Grenil Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Irregular heartbeat or palpitations
- Severe abdominal pain
- Yellowing of skin or eyes
- Blood in vomit or stool
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is diike 20mg/500mg tablet used for?
This medicine is a combination of Domperidone and Paracetamol used to treat nausea, vomiting, and pain. It works by speeding up stomach emptying and blocking pain signals. It is usually taken up to three times daily, but always follow your doctor's advice.
- Generic Name: Domperidone (20mg) + Paracetamol (500mg)
- Manufacturer: Cadila Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 diike 20mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन और पैरासिटामोल का संयोजन है, जिसका उपयोग मतली, उल्टी और दर्द के इलाज के लिए किया जाता है। यह पेट को खाली करने में मदद करती है और दर्द को कम करती है। इसका उपयोग माइग्रेन, अपच, और सर्जरी के बाद की मतली और दर्द में किया जाता है।
साइड इफेक्ट्स: सामान्य दुष्प्रभावों में मुँह सूखना, सिरदर्द, नींद आना और पेट में ऐंठन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इसमें अनियमित दिल की धड़कन, एलर्जी, और लीवर की समस्या हो सकती है।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। शराब का सेवन न करें। गाड़ी चलाने या मशीन चलाने से बचें यदि नींद आती हो। दिल, लीवर या किडनी की समस्या हो तो डॉक्टर को बताएं। 7 दिनों से अधिक इसका उपयोग न करें।
💊 diike 20mg/500mg tablet Uses & Benefits
[{"condition":"Migraine with nausea and vomiting","description":"Helps relieve headache pain and reduces nausea and vomiting associated with migraine attacks.","evidence":"Well-established"},{"condition":"Functional dyspepsia with pain","description":"Improves stomach emptying and reduces upper abdominal pain and discomfort.","evidence":"Moderate"},{"condition":"Post-operative nausea and pain","description":"Used to manage nausea and mild to moderate pain after surgery.","evidence":"Moderate"},{"condition":"Gastroparesis with pain","description":"May help with nausea and abdominal pain in diabetic gastroparesis.","evidence":"Limited"}]
Off-label uses: [{"condition":"Nausea and vomiting of pregnancy","description":"Sometimes prescribed off-label for morning sickness, but safety profile requires careful evaluation.","evidence":"Limited"},{"condition":"Prevention of chemotherapy-induced nausea","description":"Not a first-line agent but may be used in some regimens.","evidence":"Limited"}]
Primary treatment for: Migraine with nausea and vomiting
Also treats: Functional dyspepsia, Post-operative nausea and pain, Gastroparesis
📋 Drug Information
| Generic Name(s) | Domperidone (20mg) + Paracetamol (500mg) |
| Brand Name | diike 20mg/500mg tablet |
| Manufacturer | Cadila Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Domperidone is a peripheral dopamine D2 receptor antagonist that acts on the chemoreceptor trigger zone and the gastrointestinal tract. It enhances gastric motility and accelerates gastric emptying without significant central nervous system effects. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which reduces pain and fever. The combination provides both prokinetic and analgesic-antipyretic effects.
Mechanism Steps
💡 How to Take diike 20mg/500mg tablet
Strength: Tablet containing Domperidone 20 mg and Paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken up to three times daily, depending on the condition being treated. The maximum daily dose should not exceed 3 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of domperidone, especially cardiac effects. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In severe renal impairment, dose reduction may be necessary. Consult your doctor. |
| Hepatic Impairment | Avoid in severe hepatic impairment. In mild to moderate impairment, use with caution and monitor liver function. |
| Maximum Daily Dose | Maximum daily dose is 3 tablets (Domperidone 60 mg + Paracetamol 1500 mg) in 24 hours. Do not exceed. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of diike 20mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Erythromycin | Major | |
| Warfarin | Major | |
| Anticholinergics | Moderate | |
| Opioids | Moderate | |
| Alcohol | Moderate |
🚨 Major Interactions
- Ketoconazole
- Erythromycin
- Warfarin
⚡ Moderate Interactions
- Anticholinergics
- Opioid analgesics
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and may worsen drowsiness or dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to domperidone or paracetamol","Severe liver disease","Severe kidney disease","Heart conditions such as prolonged QT interval, heart failure, or arrhythmias","Gastrointestinal bleeding or obstruction","Prolactin-releasing pituitary tumor","Concomitant use with potent CYP3A4 inhibitors"]
⚠️ Warnings & Precautions
["Do not exceed recommended dose or duration.","Avoid in patients with heart rhythm disorders.","Use with caution in elderly patients.","Avoid alcohol.","Do not use for more than 7 days without medical advice.","Inform your doctor if you are pregnant or breastfeeding."]
🤱 Lactation Safety
Domperidone is excreted in breast milk and may cause side effects in the infant. Paracetamol is considered safe during breastfeeding. Consult your doctor before use.
💊 Overdose Management
Overdose can cause severe liver damage from paracetamol and cardiac arrhythmias from domperidone. Seek immediate medical attention. Treatment includes activated charcoal, acetylcysteine for paracetamol toxicity, and supportive care for arrhythmias.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and drowsiness. Do not drive or operate heavy machinery if you feel dizzy or sleepy. Inform your doctor if you have heart, liver, or kidney problems, or if you are taking other medications, especially blood thinners, antidepressants, or antibiotics. Do not use this medicine for more than 7 days without consulting a doctor. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of cardiac side effects from domperidone. Use with caution and lower doses may be appropriate. Regular monitoring of heart rhythm is advised.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy if you are taking this medicine. The safety of this combination during pregnancy is not well established.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative nausea and pain. Inform your surgeon and anesthesiologist if you are taking it before surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with certain medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy or drowsy. Light activities are generally safe. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may affect your ability to concentrate.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if symptoms persist beyond 7 days, if you experience serious side effects, or if your doctor advises discontinuation. Do not stop abruptly without medical advice if you have been on long-term therapy.
📅 Long-Term Use Effects
Long-term use of this medicine should be avoided unless prescribed and monitored. Prolonged use of domperidone can increase the risk of heart rhythm problems and elevated prolactin levels. Paracetamol overuse can lead to liver damage. Regular monitoring of liver and heart function may be required.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Eating small, frequent meals and avoiding triggers can help reduce nausea and pain.
Evidence: Well-establishedStress management can reduce the frequency of migraines and functional dyspepsia.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you are acutely ill with nausea and vomiting, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid extreme heat. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after taking it.
A: It can be taken with or without food, but taking it with food reduces the chance of stomach upset.
A: Consult your doctor. The safety of this combination during pregnancy is not well established.
🤔 Common Patient Concerns
🔄 Substitutes for diike 20mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
-
d febrol 20mg/500mg tabletVostok & Wilcure Remedies ₹18.28 47.2% CHEAPER
-
onmol 20mg/500mg tabletHuman Lifesciences ₹27.19 21.5% CHEAPER
-
jasdom-p 20mg/500mg tabletJasco Labs Pvt Ltd ₹30.00 13.4% CHEAPER
-
domrose plus 20mg/500mg tabletMedirose drug & pharma ₹32.00 7.6% CHEAPER
-
nograin 20mg/500mg tabletTotal Healthcare ₹33.75 2.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: It is specifically for pain associated with nausea and vomiting, not for general pain relief. - Myth: It is safe to take this medicine long-term.
Fact: Long-term use should be avoided unless prescribed and monitored by a doctor due to cardiac and liver risks.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Paracetamol combination generics
Brand Alternatives
- Domperidone + Paracetamol tablets