cortilone 5mg tablet - Prednisolone (5mg) medicine

cortilone 5mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Cyper Drugs & Pharmaceuticals Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 26, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 26, 2026

What is cortilone 5mg tablet used for?

Acticort 10mg Tablet (Prednisolone) is used to treat OPHTHAL OTOLOGICALS. It contains Prednisolone (5mg), which Binds to glucocorticoid receptors, modulating gene expression to reduce inflamma. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Prednisolone
  • Manufacturer: Cyper Drugs & Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š cortilone 5mg tablet Uses & Benefits

Allergic conditions, Asthma, Rheumatoid arthritis, Inflammatory bowel disease, Ophthalmic inflammation, Otological inflammation

Off-label uses: COVID-19 (severe cases), Acute respiratory distress syndrome, Adrenal insufficiency (off-label dosing)

๐Ÿ“‹ Drug Information

Generic Name(s)Prednisolone
Brand NameActicort 10mg Tablet
ManufacturerCyper Drugs & Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL OTOLOGICALS
Action ClassGlucocorticoids
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed from gastrointestinal tract after oral administration.
DistributionWidely distributed into tissues; crosses placenta and enters breast milk.
Protein Binding70-90% bound to corticosteroid-binding globulin and albumin.
MetabolismHepatic metabolism primarily via CYP3A4 to inactive metabolites.
Half-Life2-4 hours (plasma half-life); biological half-life 18-36 hours.
ExcretionRenal excretion of metabolites; less than 1% unchanged drug.
Bioavailability70-90% after oral administration.
Onset of ActionWithin 1-2 hours for anti-inflammatory effects.
Peak Plasma Time1-2 hours after oral dose.
Duration of Action18-36 hours (biological effects).

How It Works

Binds to glucocorticoid receptors, modulating gene expression to reduce inflammation and immune response.

Mechanism Steps

1Prednisolone diffuses across cell membrane and binds to glucocorticoid receptor (GR) in cytoplasm.
2Receptor-ligand complex translocates to nucleus and binds to glucocorticoid response elements (GREs) on DNA.
3Modulates gene transcription: increases anti-inflammatory proteins (e.g., lipocortin-1) and decreases pro-inflammatory cytokines (e.g., IL-1, TNF-ฮฑ).

๐Ÿ’ก How to Take cortilone 5mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of cortilone 5mg tablet

โœ… Common Side Effects

  • Increased appetite
  • Weight gain
  • Insomnia
  • Mood changes
  • Fluid retention
  • Hypertension
  • Hyperglycemia

๐Ÿšจ Serious Side Effects

  • Adrenal suppression
  • Osteoporosis
  • Peptic ulcer
  • Pancreatitis
  • Psychiatric disturbances
  • Increased infection risk

โš ๏ธ Rare Side Effects

  • Avascular necrosis of femoral head
  • Cushing's syndrome
  • Glaucoma
  • Cataracts
  • Thromboembolism

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Rifampin Major Decreased prednisolone efficacy
Ketoconazole Major Increased prednisolone levels and toxicity
NSAIDs Major Increased risk of GI ulcers and bleeding
Antidiabetic agents Major Reduced hypoglycemic effect
Diuretics Moderate Increased potassium loss
Amphotericin B Moderate Increased risk of hypokalemia
Live vaccines Moderate Risk of disseminated infection
Oral contraceptives Minor Possible increased prednisolone levels

๐Ÿšจ Major Interactions

  • Warfarin
  • CYP3A4 inducers (e.g., rifampin)
  • CYP3A4 inhibitors (e.g., ketoconazole)
  • NSAIDs
  • Antidiabetic agents

โšก Moderate Interactions

  • Diuretics
  • Amphotericin B
  • Vaccines (live attenuated)
  • Anticholinesterases

โ„น๏ธ Minor Interactions

  • Oral contraceptives
  • Estrogens
  • Antacids

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase levels; avoid high sodium foods.

๐Ÿท Alcohol Interaction

May increase risk of gastrointestinal bleeding; avoid concurrent use.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Systemic fungal infections, Hypersensitivity to prednisolone, Live virus vaccination, Peptic ulcer disease (relative)

๐Ÿ“Š Monitoring Parameters

Blood glucose, Blood pressure, Serum potassium, Bone density (long-term), Ophthalmic exam (long-term)

๐Ÿคฑ Lactation Safety

Excreted in breast milk; caution advised; use only if clearly needed.

๐Ÿ’Š Overdose Management

No specific antidote; supportive care; monitor electrolytes and glucose.

โฐ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 26, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for cortilone 5mg tablet

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Alternative brands with exact same active ingredient (Prednisolone (5mg)):

Medical Note: Always consult your doctor before switching medications.

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