glycodin activ tablet - Paracetamol (500mg) + Caffeine (25mg) medicine

Glycodin Activ Tablet: Complete Information

No reviews yet
🏭 Alembic Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for paracetamol; moderate for caffeine combination.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of skin or eyes
  • Dark urine or pale stools
  • Severe abdominal pain
  • Blood in vomit or stool
  • Difficulty breathing or swelling of face, lips, or throat
  • Unusual bruising or bleeding
  • Persistent fever for more than 3 days

If experiencing severe symptoms, call emergency services immediately.

What is glycodin activ tablet used for?

This medicine is a combination of Paracetamol 500 mg and Caffeine 25 mg used for relief of mild to moderate pain and fever. It works by reducing pain and fever and enhancing alertness.

  • Generic Name: Paracetamol (500mg) + Caffeine (25mg)
  • Manufacturer: Alembic Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 glycodin activ tablet के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल 500 मिलीग्राम और कैफीन 25 मिलीग्राम का संयोजन है। इसका उपयोग हल्के से मध्यम दर्द जैसे सिरदर्द, दांत दर्द, मासिक धर्म में ऐंठन, और मांसपेशियों के दर्द के इलाज के लिए किया जाता है। यह बुखार को भी कम करती है। कैफीन दर्द निवारक प्रभाव को बढ़ाता है और सतर्कता बढ़ाता है।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, पेट में परेशानी, बेचैनी, अनिद्रा और घबराहट शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यकृत क्षति, त्वचा पर गंभीर प्रतिक्रियाएं और एलर्जी हो सकती हैं। यदि आपको पीलिया, गहरे रंग का मूत्र, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा की अनुशंसित खुराक से अधिक न लें। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे यकृत को नुकसान का खतरा बढ़ जाता है। पैरासिटामोल युक्त अन्य उत्पादों को डॉक्टर की सलाह के बिना न लें। यदि आपको यकृत या गुर्दे की बीमारी है, या आप गर्भवती या स्तनपान करा रही हैं, तो अपने डॉक्टर को बताएं।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 glycodin activ tablet Uses & Benefits

[{"condition":"Tension headache","description":"Relieves mild to moderate headache pain and associated tension.","evidence":"Well-established"},{"condition":"Migraine headache","description":"Provides symptomatic relief of migraine pain; caffeine may enhance analgesic effect.","evidence":"Well-established"},{"condition":"Dental pain","description":"Used for short-term relief of toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Menstrual cramps","description":"Helps alleviate dysmenorrhea-related pain.","evidence":"Moderate"},{"condition":"Musculoskeletal pain","description":"Provides relief from minor aches and pains of muscles and joints.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces elevated body temperature due to various causes.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Post-operative pain","description":"Sometimes used as part of multimodal analgesia.","evidence":"Limited"},{"condition":"Cancer pain","description":"May be used as an adjunct for mild cancer pain.","evidence":"Limited"}]

Primary treatment for: Pain

Also treats: Fever, Headache, Dental pain, Menstrual cramps

📋 Drug Information

Generic Name(s)Paracetamol (500mg) + Caffeine (25mg)
Brand Nameglycodin activ tablet
ManufacturerAlembic Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Do not exceed the recommended dose to avoid liver damage.
3
Avoid alcohol while taking this medicine.
4
Do not take other paracetamol-containing products without consulting your doctor.
5
Consult your doctor if pain persists beyond 10 days or fever beyond 3 days.
6
Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Headache
This medicine is commonly used for tension headaches and migraines.
Likely Use
✅
Fever
This medicine helps reduce fever.
Likely Use
✅
Toothache
Provides temporary relief from dental pain.
Likely Use
❌
Chest pain
This medicine is not appropriate for chest pain; seek immediate medical attention.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Caffeine is also rapidly absorbed. Food may delay absorption slightly.
DistributionParacetamol distributes widely into body tissues; it crosses the placenta and is excreted in breast milk. Caffeine distributes throughout body water and crosses the placenta and blood-brain barrier.
Protein BindingParacetamol: approximately 10-25% bound to plasma proteins. Caffeine: approximately 15-35% bound to plasma proteins.
MetabolismParacetamol is metabolized primarily in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is detoxified by glutathione. Caffeine is metabolized in the liver by CYP1A2, CYP2E1, and CYP3A4.
Half-LifeParacetamol: 2-3 hours in adults. Caffeine: 3-7 hours, prolonged in liver disease and in neonates.
ExcretionParacetamol metabolites are excreted primarily in urine. Caffeine metabolites are excreted in urine.
BioavailabilityParacetamol: approximately 80-100% oral bioavailability. Caffeine: approximately 99% oral bioavailability.
Onset of ActionParacetamol: 30-60 minutes. Caffeine: 15-45 minutes.
Peak Plasma TimeParacetamol: 0.5-2 hours. Caffeine: 0.5-2 hours.
Duration of ActionParacetamol: 4-6 hours. Caffeine: 3-5 hours.

How It Works

Paracetamol reduces pain and fever primarily by inhibiting prostaglandin synthesis in the central nervous system. It acts on the hypothalamus to produce antipyresis and elevates the pain threshold. Caffeine is a central nervous system stimulant that blocks adenosine receptors, leading to increased alertness and enhanced analgesic effect of paracetamol.

Mechanism Steps

1
Paracetamol central COX inhibition: Paracetamol inhibits prostaglandin synthesis in the brain and spinal cord, reducing pain perception and fever.
2
Caffeine adenosine receptor blockade: Caffeine blocks adenosine receptors in the brain, leading to increased neuronal activity and release of neurotransmitters.
3
Enhanced analgesia: Caffeine potentiates the analgesic effect of paracetamol through central mechanisms, possibly by increasing pain threshold.

💡 How to Take glycodin activ tablet

Strength: Tablet: Paracetamol 500 mg + Caffeine 25 mg

1Take this medicine by mouth with a full glass of water.
2Take with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take exactly as prescribed by your doctor.
5Do not take more than the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is 1-2 tablets every 4-6 hours as needed for pain or fever, not to exceed 8 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to side effects. Use with caution and consult a doctor for appropriate dosing.
Renal ImpairmentDose adjustment may be needed in patients with severe renal impairment. Consult a doctor.
Hepatic ImpairmentDose reduction or avoidance is recommended in patients with hepatic impairment. Consult a doctor.
Maximum Daily DoseMaximum 8 tablets (4000 mg paracetamol and 200 mg caffeine) in 24 hours.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals or snacks
Reduces stomach upset.
Grapefruit
Avoid
May increase caffeine levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of glycodin activ tablet

✅ Common Side Effects

Nausea (Common (1-10%))
Take with food or milk to reduce nausea. If it persists, consult your doctor.
Stomach discomfort (Common (1-10%))
Take with a meal or snack. Avoid lying down immediately after taking.
Restlessness (Uncommon (0.1-1%))
Avoid taking close to bedtime. If severe, consult your doctor.
Insomnia (Uncommon (0.1-1%))
Avoid taking in the evening. Practice good sleep hygiene.
Nervousness (Uncommon (0.1-1%))
Reduce caffeine intake from other sources. Consult doctor if bothersome.

🚨 Serious Side Effects

Severe skin reactions (e.g., Stevens-Johnson syndrome) (Rare (<0.1%))
Seek immediate medical attention if you develop rash, blisters, or peeling skin.
Liver damage (Rare (<0.1%))
Seek immediate medical help if you experience yellowing of eyes or skin, dark urine, or severe abdominal pain.
Anaphylaxis (Very rare (<0.01%))
Call emergency services if you have difficulty breathing, swelling of face, lips, or throat.

⚠️ Rare Side Effects

Thrombocytopenia
Report unusual bruising or bleeding to your doctor immediately.
Agranulocytosis
Seek medical attention if you develop fever, sore throat, or mouth ulcers.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Alcohol Major
Carbamazepine Moderate
Phenytoin Moderate
Rifampicin Moderate
Cimetidine Minor
Oral contraceptives Minor

🚨 Major Interactions

  • Warfarin
  • Alcohol
  • Other paracetamol-containing products

⚡ Moderate Interactions

  • Carbamazepine
  • Phenytoin
  • Rifampicin

🍷 Alcohol Interaction

Avoid alcohol consumption while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and may worsen caffeine-related side effects.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to paracetamol or caffeine","Severe liver disease","Severe kidney disease","Alcoholism"]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose.","Avoid alcohol while taking this medicine.","Consult a doctor if you have liver or kidney disease.","Do not use for more than 10 days for pain or 3 days for fever without medical advice.","Keep out of reach of children."]

🤱 Lactation Safety

Paracetamol and caffeine are excreted in breast milk in small amounts. Use with caution and consult your doctor.

💊 Overdose Management

Seek immediate medical attention in case of overdose, even if you feel well. Paracetamol overdose can cause delayed liver damage. Treatment may include activated charcoal, N-acetylcysteine, and supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Do not exceed the recommended dose of this medicine. Avoid drinking alcohol while taking this medicine because it increases the risk of liver damage. Do not take other products containing paracetamol without consulting your doctor. Inform your doctor if you have liver or kidney disease, or if you are pregnant or breastfeeding. Keep this medicine out of reach of children. Store in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of caffeine and paracetamol. Use with caution and consult a doctor for appropriate dosing.

🤰 Pregnancy Planning (TTC)

Consult your doctor before taking this medicine if you are planning pregnancy. Paracetamol is generally considered safe, but caffeine should be limited.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain relief as part of a multimodal approach. Follow your surgeon's instructions.

🦷 Dental Procedures

This medicine can be taken for dental pain before or after procedures. Inform your dentist if you are taking it.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints.
🥗
Stay hydrated throughout the day.
😴
Get adequate sleep to help manage pain.
💧
Practice relaxation techniques to reduce tension headaches.
🧘
Limit caffeine intake from other sources.

🏋️ Exercise Considerations

Moderate exercise is generally safe while taking this medicine. However, if you experience dizziness or palpitations, avoid strenuous activities and consult your doctor.

🥗 Diet Recommendations

Include anti-inflammatory foods like fruits and vegetables.
Reduce processed food intake.
Stay well hydrated.
Limit alcohol consumption.

💼 Impact on Daily Work & Life

This medicine may cause restlessness or insomnia in some people. Avoid driving or operating heavy machinery if you feel drowsy or dizzy. It is generally safe for office work.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if pain persists beyond 10 days or fever beyond 3 days, or if you experience any serious side effects.

📅 Long-Term Use Effects

Long-term use of this medicine at high doses can lead to liver damage and kidney problems. Regular monitoring of liver and kidney function may be required if used for extended periods. Consult your doctor for alternative pain management strategies.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help manage chronic pain conditions.

Evidence: Well-established
Relaxation techniques

May reduce tension headaches.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. When traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying medications.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with tension headaches
She often experienced headaches due to work stress. Her doctor prescribed this medicine. She took one tablet with water when the headache started and found relief within 30 minutes. She was advised not to take more than 4 tablets a day and to avoid alcohol.
💡 Lesson: Taking this medicine at the first sign of headache and adhering to the maximum daily dose provides safe and effective relief.
👤 A 50-year-old man with dental pain
He had a toothache and took this medicine as prescribed by his dentist. He experienced significant pain relief but also felt slightly restless. His doctor advised him to take it with food and avoid taking it close to bedtime.
💡 Lesson: Caffeine in this medicine can cause restlessness; adjusting timing and taking with food can minimize side effects.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30-60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best to take it with food or milk to reduce stomach upset.

Q: Is it safe to take with other pain relievers?

A: Do not take other paracetamol-containing products without consulting your doctor to avoid overdose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for glycodin activ tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is safe to take in any amount.
    Fact: Exceeding the recommended dose can cause serious liver damage.
  • Myth: This medicine can be taken on an empty stomach without issues.
    Fact: It is better to take with food to reduce stomach upset.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol 500 mg + Caffeine 25 mg tablet

Brand Alternatives

  • Glycodin Activ Tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Paracetamol 500 mg + Caffeine 25 mg","uses":"Pain and fever","notes":"Caffeine enhances analgesia"},{"medicine":"Paracetamol 500 mg","composition":"Paracetamol 500 mg","uses":"Pain and fever","notes":"No caffeine"},{"medicine":"Ibuprofen 400 mg","composition":"Ibuprofen 400 mg","uses":"Pain, fever, inflammation","notes":"NSAID; different side effect profile"}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory