Pan-D Capsule PR: Complete Medicine Guide for Acid Reflux and Nausea
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or persistent vomiting
- Chest pain, palpitations, or difficulty breathing
- Sudden swelling of face, lips, tongue, or throat
- Severe skin rash with blistering or peeling
- Yellowing of skin or eyes (jaundice)
- Decreased urine output or swelling in legs
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is pantolup d 30mg/40mg tablet used for?
This medicine is a prescription combination of Domperidone 30 mg and Pantoprazole 40 mg used to treat acid reflux, heartburn, and nausea associated with delayed stomach emptying. It works by reducing stomach acid and improving gastric motility. It should be taken once daily before breakfast, usually for a limited duration as advised by a doctor.
- Generic Name: Domperidone (30mg) + Pantoprazole (40mg)
- Manufacturer: Lupin Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 pantolup d 30mg/40mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन 30 मिलीग्राम और पैंटोप्राजोल 40 मिलीग्राम का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, सीने में जलन, गैस्ट्रोएसोफेजियल रिफ्लक्स डिजीज (जीईआरडी), अपच, और पेट के खाली होने में देरी से जुड़ी मतली और उल्टी के इलाज के लिए किया जाता है। यह पेट में एसिड का उत्पादन कम करती है और पेट की गतिशीलता को बढ़ाती है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए और डॉक्टर द्वारा बताई गई अवधि तक ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, दस्त, मतली, पेट दर्द, गैस, और मुँह सूखना शामिल हैं। कुछ लोगों को चक्कर आना या नींद आना महसूस हो सकता है। दुर्लभ मामलों में गंभीर एलर्जी, अनियमित दिल की धड़कन, मैग्नीशियम की कमी, और त्वचा पर गंभीर प्रतिक्रियाएँ हो सकती हैं। अगर कोई भी दुष्प्रभाव लगातार बना रहे या गंभीर हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर सुबह नाश्ते से पहले एक कैप्सूल। कैप्सूल को पानी के साथ पूरा निगलें, इसे चबाएं या तोड़ें नहीं। शराब का सेवन न करें क्योंकि इससे पेट की जलन और नींद बढ़ सकती है। अगर आपको लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। दवा लेते समय वाहन चलाने या मशीनरी चलाने से बचें यदि आपको चक्कर या नींद आ रही हो। दवा को ठंडी और सूखी जगह पर, बच्चों की पहुंच से दूर रखें।
💊 pantolup d 30mg/40mg tablet Uses & Benefits
[{"condition":"Gastroesophageal reflux disease (GERD)","description":"Reduces acid reflux and heartburn by suppressing gastric acid secretion and improving gastric emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Helps relieve upper abdominal discomfort, bloating, and early satiety when both acid and motility are contributing factors.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with delayed gastric emptying","description":"Domperidone improves stomach emptying and reduces nausea, while Pantoprazole reduces acid irritation.","evidence":"Moderate"},{"condition":"Acid peptic disease with dysmotility symptoms","description":"Used when acid suppression and prokinetic action are both clinically needed.","evidence":"Limited"}]
Off-label uses: [{"condition":"Refractory nausea in diabetic gastroparesis","description":"Sometimes prescribed off-label when standard prokinetics are not effective, but evidence is limited.","evidence":"Limited"},{"condition":"Prevention of aspiration during anesthesia induction","description":"Not a standard use; only considered in selected high-risk patients under specialist care.","evidence":"Limited"}]
Primary treatment for: Gastroesophageal reflux disease (GERD)
Also treats: Functional dyspepsia, Nausea and vomiting associated with delayed gastric emptying, Acid peptic disease with dysmotility
📋 Drug Information
| Generic Name(s) | Domperidone (30mg) + Pantoprazole (40mg) |
| Brand Name | pantolup d 30mg/40mg tablet |
| Manufacturer | Lupin Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep the capsules in their original container and out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Pantoprazole is a proton pump inhibitor that irreversibly blocks the hydrogen-potassium ATPase enzyme in the parietal cells of the stomach, reducing both basal and stimulated acid secretion. Domperidone is a peripheral dopamine D2 receptor antagonist that increases gastric and duodenal peristalsis, accelerates gastric emptying, and enhances antroduodenal coordination without significant central nervous system penetration. Together, they reduce acid exposure and improve upper gastrointestinal motility.
Mechanism Steps
💡 How to Take pantolup d 30mg/40mg tablet
Strength: Delayed-release capsule containing Domperidone 30 mg and Pantoprazole 40 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one capsule taken orally once daily, preferably before breakfast. The dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not self-adjust the dose. Follow your doctor's instructions exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and heart rhythm changes. The dose should be individualized by a clinician, and close monitoring is advised. |
| Renal Impairment | Dose adjustment may be needed in patients with severe kidney impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | This medicine is contraindicated in severe liver disease. In mild to moderate liver impairment, dose adjustment and close monitoring are required. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is one capsule containing Domperidone 30 mg and Pantoprazole 40 mg. Do not exceed this dose unless specifically advised by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of pantolup d 30mg/40mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Amiodarone | Major | |
| Warfarin | Major | |
| Methotrexate | Major | |
| Clopidogrel | Moderate | |
| Atazanavir | Moderate | |
| Fluconazole | Moderate | |
| Digoxin | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Ketoconazole, itraconazole, clarithromycin, ritonavir
- Amiodarone, sotalol, quinidine, haloperidol
- Methotrexate
- Warfarin
⚡ Moderate Interactions
- Atazanavir, nelfinavir
- Clopidogrel
- Fluconazole
- Digoxin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase stomach acid production, worsen reflux symptoms, and add to the risk of drowsiness and dizziness caused by Domperidone. It may also increase the risk of liver-related side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to Pantoprazole, Domperidone, or any component of the formulation","Prolactin-releasing pituitary tumor (prolactinoma)","Active gastrointestinal bleeding, mechanical obstruction, or perforation","Severe liver disease or moderate to severe hepatic impairment","Known QT interval prolongation or family history of long QT syndrome","Concomitant use with strong CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, or ritonavir","Concomitant use with QT-prolonging drugs such as amiodarone, sotalol, or quinidine"]
⚠️ Warnings & Precautions
["This medicine should be used with caution in elderly patients, who may be more sensitive to its side effects.","Patients with kidney or liver disease may require dose adjustment and close monitoring.","Long-term use may lead to low magnesium levels, vitamin B12 deficiency, and an increased risk of bone fractures.","Domperidone may cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use this medicine for immediate relief of acute heartburn; it is not intended for occasional use.","Inform your doctor if you are taking any other medicines, especially those that affect heart rhythm or liver enzymes.","Stop the medicine and seek medical help immediately if you experience signs of an allergic reaction or severe skin reaction."]
🤱 Lactation Safety
Domperidone is excreted in human breast milk and may cause side effects in the nursing infant. Pantoprazole is also excreted in breast milk in small amounts. This medicine is generally not recommended during breastfeeding unless clearly needed and advised by a doctor.
💊 Overdose Management
Overdose of this medicine may cause severe drowsiness, dizziness, extrapyramidal symptoms, irregular heartbeat, and low blood pressure. If you suspect an overdose, contact your doctor or a poison control center immediately. Treatment is supportive and symptomatic, with close monitoring of vital signs and heart rhythm. There is no specific antidote. Do not induce vomiting unless advised by a medical professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is less than half the dosing interval away. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually once daily before breakfast. Swallow the capsule whole with water; do not crush, chew, or open it because the delayed-release coating is important for proper action. Do not take more than the recommended dose or continue for longer than advised without medical review. Avoid alcohol because it can worsen stomach irritation and increase drowsiness. Tell your doctor if you have liver disease, kidney disease, heart rhythm problems, or low magnesium levels. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Keep all follow-up appointments so your doctor can monitor your response and check for any need to adjust or stop treatment. Store this medicine at room temperature away from moisture and direct sunlight, and keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and heart rhythm changes. They may also have reduced kidney and liver function, requiring dose adjustment. Close monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
This medicine may be used after surgery if there is a risk of acid aspiration or if the patient develops reflux or nausea. However, it should be used only under medical supervision, and the dose may need adjustment based on the patient's condition.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may increase the risk of bleeding during dental procedures if you are also taking blood thinners. Your dentist may advise temporary adjustment of your medicines.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine. However, avoid vigorous exercise immediately after meals as it may worsen reflux. If you experience dizziness or drowsiness, avoid activities that require balance or coordination until you feel normal.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually taken once daily before breakfast, so it should not interfere with your work schedule. Inform your employer or colleagues about your condition if you need to take regular breaks for meals.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects such as irregular heartbeat, severe allergic reaction, or persistent diarrhea, stop the medicine and seek immediate medical attention. Your doctor will advise you on when and how to stop based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to low magnesium levels, vitamin B12 deficiency, and an increased risk of bone fractures. It may also increase the risk of certain infections such as Clostridium difficile-associated diarrhea. Regular monitoring of magnesium, vitamin B12, and bone health is advised. Your doctor will periodically review the need to continue this medicine.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Dietary changes, weight loss, and elevating the head of the bed can reduce reflux symptoms.
Evidence: Well-establishedOmeprazole, Rabeprazole, or Esomeprazole may be used instead of Pantoprazole based on doctor's advice.
Evidence: Well-establishedRanitidine or Famotidine may be used for milder acid suppression.
Evidence: ModerateDomperidone alone may be used if acid suppression is not needed.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your doctor about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from moisture and direct sunlight. If crossing time zones, continue taking your once-daily dose at your usual morning time or as advised by your doctor. Check local customs regulations for carrying prescription medicines. Always carry enough supply for the entire trip and keep it in your hand luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pantoprazole starts reducing acid within 1 hour, but maximum benefit may take a few days. Domperidone starts improving nausea and gastric emptying within 30 to 60 minutes.
A: It is best taken before breakfast on an empty stomach. If it causes stomach upset, you may take it with food after consulting your doctor.
A: If you remember within half the dosing interval, take it as soon as possible. Otherwise, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop without consulting your doctor. Sudden discontinuation may cause rebound acid symptoms.
A: Long-term use may require monitoring of magnesium, vitamin B12, and bone health. Your doctor will decide the duration based on your condition.
🤔 Common Patient Concerns
🔄 Substitutes for pantolup d 30mg/40mg tablet
View AllAlternative brands with exact same active ingredient:
-
pentagon d 30mg/40mg tablet srInd Swift Laboratories Ltd ₹15.23 18.2% COSTLIER
-
ulciful dsr 30mg/40mg capsuleTorrent Pharmaceuticals Ltd ₹17.50 35.8% COSTLIER
-
pantoride-dsr capsuleZeelab Pharmacy Pvt Ltd ₹22.50 74.6% COSTLIER
-
davaindia domperidone+pantoprazole 30mg/40mg capsule srDavaindia Generic Pharmacy ₹25.00 93.9% COSTLIER
-
drpan dsr capsuleDR Best pharmaceuticals Pvt Ltd ₹27.00 109.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for immediate relief of heartburn.
Fact: This medicine is not for immediate relief. It is a prescription medicine that works over time and should be taken as directed by a doctor. - Myth: It is safe to take this medicine for a long time without monitoring.
Fact: Long-term use requires periodic monitoring of magnesium, vitamin B12, and bone health, and should be reviewed by a doctor. - Myth: This medicine can be taken with any other medicine without concern.
Fact: This medicine can interact with several drugs, including those affecting heart rhythm and liver enzymes. Always inform your doctor about all medicines you take. - Myth: If I feel better, I can stop the medicine immediately.
Fact: Do not stop this medicine without consulting your doctor, as sudden discontinuation may cause rebound acid symptoms.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Pantoprazole generic capsules
Brand Alternatives
- Pan-D Capsule PR
- Pantop-D Capsule
- Dompan Capsule
- Pantocid-D Capsule
- Pansec-D Capsule