ceftex 125mg injection - Cefotaxime (125mg) medicine

ceftex 125mg injection

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🏭 Prem Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

What is ceftex 125mg injection used for?

This medicine contains Cefotaxime (125mg) and is used to treat ANTI INFECTIVES. Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting . Always consult your doctor before use.

  • Generic Name: Cefotaxime
  • Manufacturer: Prem Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category B
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 ceftex 125mg injection Uses & Benefits

Treatment of lower respiratory tract infections, urinary tract infections, septicemia, intra-abdominal infections, gynecologic infections, bone and joint infections, skin and soft tissue infections, meningitis, and surgical prophylaxis.

Off-label uses: Lyme disease, Typhoid fever, Empiric therapy in febrile neutropenia

📋 Drug Information

Generic Name(s)Cefotaxime
Brand NameAntax 1gm Injection
ManufacturerPrem Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassCephalosporins: 3 generation
Route of AdministrationIntramuscular or intravenous injection
StorageStore at 20-25°C (68-77°F). Protect from light. Reconstituted solution stable for 24 hours at room temperature and 48 hours under refrigeration.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionIntramuscular administration results in rapid and complete absorption. After intravenous administration, peak plasma concentrations are achieved immediately.
DistributionWidely distributed into body tissues and fluids including cerebrospinal fluid (especially when meninges are inflamed). Crosses placenta and enters breast milk.
Protein BindingApproximately 30-50% bound to plasma proteins.
MetabolismPartially metabolized in the liver to desacetylcefotaxime, which has antibacterial activity.
Half-LifeApproximately 1-1.5 hours in adults with normal renal function.
ExcretionPrimarily excreted unchanged in urine via glomerular filtration and tubular secretion. About 20-30% excreted as desacetylcefotaxime.
BioavailabilityNot applicable (parenteral administration).
Onset of ActionRapid; within minutes after IV administration.
Peak Plasma TimeIV: immediately after bolus; IM: 30 minutes after administration.
Duration of ActionApproximately 6-8 hours.

How It Works

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting transpeptidation, and activating autolytic enzymes.

Mechanism Steps

1Cefotaxime binds to penicillin-binding proteins (PBPs) located on the bacterial cell wall.
2Inhibition of transpeptidase activity prevents cross-linking of peptidoglycan chains.
3Disruption of cell wall synthesis leads to weakened cell wall and osmotic instability.
4Activation of autolytic enzymes (autolysins) causes bacterial cell lysis and death.

💡 How to Take ceftex 125mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of ceftex 125mg injection

✅ Common Side Effects

Diarrhea
Nausea
Vomiting
Injection site reactions (pain, induration)
Rash
Eosinophilia

🚨 Serious Side Effects

Severe hypersensitivity reactions (anaphylaxis)
Clostridioides difficile-associated diarrhea
Seizures
Hemolytic anemia
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Pseudomembranous colitis
Interstitial nephritis
Agranulocytosis
Thrombocytopenia
Hepatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Probenecid Major Decreased renal excretion of cefotaxime, increased plasma levels and toxicity risk.
Aminoglycosides Major Increased risk of nephrotoxicity and ototoxicity.
Loop diuretics Major Increased risk of nephrotoxicity.
Oral anticoagulants Moderate Enhanced anticoagulant effect, increased bleeding risk.
Live typhoid vaccine Moderate Reduced immunological response to vaccine.
BCG vaccine Moderate Reduced efficacy of BCG vaccine.
Tetracyclines Minor Possible antagonism of bactericidal effect.
Chloramphenicol Minor Possible antagonism of bactericidal effect.

🚨 Major Interactions

  • Probenecid
  • Aminoglycosides
  • Loop diuretics

⚡ Moderate Interactions

  • Oral anticoagulants
  • Live typhoid vaccine
  • BCG vaccine

🍷 Alcohol Interaction

May cause disulfiram-like reaction (nausea, vomiting, headache) if alcohol consumed within 48 hours after administration.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to cefotaxime, other cephalosporins, or any component of the formulation. History of severe immediate hypersensitivity reaction to penicillins or other beta-lactams.

🤱 Lactation Safety

Cefotaxime is excreted in breast milk in low concentrations; caution advised. Generally considered c

💊 Overdose Management

Supportive care. Hemodialysis may enhance elimination. Monitor for seizures and renal function.

⏰ Missed Dose

Administer as soon as possible. If close to next dose, skip missed dose and resume regular schedule. Do not double dose.

🔄 Substitutes for ceftex 125mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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