conest 400mg capsule - Progesterone (Natural Micronized) (400mg) medicine

conest 400mg capsule - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Vhb Life Sciences Inc ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 29, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 29, 2026

What is conest 400mg capsule used for?

Aqsusten 25 Solution for Injection (Progesterone (Natural Micronized)) is used to treat GYNAECOLOGICAL. It contains Progesterone (Natural Micronized) (400mg), which Progesterone binds to progesterone receptors, modulating gene expression and exe. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Progesterone (Natural Micronized)
  • Manufacturer: Vhb Life Sciences Inc
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š conest 400mg capsule Uses & Benefits

Luteal phase support in assisted reproductive technology, treatment of luteal phase deficiency, secondary amenorrhea, dysfunctional uterine bleeding.

Off-label uses: Prevention of preterm labor, treatment of endometriosis, menopausal hormone therapy.

๐Ÿ“‹ Drug Information

Generic Name(s)Progesterone (Natural Micronized)
Brand NameAqsusten 25 Solution for Injection
ManufacturerVhb Life Sciences Inc
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGYNAECOLOGICAL
Action ClassNatural Progesterone
Route of AdministrationIntramuscular injection.
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after intramuscular injection; peak plasma concentrations achieved within 2-6 hours.
DistributionDistributed widely; crosses placenta and enters breast milk; highly bound to plasma proteins.
Protein Binding96-99% bound to albumin and corticosteroid-binding globulin.
MetabolismPrimarily hepatic via reduction and conjugation; major metabolites include pregnanediol and pregnanolone.
Half-LifeApproximately 16-20 hours.
ExcretionPrimarily renal as metabolites; small amount in feces.
Bioavailability100% after intramuscular injection.
Onset of ActionRapid; within hours.
Peak Plasma Time2-6 hours post-injection.
Duration of ActionApproximately 24 hours.

How It Works

Progesterone binds to progesterone receptors, modulating gene expression and exerting progestational effects on the endometrium, reducing uterine contractility, and supporting pregnancy.

Mechanism Steps

1Progesterone binds to progesterone receptor (PR) in target cells.
2Receptor-ligand complex translocates to nucleus.
3Complex binds to progesterone response elements (PRE) on DNA.

๐Ÿ’ก How to Take conest 400mg capsule

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of conest 400mg capsule

โœ… Common Side Effects

  • Injection site pain
  • dizziness
  • headache
  • nausea
  • breast tenderness
  • bloating

๐Ÿšจ Serious Side Effects

  • Thromboembolism
  • stroke
  • myocardial infarction
  • pulmonary embolism
  • hepatic dysfunction

โš ๏ธ Rare Side Effects

  • Cholestatic jaundice
  • anaphylaxis
  • depression
  • visual disturbances

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Rifampin Major Reduced progesterone efficacy due to increased metabolism.
Ketoconazole Major Increased progesterone levels and risk of side effects.
Warfarin Moderate Possible altered anticoagulant effect.
Grapefruit juice Minor May slightly increase progesterone levels.

๐Ÿšจ Major Interactions

  • CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
  • CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)

โšก Moderate Interactions

  • Warfarin
  • Corticosteroids
  • Antidiabetic agents

โ„น๏ธ Minor Interactions

  • Grapefruit juice
  • St. John's Wort

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

May enhance sedative effects; caution advised.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Known hypersensitivity, undiagnosed vaginal bleeding, active thromboembolic disorders, severe hepatic dysfunction, known or suspected pregnancy (except for specific indications).

๐Ÿ“Š Monitoring Parameters

Progesterone levels, pregnancy test, liver function tests, signs of thromboembolism.

๐Ÿคฑ Lactation Safety

Excreted in breast milk; use with caution, especially in high doses.

๐Ÿ’Š Overdose Management

No specific antidote; supportive care; symptoms may include drowsiness, dizziness, nausea.

โฐ Missed Dose

Administer as soon as remembered; if close to next dose, skip missed dose and resume regular schedule; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 29, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for conest 400mg capsule

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Alternative brands with exact same active ingredient (Progesterone (Natural Micronized) (400mg)):

Medical Note: Always consult your doctor before switching medications.

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