danavish nicorandil 5mg tablet - Nicorandil (5mg) medicine

danavish nicorandil 5mg tablet

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🏭 Danavish Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

What is danavish nicorandil 5mg tablet used for?

This medicine contains Nicorandil (5mg) and is used to treat CARDIAC. Nicorandil is a potassium channel activator and a nitrate-like vasodilator. It opens ATP-sensitive p. Always consult your doctor before use.

  • Generic Name: Nicorandil
  • Manufacturer: Danavish Healthcare
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 danavish nicorandil 5mg tablet Uses & Benefits

Prophylaxis and long-term treatment of angina pectoris.

Off-label uses: Raynaud's phenomenon, heart failure (limited evidence).

📋 Drug Information

Generic Name(s)Nicorandil
Brand NameAlcoran
ManufacturerDanavish Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassPotassium channel opener
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly and completely absorbed after oral administration.
DistributionWidely distributed; volume of distribution approximately 1.4 L/kg.
Protein BindingApproximately 25% bound to plasma proteins.
MetabolismExtensively metabolized in the liver via denitration and glucuronidation.
Half-LifeApproximately 1 hour (parent drug); active metabolites have longer half-life.
ExcretionRenal excretion of metabolites; less than 1% excreted unchanged.
BioavailabilityApproximately 75-80% due to first-pass metabolism.
Onset of ActionWithin 30 minutes.
Peak Plasma Time0.5-1 hour.
Duration of ActionUp to 12 hours.

How It Works

Nicorandil is a potassium channel activator and a nitrate-like vasodilator. It opens ATP-sensitive potassium channels in vascular smooth muscle, leading to hyperpolarization and relaxation, and also acts as a nitric oxide donor, increasing cGMP.

Mechanism Steps

1Binds to ATP-sensitive potassium channels on vascular smooth muscle cells.
2Opens K_ATP channels, causing potassium efflux and membrane hyperpolarization.
3Hyperpolarization closes voltage-gated calcium channels, reducing calcium influx.
4Decreased intracellular calcium leads to smooth muscle relaxation and vasodilation.
5Additionally, nicorandil donates nitric oxide, activating guanylate cyclase.
6Increased cGMP further promotes vasodilation via protein kinase G.

💡 How to Take danavish nicorandil 5mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of danavish nicorandil 5mg tablet

✅ Common Side Effects

Headache
Flushing
Dizziness
Nausea
Vomiting

🚨 Serious Side Effects

Hypotension
Reflex tachycardia
Angioedema
Hepatic dysfunction

⚠️ Rare Side Effects

Oral ulceration
Gastrointestinal bleeding
Myocardial ischemia (paradoxical)

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Sildenafil Major Severe hypotension
Riociguat Major Severe hypotension
Alcohol Moderate Additive vasodilation and hypotension

🚨 Major Interactions

  • Phosphodiesterase-5 inhibitors (e.g., sildenafil)
  • Soluble guanylate cyclase stimulators (e.g., riociguat)

⚡ Moderate Interactions

  • Antihypertensives
  • Alcohol
  • Nitrates

🍷 Alcohol Interaction

May enhance hypotensive effect; caution advised.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, cardiogenic shock, left ventricular failure with low filling pressure, hypotension, concurrent use with PDE-5 inhibitors or riociguat.

🤱 Lactation Safety

Excreted in breast milk; caution advised.

💊 Overdose Management

Symptomatic and supportive; monitor blood pressure and heart rate; may require vasopressors.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

🔄 Substitutes for danavish nicorandil 5mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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