Apxime 125mg Injection (Cefotaxime): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, or throat, or difficulty breathing
- A sudden widespread rash or blistering of the skin
- Severe, watery, or bloody diarrhoea
- Unusual bruising or bleeding
- Passing much less urine than usual
- Yellowing of the eyes or skin
- A seizure or sudden confusion
- Chest pain or a very fast or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is Fefa 125mg Injection used for?
This medicine is a third-generation cephalosporin antibiotic given by injection to treat serious bacterial infections. It works by breaking down the bacterial cell wall, causing the bacteria to die. It is given only by a healthcare professional and must be prescribed by a doctor.
- Generic Name: Cefotaxime (125mg)
- Manufacturer: Biomedica International
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Fefa 125mg Injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक तीसरी पीढ़ी का सेफलोस्पोरिन एंटीबायोटिक है, जिसे इंजेक्शन के रूप में दिया जाता है। इसका उपयोग निमोनिया, मूत्र मार्ग के संक्रमण, खून के संक्रमण, मस्तिष्क झिल्ली की सूजन, त्वचा और हड्डियों के गंभीर बैक्टीरियल संक्रमण के इलाज के लिए किया जाता है। यह कुछ सर्जरी से पहले संक्रमण रोकने के लिए भी दी जाती है। यह दवा वायरस से होने वाले संक्रमण जैसे सर्दी-जुकाम या फ्लू पर असर नहीं करती। यह केवल डॉक्टर या प्रशिक्षित नर्स द्वारा ही दी जानी चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में इंजेक्शन वाली जगह पर दर्द, लालिमा या सूजन, हल्का दस्त, जी मिचलाना और हल्के दाने शामिल हैं। कभी-कभी मुंह या योनि में फंगल संक्रमण हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें तेज एलर्जी, गंभीर त्वचा प्रतिक्रिया, खून की कोशिकाओं में कमी, गुर्दे या लीवर की सूजन, और गंभीर दस्त शामिल हो सकते हैं। कोई भी गंभीर लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इंजेक्शन लगवाने से पहले अपने डॉक्टर को पेनिसिलिन या सेफलोस्पोरिन से एलर्जी, गुर्दे या लीवर की बीमारी, और दौरे की history के बारे में जरूर बताएं। इलाज के दौरान पर्याप्त पानी पिएं, जब तक डॉक्टर मना न करें। चेहरे या गले में सूजन, सांस लेने में कठिनाई, गंभीर या खून वाला दस्त, असामान्य चोट या खून आना, या पेशाब कम आना जैसे लक्षण दिखें तो तुरंत डॉक्टर को बताएं। यह दवा किसी और के साथ साझा न करें।
💊 Fefa 125mg Injection Uses & Benefits
[{"condition":"Lower respiratory tract infections","description":"Used to treat bacterial pneumonia and acute flare-ups of chronic bronchitis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against many gram-negative bacteria that cause complicated and uncomplicated urinary tract infections.","evidence":"Well-established"},{"condition":"Bloodstream infections (septicaemia)","description":"Used as part of therapy for serious bloodstream infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, abscesses, and wound infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"Used in the treatment of osteomyelitis and septic arthritis when the causative organism is susceptible.","evidence":"Well-established"},{"condition":"Meningitis","description":"Used for bacterial meningitis because it reaches the cerebrospinal fluid in effective concentrations.","evidence":"Well-established"},{"condition":"Intra-abdominal and pelvic infections","description":"Used in combination with other antibiotics for peritonitis, pelvic inflammatory disease, and similar infections.","evidence":"Well-established"},{"condition":"Surgical prophylaxis","description":"Given before certain surgical procedures to reduce the risk of postoperative infection.","evidence":"Well-established"},{"condition":"Gonorrhoea","description":"Has been used for gonococcal infections, although resistance patterns now guide the choice of therapy.","evidence":"Established but resistance limits use"}]
Off-label uses: [{"condition":"Prophylaxis in neutropenic patients","description":"Sometimes used as part of a regimen to prevent infection in patients with very low white blood cell counts.","evidence":"Limited"},{"condition":"Infections caused by unusual gram-negative organisms","description":"Occasionally used when culture results show susceptibility and other options are unsuitable.","evidence":"Limited"}]
Primary treatment for: Serious bacterial infections caused by susceptible organisms.
Also treats: Pneumonia, Urinary tract infection, Septicaemia, Meningitis, Cellulitis, Osteomyelitis, Pelvic inflammatory disease, Surgical site infection prevention
📋 Drug Information
| Generic Name(s) | Cefotaxime (125mg) |
| Brand Name | Fefa 125mg Injection |
| Manufacturer | Biomedica International |
| Packaging / Form | vial of 1 Injection (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store the dry powder at room temperature, between 15°C and 30°C, away from direct light and moisture. Once the powder has been mixed with a suitable liquid, the solution should be used within the time recommended by the manufacturer, which is usually within a few hours at room temperature or up to 24 hours if kept in a refrigerator. Do not freeze the prepared solution. |
| Shelf Life | The shelf life of the dry powder is usually 24 to 36 months from the date of manufacture, depending on the manufacturer. Always check the expiry date on the pack before use. |
| WHO Guideline | Not established from the available information for this specific product. Treatment guidelines for specific infections should be followed by the treating clinician. |
| ICMR Guideline | Not established from the available information for this specific product. Clinicians should follow current national and local antibiotic guidelines. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a beta-lactam antibiotic that kills bacteria by blocking the final step of cell wall construction. It binds to proteins in the bacterial cell membrane called penicillin-binding proteins, which are enzymes that cross-link the peptidoglycan strands of the cell wall. When these enzymes are blocked, the cell wall becomes weak and cannot withstand the internal pressure of the bacterium. The bacterium then bursts and dies. Because human cells do not have a peptidoglycan cell wall, this medicine is selective for bacteria and does not damage human cells in the same way.
Mechanism Steps
💡 How to Take Fefa 125mg Injection
Strength: This product is a sterile powder for injection containing cefotaxime 125 mg. It is reconstituted with a suitable liquid before use and is given by intramuscular or intravenous injection.
Dosage Information
| Adult Dosage | The dose of this medicine depends on the type and severity of the infection, the site of infection, the patient's kidney function, and the organism causing the infection. For many moderate infections, a common adult dose is 1 gram given every 8 to 12 hours, but serious infections such as meningitis may need higher and more frequent doses. The 125 mg strength is usually used for smaller doses or for children. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific 125 mg presentation. In general, this medicine is used in children under specialist supervision, with doses based on body weight and the type of infection. Consult a pediatrician for exact dosing. |
| Elderly Dosage | Older adults may need a lower dose because kidney function often declines with age. Kidney function should be checked before and during treatment, and the dose should be adjusted by the doctor if needed. |
| Renal Impairment | In people with reduced kidney function, the dose or the interval between doses may need to be adjusted. This is especially important when the creatinine clearance is low. The doctor will decide the exact adjustment based on kidney tests and the severity of the infection. |
| Hepatic Impairment | Mild liver disease usually does not require a dose change. In severe liver disease, the doctor may monitor the patient more closely, but specific dose adjustments are not well established from the available information. |
| Maximum Daily Dose | The maximum daily dose depends on the infection being treated and the patient's kidney function. In adults with normal kidney function, doses up to 12 grams per day have been used in severe infections under close medical supervision. The exact maximum for an individual must be decided by the treating clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Fefa 125mg Injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Furosemide | Major | |
| Warfarin | Major | |
| Chloramphenicol | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Live bacterial vaccines | Moderate | |
| Urine glucose tests | Minor |
🚨 Major Interactions
- Aminoglycoside antibiotics such as gentamicin
- Loop diuretics such as furosemide
- Warfarin and other anticoagulants
- Chloramphenicol
⚡ Moderate Interactions
- Probenecid
- Oral contraceptives
- Live bacterial vaccines
🍷 Alcohol Interaction
There is no well-known direct interaction between this medicine and alcohol. However, drinking alcohol while you are fighting a serious infection can slow your recovery, worsen dehydration, and increase the strain on your liver. It is best to avoid alcohol until you have fully recovered and your doctor says it is safe.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to cefotaxime or any other cephalosporin antibiotic","Previous severe immediate allergic reaction to a penicillin antibiotic","Use of calcium-containing intravenous solutions in newborn babies, because a dangerous precipitate can form","Known allergy to any ingredient in the product"]
⚠️ Warnings & Precautions
["Tell your doctor about any allergy to antibiotics before receiving this medicine.","Use with caution in people with kidney disease, and adjust the dose if needed.","Use with caution in people with liver disease.","Use with caution in people with a history of seizures or brain disease.","Watch for severe diarrhoea, which may be a sign of a serious bowel infection.","Watch for signs of a severe allergic reaction, which can occur within minutes of the injection.","Prolonged use can lead to overgrowth of bacteria that are not killed by this medicine.","This medicine should not be mixed with calcium-containing solutions in newborns.","Do not use the medicine if the solution is cloudy or contains particles.","Inform laboratory staff about this medicine before any blood or urine tests."]
🤱 Lactation Safety
This medicine passes into breast milk in small amounts. It is usually considered compatible with breastfeeding, but the baby should be watched for diarrhoea, thrush, or rash. If you are breastfeeding, tell your doctor so that the risks and benefits can be discussed.
💊 Overdose Management
There is no specific antidote for an overdose of this medicine. An overdose can cause brain-related effects such as confusion, drowsiness, or seizures, especially in people with kidney problems. Treatment is supportive and includes close monitoring, maintenance of breathing and circulation, and possibly dialysis in severe cases. If an overdose is suspected, seek emergency medical help immediately.
⏰ Missed Dose
Because this medicine is usually given by a healthcare professional in a hospital or clinic, a missed dose is uncommon. If you miss an appointment for your dose, contact your doctor or clinic as soon as possible to arrange the next dose. Do not try to make up for a missed dose by taking or injecting extra medicine on your own.
Additional Safety Advice
This medicine must only be given by a healthcare professional. Before the first dose, tell your doctor about any allergy to antibiotics, especially penicillin or cephalosporin allergies, and about any kidney or liver problems, bleeding disorders, or previous seizures. Do not attempt to inject this medicine at home. While you are receiving this medicine, drink enough fluids unless your doctor has told you to limit fluids. Report any new rash, swelling of the face or throat, difficulty breathing, severe or bloody diarrhoea, unusual bruising or bleeding, or a drop in urine output immediately. Do not share this medicine with anyone else, and do not save leftover solution for later use. Keep all follow-up appointments so your doctor can check how well the infection is responding and monitor your blood counts, kidney function, and liver function when needed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more likely to have reduced kidney function, which can cause this medicine to build up in the body. This increases the risk of side effects such as confusion and seizures. Kidney function should be checked, and the dose should be adjusted by the doctor. Older adults should also be watched closely for falls, dehydration, and interactions with other medicines.
🤰 Pregnancy Planning (TTC)
If you are planning a pregnancy, tell your doctor before starting this medicine. It is generally considered acceptable in pregnancy when needed for a serious infection, but the decision should be made with your doctor. If you become pregnant while receiving this medicine, contact your doctor promptly.
🏥 Post-Surgery Considerations
This medicine is sometimes given before or during surgery to prevent infection. After surgery, it may be continued for a short time depending on the type of operation and the risk of infection. If you have had surgery, tell your surgeon and anaesthetist about all medicines you are taking, including this one.
🦷 Dental Procedures
Tell your dentist if you are receiving this medicine. In some cases, antibiotics are given before dental procedures to prevent infection, especially in people with certain heart conditions. Your dentist and doctor will decide whether any change in your medicines is needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While you are recovering from a serious infection, avoid strenuous exercise. Light activity such as short walks may be helpful once you feel better, but you should rest if you have fever, dizziness, or weakness. Ask your doctor when it is safe to return to your normal exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You will usually need to stay in hospital or visit a clinic for this medicine, so you may need time off work or school. The infection itself can cause tiredness and weakness, and you may not feel like your usual self for some days after treatment. Do not drive or operate heavy machinery if you feel dizzy, weak, or unwell. Ask your doctor when you can safely return to work and normal activities.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor will decide when to stop based on your symptoms, test results, and how well the infection is responding. If you develop a serious side effect such as a severe allergic reaction or severe diarrhoea, the doctor may stop the medicine and change the treatment. Always ask your doctor before stopping.
📅 Long-Term Use Effects
This medicine is usually given for a short time, so long-term effects are uncommon. When it is used for a long period, there is a higher chance of fungal overgrowth, antibiotic-associated diarrhoea, and the development of resistant bacteria. Blood counts, kidney function, and liver function may need to be checked during prolonged treatment. If you need repeated or long courses, your doctor will review the benefits and risks regularly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
If you can take medicines by mouth and the infection is not severe, your doctor may switch you to an oral antibiotic.
Evidence: Well-establishedDepending on the bacteria and your allergies, other antibiotics such as ceftriaxone or cefepime may be used.
Evidence: Well-establishedRest, fluids, and fever control help you recover alongside antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics like this medicine can make live bacterial vaccines less effective. If you are due for a live bacterial vaccine, tell your doctor that you are receiving this medicine. Vaccines that are not live can usually be given safely, but the timing should be discussed with your doctor.
📦 Storage Guide
✅ DO
Store the dry powder at room temperature between 15°C and 30°C.
❌ DON'T
Do not store it in a hot place or near a flame.
✅ DO
Keep the vial in its original carton, away from direct light.
❌ DON'T
Do not transfer the powder to another container.
✅ DO
Use the prepared solution within the time recommended by the manufacturer.
❌ DON'T
Do not use a solution that is cloudy or contains particles.
✅ DO
Keep the medicine out of the reach of children.
❌ DON'T
Do not freeze the prepared solution.
✈️ Traveling with This Medicine
This medicine is usually given in a hospital or clinic, so travel while receiving it should be planned with your doctor. If you need to travel, carry a copy of your prescription and a letter from your doctor explaining the medicine and the reason for it. Keep the medicine in its original packaging and store it as advised, away from heat and direct light. If you are travelling across time zones, ask your doctor how to adjust the timing of your doses. Check the rules of your destination country about carrying prescription medicines, and carry enough for the whole trip plus a little extra.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The medicine starts fighting the bacteria soon after the injection, but you may not feel better for 24 to 72 hours. Fever and other symptoms usually improve within a few days if the infection is responding to treatment.
A: No. This medicine must be given by a doctor or nurse in a hospital or clinic. Do not try to inject it yourself.
A: It is generally considered acceptable in pregnancy when needed for a serious infection, but it should only be used under medical supervision. Tell your doctor if you are pregnant or planning pregnancy.
A: Small amounts pass into breast milk. It is usually considered compatible with breastfeeding, but watch your baby for diarrhoea, thrush, or rash and tell your doctor if you notice anything unusual.
A: The most common side effects are pain or redness at the injection site, loose stools, nausea, and mild rash. Serious side effects are rare but need urgent medical attention.
A: No. Always complete the course as advised by your doctor. Stopping early can let the infection return and can make bacteria resistant.
🤔 Common Patient Concerns
🔄 Substitutes for Fefa 125mg Injection
View AllAlternative brands with exact same active ingredient:
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cefotax 125mg injectionModern Laboratories ₹8.00 16.8% CHEAPER
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ceftax 125mg injectionAdison Laboratories ₹9.00 6.4% CHEAPER
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ceftex 125mg injectionPrem Pharmaceuticals Pvt Ltd ₹9.73 1.1% COSTLIER
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cotax 125mg injectionDynamic Laboratories Pvt Ltd ₹10.00 4% COSTLIER
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bestax 125mg injectionBiological E Ltd ₹10.42 8.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine only works against certain bacteria. It does not treat viral infections such as colds or flu. - Myth: Injections are always stronger and better than tablets.
Fact: Injections are used when a medicine cannot be taken by mouth or when a rapid effect is needed. They are not automatically better for every situation. - Myth: You can stop the antibiotic as soon as you feel better.
Fact: Stopping too early can allow the infection to come back and can encourage bacteria to become resistant. Always follow your doctor's advice on duration. - Myth: This medicine is safe to use without a prescription.
Fact: This is a prescription medicine that must be given by a healthcare professional. Using it without medical advice is unsafe.
🔄 Alternative Options
Generic Alternatives
- Cefotaxime injection
Brand Alternatives
- Apxime 125mg injection