cefotax 125mg injection

4.5 (16 reviews)

Cefotaxime (125mg)

🏭 Modern Laboratories 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is cefotax 125mg injection used for?

Antax 1gm Injection (Cefotaxime) is used to treat ANTI INFECTIVES. It contains Cefotaxime (125mg), which Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Always consult your doctor before use. Take as prescribed.

Generic Name: Cefotaxime
Manufacturer: Modern Laboratories
Form: Allopathy
Pregnancy Category: B
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 cefotax 125mg injection Uses & Benefits

Treatment of lower respiratory tract infections, urinary tract infections, septicemia, intra-abdominal infections, gynecologic infections, bone and joint infections, skin and soft tissue infections, meningitis, and surgical prophylaxis.

Off-label uses: Lyme disease, Typhoid fever, Empiric therapy in febrile neutropenia

📋 Drug Information

Generic Name(s)	Cefotaxime
Brand Name	Antax 1gm Injection
Manufacturer	Modern Laboratories
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI INFECTIVES
Action Class	Cephalosporins: 3 generation
Route of Administration	Intramuscular or intravenous injection.
Storage	Store at 20-25°C (68-77°F). Protect from light. Reconstituted solution stable for 24 hours at room temperature and 48 hours under refrigeration.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntramuscular administration results in rapid and complete absorption. After intravenous administration, peak plasma concentrations are achieved immediately.

DistributionWidely distributed into body tissues and fluids including cerebrospinal fluid (especially when meninges are inflamed). Crosses placenta and enters breast milk.

Protein BindingApproximately 30-50% bound to plasma proteins.

MetabolismPartially metabolized in the liver to desacetylcefotaxime, which has antibacterial activity.

Half-LifeApproximately 1-1.5 hours in adults with normal renal function.

ExcretionPrimarily excreted unchanged in urine via glomerular filtration and tubular secretion. About 20-30% excreted as desacetylcefotaxime.

BioavailabilityNot applicable (parenteral administration).

Onset of ActionRapid; within minutes after IV administration.

Peak Plasma TimeIV: immediately after bolus; IM: 30 minutes after administration.

Duration of ActionApproximately 6-8 hours.

How It Works

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidation, and activating autolytic enzymes.

Mechanism Steps

1Cefotaxime binds to penicillin-binding proteins (PBPs) located on the bacterial cell wall.

2Inhibition of transpeptidase activity prevents cross-linking of peptidoglycan chains.

3Disruption of cell wall synthesis leads to weakened cell wall and osmotic instability.

💡 How to Take cefotax 125mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of cefotax 125mg injection

✅ Common Side Effects

Diarrhea
Nausea
Vomiting
Injection site reactions (pain, induration)
Rash
Eosinophilia

🚨 Serious Side Effects

Severe hypersensitivity reactions (anaphylaxis)
Clostridioides difficile-associated diarrhea
Seizures
Hemolytic anemia
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Pseudomembranous colitis
Interstitial nephritis
Agranulocytosis
Thrombocytopenia
Hepatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Probenecid	Major	Decreased renal excretion of cefotaxime, increased plasma levels and toxicity risk.
Aminoglycosides	Major	Increased risk of nephrotoxicity and ototoxicity.
Loop diuretics	Major	Increased risk of nephrotoxicity.
Oral anticoagulants	Moderate	Enhanced anticoagulant effect, increased bleeding risk.
Live typhoid vaccine	Moderate	Reduced immunological response to vaccine.
BCG vaccine	Moderate	Reduced efficacy of BCG vaccine.
Tetracyclines	Minor	Possible antagonism of bactericidal effect.
Chloramphenicol	Minor	Possible antagonism of bactericidal effect.

🚨 Major Interactions

Probenecid
Aminoglycosides
Loop diuretics

⚡ Moderate Interactions

Oral anticoagulants
Live typhoid vaccine
BCG vaccine

ℹ️ Minor Interactions

Tetracyclines
Chloramphenicol

🍽️ Food Interactions

No significant food interactions (parenteral drug).

🍷 Alcohol Interaction

May cause disulfiram-like reaction (nausea, vomiting, headache) if alcohol consumed within 48 hours after administration.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to cefotaxime, other cephalosporins, or any component of the formulation. History of severe immediate hypersensitivity reaction to penicillins or other beta-lactams.

📊 Monitoring Parameters

Renal function, hepatic function, complete blood count, signs of superinfection, and hypersensitivity reactions.

🤱 Lactation Safety

Cefotaxime is excreted in breast milk in low concentrations; caution advised. Generally considered c

💊 Overdose Management

Supportive care. Hemodialysis may enhance elimination. Monitor for seizures and renal function.

⏰ Missed Dose

Administer as soon as possible. If close to next dose, skip missed dose and resume regular schedule. Do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for cefotax 125mg injection

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Alternative brands with exact same active ingredient (Cefotaxime (125mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Found this to be a helpful product. Good results.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.