danavish pregabalin+methylcobalamin 75mg/750mcg capsule - Methylcobalamin (750mcg) + Pregabalin (75mg) medicine

danavish pregabalin+methylcobalamin 75mg/750mcg capsule

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🏭 Danavish Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

What is danavish pregabalin+methylcobalamin 75mg/750mcg capsule used for?

This medicine contains Methylcobalamin (750mcg) + Pregabalin (75mg) and is used to treat NEURO CNS. Methylcobalamin: Coenzyme for myelin synthesis; Pregabalin: Binds to alpha2-delta subunit of voltage. Always consult your doctor before use.

  • Generic Name: Methylcobalamin + Pregabalin
  • Manufacturer: Danavish Healthcare
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 danavish pregabalin+methylcobalamin 75mg/750mcg capsule Uses & Benefits

Diabetic neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury.

Off-label uses: Generalized anxiety disorder, social anxiety disorder, restless legs syndrome.

📋 Drug Information

Generic Name(s)Methylcobalamin + Pregabalin
Brand NameAxogurd-SR Tablet
ManufacturerDanavish Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassNeurotropic vitamin + Gabapentinoid
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMethylcobalamin: Well absorbed orally; Pregabalin: Rapidly absorbed after oral administration with peak plasma concentrations within 1 hour.
DistributionMethylcobalamin: Distributed to tissues including CNS; Pregabalin: Crosses blood-brain barrier, distributed throughout body.
Protein BindingMethylcobalamin: Low (<10%); Pregabalin: <1% bound to plasma proteins.
MetabolismMethylcobalamin: Metabolized in the liver; Pregabalin: Negligible metabolism (<2% of dose).
Half-LifeMethylcobalamin: Approximately 6 hours; Pregabalin: Approximately 6.3 hours.
ExcretionMethylcobalamin: Renal excretion; Pregabalin: Primarily excreted unchanged in urine (90-99%).
BioavailabilityMethylcobalamin: Variable, approximately 50%; Pregabalin: >90%.
Onset of ActionMethylcobalamin: Days to weeks; Pregabalin: Within 1 hour.
Peak Plasma TimeMethylcobalamin: 2-3 hours; Pregabalin: 1 hour.
Duration of ActionMethylcobalamin: Several hours; Pregabalin: 6-8 hours.

How It Works

Methylcobalamin: Coenzyme for myelin synthesis; Pregabalin: Binds to alpha2-delta subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release.

Mechanism Steps

1Methylcobalamin acts as a cofactor for methionine synthase, promoting myelin synthesis.
2Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels in the CNS.
3Binding reduces calcium influx at nerve terminals.
4Decreased calcium influx reduces release of excitatory neurotransmitters (e.g., glutamate, substance P).
5This leads to reduced neuronal excitability and pain transmission.

💡 How to Take danavish pregabalin+methylcobalamin 75mg/750mcg capsule

Follow your doctor's prescription exactly.

⚠️ Side Effects of danavish pregabalin+methylcobalamin 75mg/750mcg capsule

✅ Common Side Effects

Dizziness
Somnolence
Dry mouth
Edema
Blurred vision
Weight gain
Constipation

🚨 Serious Side Effects

Angioedema
Hypersensitivity reactions
Suicidal thoughts
Rhabdomyolysis
PR interval prolongation

⚠️ Rare Side Effects

Stevens-Johnson syndrome
Hepatotoxicity
Pancreatitis
Blood dyscrasias

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
CNS depressants Major Increased sedation and respiratory depression
Thalidomide Major Increased risk of peripheral neuropathy
ACE inhibitors Major Increased risk of angioedema
Oral hypoglycemics Moderate May enhance hypoglycemic effect
Antihypertensives Moderate Additive hypotensive effect
Antacids Minor Reduced absorption of pregabalin
H2 blockers Minor Possible reduced absorption of pregabalin

🚨 Major Interactions

  • Central nervous system depressants
  • Thalidomide
  • Angiotensin-converting enzyme inhibitors

⚡ Moderate Interactions

  • Oral hypoglycemics
  • Antihypertensives

🍷 Alcohol Interaction

Additive CNS depression; avoid concurrent use.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to any component; severe renal impairment (CrCl

🤱 Lactation Safety

Pregabalin excreted in breast milk; caution advised.

💊 Overdose Management

Supportive care; activated charcoal if recent ingestion; hemodialysis may remove pregabalin.

⏰ Missed Dose

Take as soon as remembered unless near next dose; skip missed dose if close to next dose; do not double dose.

🔄 Substitutes for danavish pregabalin+methylcobalamin 75mg/750mcg capsule

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Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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