doxstem 20mg/20mg tablet - Doxylamine (20mg) + Vitamin B6 (Pyridoxine) (20mg) medicine

doxstem 20mg/20mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Abbott ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 27, 2026

What is doxstem 20mg/20mg tablet used for?

Act NVP Tablet (Doxylamine + Vitamin B6) is used to treat GASTRO INTESTINAL. It contains Doxylamine (20mg) + Vitamin B6 (Pyridoxine) (20mg), which Doxylamine: H1-receptor antagonist; Pyridoxine: cofactor for neurotransmitter sy. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Doxylamine + Vitamin B6
  • Manufacturer: Abbott
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š doxstem 20mg/20mg tablet Uses & Benefits

Nausea and vomiting in pregnancy.

Off-label uses: Insomnia, Allergic rhinitis

๐Ÿ“‹ Drug Information

Generic Name(s)Doxylamine + Vitamin B6
Brand NameAct NVP Tablet
ManufacturerAbbott
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassAntihistamine + Vitamin Supplement
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed from the gastrointestinal tract.
DistributionDistributes widely in body tissues; crosses the placenta.
Protein BindingDoxylamine: ~50% bound to plasma proteins; Pyridoxine: minimal binding.
MetabolismDoxylamine: Hepatic via CYP450; Pyridoxine: Hepatic to pyridoxal phosphate.
Half-LifeDoxylamine: 10-12 hours; Pyridoxine: 15-20 days.
ExcretionDoxylamine: Renal (as metabolites); Pyridoxine: Renal (as metabolites).
BioavailabilityDoxylamine: ~70%; Pyridoxine: ~80%.
Onset of Action30-60 minutes.
Peak Plasma TimeDoxylamine: 2-3 hours; Pyridoxine: 1-2 hours.
Duration of Action4-6 hours.

How It Works

Doxylamine: H1-receptor antagonist; Pyridoxine: cofactor for neurotransmitter synthesis.

Mechanism Steps

1Doxylamine competitively blocks histamine at H1 receptors in the vomiting center.
2Pyridoxine acts as a cofactor for enzymes involved in neurotransmitter synthesis, reducing nausea.
3Combined effect reduces emetic signals and provides sedation.

๐Ÿ’ก How to Take doxstem 20mg/20mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of doxstem 20mg/20mg tablet

โœ… Common Side Effects

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Constipation

๐Ÿšจ Serious Side Effects

  • Severe allergic reaction
  • Urinary retention
  • Blurred vision

โš ๏ธ Rare Side Effects

  • Blood dyscrasias
  • Hepatotoxicity

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
CNS depressants Major Enhanced sedation and respiratory depression
MAO inhibitors Major Increased anticholinergic and sedative effects
Anticholinergics Moderate Additive anticholinergic effects
Alcohol Moderate Increased sedation
Oral contraceptives Minor Reduced pyridoxine levels
Isoniazid Minor Reduced pyridoxine levels

๐Ÿšจ Major Interactions

  • CNS depressants
  • MAO inhibitors

โšก Moderate Interactions

  • Anticholinergics
  • Alcohol

โ„น๏ธ Minor Interactions

  • Oral contraceptives
  • Isoniazid

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase absorption

๐Ÿท Alcohol Interaction

Increased sedation and CNS depression.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to doxylamine or pyridoxine; narrow-angle glaucoma; urinary retention; asthma attack.

๐Ÿ“Š Monitoring Parameters

Nausea/vomiting relief; sedation level; anticholinergic effects.

๐Ÿคฑ Lactation Safety

Use with caution; may cause drowsiness in infant.

๐Ÿ’Š Overdose Management

Symptomatic and supportive; activated charcoal if recent ingestion; monitor for CNS depression and anticholinergic effects.

โฐ Missed Dose

Take as soon as remembered unless near next dose; skip if close to next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

๐Ÿ”— View Profile

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