ciflan tz 500mg/600mg tablet - Uses, Price, Side Effects & Substitutes
What is ciflan tz 500mg/600mg tablet used for?
Alcipro TN 500 mg/600 mg Tablet (Ciprofloxacin + Tinidazole) is used to treat GASTRO INTESTINAL. It contains Ciprofloxacin (500mg) + Tinidazole (600mg), which Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV; Tinidazole dis. Always consult your doctor before use. Take as prescribed.
- Generic Name: Ciprofloxacin + Tinidazole
- Manufacturer: Centurion Remedies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ ciflan tz 500mg/600mg tablet Uses & Benefits
Infectious diarrhea, dysentery, intra-abdominal infections, gynecologic infections, and mixed infections caused by susceptible bacteria and protozoa.
Off-label uses: Prophylaxis in travelers' diarrhea, treatment of Helicobacter pylori (with other agents).
๐ Drug Information
| Generic Name(s) | Ciprofloxacin + Tinidazole |
| Brand Name | Alcipro TN 500 mg/600 mg Tablet |
| Manufacturer | Centurion Remedies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antibiotic + Antiprotozoal |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV; Tinidazole disrupts DNA structure in protozoa and anaerobic bacteria.
Mechanism Steps
๐ก How to Take ciflan tz 500mg/600mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of ciflan tz 500mg/600mg tablet
โ Common Side Effects
- Nausea
- Diarrhea
- Headache
- Dizziness
- Metallic taste
- Vomiting
๐จ Serious Side Effects
- Tendon rupture
- Peripheral neuropathy
- CNS effects (seizures, confusion)
- QT prolongation
- Clostridioides difficile colitis
- Severe hypersensitivity
โ ๏ธ Rare Side Effects
- Hemolytic anemia
- Stevens-Johnson syndrome
- Hepatotoxicity
- Nephritis
- Photosensitivity
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Theophylline | Major | Increased theophylline toxicity |
| Tizanidine | Major | Severe hypotension and sedation |
| NSAIDs | Major | Increased CNS stimulation and seizure risk |
| Oral hypoglycemics | Major | Hypoglycemia |
| Cyclosporine | Moderate | Increased nephrotoxicity |
| Methotrexate | Moderate | Increased methotrexate toxicity |
| Phenytoin | Moderate | Altered phenytoin levels |
| Probenecid | Moderate | Increased ciprofloxacin levels |
| Ropinirole | Moderate | Increased ropinirole levels |
| Caffeine | Minor | Increased caffeine effects |
| Duloxetine | Minor | Possible increased duloxetine levels |
| Metformin | Minor | Possible lactic acidosis risk |
| Omeprazole | Minor | Reduced ciprofloxacin absorption |
๐จ Major Interactions
- Warfarin
- Theophylline
- Tizanidine
- NSAIDs
- Oral hypoglycemics
โก Moderate Interactions
- Cyclosporine
- Methotrexate
- Phenytoin
- Probenecid
- Ropinirole
โน๏ธ Minor Interactions
- Caffeine
- Duloxetine
- Metformin
- Omeprazole
๐ฝ๏ธ Food Interactions
Avoid dairy products, calcium-fortified juices, and antacids within 2 hours of ciprofloxacin; Tinidazole may be taken with food to reduce GI upset.
๐ท Alcohol Interaction
Avoid alcohol during and for 3 days after tinidazole due to disulfiram-like reaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to quinolones or nitroimidazoles; history of tendon disorders with quinolones; pregnancy (first trimester for tinidazole); lactation; children <18 years (for ciprofloxacin).
๐ Monitoring Parameters
Renal function, liver function, blood glucose, signs of tendonitis, CNS effects, and QT interval.
๐คฑ Lactation Safety
Ciprofloxacin: Excreted in milk, avoid; Tinidazole: Excreted in milk, avoid.
๐ Overdose Management
Supportive care; monitor ECG, renal function; dialysis may help remove ciprofloxacin.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.