Alrof 50mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Chest pain, pressure, or tightness
- Shortness of breath or difficulty breathing
- Sudden weakness or numbness on one side of the body
- Slurred speech or confusion
- Black, tarry stools or blood in vomit
- Severe abdominal pain
- Swelling of the face, lips, or throat
- Decreased urine output or swelling of the legs
- Yellowing of the skin or eyes
- Severe skin rash or blisters
If experiencing severe symptoms, call emergency services immediately.
What is Roflam 50mg Tablet used for?
This medicine contains rofecoxib 50 mg, a selective COX-2 inhibitor used for pain and inflammation. It was withdrawn in many countries due to an increased risk of heart attack and stroke. It should only be used if specifically prescribed by a doctor.
- Generic Name: Rofecoxib (50mg)
- Manufacturer: Micro Labs Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Roflam 50mg Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा रोफेकोक्सिब 50 मिलीग्राम की गोली है, जिसका उपयोग जोड़ों के दर्द, सूजन और अकड़न को कम करने के लिए किया जाता है। यह ऑस्टियोआर्थराइटिस, रूमेटॉइड आर्थराइटिस, मांसपेशियों के दर्द और मासिक धर्म के दर्द में राहत देती है। यह दवा शरीर में सूजन पैदा करने वाले एंजाइम को रोककर काम करती है। हालांकि, दिल के दौरे और स्ट्रोक का खतरा बढ़ने के कारण इसे कई देशों में बाजार से हटा लिया गया है। इसलिए इसका उपयोग केवल डॉक्टर की सलाह पर ही करें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में पेट में जलन, अपच, मतली, सिरदर्द, चक्कर आना और पैरों में हल्की सूजन शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, अल्सर, गुर्दे की समस्या, हृदयाघात और स्ट्रोक शामिल हो सकते हैं। यदि आपको काला या खून वाला मल, खून की उल्टी, सीने में दर्द, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर त्वचा पर दाने दिखाई दें, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लेने से पेट की जलन कम हो सकती है। शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ सकता है। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, खासकर खून पतला करने वाली दवाएं, ब्लड प्रेशर की दवाएं और दर्द निवारक दवाएं। यदि आपको दिल, गुर्दे, या जिगर की बीमारी है, तो डॉक्टर को जरूर बताएं। इस दवा को बच्चों की पहुंच से दूर रखें और ठंडी, सूखी जगह पर स्टोर करें।
💊 Roflam 50mg Tablet Uses & Benefits
[{"condition":"Osteoarthritis","description":"This medicine was used to relieve joint pain, stiffness, and inflammation" class="semantic-link" title="Medicines for swelling">swelling in osteoarthritis of the knee, hip, and hand, helping patients move more comfortably.","evidence":"Well-established for short-term symptom relief, but use is now severely restricted due to cardiovascular safety concerns."},{"condition":"Rheumatoid arthritis","description":"It was prescribed to reduce pain and inflammation in rheumatoid arthritis, often as part of a broader treatment plan that includes disease-modifying medicines.","evidence":"Well-established for symptom relief, but no longer routinely recommended because of safety issues."},{"condition":"Acute musculoskeletal pain","description":"This medicine was used for short-term relief of pain from muscle strains, sprains, and other soft tissue injuries.","evidence":"Moderate evidence for short-term use, but safer alternatives are preferred."},{"condition":"Primary dysmenorrhea","description":"It was used to relieve painful menstrual cramps by reducing prostaglandin production in the uterus.","evidence":"Moderate evidence, but other medicines are now preferred due to safety concerns."}]
Off-label uses: [{"condition":"Acute gouty arthritis","description":"Sometimes used off-label for short-term relief of gout pain and inflammation, though safer alternatives are generally preferred.","evidence":"Limited"},{"condition":"Ankylosing spondylitis","description":"Occasionally prescribed off-label to reduce pain and stiffness in ankylosing spondylitis, but only under specialist supervision.","evidence":"Limited"}]
Primary treatment for: Osteoarthritis
Also treats: Rheumatoid arthritis, Acute musculoskeletal pain, Primary dysmenorrhea
📋 Drug Information
| Generic Name(s) | Rofecoxib (50mg) |
| Brand Name | Roflam 50mg Tablet |
| Manufacturer | Micro Labs Ltd |
| Packaging / Form | strip of 10 tablets (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | Not established from the available information. Check the expiry date on the pack. |
| WHO Guideline | Not established from the available information. Rofecoxib has been withdrawn from the market in many countries, and its use is not recommended in current guidelines. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively blocking the COX-2 enzyme, which is produced in the body during inflammation and injury. By blocking COX-2, it reduces the production of prostaglandins, which are chemicals that cause pain, swelling, and fever. Because it is selective for COX-2, it was designed to have less effect on the stomach lining compared with older non-steroidal anti-inflammatory drugs that also block COX-1. However, this selectivity does not eliminate all risks, and it may affect blood flow and clotting in ways that can increase cardiovascular risk.
Mechanism Steps
💡 How to Take Roflam 50mg Tablet
Strength: 50 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 12.5 mg to 25 mg once daily for osteoarthritis and rheumatoid arthritis, and 50 mg once daily for acute pain and painful menstrual periods. The maximum recommended dose is 50 mg once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and cardiovascular risk. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are at higher risk of stomach bleeding, kidney problems, and cardiovascular events. The lowest effective dose should be used for the shortest possible duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | This medicine should be used with caution in patients with kidney disease. Dose reduction may be needed in moderate kidney impairment, and it is contraindicated in severe kidney disease. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with mild liver impairment, the dose may need to be reduced. This medicine is contraindicated in severe liver disease. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | 50 mg once daily |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Roflam 50mg Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Lithium | Major | |
| Corticosteroids | Moderate | |
| Other NSAIDs | Moderate | |
| Methotrexate | Moderate | |
| Antacids | Minor | |
| Aspirin | Minor |
🚨 Major Interactions
- Warfarin
- ACE inhibitors and angiotensin receptor blockers
- Diuretics
- Lithium
⚡ Moderate Interactions
- Corticosteroids
- Other NSAIDs
- Methotrexate
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of stomach irritation, ulcers, and bleeding, and it can also add to dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["History of heart attack, stroke, or transient ischemic attack","Active or recent gastrointestinal ulcer or bleeding","Severe kidney disease","Severe liver disease","Known allergy to rofecoxib or other COX-2 inhibitors","Pregnancy, especially in the third trimester","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine increases the risk of serious cardiovascular events, including heart attack and stroke. It should only be used when other treatments are not suitable.","It can cause stomach ulcers and bleeding, especially in the elderly and those with a history of ulcers.","It may worsen kidney function, particularly in dehydrated patients or those with existing kidney disease.","It can raise blood pressure and cause fluid retention. Monitor blood pressure regularly.","Do not use this medicine for more than the recommended duration without medical supervision.","Avoid alcohol and other NSAIDs while taking this medicine.","Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]
🤱 Lactation Safety
This medicine may pass into breast milk. It is not recommended during breastfeeding because of potential risks to the baby. Consult your doctor for safer options.
💊 Overdose Management
If you suspect an overdose, seek emergency medical attention immediately. Symptoms of overdose may include severe stomach pain, nausea, vomiting, drowsiness, and difficulty breathing. Treatment is supportive and may include activated charcoal if the overdose is recent. Do not try to treat yourself at home.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, with or without food, but taking it with food or milk may reduce stomach upset. Do not crush, chew, or break the tablet unless your doctor or pharmacist has told you it is safe to do so. Never take more than the prescribed dose or use it for longer than recommended, because higher doses and long-term use increase the risk of serious heart and stomach problems. Avoid alcohol while taking this medicine, as it can increase the chance of stomach bleeding. Tell your doctor about all other medicines you take, especially blood thinners, blood pressure medicines, diuretics, and other pain relievers, because interactions can be dangerous. If you have heart disease, kidney disease, liver disease, high blood pressure, or a history of stomach ulcers, your doctor will need to monitor you closely. Do not share this medicine with anyone else, even if they have similar symptoms. Keep it out of reach of children and store it in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of stomach bleeding, kidney problems, and cardiovascular events. The lowest effective dose should be used for the shortest possible duration. Regular monitoring of blood pressure, kidney function, and signs of bleeding is recommended.
🤰 Pregnancy Planning (TTC)
This medicine should be avoided if you are planning to become pregnant or are pregnant. It may harm the unborn baby, especially in the third trimester. Consult your doctor for safer alternatives for pain relief.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding and kidney problems after surgery. It should be used with caution and only under medical supervision. Inform your surgeon and anesthesiologist about all medicines you are taking before surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may increase the risk of bleeding during dental procedures. Your dentist may recommend stopping it temporarily or taking precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may still exercise, but avoid high-impact activities that strain your joints. If you experience dizziness or fatigue, avoid strenuous exercise. Listen to your body and stop if you feel pain or discomfort. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food. If your work involves physical strain, discuss with your doctor about modifying activities to avoid injury.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as chest pain, difficulty breathing, black stools, or severe allergic reactions, stop the medicine and seek emergency medical help immediately. Your doctor will advise you on whether to stop or switch to a safer alternative.
📅 Long-Term Use Effects
Long-term use of this medicine is associated with an increased risk of serious cardiovascular events, including heart attack and stroke, as well as stomach ulcers, bleeding, and kidney problems. Regular monitoring of blood pressure, kidney function, and cardiovascular health is essential. It should be used for the shortest possible duration and at the lowest effective dose. Discuss with your doctor if you need long-term pain relief.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedCreams or gels containing NSAIDs may provide local relief with fewer systemic side effects.
Evidence: ModerateMay help reduce pain in some people with osteoarthritis.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. Store it at room temperature and away from direct sunlight. If you are crossing time zones, continue taking your dose at the same interval as prescribed, but consult your doctor if you are unsure. Check the customs regulations of your destination country, as some medicines may be restricted.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 1 to 2 hours after taking a dose, with peak effects in about 2 to 3 hours.
A: You should not take other NSAIDs or pain relievers without consulting your doctor, as this can increase the risk of stomach bleeding and kidney problems.
A: This medicine has been linked to an increased risk of heart attack and stroke. It should not be used by people with a history of heart disease. Discuss your cardiovascular risk with your doctor.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for Roflam 50mg Tablet
View AllAlternative brands with exact same active ingredient:
-
Rofidin 50mg TabletMankind Pharma Ltd ₹23.34 28.8% CHEAPER
-
Ronace 50mg TabletOchoa Laboratories Ltd ₹32.81 0.1% COSTLIER
-
ninja 50mg tabletWanbury Ltd ₹33.00 0.6% COSTLIER
-
Rofica 50mg TabletMicro Labs Ltd ₹33.56 2.3% COSTLIER
-
ozex 50mg tabletBlue Cross Laboratories Ltd ₹35.63 8.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is completely safe for the stomach.
Fact: Although it is gentler on the stomach than some older pain relievers, it can still cause stomach ulcers and bleeding. - Myth: This medicine can be taken for any type of pain.
Fact: It is only for specific inflammatory conditions and should not be used for minor aches without medical advice. - Myth: This medicine is safe for everyone.
Fact: It is not safe for people with heart disease, kidney disease, liver disease, or a history of stomach ulcers.
🔄 Alternative Options
Generic Alternatives
- Rofecoxib 50 mg tablet
Brand Alternatives
- Alrof 50mg Tablet