Endogest 400 SR Tablet: Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Sudden severe headache or vision changes
- Chest pain, shortness of breath, or coughing up blood
- Pain, swelling, or redness in one leg
- Severe abdominal pain or yellowing of skin or eyes
- Signs of allergic reaction: rash, itching, swelling of face or throat, difficulty breathing
- Unusual vaginal bleeding or spotting
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is prepgest-ron 400 soft gelatin capsule used for?
This medicine is a sustained-release oral tablet containing natural micronized progesterone 400 mg. It is used to support pregnancy in assisted reproduction, protect the uterine lining during hormone replacement therapy, and treat menstrual disorders caused by progesterone deficiency. It works by binding to progesterone receptors and preparing the endometrium for implantation. It is a prescription-only medicine and should be taken at bedtime to reduce drowsiness.
- Generic Name: Progesterone (Natural Micronized) (400mg)
- Manufacturer: Sinag Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 prepgest-ron 400 soft gelatin capsule के बारे में (Hindi Summary)
उपयोग: यह दवा प्राकृतिक माइक्रोनाइज़्ड प्रोजेस्टेरोन 400 मिलीग्राम का सस्टेन्ड-रिलीज़ टैबलेट है। इसका उपयोग मुख्य रूप से सहायक प्रजनन तकनीक (जैसे आईवीएफ) में भ्रूण के आरोपण और प्रारंभिक गर्भावस्था का समर्थन करने के लिए किया जाता है। इसके अलावा, यह हार्मोन रिप्लेसमेंट थेरेपी में गर्भाशय की परत की रक्षा करने, अनियमित मासिक धर्म को नियंत्रित करने और प्रोजेस्टेरोन की कमी से होने वाली समस्याओं के इलाज में भी प्रयोग किया जाता है। यह दवा प्रोजेस्टेरोन रिसेप्टर्स से जुड़कर गर्भाशय की परत को गर्भावस्था के लिए तैयार करती है। यह केवल डॉक्टर के पर्चे पर ही मिलती है और इसे रात को सोने से पहले लेना चाहिए ताकि दिन में नींद न आए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, सिरदर्द, स्तनों में कोमलता, मतली, पेट में सूजन और मूड में बदलाव शामिल हैं। ये आमतौर पर हल्के होते हैं और शरीर के अनुकूल होने पर कम हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें तेज एलर्जी, दृष्टि में बदलाव, गंभीर सिरदर्द, सीने में दर्द या खून के थक्के के लक्षण जैसे पैर में दर्द या सांस लेने में कठिनाई शामिल हो सकते हैं। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। टैबलेट को पानी के साथ पूरा निगलें, इसे चबाएं या तोड़ें नहीं। इसे रात को सोने से पहले लेना सबसे अच्छा है ताकि दिन में नींद न आए। इस दवा के साथ शराब न लें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं या मशीनरी न चलाएं। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं या स्तनपान करा रही हैं, तो अपने डॉक्टर को बताएं। डॉक्टर की सलाह के बिना दवा शुरू या बंद न करें।
💊 prepgest-ron 400 soft gelatin capsule Uses & Benefits
[{"condition":"Luteal phase support in assisted reproductive technology (ART)","description":"This medicine is used to support the luteal phase in women undergoing in vitro fertilization (IVF) or other ART procedures, helping to prepare the endometrium for embryo implantation and maintaining early pregnancy.","evidence":"Well-established"},{"condition":"Hormone replacement therapy (HRT) in postmenopausal women with an intact uterus","description":"This medicine is combined with estrogen to protect the uterine lining from endometrial hyperplasia and cancer in women receiving estrogen replacement therapy.","evidence":"Well-established"},{"condition":"Secondary amenorrhea","description":"This medicine is used to induce withdrawal bleeding in women with secondary amenorrhea due to progesterone deficiency.","evidence":"Well-established"},{"condition":"Abnormal uterine bleeding due to hormonal imbalance","description":"This medicine helps regulate the menstrual cycle and reduce abnormal bleeding in women with progesterone deficiency.","evidence":"Well-established"},{"condition":"Prevention of preterm birth in women with a history of spontaneous preterm birth","description":"This medicine may be prescribed to reduce the risk of preterm birth in certain high-risk women, although evidence is more established for other progesterone formulations.","evidence":"Emerging"}]
Off-label uses: [{"condition":"Catamenial epilepsy","description":"Sometimes prescribed off-label to reduce seizure frequency related to menstrual cycles.","evidence":"Limited"},{"condition":"Menopausal symptoms","description":"May be used off-label to alleviate hot flashes and night sweats, though evidence is mixed.","evidence":"Limited"}]
Primary treatment for: Progesterone deficiency
Also treats: Infertility, Amenorrhea, Abnormal uterine bleeding, Menopausal symptoms
📋 Drug Information
| Generic Name(s) | Progesterone (Natural Micronized) (400mg) |
| Brand Name | prepgest-ron 400 soft gelatin capsule |
| Manufacturer | Sinag Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Natural Progesterone |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to and activating progesterone receptors in target tissues such as the endometrium, myometrium, and mammary glands. Upon binding, the progesterone-receptor complex translocates to the nucleus and modulates gene transcription, leading to changes in protein synthesis that transform the endometrium from a proliferative to a secretory state, which is essential for implantation and maintenance of pregnancy. It also suppresses the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus, thereby reducing pituitary secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which helps regulate the menstrual cycle. Additionally, it has mild anti-mineralocorticoid and anti-androgenic effects.
Mechanism Steps
💡 How to Take prepgest-ron 400 soft gelatin capsule
Strength: Sustained-release tablet, 400 mg
Dosage Information
| Adult Dosage | The dosage of this medicine is individualized by a qualified clinician based on the indication, patient's age, weight, renal and hepatic function, and response to therapy. For luteal support in ART, a common dose is 400 mg once daily or in divided doses, starting from the day of embryo transfer or as advised. For hormone replacement therapy, 200-400 mg daily is typical. For secondary amenorrhea, 400 mg daily for 10 days is often prescribed. Always follow your doctor's prescription exactly. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the sedative effects of this medicine. Dose adjustment may be necessary based on renal and hepatic function. Consult your doctor. |
| Renal Impairment | No specific dose adjustment is provided in the literature for renal impairment. Use with caution and monitor for side effects. Consult your doctor. |
| Hepatic Impairment | This medicine is metabolized in the liver. Dose reduction may be necessary in patients with hepatic impairment. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose of this medicine is 400 mg, but it may be higher in certain conditions as prescribed by a clinician. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of prepgest-ron 400 soft gelatin capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampin | Major | |
| Ketoconazole | Major | |
| Warfarin | Major | |
| Diazepam | Moderate | |
| Lisinopril | Moderate | |
| Levothyroxine | Moderate | |
| Grapefruit juice | Minor | |
| Alcohol | Minor |
🚨 Major Interactions
- CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John's wort)
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir)
- Anticoagulants (e.g., warfarin)
⚡ Moderate Interactions
- Benzodiazepines (e.g., diazepam, lorazepam)
- Antihypertensives
- Thyroid hormones
🍷 Alcohol Interaction
Alcohol may increase the sedative effects of this medicine, leading to excessive drowsiness, dizziness, and impaired coordination. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to progesterone or any component of the formulation","Undiagnosed vaginal bleeding","Known or suspected breast cancer or other hormone-sensitive cancers","Active liver disease or history of cholestatic jaundice","History of blood clots (thrombophlebitis, pulmonary embolism, stroke)","Known or suspected pregnancy (for certain indications, except when used for luteal support)","Use as a contraceptive"]
⚠️ Warnings & Precautions
["This medicine may cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not crush, chew, or break the tablet; swallow it whole.","Take at bedtime to minimize daytime drowsiness.","Avoid alcohol while taking this medicine.","Inform your doctor if you have a history of depression, epilepsy, migraine, or heart disease.","Use with caution in patients with renal or hepatic impairment.","Do not use if you are allergic to progesterone or peanuts (some formulations may contain peanut oil).","This medicine may increase the risk of blood clots; seek immediate care if you experience symptoms.","Regular monitoring may be required during long-term therapy."]
🤱 Lactation Safety
This medicine is excreted in breast milk. Caution is advised when used during breastfeeding. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose of this medicine may cause excessive drowsiness, dizziness, nausea, and vomiting. There is no specific antidote. Treatment is supportive and symptomatic. In case of suspected overdose, contact your doctor or a poison control center immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water; do not crush, chew, or break it, as this can affect the sustained-release properties. It is best taken at bedtime to reduce drowsiness during the day. Avoid alcohol while taking this medicine, as it can increase drowsiness and dizziness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not start or stop this medicine without consulting your doctor. Keep all appointments for monitoring, including blood tests and imaging if advised. Store this medicine at room temperature, away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the sedative effects of this medicine. Dose adjustment may be necessary based on renal and hepatic function. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is often used to support early pregnancy in assisted reproduction, but should only be used under medical supervision.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist if you are taking this medicine before any surgery. It may affect blood clotting and interact with anesthetic agents.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may increase the risk of bleeding and interact with certain medications used in dentistry.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities that require alertness until you know how it affects you. Light to moderate exercise is generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, which may affect your ability to drive or operate machinery. It is best to take it at bedtime. If you experience persistent drowsiness, consult your doctor. Otherwise, it should not significantly impact your daily work life.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will determine when it is appropriate to stop based on your condition and treatment response. Abrupt discontinuation may lead to withdrawal bleeding or other symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with an increased risk of breast cancer, cardiovascular events, and thromboembolic disorders, especially when combined with estrogen. Regular monitoring by your doctor is essential. Discuss the risks and benefits of long-term therapy with your healthcare provider.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Regular exercise, healthy diet, and stress management can complement medical therapy.
Evidence: Well-establishedDydrogesterone or medroxyprogesterone acetate may be alternatives, but they have different properties.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or exposure to extreme temperatures. Store at room temperature and away from direct sunlight. If crossing time zones, consult your doctor about adjusting the timing of your dose. Check customs regulations for carrying prescription medicines to your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action varies by indication. For endometrial transformation, effects may begin within 2-3 days, but clinical benefits such as regulation of menstrual cycles may take a few weeks. Follow your doctor's guidance.
A: Yes, you can take it with or without food, but taking it with food may improve absorption and reduce nausea. Be consistent.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: This medicine may cause drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.
A: No, do not stop taking this medicine without consulting your doctor. Abrupt discontinuation may cause withdrawal bleeding or other effects.
🤔 Common Patient Concerns
🔄 Substitutes for prepgest-ron 400 soft gelatin capsule
View AllAlternative brands with exact same active ingredient:
-
ets 400 mg capsuleEmcure Pharmaceuticals Ltd ₹327.56 10.4% CHEAPER
-
gesterol 400mg tablet srNeon Laboratories Ltd ₹369.14 1% COSTLIER
-
sugest 400 mg capsuleSanzyme Ltd ₹394.93 8% COSTLIER
-
uterone 400 capsuleJagsonpal Pharmaceuticals Ltd ₹412.50 12.8% COSTLIER
-
conest 400mg capsuleVhb Life Sciences Inc ₹420.00 14.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a contraceptive.
Fact: This medicine is not a contraceptive and does not prevent pregnancy. - Myth: This medicine can be taken at any time of day.
Fact: It is best taken at bedtime to reduce daytime drowsiness. - Myth: This medicine is safe to use without a prescription.
Fact: This medicine is a prescription-only drug and must be used under medical supervision. - Myth: This medicine causes weight gain in everyone.
Fact: Weight changes are not a common side effect and vary among individuals.
🔄 Alternative Options
Generic Alternatives
- Natural micronized progesterone 400 mg sustained-release tablets
Brand Alternatives
- Endogest 400 SR Tablet