dubinor ointment - Uses, Price, Side Effects & Substitutes
What is dubinor ointment used for?
Dubinor Ointment (Gabapentin + Diclofenac) is used to treat NEURO CNS. It contains Gabapentin (8% w/w) + Diclofenac (4% w/w), which Gabapentin binds to alpha-2-delta subunit of voltage-gated calcium channels, red. Always consult your doctor before use. Take as prescribed.
- Generic Name: Gabapentin + Diclofenac
- Manufacturer: Integrace Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ dubinor ointment Uses & Benefits
Topical relief of neuropathic pain, musculoskeletal pain, osteoarthritis
Off-label uses: Postherpetic neuralgia, Diabetic neuropathy
๐ Drug Information
| Generic Name(s) | Gabapentin + Diclofenac |
| Brand Name | Dubinor Ointment |
| Manufacturer | Integrace Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Analgesic, Anticonvulsant, NSAID |
| Route of Administration | Topical |
| Storage | Store at room temperature (20-25ยฐC), away from moisture and heat |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Gabapentin binds to alpha-2-delta subunit of voltage-gated calcium channels, reducing neurotransmitter release; Diclofenac inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis
Mechanism Steps
๐ก How to Take dubinor ointment
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of dubinor ointment
โ Common Side Effects
- Skin irritation
- Rash
- Pruritus
- Dry skin
๐จ Serious Side Effects
- Severe allergic reaction
- Angioedema
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Nephrotoxicity
- Blood dyscrasias
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Lithium | Major | Increased lithium toxicity |
| Methotrexate | Major | Increased methotrexate toxicity |
| Other NSAIDs | Major | Additive GI toxicity |
| Anticoagulants | Major | Increased bleeding risk |
| ACE inhibitors | Moderate | Reduced antihypertensive effect |
| Diuretics | Moderate | Reduced diuretic effect |
| Aspirin | Moderate | Increased GI ulcer risk |
| Corticosteroids | Moderate | Increased GI ulcer risk |
| Cyclosporine | Moderate | Increased nephrotoxicity |
| Antacids | Minor | Reduced gabapentin absorption |
| Cimetidine | Minor | Reduced gabapentin clearance |
| Digoxin | Minor | Increased digoxin levels |
๐จ Major Interactions
- Warfarin
- Lithium
- Methotrexate
- Other NSAIDs
- Anticoagulants
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Aspirin
- Corticosteroids
- Cyclosporine
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
- Digoxin
๐ฝ๏ธ Food Interactions
No significant food interactions for topical use
๐ท Alcohol Interaction
Increased risk of GI bleeding with alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to components, active peptic ulcer, severe renal impairment, history of asthma with NSAIDs
๐ Monitoring Parameters
Monitor for skin irritation, signs of systemic effects (rare)
๐คฑ Lactation Safety
Limited data; avoid use or consult physician
๐ Overdose Management
Remove product, symptomatic treatment; unlikely due to low systemic absorption
โฐ Missed Dose
Apply as soon as remembered; skip if almost time for next dose