combizol t 300 mg/200 mg tablet - Uses, Price, Side Effects & Substitutes
What is combizol t 300 mg/200 mg tablet used for?
Bacigyl-N Suspension (Metronidazole + Norfloxacin) is used to treat GASTRO INTESTINAL. It contains Metronidazole (300mg) + Norfloxacin (200mg), which Metronidazole: Inhibits nucleic acid synthesis by disrupting DNA; Norfloxacin: I. Always consult your doctor before use. Take as prescribed.
- Generic Name: Metronidazole + Norfloxacin
- Manufacturer: Navil Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ combizol t 300 mg/200 mg tablet Uses & Benefits
Gastrointestinal infections (e.g., diarrhea, dysentery, giardiasis, amebiasis)
Off-label uses: Bacterial vaginosis (metronidazole component)
๐ Drug Information
| Generic Name(s) | Metronidazole + Norfloxacin |
| Brand Name | Bacigyl-N Suspension |
| Manufacturer | Navil Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antibiotic, Antiprotozoal |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC); protect from light |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Metronidazole: Inhibits nucleic acid synthesis by disrupting DNA; Norfloxacin: Inhibits DNA gyrase and topoisomerase IV
Mechanism Steps
๐ก How to Take combizol t 300 mg/200 mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of combizol t 300 mg/200 mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Metallic taste
๐จ Serious Side Effects
- Peripheral neuropathy
- Seizures
- Tendon rupture
- Pseudomembranous colitis
โ ๏ธ Rare Side Effects
- Blood dyscrasias
- Hepatotoxicity
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Disulfiram | Major | Psychotic reactions |
| Lithium | Major | Increased lithium toxicity |
| Cimetidine | Moderate | Increased metronidazole levels |
| Phenytoin | Moderate | Increased phenytoin levels |
| Antacids | Minor | Decreased norfloxacin absorption |
๐จ Major Interactions
- Warfarin
- Disulfiram
- Lithium
- Anticoagulants
โก Moderate Interactions
- Cimetidine
- Phenytoin
- Phenobarbital
- Cyclosporine
โน๏ธ Minor Interactions
- Antacids
- Sucralfate
- Iron supplements
๐ฝ๏ธ Food Interactions
Avoid alcohol; food may delay absorption but not extent
๐ท Alcohol Interaction
Disulfiram-like reaction (nausea, vomiting, headache)
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to metronidazole, norfloxacin, or quinolones; pregnancy (first trimester); lactation; children <18 years (for norfloxacin)
๐ Monitoring Parameters
Renal function, hepatic function, blood counts, neurological symptoms
๐คฑ Lactation Safety
Use with caution; excreted in breast milk
๐ Overdose Management
Symptomatic and supportive treatment; gastric lavage if recent
โฐ Missed Dose
Take as soon as remembered; skip if almost time for next dose