakfast. After two weeks, his heartburn and nausea significantly improved. He noted that taking it on an empty stomach was key to its effectiveness.
💡 Lesson: Consistent timing on an empty stomach enhances the medicine's efficacy.
👤 A 60-year-old woman with functional dyspepsia
She experienced bloating and early fullness after meals. Her doctor prescribed this medicine, and within a month, her symptoms reduced. She was advised to avoid alcohol and to monitor for any cardiac symptoms.
💡 Lesson: Combining medication with lifestyle changes improves outcomes in dyspepsia.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Domperidone starts relieving nausea within 30-60 minutes, while esomeprazole begins suppressing acid within 1 hour. Full effects may take 1-4 days.

Q: Can I take it with food?

A: It is best taken on an empty stomach, at least 30-60 minutes before a meal, to maximize absorption.

Q: Is it safe during pregnancy?

A: Consult your doctor. The safety of this combination during pregnancy is not well established.

Q: What are the common side effects?

A: Common side effects include headache, diarrhea, nausea, abdominal pain, and dizziness.

Q: Can I stop taking it suddenly?

A: Do not stop without consulting your doctor, as abrupt discontinuation may cause rebound acid hypersecretion.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for gasgocid d 30mg/40mg capsule sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken anytime.
    Fact: It should be taken on an empty stomach before a meal for best effect.
  • Myth: It is safe to take indefinitely.
    Fact: Long-term use requires medical supervision due to potential side effects.
  • Myth: It can be crushed for easier swallowing.
    Fact: Capsules should be swallowed whole; crushing may affect release and efficacy.

🔄 Alternative Options

Generic Alternatives

  • Domperidone + Esomeprazole generic capsules

Brand Alternatives

  • Nexpro RD 40 Capsule SR

📊 Comparison with Similar Medicines

[{"medicine":"Domperidone + Esomeprazole","composition":"Domperidone 30 mg + Esomeprazole 40 mg","release_type":"Sustained release","usual_frequency":"Once daily"},{"medicine":"Domperidone + Pantoprazole","composition":"Domperidone 30 mg + Pantoprazole 40 mg","release_type":"Sustained release","usual_frequency":"Once daily"},{"medicine":"Domperidone + Rabeprazole","composition":"Domperidone 30 mg + Rabeprazole 20 mg","release_type":"Sustained release","usual_frequency":"Once daily"}]

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