coldcure tablet

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Caffeine (25mg) Cetirizine (5mg)

🏭 Balsons Pharmaceutical 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

11 min read

Reviewed by

SaathiMed Expert Panel | Sep 25, 2026

🩺

Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is coldcure tablet used for?

This medicine contains Caffeine (25mg) + Cetirizine (5mg) and is used to treat RESPIRATORY. Cetirizine selectively inhibits peripheral H1 receptors; caffeine antagonizes adenosine receptors an. Always consult your doctor before use.

Generic Name: Caffeine + Cetirizine
Manufacturer: Balsons Pharmaceutical
Form: Allopathy
Pregnancy Category: Category A
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 coldcure tablet Uses & Benefits

Symptomatic relief of allergic rhinitis, urticaria, and common cold symptoms.

Off-label uses: Motion sickness (cetirizine), adjunct in weight loss (caffeine).

📋 Drug Information

Generic Name(s)	Caffeine + Cetirizine
Brand Name	Azicold Plus Tablet
Manufacturer	Balsons Pharmaceutical
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	RESPIRATORY
Action Class	Antihistamine + CNS Stimulant
Route of Administration	Oral
Storage	Store at room temperature (20-25°C), protect from moisture.
Shelf Life	As per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionCetirizine is rapidly absorbed after oral administration; caffeine is well absorbed from the GI tract.

DistributionCetirizine is distributed throughout the body; caffeine crosses the blood-brain barrier and placenta.

Protein BindingCetirizine: ~93% bound to plasma proteins; Caffeine: ~35% bound.

MetabolismCetirizine undergoes minimal hepatic metabolism; caffeine is primarily metabolized by CYP1A2 in the liver.

Half-LifeCetirizine: ~8-11 hours; Caffeine: ~3-5 hours.

ExcretionCetirizine is primarily excreted unchanged in urine; caffeine metabolites are excreted in urine.

BioavailabilityCetirizine: ~70%; Caffeine: ~100%.

Onset of ActionCetirizine: 1 hour; Caffeine: 30-45 minutes.

Peak Plasma TimeCetirizine: 1 hour; Caffeine: 1-2 hours.

Duration of ActionCetirizine: 24 hours; Caffeine: 4-6 hours.

How It Works

Cetirizine selectively inhibits peripheral H1 receptors; caffeine antagonizes adenosine receptors and inhibits phosphodiesterase.

Mechanism Steps

1Cetirizine binds to H1 receptors on target cells, blocking histamine binding.

2Inhibition of histamine reduces vasodilation, vascular permeability, and pruritus.

3Caffeine antagonizes adenosine receptors, preventing adenosine-induced sedation and vasodilation.

4Caffeine inhibits phosphodiesterase, increasing cAMP levels, leading to CNS stimulation.

5Combined effects provide relief from allergy symptoms and fatigue.

💡 How to Take coldcure tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of coldcure tablet

✅ Common Side Effects

Drowsiness

Dry mouth

Headache

Nervousness

Insomnia

🚨 Serious Side Effects

Severe allergic reactions

Tachycardia

Seizures (caffeine overdose)

⚠️ Rare Side Effects

Hepatotoxicity

Thrombocytopenia

Angioedema

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug	Severity	Effect
MAOIs	Major	Increased risk of hypertensive crisis
CYP1A2 inhibitors	Major	Increased caffeine toxicity
Alcohol	Moderate	Enhanced CNS depression
Sedatives	Moderate	Additive sedation
Anticholinergics	Moderate	Increased anticholinergic effects
Theophylline	Minor	Additive CNS stimulation
Phenytoin	Minor	Decreased caffeine metabolism

🚨 Major Interactions

Monoamine oxidase inhibitors (MAOIs)
CYP1A2 inhibitors (e.g., ciprofloxacin)

⚡ Moderate Interactions

Alcohol
Sedatives
Anticholinergics

🍷 Alcohol Interaction

Increased sedation and impaired coordination; avoid concurrent use.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to cetirizine or caffeine, severe hypertension, arrhythmias, peptic ulcer.

🤱 Lactation Safety

Cetirizine and caffeine are excreted in breast milk; use with caution.

💊 Overdose Management

Supportive care; activated charcoal if recent ingestion; monitor for CNS stimulation and cardiac effects.

⏰ Missed Dose

Take as soon as remembered; skip if almost time for next dose; do not double dose.

🔄 Substitutes for coldcure tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

coldcure tablet

What is coldcure tablet used for?

💊 coldcure tablet Uses & Benefits

📋 Drug Information

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take coldcure tablet

⚠️ Side Effects of coldcure tablet

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

🍷 Alcohol Interaction

🛡️ Safety & Warnings

🚫 Contraindications

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

🔄 Substitutes for coldcure tablet

😊 Was this information helpful?

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coldcure tablet

What is coldcure tablet used for?

💊 coldcure tablet Uses & Benefits

📋 Drug Information

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take coldcure tablet

⚠️ Side Effects of coldcure tablet

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

🍷 Alcohol Interaction

🛡️ Safety & Warnings

🚫 Contraindications

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

🔄 Substitutes for coldcure tablet

😊 Was this information helpful?

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