Chromostat Tablet: Complete Guide to Uses, Dosage, and Safety
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Sudden swelling or pain in an arm or leg
- Severe headache with visual changes
- Yellowing of skin or eyes
- Decreased urine output
- Rash or swelling of face, lips, or throat
If experiencing severe symptoms, call emergency services immediately.
What is abdotic plus tablet used for?
This medicine is a combination of Tranexamic Acid 500 mg and Mefenamic Acid 250 mg used to treat heavy menstrual bleeding and menstrual pain. It works by reducing blood clot breakdown and decreasing pain-causing prostaglandins. It is taken orally with food, usually for up to 5 days during menstruation, as prescribed by a doctor.
- Generic Name: Tranexamic Acid + Mefenamic Acid
- Manufacturer: Ernst Pharmacia
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 abdotic plus tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ट्रैनेक्सैमिक एसिड और मेफेनैमिक एसिड का संयोजन है, जिसका उपयोग अत्यधिक मासिक धर्म रक्तस्राव (मेनोरेजिया) और मासिक धर्म के दर्द के इलाज के लिए किया जाता है। यह रक्त के थक्के बनने में मदद करती है और दर्द पैदा करने वाले प्रोस्टाग्लैंडिन को कम करती है। इसे भोजन के साथ मुँह से लिया जाता है, आमतौर पर मासिक धर्म के दौरान 5 दिनों तक, डॉक्टर के निर्देशानुसार।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द, चक्कर आना और थकान शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें रक्त के थक्के बनना, गंभीर एलर्जी प्रतिक्रिया, और गैस्ट्रोइंटेस्टाइनल रक्तस्राव शामिल हो सकते हैं। यदि आपको कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन या दूध के साथ लें ताकि पेट की परेशानी कम हो। दवा लेने के बाद कम से कम 30 मिनट तक सीधे बैठें या खड़े रहें। इस दवा के साथ शराब न पिएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। अन्य दवाओं के साथ इसका सेवन करने से पहले डॉक्टर को बताएं। 5 दिनों से अधिक इसका उपयोग न करें।
💊 abdotic plus tablet Uses & Benefits
[{"condition":"Heavy menstrual bleeding (menorrhagia)","description":"This medicine reduces the volume of menstrual blood loss and relieves associated pain in women with heavy periods.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"The mefenamic acid component helps relieve menstrual cramps and pelvic pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Epistaxis (nosebleeds)","description":"Tranexamic acid has been used off-label to reduce bleeding in recurrent nosebleeds, but this combination is not standard for this use.","evidence":"Limited"},{"condition":"Trauma-related bleeding","description":"Tranexamic acid alone is used in trauma, but the combination with mefenamic acid is not indicated for this purpose.","evidence":"Limited"}]
Primary treatment for: Heavy menstrual bleeding (menorrhagia)
Also treats: Primary dysmenorrhea, Menstrual cramps
📋 Drug Information
| Generic Name(s) | Tranexamic Acid + Mefenamic Acid |
| Brand Name | Abdotic Plus Tablet |
| Manufacturer | Ernst Pharmacia |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Antifibrinolytic + NSAID |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Tranexamic acid is an antifibrinolytic agent that reversibly binds to plasminogen and blocks its activation to plasmin. Plasmin is responsible for breaking down fibrin clots. By inhibiting plasmin, tranexamic acid helps stabilize blood clots and reduces bleeding. Mefenamic acid is a nonsteroidal anti-inflammatory drug that inhibits the cyclooxygenase enzymes, leading to decreased production of prostaglandins. Prostaglandins are involved in pain, inflammation, and uterine contractions. By reducing prostaglandin levels, mefenamic acid relieves pain and reduces menstrual cramping and bleeding.
Mechanism Steps
💡 How to Take abdotic plus tablet
Strength: Each immediate-release tablet contains Tranexamic Acid 500 mg and Mefenamic Acid 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times a day during menstrual bleeding, not exceeding 5 days per cycle. The exact dose and duration must be individualized by a qualified clinician based on the indication, severity of bleeding, age, weight, renal and hepatic function, and response to treatment. Do not self-adjust the dose. Take with food to reduce stomach upset. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially renal and gastrointestinal side effects. Dose adjustment may be necessary based on renal function. Consult a doctor for individualized dosing. |
| Renal Impairment | In patients with renal impairment, dose reduction is recommended. For tranexamic acid, the dose should be reduced in patients with serum creatinine above 1.4 mg/dL. For mefenamic acid, avoid use in severe renal impairment. Consult a nephrologist or clinician for specific dosing. |
| Hepatic Impairment | In patients with hepatic impairment, mefenamic acid should be used with caution due to potential for increased liver toxicity. Tranexamic acid does not require dose adjustment in mild to moderate hepatic impairment. Consult a hepatologist or clinician for specific dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets (Tranexamic Acid 1500 mg + Mefenamic Acid 750 mg) per day. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of abdotic plus tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Methotrexate | Moderate | |
| Lithium | Moderate | |
| Diuretics | Moderate | |
| ACE inhibitors | Moderate | |
| Antacids | Minor | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Warfarin
- Other anticoagulants (e.g., heparin, rivaroxaban)
- Thrombolytic agents (e.g., alteplase)
⚡ Moderate Interactions
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Selective serotonin reuptake inhibitors (SSRIs)
- Methotrexate
- Lithium
- Diuretics
- ACE inhibitors
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding and may worsen side effects such as dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active thromboembolic disease (e.g., deep vein thrombosis, pulmonary embolism)","History of blood clots or stroke","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Use with caution in patients with a history of blood clots or cardiovascular disease.","Avoid in patients with active bleeding or risk of thrombosis.","Monitor renal function in patients with kidney disease.","Monitor liver function in patients with liver disease.","Avoid concurrent use with other NSAIDs or anticoagulants.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use for more than 5 days without medical supervision.","Not recommended for children under 12 years of age.","Elderly patients may be more susceptible to side effects; use with caution."]
🤱 Lactation Safety
Tranexamic acid is excreted in breast milk at low concentrations. Mefenamic acid is also excreted in breast milk. This medicine is not recommended during breastfeeding due to potential risks to the infant. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, abdominal pain, dizziness, and in severe cases, seizures, hypotension, and thromboembolic events. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs, renal function, and coagulation parameters.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not take more or less than the recommended dose. Swallow the tablet whole with a full glass of water. Take it with food or milk to reduce the risk of stomach upset. Do not lie down immediately after taking this medicine; stay upright for at least 30 minutes. Avoid drinking alcohol while taking this medicine, as it can increase the risk of stomach bleeding. Inform your doctor if you have a history of blood clots, kidney disease, liver disease, asthma, or stomach ulcers. Tell your doctor about all other medicines you are taking, especially blood thinners, other pain relievers, and oral contraceptives. Do not use this medicine for more than 5 days in a row without consulting your doctor. If you are pregnant or planning to become pregnant, consult your doctor before using this medicine. This medicine is not recommended during breastfeeding. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. Do not use it after the expiry date. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the renal and gastrointestinal side effects of this medicine. Dose adjustment may be necessary based on renal function. Use with caution and monitor closely.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for alternative treatments for heavy menstrual bleeding if you are trying to conceive.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding after surgery. Inform your surgeon if you are taking this medicine. It is usually stopped before surgery to reduce bleeding risk.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may affect bleeding. Your dentist may recommend stopping it temporarily.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you have heavy bleeding or are at risk of blood clots. Light to moderate exercise like walking or yoga is generally safe. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually taken for a short duration, so work impact is minimal. If you experience side effects that interfere with your daily activities, consult your doctor.
🛑 When to Stop This Medicine
Stop taking this medicine after the prescribed duration, usually 5 days per menstrual cycle, unless your doctor advises otherwise. If you experience any serious side effects, stop the medicine and seek immediate medical attention. Do not stop or change the dose without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of mefenamic acid can increase the risk of kidney and liver problems, gastrointestinal bleeding, and cardiovascular events. Tranexamic acid may increase the risk of blood clots with extended use. Regular monitoring of renal and hepatic function is advised if used for more than a few days. Consult your doctor for alternative treatments if you need long-term management of heavy menstrual bleeding.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can regulate menstrual cycles and reduce heavy bleeding.
Evidence: Well-establishedCan reduce menstrual pain and bleeding.
Evidence: Well-establishedHelps prevent or treat anemia caused by heavy bleeding.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established from available information. However, consult your doctor before receiving any vaccine while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from moisture and direct sunlight. If crossing time zones, continue taking the medicine as prescribed; adjust the timing gradually if needed. Check customs regulations for carrying prescription medicines. Keep it in your carry-on luggage to avoid loss.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 1 to 2 hours. The effect on bleeding may take a few hours to become noticeable.
A: Do not take other NSAIDs or blood thinners without consulting your doctor, as it may increase the risk of bleeding.
A: This medicine is not recommended during pregnancy, especially in the third trimester. Consult your doctor for alternative options.
A: This medicine is usually taken for up to 5 days during menstruation. Do not exceed the prescribed duration without consulting your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for abdotic plus tablet
View AllAlternative brands with exact same active ingredient:
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cyclosym tx tabletSymbiosis Lab ₹13.14 93% CHEAPER
-
tramed p 500 mg/250 mg tabletView Laboratories ₹26.25 86% CHEAPER
-
femidol 500 mg/250 mg tabletWest-Coast Pharmaceutical Works Ltd ₹29.84 84% CHEAPER
-
orsik tabletOrnate Labs Pvt Ltd ₹44.01 76.5% CHEAPER
-
Transpa 500mg/250mg TabletNature Biotech ₹45.00 75.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of bleeding.
Fact: This medicine is specifically indicated for heavy menstrual bleeding and should not be used for other types of bleeding without medical advice. - Myth: This medicine is safe to take long-term.
Fact: This medicine is intended for short-term use during menstrual periods, usually not exceeding 5 days per cycle, unless otherwise directed by a doctor. - Myth: This medicine can be taken without a prescription.
Fact: This medicine is a prescription drug and should only be taken under the supervision of a qualified clinician.
🔄 Alternative Options
Generic Alternatives
- Tranexamic Acid + Mefenamic Acid combination tablets from other manufacturers.
Brand Alternatives
- Other brands containing Tranexamic Acid and Mefenamic Acid may be available. Consult your pharmacist for alternatives.