Fylyxor M 400mg/10mg Tablet - Doxofylline (400mg) + Montelukast (10mg) medicine

Ventidox-M Tablet SR: Complete Medicine Guide

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🏭 Trireme Life Sciences Pvt Ltd 📦 strip of 10 tablets 💊 Allopathy 📅 Updated: Sep 24, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Fast or irregular heartbeat
  • Severe allergic reaction (rash, swelling, difficulty breathing)
  • Mood changes or depression
  • Seizures
  • Yellowing of skin or eyes
  • Severe stomach pain

If experiencing severe symptoms, call emergency services immediately.

What is Fylyxor M 400mg/10mg Tablet used for?

This medicine is a combination of Doxofylline and Montelukast used to treat asthma and COPD. It works by relaxing airway muscles and reducing inflammation. It is taken once daily by mouth.

  • Generic Name: Doxofylline (400mg) + Montelukast (10mg)
  • Manufacturer: Trireme Life Sciences Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 Fylyxor M 400mg/10mg Tablet के बारे में (Hindi Summary)

उपयोग: यह दवा दमा (अस्थमा) और क्रॉनिक ऑब्सट्रक्टिव पल्मोनरी डिजीज (सीओपीडी) के इलाज में इस्तेमाल होती है। यह सांस की नली की मांसपेशियों को आराम देकर सांस लेने में आसानी करती है और सूजन को कम करती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, जी मिचलाना, पेट दर्द और बेचैनी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन धड़कन तेज होना, एलर्जी या मूड में बदलाव हो सकते हैं। किसी भी असामान्य लक्षण पर डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं नहीं, पूरा निगल लें। शराब न पिएं। यदि आपको हृदय, यकृत या गुर्दे की समस्या है तो डॉक्टर को बताएं। दवा अचानक बंद न करें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 Fylyxor M 400mg/10mg Tablet Uses & Benefits

[{"condition":"Asthma","description":"Used for long-term control of asthma symptoms and prevention of attacks.","evidence":"Well-established"},{"condition":"Chronic Obstructive Pulmonary Disease (COPD)","description":"Helps relieve bronchospasm and improve breathing in COPD patients.","evidence":"Well-established"},{"condition":"Exercise-induced bronchoconstriction","description":"May help prevent breathing difficulty during exercise.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Allergic rhinitis","description":"Sometimes used to relieve nasal allergy symptoms, but not a primary treatment.","evidence":"Limited"}]

Primary treatment for: Asthma

Also treats: COPD, Exercise-induced bronchoconstriction

📋 Drug Information

Generic Name(s)Doxofylline (400mg) + Montelukast (10mg)
Brand NameFylyxor M 400mg/10mg Tablet
ManufacturerTrireme Life Sciences Pvt Ltd
Packaging / Formstrip of 10 tablets (Allopathy)
Therapeutic Class
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day for best results.
2
Do not use it for sudden breathing attacks; keep a rescue inhaler handy.
3
Avoid alcohol and caffeine while taking this medicine.
4
Inform your doctor if you have heart, liver, or kidney problems.
5
Do not stop this medicine without consulting your doctor.
6
Report any mood changes or sleep disturbances to your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Wheezing
This medicine is commonly prescribed for this.
Likely Use
✅
Shortness of breath
This medicine helps improve breathing.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDoxofylline is rapidly absorbed from the gastrointestinal tract after oral administration. Montelukast is also well absorbed orally. Food does not significantly affect the absorption of either ingredient.
DistributionBoth drugs are widely distributed in the body. Doxofylline has a volume of distribution of approximately 1 L/kg. Montelukast is highly protein-bound and distributes into tissues.
Protein BindingDoxofylline is about 48% bound to plasma proteins. Montelukast is more than 99% bound to plasma proteins.
MetabolismDoxofylline is metabolized in the liver by cytochrome P450 enzymes. Montelukast is extensively metabolized in the liver, primarily by CYP2C8 and CYP3A4.
Half-LifeDoxofylline half-life is about 6-8 hours. Montelukast half-life is about 2.7-5.5 hours.
ExcretionDoxofylline is excreted mainly in urine as metabolites. Montelukast is excreted primarily in bile and feces.
BioavailabilityDoxofylline oral bioavailability is about 60-70%. Montelukast oral bioavailability is about 64% for the 10 mg tablet.
Onset of ActionDoxofylline starts working within 30 minutes to 1 hour. Montelukast takes about 1-3 hours to reach peak effect.
Peak Plasma TimeDoxofylline peak plasma time is about 1-2 hours. Montelukast peak plasma time is about 3-4 hours.
Duration of ActionDoxofylline effect lasts about 6-8 hours. Montelukast effect lasts about 24 hours, allowing once-daily dosing.

How It Works

This medicine combines two active ingredients with different ways of opening the airways. Doxofylline works by relaxing the smooth muscles in the lungs, which widens the airways and makes breathing easier. It also reduces inflammation. Montelukast blocks leukotriene receptors, preventing leukotrienes from causing airway narrowing and swelling. Together, they provide better control of asthma and COPD symptoms.

Mechanism Steps

1
Doxofylline inhibits phosphodiesterase: Doxofylline blocks phosphodiesterase enzymes, increasing cyclic AMP levels in airway smooth muscle cells, which causes relaxation and bronchodilation.
2
Montelukast blocks leukotriene receptors: Montelukast selectively binds to CysLT1 receptors, preventing leukotrienes from triggering airway constriction, inflammation, and mucus production.
3
Combined effect: The two actions work together to reduce airway resistance, decrease inflammation, and improve overall lung function.

💡 How to Take Fylyxor M 400mg/10mg Tablet

Strength: Tablet containing Doxofylline 400 mg and Montelukast 10 mg.

1Take the tablet at the same time each day.
2Swallow it whole with a glass of water.
3Do not crush or chew the tablet.
4Take with or without food.
5Follow your doctor's instructions exactly.

Dosage Information

Adult DosageThe usual adult dose is one tablet once daily, preferably in the evening. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may require dose adjustment based on kidney and liver function. Consult your doctor.
Renal ImpairmentDose adjustment may be needed in kidney disease. Consult your doctor.
Hepatic ImpairmentDose adjustment may be needed in liver disease. Consult your doctor.
Maximum Daily DoseOne tablet daily. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.
Caffeine
Limit
May increase restlessness.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours since missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours since missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of Fylyxor M 400mg/10mg Tablet

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent.
Nausea (Common (5-10%))
Take with food to reduce nausea. Consult doctor if severe.
Stomach pain (Common (5-10%))
Take with food. Consult doctor if pain persists.
Restlessness (Uncommon (1-5%))
Avoid caffeine. Consult doctor if bothersome.

🚨 Serious Side Effects

Fast or irregular heartbeat (Rare (<0.1%))
Seek immediate medical attention.
Severe allergic reaction (rash, swelling, difficulty breathing) (Rare (<0.1%))
Seek emergency medical help.
Mood changes or depression (Rare (<0.1%))
Consult doctor immediately.

⚠️ Rare Side Effects

Seizures
Seek emergency medical attention.
Liver problems (yellowing of skin or eyes)
Consult doctor immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ciprofloxacin Major
Erythromycin Major
Phenytoin Major
Beta-blockers Moderate
Diuretics Moderate
Antacids Minor

🚨 Major Interactions

  • Ciprofloxacin
  • Erythromycin
  • Phenytoin

⚡ Moderate Interactions

  • Beta-blockers
  • Diuretics

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol may increase drowsiness, dizziness, and the risk of stomach upset.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Allergy to doxofylline or montelukast","Active peptic ulcer","Severe heart disease","Severe liver disease"]

⚠️ Warnings & Precautions

["Do not use for acute asthma attacks.","Avoid in patients with irregular heartbeat.","Use with caution in liver or kidney disease.","May cause drowsiness; avoid driving if affected.","Do not stop suddenly without medical advice."]

🤱 Lactation Safety

It is not known if this medicine passes into breast milk. Consult your doctor before breastfeeding.

💊 Overdose Management

Seek emergency medical help if you suspect an overdose. Symptoms may include severe nausea, vomiting, fast heartbeat, and seizures. Treatment is supportive.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush or chew the tablet; swallow it whole with water. Avoid drinking alcohol while taking this medicine as it may increase drowsiness and dizziness. Inform your doctor if you have heart, liver, or kidney problems. Do not stop taking this medicine suddenly without medical advice. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to side effects. Dose adjustment may be needed based on kidney and liver function.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy. The safety of this combination in pregnancy is not well established.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist about this medicine before surgery. It may interact with anesthesia.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure. It may cause dry mouth or interact with sedatives.

💚 Lifestyle Tips for Better Results

🏃
Avoid smoking and secondhand smoke.
🥗
Maintain a healthy weight.
😴
Exercise regularly but avoid triggers.
💧
Use air purifiers to reduce allergens.
🧘
Get adequate sleep.

🏋️ Exercise Considerations

Exercise may trigger breathing difficulty. Use your rescue inhaler if prescribed. Warm up before exercise and avoid cold, dry air.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits and vegetables.
Avoid foods that trigger allergies.
Stay hydrated.
Limit caffeine and alcohol.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness. Avoid driving or operating machinery until you know how it affects you.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Stopping suddenly may worsen your condition.

📅 Long-Term Use Effects

Long-term use may require periodic monitoring of heart, liver, and kidney function. Do not stop without medical advice. Report any new symptoms to your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Inhaled corticosteroids

Can be used as an alternative or add-on for asthma control.

Evidence: Well-established
Breathing exercises

Can complement medicine for symptom relief.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. Keep vaccinations up to date, especially flu and pneumonia vaccines for respiratory conditions.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, consult your doctor about dose timing. Keep enough supply for your trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 50-year-old man with chronic asthma
He was prescribed this medicine for long-term asthma control. After a few weeks, he noticed fewer asthma attacks and better breathing. He learned to take it regularly and avoid alcohol.
💡 Lesson: Consistency and avoiding alcohol improve outcomes.
👤 A 65-year-old woman with COPD
She started this medicine and experienced mild nausea initially. Taking it with food helped. Her breathing improved significantly over a month.
💡 Lesson: Taking with food reduces stomach upset.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Doxofylline starts working within 30 minutes to 1 hour, while montelukast takes about 1-3 hours. Full benefits may take a few days.

Q: Can I take it with food?

A: Yes, you can take it with or without food. Taking with food may reduce stomach upset.

Q: Is it safe during pregnancy?

A: Consult your doctor before taking this medicine during pregnancy. Safety is not well established.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for Fylyxor M 400mg/10mg Tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be used for sudden breathing attacks.
    Fact: It is for long-term control, not for acute attacks.
  • Myth: It is safe to stop taking this medicine once you feel better.
    Fact: Do not stop without consulting your doctor.

🔄 Alternative Options

Generic Alternatives

  • Doxofylline + Montelukast combination generics

Brand Alternatives

  • Ventidox-M Tablet SR

📊 Comparison with Similar Medicines

[{"medicine":"Ventidox-M Tablet SR","composition":"Doxofylline 400 mg + Montelukast 10 mg","use":"Asthma, COPD"},{"medicine":"Montelukast + Levocetirizine","composition":"Montelukast 10 mg + Levocetirizine 5 mg","use":"Allergic rhinitis, asthma"}]

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