clinpride gel - Clindamycin (1% w/w) + Nicotinamide (4% w/w) medicine

clinpride gel

4.6 (14 reviews)
๐Ÿญ Care Pride Pharma ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is clinpride gel used for?

Acnetoin Gel (Clindamycin + Nicotinamide) is used to treat DERMA. It contains Clindamycin (1% w/w) + Nicotinamide (4% w/w), which Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal sub. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Clindamycin + Nicotinamide
  • Manufacturer: Care Pride Pharma
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š clinpride gel Uses & Benefits

Acne vulgaris, inflammatory acne.

Off-label uses: Rosacea, perioral dermatitis.

๐Ÿ“‹ Drug Information

Generic Name(s)Clindamycin + Nicotinamide
Brand NameAcnetoin Gel
ManufacturerCare Pride Pharma
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassAntibiotic + Vitamin B3 derivative
Route of AdministrationTopical
StorageStore at room temperature (20-25ยฐC), away from moisture and heat.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionTopical absorption is minimal; systemic absorption is low.
DistributionDistributes locally in skin layers; minimal systemic distribution.
Protein BindingClindamycin: ~94% bound to plasma proteins; Nicotinamide: minimal binding.
MetabolismClindamycin: Hepatic metabolism via CYP3A4; Nicotinamide: Hepatic metabolism to N-methylnicotinamide.
Half-LifeClindamycin: ~2-3 hours; Nicotinamide: ~1-2 hours.
ExcretionClindamycin: Renal and biliary; Nicotinamide: Renal.
BioavailabilityLow systemic bioavailability due to topical application.
Onset of ActionWithin a few days to weeks.
Peak Plasma TimeNot applicable for topical use.
Duration of ActionSustained with regular application.

How It Works

Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal subunit; Nicotinamide reduces sebum production and has anti-inflammatory effects.

Mechanism Steps

1Clindamycin binds to 50S ribosomal subunit of bacteria, inhibiting protein synthesis.
2Nicotinamide inhibits sebocyte lipid synthesis and reduces inflammatory cytokine production.
3Combination reduces P. acnes population and inflammation.

๐Ÿ’ก How to Take clinpride gel

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of clinpride gel

โœ… Common Side Effects

  • Skin dryness
  • Peeling
  • Erythema
  • Burning sensation

๐Ÿšจ Serious Side Effects

  • Pseudomembranous colitis
  • Severe allergic reactions

โš ๏ธ Rare Side Effects

  • Contact dermatitis
  • Urticaria

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Neuromuscular blocking agents Major Enhanced neuromuscular blockade
Erythromycin Major Antagonism of clindamycin effect
Other topical antibiotics Moderate Possible additive irritation
Retinoids Moderate Increased skin irritation

๐Ÿšจ Major Interactions

  • Neuromuscular blocking agents
  • Erythromycin

โšก Moderate Interactions

  • Other topical antibiotics
  • Retinoids

โ„น๏ธ Minor Interactions

  • None significant

๐Ÿฝ๏ธ Food Interactions

None known.

๐Ÿท Alcohol Interaction

No known interaction.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to clindamycin, nicotinamide, or any component; history of antibiotic-associated colitis.

๐Ÿ“Š Monitoring Parameters

Skin irritation, signs of hypersensitivity, improvement in acne lesions.

๐Ÿคฑ Lactation Safety

Clindamycin is excreted in breast milk; use with caution. Nicotinamide is safe.

๐Ÿ’Š Overdose Management

Topical overdose unlikely; if ingested, symptomatic and supportive care.

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

โญ User Reviews

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

Happy Patient Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

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