clom 75mg tablet sr
What is clom 75mg tablet sr used for?
Anafranil (Clomipramine) is used to treat NEURO CNS. It contains Clomipramine (75mg), which Inhibits the reuptake of serotonin and norepinephrine at the presynaptic neurona. Always consult your doctor before use. Take as prescribed.
- Generic Name: Clomipramine
- Manufacturer: Orchid Chemicals & Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ clom 75mg tablet sr Uses & Benefits
Major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, chronic pain syndromes, cataplexy associated with narcolepsy.
Off-label uses: Premenstrual dysphoric disorder, body dysmorphic disorder, trichotillomania, pathological gambling, neuropathic pain.
๐ Drug Information
| Generic Name(s) | Clomipramine |
| Brand Name | Anafranil |
| Manufacturer | Orchid Chemicals & Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressants |
| Route of Administration | Oral. |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits the reuptake of serotonin and norepinephrine at the presynaptic neuronal membrane, increasing their concentrations in the synaptic cleft.
Mechanism Steps
๐ก How to Take clom 75mg tablet sr
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of clom 75mg tablet sr
โ Common Side Effects
- Dry mouth
- Constipation
- Blurred vision
- Drowsiness
- Dizziness
- Weight gain
- Sweating
- Tremor
- Sexual dysfunction
๐จ Serious Side Effects
- Serotonin syndrome
- Seizures
- QT prolongation
- Arrhythmias
- Orthostatic hypotension
- Agranulocytosis
- Hepatitis
- Suicidal thoughts/behavior
โ ๏ธ Rare Side Effects
- Pancreatitis
- Pulmonary fibrosis
- Lupus-like syndrome
- Photosensitivity
- Galactorrhea
- SIADH
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Risk of serotonin syndrome; contraindicated within 14 days of MAOI use. |
| CYP1A2 inhibitors | Major | Increased clomipramine levels; monitor for toxicity. |
| CYP2D6 inhibitors | Major | Increased clomipramine levels; dose adjustment may be needed. |
| Serotonergic drugs | Major | Risk of serotonin syndrome; avoid combination. |
| CNS depressants | Major | Additive sedation; use caution. |
| Anticholinergic drugs | Moderate | Additive anticholinergic effects. |
| Antihypertensives | Moderate | May enhance hypotensive effects. |
| Sympathomimetics | Moderate | Risk of hypertension and arrhythmias. |
| Oral anticoagulants | Moderate | Increased anticoagulant effect; monitor INR. |
| Cimetidine | Minor | May increase clomipramine levels. |
| Methylphenidate | Minor | May increase clomipramine levels. |
| Smoking | Minor | May decrease clomipramine levels via CYP1A2 induction. |
๐จ Major Interactions
- MAOIs
- CYP1A2 inhibitors
- CYP2D6 inhibitors
- Serotonergic drugs
- CNS depressants
โก Moderate Interactions
- Anticholinergic drugs
- Antihypertensives
- Sympathomimetics
- Oral anticoagulants
โน๏ธ Minor Interactions
- Cimetidine
- Methylphenidate
- Smoking
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase clomipramine levels via CYP3A4 inhibition.
๐ท Alcohol Interaction
Alcohol may potentiate CNS depressant effects; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to clomipramine or any component; recent myocardial infarction; concurrent use with MAOIs; narrow-angle glaucoma; urinary retention; severe hepatic impairment.
๐ Monitoring Parameters
Mental status, blood pressure, heart rate, ECG (QT interval), liver function tests, serum drug levels (if toxicity suspected), suicidal ideation.
๐คฑ Lactation Safety
Clomipramine is excreted in breast milk; caution advised; monitor infant for drowsiness and feeding
๐ Overdose Management
Activated charcoal, gastric lavage, supportive care; monitor ECG, vital signs; treat arrhythmias with sodium bicarbonate; avoid physostigmine due to risk of seizures.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for clom 75mg tablet sr
View AllAlternative brands with exact same active ingredient (Clomipramine (75mg)):
-
depramine 75mg tabletRKG Pharma โน32.81 62.8% CHEAPER
-
imi-ci 75mg tabletSunrise Remedies Pvt Ltd โน82.03 6.9% CHEAPER
-
obnil 75mg tabletA N Pharmacia โน85.48 3% CHEAPER
-
syconil 75mg tabletPsycormedies โน98.58 11.9% COSTLIER
-
clomistar 75mg tablet srGentech Healthcare Pvt Ltd โน100.50 14% COSTLIER
-
clomine 75mg tabletPsychotropics India Ltd โน110.00 24.8% COSTLIER
-
closty 75mg tablet srCuris Lifecare โน120.00 36.2% COSTLIER
-
liprax 75mg tablet srEmocare โน120.00 36.2% COSTLIER
-
clomicare 75 tablet srLifecare Neuro Products Ltd โน122.81 39.4% COSTLIER
-
ocifril 75mg tablet xrLa Pharmaceuticals โน135.94 54.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
โญ User Reviews
Helpful and effective medicine as per my experience. Always consult a doctor.
Found this to be a helpful product. Good results.
Helpful and effective medicine as per my experience. Always consult a doctor.
This medicine was effective for me. I followed the doctor's advice.
Found this to be a helpful product. Good results.