depolin 10mg tablet - Medroxyprogesterone acetate (10mg) medicine

depolin 10mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Ernst Pharmacia ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 28, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 28, 2026

What is depolin 10mg tablet used for?

Bioprate 10mg tablet (Medroxyprogesterone acetate) is used to treat GYNAECOLOGICAL. It contains Medroxyprogesterone acetate (10mg), which Binds to progesterone receptors, suppressing gonadotropin release and inhibiting. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Medroxyprogesterone acetate
  • Manufacturer: Ernst Pharmacia
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š depolin 10mg tablet Uses & Benefits

Contraception, endometriosis, secondary amenorrhea, abnormal uterine bleeding, adjunctive therapy in endometrial cancer.

Off-label uses: Hormone replacement therapy, male contraception (investigational).

๐Ÿ“‹ Drug Information

Generic Name(s)Medroxyprogesterone acetate
Brand NameBioprate 10mg tablet
ManufacturerErnst Pharmacia
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGYNAECOLOGICAL
Action ClassProgestins (First generation)
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC) in a dry place.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally; bioavailability approximately 100%.
DistributionDistributes widely; crosses placenta; enters breast milk.
Protein Binding90-95% bound to albumin.
MetabolismHepatic via hydroxylation and conjugation; CYP3A4 involved.
Half-Life12-17 hours
ExcretionPrimarily renal (metabolites); small amount in feces.
Bioavailability~100%
Onset of Action1-2 hours
Peak Plasma Time2-4 hours
Duration of Action24 hours

How It Works

Binds to progesterone receptors, suppressing gonadotropin release and inhibiting ovulation; also alters endometrial lining.

Mechanism Steps

1Binds to progesterone receptors in target tissues.
2Suppresses hypothalamic GnRH secretion.
3Reduces pituitary LH and FSH release.

๐Ÿ’ก How to Take depolin 10mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of depolin 10mg tablet

โœ… Common Side Effects

  • Weight gain
  • Headache
  • Nausea
  • Breast tenderness
  • Irregular bleeding

๐Ÿšจ Serious Side Effects

  • Thromboembolism
  • Stroke
  • Myocardial infarction
  • Hepatic adenoma

โš ๏ธ Rare Side Effects

  • Anaphylaxis
  • Cholestatic jaundice
  • Optic neuritis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Rifampin Major Reduced contraceptive efficacy
Ketoconazole Major Increased progestin levels
Warfarin Moderate Altered anticoagulant effect
Insulin Moderate Altered glucose tolerance

๐Ÿšจ Major Interactions

  • CYP3A4 inducers (e.g., rifampin, carbamazepine)
  • CYP3A4 inhibitors (e.g., ketoconazole)

โšก Moderate Interactions

  • Warfarin
  • Insulin
  • Oral hypoglycemics

โ„น๏ธ Minor Interactions

  • Corticosteroids
  • Theophylline

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

No specific interaction; alcohol may worsen side effects like dizziness.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Pregnancy, known or suspected breast cancer, active thromboembolic disorders, liver disease, undiagnosed vaginal bleeding.

๐Ÿ“Š Monitoring Parameters

Blood pressure, liver function, signs of thromboembolism, menstrual pattern.

๐Ÿคฑ Lactation Safety

Excreted in breast milk; use with caution.

๐Ÿ’Š Overdose Management

Induce vomiting or gastric lavage; supportive care.

โฐ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose. Do not double.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 28, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for depolin 10mg tablet

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Alternative brands with exact same active ingredient (Medroxyprogesterone acetate (10mg)):

Medical Note: Always consult your doctor before switching medications.

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