Drnic 5mg Tablet (Nicorandil): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Painful mouth ulcers or sores
- Severe dizziness or fainting
- Chest pain that does not go away with rest or usual medication
- Swelling of the face, lips, tongue, or throat
- Difficulty breathing or wheezing
- Yellowing of the skin or eyes
- Unusual bruising or bleeding
- Severe headache that does not improve
If experiencing severe symptoms, call emergency services immediately.
What is mayonil 5mg tablet used for?
This medicine is a potassium channel activator used to prevent angina attacks. It works by relaxing blood vessels and improving blood flow to the heart. It is not for immediate relief of acute chest pain.
- Generic Name: Nicorandil (5mg)
- Manufacturer: El-Dorado Bio-Tech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 mayonil 5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एंजाइना पेक्टोरिस (सीने में दर्द) को रोकने और इलाज करने के लिए इस्तेमाल की जाती है। यह दिल की मांसपेशियों तक रक्त का प्रवाह बढ़ाती है और दिल पर दबाव कम करती है। यह दवा उन वयस्कों के लिए है जिन्हें दिल की बीमारी के कारण बार-बार सीने में दर्द होता है। यह दवा तुरंत दर्द से राहत के लिए नहीं है, बल्कि दर्द को रोकने के लिए है। इसे डॉक्टर के बताए अनुसार ही लें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में सिरदर्द, चक्कर आना, चेहरे पर गर्मी लगना और जी मिचलाना शामिल हैं। सिरदर्द शुरुआत में आम है और कुछ दिनों में कम हो जाता है। कुछ लोगों को ब्लड प्रेशर कम होने के कारण चक्कर आ सकते हैं। मुंह में दर्दनाक छाले होना एक गंभीर दुष्प्रभाव है, जिसके लिए तुरंत डॉक्टर से मिलना चाहिए। अगर कोई भी दुष्प्रभाव परेशान करे तो डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से डोज न बदलें और न ही दवा बंद करें। इस दवा से चक्कर आ सकते हैं, इसलिए उठते समय धीरे-धीरे उठें। शराब न पिएं क्योंकि इससे चक्कर और ब्लड प्रेशर कम हो सकता है। सिल्डेनाफिल, टैडालाफिल जैसी दवाओं के साथ इस दवा को न लें, क्योंकि इससे ब्लड प्रेशर खतरनाक रूप से कम हो सकता है। अगर आपको किडनी या लिवर की बीमारी है तो डॉक्टर को बताएं। नियमित जांच के लिए डॉक्टर के पास जाएं।
💊 mayonil 5mg tablet Uses & Benefits
- [{"condition":"Chronic stable angina pectoris","description":"This medicine is used to prevent angina attacks and improve exercise tolerance in adults with chronic stable angina.
- It helps reduce the frequency of chest pain episodes.","evidence":"Well-established"},{"condition":"Unstable angina","description":"In some hospital settings, this medicine may be used as part of treatment for unstable angina under close medical supervision.","evidence":"Moderate"},{"condition":"Adjunctive therapy in acute myocardial infarction","description":"This medicine has been studied as an add-on therapy in the acute phase of heart attack in some countries, but this use is not universally established.","evidence":"Limited"}]
Off-label uses: [{"condition":"Prevention of contrast-induced nephropathy","description":"Some small studies have explored the use of nicorandil to protect kidney function before procedures involving contrast dye, but this is not a standard approved use.","evidence":"Limited"},{"condition":"Raynaud's phenomenon","description":"Rarely, nicorandil has been tried for Raynaud's phenomenon due to its vasodilatory effects, but evidence is insufficient.","evidence":"Limited"}]
Primary treatment for: Angina pectoris
Also treats: Coronary artery disease, Chronic stable angina, Unstable angina
📋 Drug Information
| Generic Name(s) | Nicorandil (5mg) |
| Brand Name | mayonil 5mg tablet |
| Manufacturer | El-Dorado Bio-Tech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Potassium channel opener |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C. Keep it in its original container, tightly closed, away from moisture, heat, and direct sunlight. Do not refrigerate unless specified on the packaging. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the packaging before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary mechanisms. It acts as a potassium channel activator, opening ATP-sensitive potassium channels in vascular smooth muscle cells, which leads to relaxation of blood vessels. Additionally, it has a nitrate-like effect that increases cyclic guanosine monophosphate levels, further promoting vasodilation. Together, these actions dilate both arteries and veins, reduce cardiac preload and afterload, and improve blood flow to the heart muscle, thereby relieving and preventing angina.
Mechanism Steps
💡 How to Take mayonil 5mg tablet
Strength: Immediate-release tablet containing 5 mg of nicorandil.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 mg to 10 mg taken twice daily, with or without food. The dose may be increased gradually up to a maximum of 40 mg per day, depending on your response and tolerance. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and other medicines you are taking. Do not adjust the dose yourself. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a low dose and monitor blood pressure closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be needed in patients with severe kidney impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Dose adjustment may be needed in patients with severe liver impairment. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 40 mg, usually divided into two doses. Do not exceed this unless directed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of mayonil 5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Sildenafil | Major | |
| Tadalafil | Major | |
| Vardenafil | Major | |
| Nitroglycerin | Major | |
| Isosorbide mononitrate | Major | |
| Riociguat | Major | |
| Alcohol | Moderate | |
| Metoprolol | Moderate | |
| Amlodipine | Moderate | |
| Lisinopril | Moderate |
🚨 Major Interactions
- Phosphodiesterase-5 inhibitors (sildenafil, tadalafil, vardenafil)
- Other nitrates (nitroglycerin, isosorbide mononitrate, isosorbide dinitrate)
- Riociguat
⚡ Moderate Interactions
- Alcohol
- Antihypertensive drugs (beta-blockers, calcium channel blockers, ACE inhibitors, ARBs, diuretics)
- Tricyclic antidepressants
🍷 Alcohol Interaction
Alcohol can enhance the blood pressure-lowering effect of this medicine and increase the risk of dizziness, light-headedness, and fainting. It is best to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to nicorandil or any component of the tablet","Severe low blood pressure (hypotension)","Cardiogenic shock","Acute myocardial infarction with low filling pressures","Concomitant use of phosphodiesterase-5 inhibitors (sildenafil, tadalafil, vardenafil)","Concomitant use of riociguat","Severe aortic or mitral valve stenosis","Constrictive pericarditis","Hypertrophic obstructive cardiomyopathy"]
⚠️ Warnings & Precautions
["This medicine can cause severe low blood pressure, especially when standing up. Rise slowly from sitting or lying positions.","Do not use this medicine to treat an acute angina attack. It is not a rescue medicine.","Painful mouth ulcers can occur and may be a sign of a serious condition. Stop the medicine and seek medical advice if they develop.","Avoid alcohol while taking this medicine as it can worsen dizziness and low blood pressure.","Inform your doctor if you have kidney or liver disease, as dose adjustment may be needed.","This medicine may cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not stop taking this medicine suddenly without consulting your doctor, as this may worsen angina."]
🤱 Lactation Safety
This medicine is excreted in breast milk in small amounts. It is not known whether it is safe during breastfeeding. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe low blood pressure, dizziness, fainting, and reflex tachycardia. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include intravenous fluids and medications to raise blood pressure. Do not try to vomit unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. This medicine can cause dizziness or light-headedness, especially when you stand up quickly, so rise slowly from sitting or lying positions. Avoid alcohol while taking this medicine because it can worsen dizziness and low blood pressure. Do not take this medicine with medicines for erectile dysfunction such as sildenafil, tadalafil, or vardenafil, as this can cause a dangerous drop in blood pressure. Inform your doctor if you have low blood pressure, heart valve problems, or kidney or liver disease. Keep all follow-up appointments so your doctor can monitor your blood pressure and heart symptoms. Store this medicine in its original container at room temperature, away from moisture and direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a low dose and monitor blood pressure regularly. Falls due to dizziness are a concern, so advise rising slowly and using support when standing.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established, and your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped or adjusted to prevent blood pressure fluctuations during the procedure.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dizziness or low blood pressure, so it is important for the dental team to be aware. Local anesthetics with epinephrine should be used with caution.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause dizziness or low blood pressure, especially when you start treatment or change doses. Avoid strenuous exercise until you know how the medicine affects you. If you feel dizzy or faint during exercise, stop immediately and rest. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or light-headedness, especially when standing up quickly. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal work activities with caution. Inform your employer if your job involves operating machinery or driving.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as painful mouth ulcers, severe dizziness, or allergic reactions, stop the medicine and seek immediate medical attention. Your doctor may adjust the dose or switch to another medicine if needed.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well tolerated. However, regular monitoring of blood pressure, heart rate, and kidney function is recommended. Some patients may develop tolerance to the nitrate-like effects, but this is less common with nicorandil. Periodic review with your doctor is necessary to assess ongoing benefit and adjust the dose if needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Heart-healthy diet, regular exercise, smoking cessation, and stress management can complement medicine for angina.
Evidence: Well-establishedBeta-blockers, calcium channel blockers, and nitrates are alternative or additional options for angina management.
Evidence: Well-establishedAngioplasty or bypass surgery may be considered for severe coronary artery disease.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Store at room temperature and avoid direct sunlight. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 to 60 minutes after taking a dose, but its full benefits in preventing angina may take a few days to weeks.
A: Yes, you can take it with or without food. Taking it with food may help reduce headache and stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: The safety of this medicine during pregnancy is not well established. Consult your doctor before taking it if you are pregnant or planning to become pregnant.
A: No, do not stop taking this medicine without consulting your doctor. Stopping suddenly may worsen your angina.
🤔 Common Patient Concerns
🔄 Substitutes for mayonil 5mg tablet
View AllAlternative brands with exact same active ingredient:
-
davaindia nicorandil 5mg tabletDavaindia Generic Pharmacy ₹20.00 64.4% CHEAPER
-
drnic 5mg tabletDR Best pharmaceuticals Pvt Ltd ₹37.50 33.3% CHEAPER
-
danavish nicorandil 5mg tabletDanavish Healthcare ₹44.91 20.2% CHEAPER
-
nicotis tabletPositif Life sciences ₹45.94 18.3% CHEAPER
-
nicotif 5mg tabletSmayan Healthcare Pvt Ltd ₹55.00 2.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used to relieve an acute angina attack.
Fact: This medicine is for prevention of angina, not for immediate relief. For acute attacks, use a fast-acting nitrate as prescribed. - Myth: This medicine is safe to take with erectile dysfunction drugs.
Fact: Combining this medicine with sildenafil, tadalafil, or vardenafil can cause a dangerous drop in blood pressure and is contraindicated. - Myth: Once you feel better, you can stop taking this medicine.
Fact: Do not stop this medicine without consulting your doctor, as it may worsen angina.
🔄 Alternative Options
Generic Alternatives
- Nicorandil 5 mg tablet (generic)
Brand Alternatives
- Drnic 5mg Tablet