dubagest vaginal gel - Uses, Price, Side Effects & Substitutes
What is dubagest vaginal gel used for?
Aqsusten 25 Solution for Injection (Progesterone (Natural Micronized)) is used to treat GYNAECOLOGICAL. It contains Progesterone (Natural Micronized) (8% w/w), which Progesterone binds to progesterone receptors, modulating gene expression and exe. Always consult your doctor before use. Take as prescribed.
- Generic Name: Progesterone (Natural Micronized)
- Manufacturer: Integrace Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ dubagest vaginal gel Uses & Benefits
Luteal phase support in assisted reproductive technology, treatment of luteal phase deficiency, secondary amenorrhea, dysfunctional uterine bleeding.
Off-label uses: Prevention of preterm labor, treatment of endometriosis, menopausal hormone therapy.
๐ Drug Information
| Generic Name(s) | Progesterone (Natural Micronized) |
| Brand Name | Aqsusten 25 Solution for Injection |
| Manufacturer | Integrace Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Natural Progesterone |
| Route of Administration | Intramuscular injection. |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Progesterone binds to progesterone receptors, modulating gene expression and exerting progestational effects on the endometrium, reducing uterine contractility, and supporting pregnancy.
Mechanism Steps
๐ก How to Take dubagest vaginal gel
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of dubagest vaginal gel
โ Common Side Effects
- Injection site pain
- dizziness
- headache
- nausea
- breast tenderness
- bloating
๐จ Serious Side Effects
- Thromboembolism
- stroke
- myocardial infarction
- pulmonary embolism
- hepatic dysfunction
โ ๏ธ Rare Side Effects
- Cholestatic jaundice
- anaphylaxis
- depression
- visual disturbances
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Rifampin | Major | Reduced progesterone efficacy due to increased metabolism. |
| Ketoconazole | Major | Increased progesterone levels and risk of side effects. |
| Warfarin | Moderate | Possible altered anticoagulant effect. |
| Grapefruit juice | Minor | May slightly increase progesterone levels. |
๐จ Major Interactions
- CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
โก Moderate Interactions
- Warfarin
- Corticosteroids
- Antidiabetic agents
โน๏ธ Minor Interactions
- Grapefruit juice
- St. John's Wort
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
May enhance sedative effects; caution advised.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Known hypersensitivity, undiagnosed vaginal bleeding, active thromboembolic disorders, severe hepatic dysfunction, known or suspected pregnancy (except for specific indications).
๐ Monitoring Parameters
Progesterone levels, pregnancy test, liver function tests, signs of thromboembolism.
๐คฑ Lactation Safety
Excreted in breast milk; use with caution, especially in high doses.
๐ Overdose Management
No specific antidote; supportive care; symptoms may include drowsiness, dizziness, nausea.
โฐ Missed Dose
Administer as soon as remembered; if close to next dose, skip missed dose and resume regular schedule; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for dubagest vaginal gel
View AllAlternative brands with exact same active ingredient (Progesterone (Natural Micronized) (8% w/w)):
-
susten 8% gelSun Pharmaceutical Industries Ltd โน171.56 166.4% COSTLIER
-
gestone 8% vaginal gelFerring Pharmaceuticals โน182.82 183.8% COSTLIER
-
michelle vaginal gelAkumentis Healthcare Ltd โน204.38 217.3% COSTLIER
-
crinone 8% vaginal gelMerck Ltd โน205.80 219.5% COSTLIER
-
naturogest 8% vaginal gelZydus Cadila โน229.71 256.6% COSTLIER
-
utreva vaginal gelIntas Pharmaceuticals Ltd โน269.06 317.7% COSTLIER
-
emprogest 8% vaginal gelEmcure Pharmaceuticals Ltd โน272.40 322.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.