dexa sr capsule - Domperidone (30mg) + Dexrabeprazole (10mg) medicine

Dirab D 30mg/10mg Capsule SR: Complete Medicine Guide

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🏭 Zunison Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 24, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate
Reviewed by
SaathiMed Expert Panel | Oct 24, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Irregular heartbeat or palpitations
  • Severe allergic reaction (rash, swelling, difficulty breathing)
  • Muscle stiffness or tremors
  • Blood in vomit or stool
  • Severe abdominal pain
  • Yellowing of eyes or skin

If experiencing severe symptoms, call emergency services immediately.

What is dexa sr capsule used for?

This medicine is a combination of Domperidone and Dexrabeprazole used to treat acid reflux, heartburn, and nausea by reducing stomach acid and improving gastric emptying.

  • Generic Name: Domperidone + Dexrabeprazole
  • Manufacturer: Zunison Healthcare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 dexa sr capsule के बारे में (Hindi Summary)

उपयोग: यह दवा डोम्पेरिडोन और डेक्सराबेप्राजोल का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, सीने में जलन, अपच और मतली के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पेट खाली होने में मदद करती है।

साइड इफेक्ट्स: सामान्य दुष्प्रभावों में सिरदर्द, दस्त, मतली, पेट दर्द और मुँह सूखना शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यदि आपको दिल की धड़कन अनियमित लगे, एलर्जी हो, या मांसपेशियों में अकड़न हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। निर्धारित मात्रा से अधिक न लें। इस दवा के साथ शराब न पिएं। यदि आपको हृदय, यकृत या गुर्दे की समस्या है तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के लंबे समय तक इसका उपयोग न करें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 dexa sr capsule Uses & Benefits

[{"condition":"Gastroesophageal reflux disease (GERD)","description":"Reduces acid reflux and heartburn by decreasing stomach acid production and improving gastric emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Helps relieve symptoms like bloating, early satiety, and upper abdominal discomfort.","evidence":"Moderate"},{"condition":"Nausea and vomiting","description":"Domperidone component helps reduce nausea and vomiting by blocking dopamine receptors in the brain.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes prescribed off-label to improve gastric emptying in diabetic patients.","evidence":"Limited"}]

Primary treatment for: Gastroesophageal reflux disease (GERD)

Also treats: Functional dyspepsia, Nausea and vomiting

📋 Drug Information

Generic Name(s)Domperidone + Dexrabeprazole
Brand NameDirab D 30mg/10mg Capsule SR
ManufacturerZunison Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassProkinetic agent + Proton pump inhibitor
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine before breakfast for best results.
2
Do not crush or chew the capsule; swallow it whole.
3
Avoid alcohol while taking this medicine.
4
Report any irregular heartbeat or muscle stiffness immediately.
5
Do not use for more than 8 weeks without medical review.
6
Inform your doctor if you have heart or liver problems.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Heartburn
This medicine is commonly prescribed for this.
Likely Use
✅
Nausea
Domperidone component helps relieve nausea.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDomperidone is rapidly absorbed after oral administration, with peak plasma levels occurring within 30-60 minutes. Dexrabeprazole is also rapidly absorbed, with peak concentrations reached in about 1-2 hours.
DistributionDomperidone is widely distributed in tissues but does not readily cross the blood-brain barrier. Dexrabeprazole is distributed mainly in the stomach lining and liver.
Protein BindingDomperidone is approximately 91-93% bound to plasma proteins. Dexrabeprazole is about 96% bound to plasma proteins.
MetabolismDomperidone undergoes extensive first-pass metabolism in the liver via CYP3A4 and CYP1A2 enzymes. Dexrabeprazole is metabolized in the liver by CYP2C19 and CYP3A4 enzymes.
Half-LifeThe elimination half-life of domperidone is approximately 7-9 hours. Dexrabeprazole has a half-life of about 1-2 hours.
ExcretionDomperidone is excreted mainly in feces (about 66%) and urine (about 33%). Dexrabeprazole is excreted primarily as metabolites in urine (about 80%) and feces (about 20%).
BioavailabilityThe oral bioavailability of domperidone is about 13-17% due to first-pass metabolism. Dexrabeprazole has a bioavailability of approximately 52%.
Onset of ActionDomperidone onset of action is within 30-60 minutes. Dexrabeprazole onset of acid suppression occurs within 1 hour.
Peak Plasma TimeDomperidone peak plasma time is 0.5-1 hour. Dexrabeprazole peak plasma time is 1-2 hours.
Duration of ActionDomperidone duration of action is about 6-8 hours. Dexrabeprazole acid suppression lasts up to 24 hours.

How It Works

This medicine combines two active ingredients with complementary actions. Domperidone is a peripheral dopamine D2 receptor antagonist that enhances gastric motility and emptying without crossing the blood-brain barrier significantly. Dexrabeprazole is a proton pump inhibitor that irreversibly blocks the hydrogen-potassium ATPase enzyme in gastric parietal cells, thereby suppressing both basal and stimulated acid secretion.

Mechanism Steps

1
Domperidone action: Domperidone blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, leading to increased gastric motility and reduced nausea.
2
Dexrabeprazole action: Dexrabeprazole is activated in the acidic environment of parietal cells and binds irreversibly to the proton pump, inhibiting acid secretion.
3
Combined effect: The combination improves gastric emptying and reduces acid exposure, providing relief from reflux and dyspepsia symptoms.

💡 How to Take dexa sr capsule

Strength: Capsule containing Domperidone 30 mg and Dexrabeprazole 10 mg.

1Take the capsule whole with a glass of water.
2Swallow it whole; do not crush or chew.
3Take it at the same time each day.
4Take it before meals for best effect.

Dosage Information

Adult DosageThe usual adult dose is one capsule taken orally once daily before breakfast, or as directed by your doctor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to side effects. Use with caution and adjust dose as needed under medical supervision.
Renal ImpairmentUse with caution in severe renal impairment. Dose adjustment may be necessary.
Hepatic ImpairmentAvoid in severe hepatic impairment. Dose adjustment may be needed in mild to moderate impairment.
Maximum Daily DoseThe maximum recommended daily dose is one capsule (30 mg domperidone + 10 mg dexrabeprazole).

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take before meals
Enhances absorption and reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of dexa sr capsule

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent.
Diarrhea (Common (5-10%))
Stay hydrated. Consult doctor if severe or persistent.
Nausea (Common (5-10%))
Take with food. Consult doctor if it continues.
Abdominal pain (Common (5-10%))
Usually mild. Consult doctor if severe.
Dry mouth (Common (5-10%))
Drink water. Consult doctor if bothersome.

🚨 Serious Side Effects

Irregular heartbeat (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations or fainting.
Allergic reactions (Rare (<0.1%))
Seek immediate medical help if you notice rash, swelling, or difficulty breathing.
Extrapyramidal symptoms (Rare (<0.1%))
Report muscle stiffness, tremors, or involuntary movements to your doctor immediately.

⚠️ Rare Side Effects

Galactorrhea
Consult your doctor if you notice breast milk secretion.
Gynecomastia
Consult your doctor if breast enlargement occurs.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Clarithromycin Major
Warfarin Moderate
Anticholinergics Moderate
Antacids Minor

🚨 Major Interactions

  • Ketoconazole
  • Clarithromycin

⚡ Moderate Interactions

  • Anticholinergics
  • Warfarin

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine as it may increase drowsiness, dizziness, and stomach irritation.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to domperidone or dexrabeprazole","Gastrointestinal bleeding, obstruction, or perforation","Prolactin-releasing pituitary tumor","Severe hepatic impairment","Concurrent use with QT-prolonging drugs"]

⚠️ Warnings & Precautions

["Use with caution in patients with heart disease.","Avoid in patients with electrolyte imbalances.","Do not use for prolonged periods without medical supervision.","May cause drowsiness; avoid driving if affected.","Consult doctor before use in pregnancy or breastfeeding."]

🤱 Lactation Safety

Domperidone may pass into breast milk. Dexrabeprazole is not recommended during breastfeeding. Consult your doctor before use.

💊 Overdose Management

Seek immediate medical attention. Treatment is symptomatic and supportive. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid alcohol while taking this medicine as it may increase drowsiness and stomach irritation. Inform your doctor if you have heart, liver, or kidney problems. Do not use this medicine for longer than recommended without medical supervision. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to side effects like drowsiness and arrhythmias. Use with caution and monitor regularly.

🤰 Pregnancy Planning (TTC)

Consult your doctor if you are planning pregnancy or are pregnant. This medicine may not be suitable during pregnancy.

🏥 Post-Surgery Considerations

Consult your doctor before resuming this medicine after surgery, especially gastrointestinal surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may affect bleeding risk or interact with anesthetics.

💚 Lifestyle Tips for Better Results

🏃
Avoid spicy and fatty foods.
🥗
Eat smaller, more frequent meals.
😴
Do not lie down immediately after eating.
💧
Maintain a healthy weight.
🧘
Avoid smoking and alcohol.

🏋️ Exercise Considerations

Avoid strenuous exercise immediately after taking this medicine if you feel dizzy or drowsy. Stay hydrated during exercise.

🥗 Diet Recommendations

Eat a balanced diet rich in fiber.
Avoid trigger foods like citrus, chocolate, and caffeine.
Stay well hydrated.
Limit alcohol and caffeine intake.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects, seek medical advice immediately.

📅 Long-Term Use Effects

Long-term use may increase the risk of bone fractures, low magnesium levels, and vitamin B12 deficiency. Regular monitoring by a doctor is recommended. Do not use for extended periods without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet changes, weight loss, and elevating the head of the bed can help reduce reflux symptoms.

Evidence: Well-established
Other acid-suppressing medicines

H2 blockers or other PPIs may be alternatives based on your condition.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions reported. Consult your doctor for routine vaccinations.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old man with chronic heartburn
He was prescribed this medicine for GERD. After taking it daily before breakfast for two weeks, his heartburn and regurgitation significantly improved. He reported mild headache initially, which resolved.
💡 Lesson: Consistent use before meals enhances effectiveness.
👤 A 60-year-old woman with nausea and bloating
She started this medicine for functional dyspepsia. Her nausea reduced within a few days, and bloating improved over two weeks. She was advised to avoid alcohol and take it regularly.
💡 Lesson: Adherence to prescribed schedule and lifestyle modifications improve outcomes.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within 1 hour, but symptom relief may take a few days of regular use.

Q: Can I take it with other medicines?

A: Inform your doctor about all medicines you take, as interactions may occur.

Q: Is it safe during pregnancy?

A: Consult your doctor before use during pregnancy or breastfeeding.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my heart?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for dexa sr capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure acid reflux permanently.
    Fact: It provides symptomatic relief but does not cure the underlying condition.
  • Myth: It is safe to take indefinitely.
    Fact: Long-term use should be under medical supervision due to potential side effects.

🔄 Alternative Options

Generic Alternatives

  • Domperidone + Dexrabeprazole generic capsules

Brand Alternatives

  • Dirab D 30mg/10mg Capsule SR

📊 Comparison with Similar Medicines

[{"medicine":"Domperidone + Dexrabeprazole","composition":"Domperidone 30mg + Dexrabeprazole 10mg","uses":"GERD, dyspepsia, nausea","notes":"Combination of prokinetic and PPI"},{"medicine":"Domperidone + Rabeprazole","composition":"Domperidone 30mg + Rabeprazole 20mg","uses":"GERD, dyspepsia","notes":"Similar but different PPI"}]

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