centri 800mg/160mg tablet - Uses, Price, Side Effects & Substitutes
What is centri 800mg/160mg tablet used for?
Antrima DS (Sulfamethoxazole + Trimethoprim) is used to treat ANTI INFECTIVES. It contains Sulfamethoxazole (800mg) + Trimethoprim (160mg), which Sequential inhibition of folate synthesis: Sulfamethoxazole inhibits dihydropter. Always consult your doctor before use. Take as prescribed.
- Generic Name: Sulfamethoxazole + Trimethoprim
- Manufacturer: Centurion Remedies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ centri 800mg/160mg tablet Uses & Benefits
Urinary tract infections, Acute otitis media, Pneumocystis jirovecii pneumonia, Traveler's diarrhea, Shigellosis, Bronchitis
Off-label uses: Toxoplasmosis, Nocardiosis, Whipple's disease
๐ Drug Information
| Generic Name(s) | Sulfamethoxazole + Trimethoprim |
| Brand Name | Antrima DS |
| Manufacturer | Centurion Remedies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Sulfonamide + Folate antagonist |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Sequential inhibition of folate synthesis: Sulfamethoxazole inhibits dihydropteroate synthase; Trimethoprim inhibits dihydrofolate reductase
Mechanism Steps
๐ก How to Take centri 800mg/160mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of centri 800mg/160mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Photosensitivity
๐จ Serious Side Effects
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Aplastic anemia
- Agranulocytosis
- Hepatitis
- Interstitial nephritis
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Pancreatitis
- Serum sickness
- Lupus-like syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Phenytoin | Major | Increased phenytoin levels |
| Sulfonylureas | Major | Increased hypoglycemic effect |
| Cyclosporine | Major | Increased nephrotoxicity |
| ACE inhibitors | Moderate | Increased risk of hyperkalemia |
| Diuretics | Moderate | Increased risk of thrombocytopenia |
| Procainamide | Moderate | Increased procainamide levels |
| Amantadine | Moderate | Increased amantadine toxicity |
| Oral contraceptives | Minor | Reduced contraceptive efficacy |
| Rifampin | Minor | Reduced sulfamethoxazole levels |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Phenytoin
- Sulfonylureas
- Cyclosporine
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Procainamide
- Amantadine
โน๏ธ Minor Interactions
- Oral contraceptives
- Rifampin
๐ฝ๏ธ Food Interactions
Folate-rich foods may reduce efficacy
๐ท Alcohol Interaction
Avoid alcohol; may cause disulfiram-like reaction
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to sulfonamides or trimethoprim, Severe hepatic or renal impairment, Megaloblastic anemia due to folate deficiency, Pregnancy (especially 1st and 3rd trimester), Infants <2 months
๐ Monitoring Parameters
Renal function, Hepatic function, CBC with differential, Serum potassium, Signs of hypersensitivity
๐คฑ Lactation Safety
Caution; excreted in breast milk; avoid in nursing infants <2 months
๐ Overdose Management
Gastric lavage, activated charcoal, supportive care; folate supplementation for trimethoprim toxicity
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose