coxtwo 50mg tablet

4.8 (16 reviews)

Rofecoxib (50mg)

🏭 Systopic Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is coxtwo 50mg tablet used for?

Alrof (Rofecoxib) is used to treat PAIN ANALGESICS. It contains Rofecoxib (50mg), which Selective inhibition of cyclooxygenase-2 (COX-2), reducing prostaglandin synthes. Always consult your doctor before use. Take as prescribed.

Generic Name: Rofecoxib
Manufacturer: Systopic Laboratories Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 coxtwo 50mg tablet Uses & Benefits

Osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea.

Off-label uses: Ankylosing spondylitis, gout, migraine.

📋 Drug Information

Generic Name(s)	Rofecoxib
Brand Name	Alrof
Manufacturer	Systopic Laboratories Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	PAIN ANALGESICS
Action Class	NSAID's -Selective COX-2 Inhibitors
Route of Administration	Oral.
Storage	Store at room temperature (20-25°C), protect from moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally; peak plasma concentrations achieved in 2-3 hours.

DistributionExtensively distributed; crosses placenta and enters breast milk.

Protein BindingApproximately 87% bound to plasma proteins.

MetabolismHepatic metabolism via reduction, oxidation, and glucuronidation; CYP enzymes minimally involved.

Half-LifeApproximately 17 hours.

ExcretionPrimarily excreted in urine as metabolites; small amount in feces.

BioavailabilityApproximately 93%.

Onset of ActionWithin 1 hour.

Peak Plasma Time2-3 hours.

Duration of ActionUp to 24 hours.

How It Works

Selective inhibition of cyclooxygenase-2 (COX-2), reducing prostaglandin synthesis.

Mechanism Steps

1Inhibition of COX-2 enzyme

2Reduction of prostaglandin synthesis

3Decreased inflammation and pain

💡 How to Take coxtwo 50mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of coxtwo 50mg tablet

✅ Common Side Effects

Dyspepsia
Nausea
Diarrhea
Headache
Dizziness
Edema

🚨 Serious Side Effects

GI bleeding
Perforation
Myocardial infarction
Stroke
Hypertension
Renal failure

⚠️ Rare Side Effects

Stevens-Johnson syndrome
Toxic epidermal necrolysis
Hepatitis
Pancreatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Aspirin	Major	Increased risk of GI ulceration and bleeding
Methotrexate	Major	Increased methotrexate toxicity
Lithium	Major	Increased lithium levels and toxicity
ACE inhibitors	Major	Reduced antihypertensive effect
Diuretics	Major	Reduced diuretic effect
Corticosteroids	Moderate	Increased risk of GI ulceration
Anticoagulants	Moderate	Increased bleeding risk
Antiplatelet agents	Moderate	Increased bleeding risk
SSRIs	Moderate	Increased bleeding risk
Antacids	Minor	Slight decrease in absorption
Cimetidine	Minor	No significant interaction

🚨 Major Interactions

Warfarin
Aspirin
Methotrexate
Lithium
ACE inhibitors
Diuretics

⚡ Moderate Interactions

Corticosteroids
Anticoagulants
Antiplatelet agents
SSRIs

ℹ️ Minor Interactions

Antacids
Cimetidine

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

May increase risk of gastrointestinal bleeding.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to rofecoxib or NSAIDs; history of asthma, urticaria; active GI bleeding; severe renal impairment; pregnancy (third trimester); coronary artery bypass graft surgery.

📊 Monitoring Parameters

Renal function, liver function, blood pressure, signs of GI bleeding, cardiovascular status.

🤱 Lactation Safety

Not recommended; excreted in breast milk.

💊 Overdose Management

Symptomatic and supportive care; no specific antidote; consider activated charcoal if recent ingestion.

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for coxtwo 50mg tablet

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Alternative brands with exact same active ingredient (Rofecoxib (50mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Happy Patient Jul 10, 2026

Found this to be a helpful product. Good results.