coldmine tablet - Caffeine (30mg) + Chlorpheniramine Maleate (2mg) medicine

Anti CC Tablet: Complete Medicine Guide

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🏭 Leeford Healthcare Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 24, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for allergic rhinitis and common cold.
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of face, lips, or throat
  • Fast, irregular, or pounding heartbeat
  • Seizures or convulsions
  • Severe drowsiness or confusion
  • Yellowing of skin or eyes
  • Blood in vomit or stool
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is coldmine tablet used for?

This medicine is a combination of caffeine and chlorpheniramine maleate used to relieve allergy and cold symptoms such as sneezing, runny nose, and itchy eyes. It works by blocking histamine and reducing drowsiness.

  • Generic Name: Caffeine + Chlorpheniramine Maleate
  • Manufacturer: Leeford Healthcare Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 coldmine tablet के बारे में (Hindi Summary)

उपयोग: यह दवा कैफीन और क्लोरफेनिरामाइन मेलिएट का संयोजन है, जिसका उपयोग एलर्जी और सर्दी-जुकाम के लक्षणों जैसे छींक आना, नाक बहना, आंखों में खुजली और पानी आना आदि के राहत के लिए किया जाता है। यह दवा एलर्जी के कारण होने वाली प्रतिक्रियाओं को कम करती है और कैफीन के कारण नींद नहीं आती।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना, धुंधली दृष्टि, मतली और बेचैनी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, तेज धड़कन, दौरे या भ्रम जैसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को ग्लूकोमा, प्रोस्टेट की समस्या, अस्थमा, हृदय रोग, उच्च रक्तचाप या मधुमेह के बारे में बताएं। यह दवा नींद और चक्कर ला सकती है, इसलिए वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन न करें। 7 दिनों से अधिक इसका उपयोग बिना डॉक्टर की सलाह के न करें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 coldmine tablet Uses & Benefits

[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itchy and watery eyes, and nasal congestion associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Common cold","description":"Provides symptomatic relief from sneezing, runny nose, and watery eyes caused by the common cold.","evidence":"Well-established"},{"condition":"Urticaria","description":"Helps reduce itching and hives associated with allergic skin reactions.","evidence":"Well-established"},{"condition":"Allergic conjunctivitis","description":"Reduces itching, redness, and tearing of the eyes due to allergies.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Motion sickness","description":"Sometimes used off-label to prevent nausea and vomiting associated with motion sickness due to the antihistamine effect.","evidence":"Limited"},{"condition":"Insomnia","description":"Occasionally used off-label for its sedative effects to promote sleep, though not recommended as a first-line treatment.","evidence":"Limited"}]

Primary treatment for: Allergic rhinitis

Also treats: Common cold, Urticaria, Allergic conjunctivitis

📋 Drug Information

Generic Name(s)Caffeine + Chlorpheniramine Maleate
Brand NameAlmolet Tablet
ManufacturerLeeford Healthcare Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntihistamine + CNS Stimulant
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Avoid driving or operating heavy machinery until you know how this medicine affects you.
3
Do not consume alcohol while taking this medicine as it increases drowsiness.
4
Limit intake of caffeine-containing foods and beverages to avoid excessive stimulation.
5
Do not use this medicine for more than 7 days without consulting your doctor.
6
If you have glaucoma, prostate problems, or heart disease, inform your doctor before use.
7
Keep out of reach of children and store in a cool, dry place.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Sneezing
This medicine is commonly prescribed for this.
Likely Use
Runny nose
This medicine helps reduce nasal secretions.
Likely Use
Itchy, watery eyes
This medicine relieves allergic eye symptoms.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionChlorpheniramine maleate is well absorbed from the gastrointestinal tract after oral administration. Caffeine is also rapidly and completely absorbed from the gastrointestinal tract. The presence of food may slightly delay the absorption of both components, but the overall extent of absorption is not significantly affected.
DistributionChlorpheniramine maleate is widely distributed throughout the body, including the central nervous system. It crosses the blood-brain barrier and the placenta. Caffeine is also widely distributed and crosses the blood-brain barrier and placenta. Both compounds are distributed into breast milk.
Protein BindingChlorpheniramine maleate is approximately 70% bound to plasma proteins. Caffeine is approximately 10-35% bound to plasma proteins.
MetabolismChlorpheniramine maleate is metabolized in the liver primarily by cytochrome P450 enzymes, including CYP2D6 and CYP3A4. Caffeine is metabolized in the liver by CYP1A2, CYP2E1, and CYP3A4 into paraxanthine, theobromine, and theophylline.
Half-LifeThe elimination half-life of chlorpheniramine maleate is approximately 12-43 hours, with an average of 20 hours. The elimination half-life of caffeine is approximately 3-7 hours in healthy adults.
ExcretionChlorpheniramine maleate and its metabolites are primarily excreted in the urine. Caffeine and its metabolites are also excreted in the urine, with about 1-2% of caffeine excreted unchanged.
BioavailabilityThe oral bioavailability of chlorpheniramine maleate is approximately 25-50% due to first-pass metabolism. Caffeine has nearly 100% oral bioavailability.
Onset of ActionThe onset of action for chlorpheniramine is typically within 30-60 minutes after oral administration. Caffeine's stimulant effects begin within 15-30 minutes.
Peak Plasma TimePeak plasma concentrations of chlorpheniramine are reached in about 2-6 hours. Caffeine reaches peak plasma levels in about 30-60 minutes.
Duration of ActionThe effects of chlorpheniramine last approximately 4-6 hours, while caffeine's effects last about 3-5 hours. The combination may provide symptom relief for up to 6 hours.

How It Works

This medicine combines two active ingredients with distinct mechanisms. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. This action prevents histamine-mediated symptoms such as sneezing, vasodilation, increased vascular permeability, and itching. Caffeine is a central nervous system stimulant that acts as an adenosine receptor antagonist, which increases neuronal activity and the release of neurotransmitters like dopamine and norepinephrine. This stimulant effect helps to counteract the sedation caused by chlorpheniramine. Together, they provide symptomatic relief from allergic symptoms while reducing drowsiness.

Mechanism Steps

1
Histamine H1 receptor blockade: Chlorpheniramine maleate binds to H1 receptors on smooth muscle cells, endothelial cells, and nerve endings, preventing histamine from binding and triggering allergic responses.
2
Reduction of allergic symptoms: By blocking H1 receptors, chlorpheniramine reduces sneezing, nasal congestion, itching, and watery eyes.
3
Adenosine receptor antagonism: Caffeine blocks adenosine A1 and A2A receptors in the brain, leading to increased release of excitatory neurotransmitters and reduced perception of fatigue.
4
Counteraction of sedation: The stimulant effect of caffeine helps to offset the drowsiness caused by chlorpheniramine, allowing better daytime functioning.

💡 How to Take coldmine tablet

Strength: Each tablet contains caffeine 30 mg and chlorpheniramine maleate 2 mg.

1Take this medicine orally with a full glass of water.
2Swallow the tablet whole; do not crush or chew unless advised by your doctor.
3Take with food or milk if it upsets your stomach.
4Follow the dosage schedule prescribed by your doctor.
5Do not take more than the recommended dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally every 4 to 6 hours as needed for symptoms, not to exceed 6 tablets in 24 hours. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not self-medicate; follow your doctor's instructions.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients (above 65 years) are more sensitive to the sedative and anticholinergic effects of chlorpheniramine. A lower initial dose may be considered, and the dose should be individualized by a clinician. Caffeine may also cause more pronounced stimulant effects in the elderly.
Renal ImpairmentIn patients with renal impairment, the dose may need to be reduced because both chlorpheniramine and caffeine are excreted renally. Consult a doctor for appropriate dose adjustment.
Hepatic ImpairmentIn patients with hepatic impairment, the metabolism of both chlorpheniramine and caffeine may be reduced, leading to increased plasma levels. Dose reduction may be necessary. Consult a doctor.
Maximum Daily DoseThe maximum recommended daily dose for adults is 6 tablets in 24 hours. Do not exceed this dose without medical supervision.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.
Caffeine-containing beverages
Limit
May increase stimulant effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of coldmine tablet

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery. If drowsiness persists, consult your doctor.
Dry mouth (Common (5-15%))
Sip water, chew sugarless gum, or use a saliva substitute. Consult doctor if severe.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying positions. Avoid sudden movements.
Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset.
Nervousness or restlessness (Common (5-10%))
Reduce caffeine intake from other sources. Consult doctor if persistent.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of face, lips, or throat, difficulty breathing, or dizziness.
Fast or irregular heartbeat (Rare (<0.1%))
Contact your doctor immediately if you notice palpitations or irregular pulse.
Seizures (Very rare (<0.01%))
Seek emergency medical care if seizures occur.
Hallucinations or confusion (Rare (<0.1%))
Discontinue use and consult a doctor immediately.

⚠️ Rare Side Effects

Blood dyscrasias (e.g., agranulocytosis, thrombocytopenia)
Report unusual bruising, bleeding, or signs of infection to your doctor.
Hepatotoxicity
Seek medical attention if you notice yellowing of skin or eyes, dark urine, or abdominal pain.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major
Alcohol Major
Anticholinergics Major
CYP2D6 inhibitors Moderate
CYP1A2 inhibitors Moderate
Beta-blockers Moderate
Antacids Minor
Oral contraceptives Minor

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Alcohol and other CNS depressants
  • Anticholinergic drugs (e.g., atropine, benztropine)

⚡ Moderate Interactions

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
  • CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine)
  • Beta-blockers (e.g., propranolol)

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impairment of judgment and coordination. The combination may also increase the risk of respiratory depression. Patients should be advised not to drive or operate machinery after consuming alcohol with this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to chlorpheniramine maleate, caffeine, or any component of the formulation","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Severe hypertension or coronary artery disease","Use with MAOIs","Children under 12 years of age (unless directed by a doctor)"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Use with caution in patients with asthma, COPD, or other respiratory conditions.","Use with caution in elderly patients due to increased risk of confusion, sedation, and anticholinergic effects.","Do not exceed the recommended dose or duration of use without medical advice.","Consult a doctor if symptoms persist beyond 7 days or are accompanied by fever, rash, or persistent headache."]

🤱 Lactation Safety

Both chlorpheniramine and caffeine are excreted in human breast milk. Chlorpheniramine may cause drowsiness or irritability in nursing infants. Caffeine may accumulate in the infant and cause stimulation. Breastfeeding mothers should consult their doctor before using this medicine; alternative antihistamines with better safety profiles may be preferred.

💊 Overdose Management

Overdose of this medicine may cause severe drowsiness, confusion, hallucinations, seizures, irregular heartbeat, and respiratory depression. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Before taking this medicine, inform your doctor if you have glaucoma, an enlarged prostate, difficulty urinating, asthma, heart disease, high blood pressure, thyroid problems, or diabetes. This medicine may cause drowsiness and impair your ability to drive or operate machinery. Avoid alcohol and other central nervous system depressants while taking this product, as they can increase drowsiness. Do not take this medicine for longer than 7 days without consulting a doctor. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before use. Keep this medicine out of reach of children. Do not share this medicine with others, even if they have similar symptoms. Store at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more susceptible to the sedative and anticholinergic effects of chlorpheniramine, such as confusion, dry mouth, and urinary retention. Caffeine may cause increased nervousness and insomnia. Lower doses and close monitoring are recommended.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. Chlorpheniramine is considered relatively safe but should be used only if clearly needed. Caffeine intake should be limited during pregnancy.

🏥 Post-Surgery Considerations

After surgery, use this medicine with caution as it may interact with anesthetics and other medications. Consult your surgeon or anesthesiologist before use.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may cause dry mouth and increase the risk of dental caries. It may also interact with sedatives used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Avoid alcohol and other CNS depressants.
🥗
Maintain good hydration.
😴
Get adequate rest to support recovery.
💧
Avoid driving or operating machinery until you know how the medicine affects you.
🧘
Limit caffeine intake from other sources.
🌞
Follow a healthy diet rich in fruits and vegetables.

🏋️ Exercise Considerations

This medicine may cause drowsiness and dizziness, which can impair your ability to exercise safely. Avoid strenuous exercise or activities requiring alertness until you know how the medicine affects you. Stay hydrated during exercise.

🥗 Diet Recommendations

Take with food to reduce stomach upset.
Avoid grapefruit juice.
Limit caffeine-containing foods and beverages.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job requires alertness.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms persist beyond 7 days, worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to tolerance to the stimulant effects of caffeine and increased sedation from chlorpheniramine. It may also cause dependence and withdrawal symptoms. Regular monitoring of liver and kidney function may be advised. Use for more than 7 days should be under medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Allergen avoidance

Identifying and avoiding allergens can reduce the need for medication.

Evidence: Well-established
Nasal saline irrigation

Helps clear nasal passages and reduce congestion.

Evidence: Moderate
Second-generation antihistamines

Less sedating alternatives for allergy relief.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing intervals as advised by your doctor. Check local customs regulations regarding carrying medications. Do not leave it in a hot car or checked luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with seasonal allergies
She was prescribed this medicine for her sneezing and runny nose. She found that taking it with breakfast reduced her stomach upset and the caffeine helped her stay alert during the day. She was advised not to drive until she knew how it affected her.
💡 Lesson: Taking with food improves tolerability, and caffeine counteracts drowsiness, but individual response varies.
👤 A 60-year-old man with allergic rhinitis and hypertension
He was started on this medicine but experienced dizziness and dry mouth. His doctor reduced the dose and monitored his blood pressure. He was advised to avoid alcohol and to rise slowly from sitting positions.
💡 Lesson: Elderly patients may be more sensitive to side effects and require dose adjustment and monitoring.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 to 60 minutes after oral administration.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce stomach upset.

Q: Is it safe during pregnancy?

A: Consult your doctor before use. Chlorpheniramine is Category B and caffeine is Category C; use only if clearly needed.

Q: Can I take it with other allergy medicines?

A: Do not take with other antihistamines without consulting your doctor due to additive effects.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for coldmine tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure allergies permanently.
    Fact: This medicine only provides symptomatic relief and does not cure allergies.
  • Myth: It is safe to take this medicine for long periods without doctor supervision.
    Fact: Prolonged use without medical supervision can lead to tolerance and other side effects.
  • Myth: This medicine is safe to take with alcohol.
    Fact: Alcohol increases the risk of severe drowsiness and other CNS effects.

🔄 Alternative Options

Generic Alternatives

  • Caffeine + Chlorpheniramine Maleate tablets

Brand Alternatives

  • Anti CC Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Chlorpheniramine alone","difference":"Lacks caffeine, so may cause more drowsiness."},{"medicine":"Caffeine alone","difference":"Lacks antihistamine, so does not relieve allergy symptoms."}]

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