Amrizol-DSR Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe chest pain or difficulty breathing
- Irregular heartbeat or palpitations
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Severe abdominal pain
- Uncontrollable muscle spasms or tremors
If experiencing severe symptoms, call emergency services immediately.
What is davaindia domperidone+esomeprazole 30mg/40mg capsule sr used for?
This medicine is a combination of Domperidone and Esomeprazole used to treat acid reflux and dyspepsia. It works by improving stomach emptying and reducing acid production. It is usually taken once daily before breakfast.
- Generic Name: Domperidone + Esomeprazole
- Manufacturer: Davaindia Generic Pharmacy
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 davaindia domperidone+esomeprazole 30mg/40mg capsule sr के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन और एसोमेप्राजोल का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, हार्टबर्न, अपच और पेट की गैस जैसी समस्याओं के इलाज के लिए किया जाता है। यह पेट में एसिड का उत्पादन कम करती है और पेट खाली होने की गति को बढ़ाती है, जिससे जी मिचलाना और पेट फूलना कम होता है। इसे आमतौर पर नाश्ते से 30-60 मिनट पहले खाली पेट लिया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, दस्त, मतली, पेट दर्द, गैस और मुँह सूखना शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, स्तनों में सूजन या दर्द, और मांसपेशियों में अकड़न शामिल हो सकते हैं। यदि आपको कोई भी असामान्य लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे चबाएं या तोड़ें नहीं, पूरा निगल लें। इसे सुबह नाश्ते से 30-60 मिनट पहले खाली पेट लेना सबसे अच्छा है। इस दवा के साथ शराब न लें, क्योंकि इससे पेट में जलन और दुष्प्रभाव बढ़ सकते हैं। यदि आपको चक्कर या नींद आती है, तो वाहन न चलाएं। यदि आपको दिल की धड़कन में गड़बड़ी, पैरों में सूजन, या पीलिया जैसे लक्षण दिखें, तो तुरंत डॉक्टर से मिलें।
💊 davaindia domperidone+esomeprazole 30mg/40mg capsule sr Uses & Benefits
[{"condition":"Gastroesophageal reflux disease (GERD)","description":"Reduces acid reflux and heartburn by decreasing stomach acid production and improving gastric emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Relieves upper abdominal discomfort, bloating, and early fullness by enhancing gastric motility and reducing acid.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with gastroparesis","description":"Domperidone component helps to accelerate stomach emptying and reduce nausea.","evidence":"Moderate"},{"condition":"Peptic ulcer disease","description":"Esomeprazole heals ulcers by suppressing acid secretion; Domperidone may help with associated dysmotility.","evidence":"Well-established for Esomeprazole component"}]
Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes prescribed off-label to improve gastric emptying in diabetic patients.","evidence":"Limited"},{"condition":"Refractory nausea in palliative care","description":"Occasionally used off-label for nausea not responding to other treatments.","evidence":"Limited"}]
Primary treatment for: Gastroesophageal reflux disease (GERD)
Also treats: Functional dyspepsia, Gastroparesis, Peptic ulcer disease
📋 Drug Information
| Generic Name(s) | Domperidone + Esomeprazole |
| Brand Name | Amrizol-DSR Capsule |
| Manufacturer | Davaindia Generic Pharmacy |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + Proton pump inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and the gastrointestinal tract, leading to enhanced gastric motility and accelerated gastric emptying without significant central nervous system effects. Esomeprazole is a proton pump inhibitor that irreversibly inhibits the H+/K+ ATPase enzyme in gastric parietal cells, thereby suppressing both basal and stimulated acid secretion. The combination provides both prokinetic and acid-suppressive effects, addressing both motility and acid-related symptoms.
Mechanism Steps
💡 How to Take davaindia domperidone+esomeprazole 30mg/40mg capsule sr
Strength: Capsule containing Domperidone 30 mg and Esomeprazole 40 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one capsule taken orally once daily, preferably 30 to 60 minutes before breakfast. However, the dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, age, and renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine. Dose adjustment may be necessary based on renal and hepatic function. Consult a doctor. |
| Renal Impairment | In patients with severe renal impairment (creatinine clearance <30 mL/min), Domperidone is contraindicated. Esomeprazole dose may need adjustment. Consult a doctor. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, no dose adjustment is needed for Esomeprazole. Domperidone is contraindicated in severe hepatic impairment. Consult a doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is one capsule (Domperidone 30 mg + Esomeprazole 40 mg) per day. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of davaindia domperidone+esomeprazole 30mg/40mg capsule sr
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Warfarin | Major | |
| Methotrexate | Major | |
| Atazanavir | Major | |
| Diazepam | Moderate | |
| Phenytoin | Moderate | |
| Clopidogrel | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor | |
| Grapefruit juice | Moderate |
🚨 Major Interactions
- Ketoconazole, Itraconazole, Clarithromycin
- Warfarin
- Methotrexate
- Atazanavir, Nelfinavir
⚡ Moderate Interactions
- Diazepam
- Phenytoin
- Clopidogrel
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach irritation and worsen side effects such as dizziness, drowsiness, and gastrointestinal discomfort. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Domperidone, Esomeprazole, or any component","Prolactin-releasing pituitary tumor (prolactinoma)","Severe hepatic impairment","Known QT prolongation or congenital long QT syndrome","Concomitant use with QT-prolonging drugs or potent CYP3A4 inhibitors","Gastrointestinal obstruction, perforation, or bleeding","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Use with caution in patients with cardiovascular disease or risk factors for QT prolongation.","Avoid in patients with electrolyte imbalances (hypokalemia, hypomagnesemia).","May increase risk of bone fractures with long-term use.","Can mask symptoms of gastric malignancy; rule out malignancy before starting.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Use with caution in elderly patients due to increased risk of side effects.","Do not use for longer than 12 weeks without medical reassessment."]
🤱 Lactation Safety
Domperidone is excreted in breast milk and may cause side effects in the infant. Esomeprazole is also excreted in breast milk but is considered compatible with breastfeeding. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose may cause severe drowsiness, extrapyramidal symptoms, and cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1 hour of ingestion. Monitor ECG and vital signs.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the capsule; swallow it whole with water. It is best taken on an empty stomach, at least 30 to 60 minutes before breakfast, to maximize the effect of Esomeprazole. Avoid alcohol while taking this medicine, as it can worsen stomach irritation and increase the risk of side effects. Do not drive or operate heavy machinery if you feel dizzy or drowsy after taking it. Inform your doctor if you have a history of heart rhythm problems, low magnesium levels, or liver disease. Do not use this medicine for longer than recommended without medical supervision. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of side effects such as QT prolongation, electrolyte imbalances, and falls due to dizziness. Dose adjustment and close monitoring are recommended. Use with caution.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established. Your doctor may recommend alternative treatments.
🏥 Post-Surgery Considerations
After surgery, use this medicine only if prescribed by your surgeon. It may affect gastric motility and acid secretion, which could impact recovery. Inform your surgeon about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may increase the risk of bleeding during dental procedures. Your dentist may recommend temporary discontinuation or monitoring.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid vigorous exercise immediately after taking this medicine, especially if you experience dizziness or drowsiness. Light to moderate exercise is generally safe. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause frequent urination or diarrhea, which can affect work. Plan your dose timing to minimize disruption.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or your symptoms resolve, your doctor may advise tapering or stopping. Abrupt discontinuation may cause rebound acid hypersecretion.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency, low magnesium levels, and an increased risk of bone fractures. Domperidone may cause hyperprolactinemia with prolonged use. Regular monitoring and periodic reassessment by a doctor are recommended. Do not use for more than 12 weeks without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Dietary changes, weight loss, and elevating the head of the bed can reduce reflux symptoms.
Evidence: Well-establishedH2 blockers or other PPIs may be alternatives if this combination is not suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, if you are scheduled for any vaccination, inform your healthcare provider about this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue taking your dose at the usual time relative to your new local time, but consult your doctor if unsure. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling relief from heartburn and nausea within a few hours, but full effects on acid suppression may take 1-2 days.
A: Some medicines can interact. Always inform your doctor about all medications you are taking.
A: Consult your doctor. The safety of this combination during pregnancy is not well established.
🤔 Common Patient Concerns
🔄 Substitutes for davaindia domperidone+esomeprazole 30mg/40mg capsule sr
View AllAlternative brands with exact same active ingredient:
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espdom-dsr capsuleCapsutab Drugs Pvt Ltd ₹15.94 43.1% CHEAPER
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eszone d 30mg/40mg capsule srZeelab Pharmacy Pvt Ltd ₹24.00 14.3% CHEAPER
-
StayHappi Domperidone+Esomeprazole 30mg/40mg CapsuleSarvagunaushdhi Pvt Ltd ₹33.75 20.5% COSTLIER
-
ranidom o nf 30 mg/40 mg tabletMankind Pharma Ltd ₹41.18 47.1% COSTLIER
-
spson d 30mg/40mg capsuleUnison Pharmaceuticals Pvt Ltd ₹42.80 52.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any stomach pain.
Fact: It is specifically for acid-related and motility disorders; it is not a general painkiller. - Myth: It is safe to take indefinitely.
Fact: Long-term use should be under medical supervision due to potential side effects.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Esomeprazole generic capsules
Brand Alternatives
- Amrizol-DSR Capsule