chlorpro 50mg tablet - Chlorpromazine (50mg) medicine

Chlorpromazine 50mg Tablet: Complete Guide to Uses, Side Effects, and Safety

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🏭 Psycormedies 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 17, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for schizophrenia and bipolar mania; limited for other uses.
Reviewed by
SaathiMed Expert Panel | Oct 17, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • High fever with muscle rigidity and confusion
  • Involuntary movements of the face, tongue, or limbs
  • Severe dizziness or fainting
  • Palpitations or irregular heartbeat
  • Yellowing of skin or eyes
  • Unusual bruising or bleeding
  • Difficulty breathing or swallowing
  • Prolonged erection

If experiencing severe symptoms, call emergency services immediately.

What is chlorpro 50mg tablet used for?

Chlorpromazine 50 mg tablet is a typical antipsychotic used to treat schizophrenia, bipolar mania, and severe agitation. It works by blocking dopamine receptors in the brain. It is taken orally, usually 1-4 times daily, and must be prescribed and monitored by a doctor.

  • Generic Name: Chlorpromazine
  • Manufacturer: Psycormedies
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 chlorpro 50mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा क्लोरप्रोमाज़ीन 50 मिलीग्राम की गोली है, जिसका उपयोग मानसिक विकारों जैसे सिज़ोफ्रेनिया, बाइपोलर डिसऑर्डर के मैनिक चरण, और गंभीर आंदोलन या आक्रामकता के इलाज के लिए किया जाता है। यह मतली और उल्टी को रोकने में भी मदद करती है। यह दवा मस्तिष्क में डोपामिन नामक रसायन को संतुलित करके काम करती है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए।

साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, धुंधली दृष्टि, कब्ज, और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में दिल की धड़कन में गड़बड़ी, बहुत कम रक्तचाप, और टार्डिव डिस्किनेसिया जैसी अनैच्छिक हरकतें शामिल हैं। न्यूरोलेप्टिक मैलिग्नेंट सिंड्रोम एक दुर्लभ लेकिन जानलेवा प्रतिक्रिया है। कोई भी गंभीर लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अचानक बंद न करें। शराब और अन्य नींद लाने वाली दवाओं से बचें। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है। नियमित रूप से रक्तचाप, हृदय, और यकृत की जाँच कराएँ। धूप से बचाव करें। गर्भवती या स्तनपान कराने वाली महिलाएँ डॉक्टर से सलाह लें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 chlorpro 50mg tablet Uses & Benefits

[{"condition":"Schizophrenia","description":"Helps reduce hallucinations, delusions, and disorganized thinking in patients with schizophrenia.","evidence":"Well-established"},{"condition":"Bipolar disorder (manic phase)","description":"Used to control acute mania and agitation in bipolar disorder.","evidence":"Well-established"},{"condition":"Severe agitation and aggression","description":"Short-term management of severe agitation or aggression in psychiatric emergencies.","evidence":"Well-established"},{"condition":"Nausea and vomiting","description":"Used for severe nausea and vomiting when other treatments are not effective.","evidence":"Well-established"},{"condition":"Intractable hiccups","description":"May be used for persistent hiccups that do not respond to other treatments.","evidence":"Limited"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label to prevent migraines, but evidence is limited.","evidence":"Limited"},{"condition":"Anxiety disorders","description":"Occasionally used for severe anxiety when other treatments fail, but not a first-line option.","evidence":"Limited"},{"condition":"Porphyria","description":"May be used in acute porphyria to control symptoms, but specialist supervision is required.","evidence":"Limited"}]

Primary treatment for: Schizophrenia

Also treats: Bipolar disorder, Severe agitation, Nausea and vomiting, Intractable hiccups

📋 Drug Information

Generic Name(s)Chlorpromazine
Brand NameChlorpromazine 50mg Tablet
ManufacturerPsycormedies
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassTypical Antipsychotics
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent levels.
2
Avoid driving or operating heavy machinery until you know how this medicine affects you.
3
Do not stop this medicine suddenly; always taper under medical supervision.
4
Report any involuntary movements of the face, tongue, or limbs immediately.
5
Avoid alcohol and other CNS depressants while taking this medicine.
6
Stay hydrated and rise slowly from sitting or lying positions to prevent dizziness.
7
Use sunscreen and protective clothing when outdoors due to increased sun sensitivity.
8
Keep all appointments for blood tests, heart checks, and eye exams.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Hallucinations
This medicine is commonly prescribed for this.
Likely Use
✅
Delusions
This medicine is commonly prescribed for this.
Likely Use
✅
Severe agitation
This medicine is commonly prescribed for this.
Likely Use
✅
Nausea and vomiting
This medicine may be used for severe cases.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Headache
This medicine is not a primary headache treatment.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionChlorpromazine is well absorbed from the gastrointestinal tract after oral administration, but undergoes significant first-pass metabolism, resulting in variable bioavailability.
DistributionChlorpromazine is widely distributed throughout the body, including the brain, lungs, liver, and kidneys. It crosses the placenta and is excreted in breast milk.
Protein BindingChlorpromazine is highly bound to plasma proteins, approximately 90-99%.
MetabolismChlorpromazine is extensively metabolized in the liver by cytochrome P450 enzymes, primarily CYP2D6, CYP1A2, and CYP3A4. It has many active metabolites.
Half-LifeThe elimination half-life of chlorpromazine is approximately 30 hours, but it can range from 10 to 50 hours.
ExcretionChlorpromazine and its metabolites are excreted mainly in the urine and feces.
BioavailabilityOral bioavailability is variable, approximately 10-30% due to first-pass metabolism.
Onset of ActionSedation and antipsychotic effects may begin within 30-60 minutes after oral administration, but full therapeutic effects may take several days to weeks.
Peak Plasma TimePeak plasma concentrations are reached approximately 2-4 hours after oral administration.
Duration of ActionThe sedative effects last about 4-6 hours, while antipsychotic effects require regular dosing to maintain therapeutic levels.

How It Works

This medicine works by blocking dopamine D2 receptors in the brain, which helps reduce psychotic symptoms. It also blocks serotonin, histamine, and muscarinic receptors, contributing to its sedative and antiemetic effects.

Mechanism Steps

1
Dopamine D2 receptor blockade: This medicine binds to and blocks dopamine D2 receptors in the mesolimbic pathway, reducing positive symptoms of psychosis such as hallucinations and delusions.
2
Serotonin 5-HT2A receptor blockade: Blockade of serotonin receptors contributes to its antipsychotic effects and may help with mood stabilization.
3
Histamine H1 receptor blockade: This action causes sedation and helps with agitation and sleep disturbances.
4
Muscarinic acetylcholine receptor blockade: This leads to anticholinergic side effects such as dry mouth, blurred vision, and constipation.
5
Alpha-adrenergic receptor blockade: This can cause orthostatic hypotension and dizziness.

💡 How to Take chlorpro 50mg tablet

Strength: Chlorpromazine 50 mg immediate-release tablet for oral administration.

1Take this medicine by mouth with or without food, but with food if it upsets your stomach.
2Swallow the tablet whole with a glass of water. Do not crush or chew.
3Take it at the same times each day to maintain consistent levels.
4Do not take more or less than prescribed.
5If you miss a dose, follow the missed dose instructions.
6Avoid alcohol while taking this medicine.

Dosage Information

Adult DosageThe usual adult dose for psychiatric conditions ranges from 25 mg to 100 mg taken 1 to 4 times daily, depending on the condition and response. For nausea and vomiting, a lower dose may be used. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not adjust the dose without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients are more sensitive to the effects of this medicine, especially drowsiness, low blood pressure, and extrapyramidal symptoms. Start with a lower dose and titrate slowly. Regular monitoring is essential.
Renal ImpairmentNo specific dose adjustment is established for renal impairment. Use with caution and monitor closely.
Hepatic ImpairmentUse with caution in patients with liver disease. Dose reduction may be necessary. Regular liver function tests are recommended.
Maximum Daily DoseThe maximum daily dose is not established from available information. Doses up to 1000 mg per day have been used in some severe cases under close supervision, but this must be determined by a specialist.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases sedation and low blood pressure.
Grapefruit juice
Avoid
May increase drug levels.
Caffeine
Limit
May increase anxiety and restlessness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of chlorpro 50mg tablet

✅ Common Side Effects

Drowsiness (Very common (>10%))
Avoid driving or operating machinery until you know how it affects you. It often improves with time.
Dry mouth (Common (5-10%))
Sip water, chew sugar-free gum, or use saliva substitutes. Consult your doctor if it persists.
Constipation (Common (5-10%))
Increase fiber and fluid intake. If constipation persists, talk to your doctor about laxatives.
Blurred vision (Common (5-10%))
Usually temporary. Avoid driving if vision is affected. Consult your doctor if it continues.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying positions. Stay hydrated. Report if severe.
Weight gain (Common (5-10%))
Maintain a healthy diet and regular exercise. Monitor weight regularly.

🚨 Serious Side Effects

Tardive dyskinesia (Uncommon (0.1-1%))
Report any involuntary movements of the face, tongue, or limbs to your doctor immediately. It may be irreversible.
Neuroleptic malignant syndrome (Rare (<0.1%))
Seek emergency care if you experience high fever, muscle rigidity, confusion, or irregular heartbeat.
Severe low blood pressure (orthostatic hypotension) (Uncommon (0.1-1%))
Lie down and elevate your legs if you feel faint. Seek medical attention if it persists.
Abnormal heart rhythms (QT prolongation) (Rare (<0.1%))
Report palpitations, fainting, or shortness of breath to your doctor immediately.
Blood disorders (agranulocytosis, leukopenia) (Rare (<0.1%))
Get regular blood tests. Report fever, sore throat, or unusual bruising to your doctor.
Liver damage (cholestatic jaundice) (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or abdominal pain to your doctor.

⚠️ Rare Side Effects

Ocular changes (pigmentary retinopathy)
Regular eye exams are recommended for long-term use. Report any vision changes.
Skin pigmentation
Avoid excessive sun exposure. Consult a dermatologist if concerned.
Seizures
Seek immediate medical attention if seizures occur.
Priapism
Seek emergency medical care if you have a prolonged erection.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Moderate
Fluoxetine Moderate
Carbamazepine Moderate
Ritonavir Major
Clozapine Major
Haloperidol Major
Morphine Major
Phenytoin Moderate
Prochlorperazine Moderate
Tramadol Moderate

🚨 Major Interactions

  • CNS depressants (e.g., alcohol, benzodiazepines, opioids)
  • QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
  • Anticholinergic drugs (e.g., benztropine, diphenhydramine)
  • Levodopa
  • Epinephrine

⚡ Moderate Interactions

  • Antihypertensive drugs
  • Lithium
  • Metoclopramide
  • Propranolol

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase drowsiness, dizziness, and the risk of severe low blood pressure. It can also worsen the sedative effects and impair your ability to drive or operate machinery.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to chlorpromazine or other phenothiazines","Severe heart disease or recent heart attack","Severe liver disease","Parkinson's disease","Bone marrow depression","Coma or severe CNS depression","Breastfeeding"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","May cause low blood pressure; rise slowly from sitting or lying positions.","May cause QT prolongation; tell your doctor if you have heart problems.","May cause tardive dyskinesia with long-term use; report any involuntary movements.","May cause neuroleptic malignant syndrome; seek emergency care for high fever, muscle rigidity, or confusion.","May increase sensitivity to sunlight; use sunscreen and protective clothing.","May cause blood disorders; report fever, sore throat, or unusual bruising.","May cause liver problems; report yellowing of skin or eyes.","Use with caution in elderly patients with dementia; increased risk of death.","Do not stop suddenly; withdrawal symptoms may occur."]

🤱 Lactation Safety

Chlorpromazine is excreted in breast milk. Breastfeeding is not recommended while taking this medicine due to potential serious adverse effects in the infant. Consult your doctor for alternative options.

💊 Overdose Management

Overdose of chlorpromazine can cause severe drowsiness, coma, low blood pressure, abnormal heart rhythms, and seizures. Seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal, intravenous fluids, and medications to control seizures and heart rhythm. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not stop suddenly, as withdrawal symptoms may occur. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness. Avoid alcohol and other central nervous system depressants because they can increase drowsiness and low blood pressure. Tell your doctor about all other medicines you take, including over-the-counter drugs and herbal supplements. This medicine can make your skin more sensitive to sunlight, so use sunscreen and protective clothing. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor about the risks and benefits. Keep all appointments for monitoring, including blood tests and heart checks. Store this medicine at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the effects of chlorpromazine, especially drowsiness, low blood pressure, and extrapyramidal symptoms. There is an increased risk of death when used in elderly patients with dementia-related psychosis. Use with caution and start with a lower dose.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Use effective contraception while on this medicine. Discuss the risks and benefits with your doctor.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and increase the risk of low blood pressure and sedation. Your doctor may adjust the dose before surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It can cause dry mouth, which may increase the risk of dental problems. It may also interact with local anesthetics and sedatives used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight through diet and exercise.
🥗
Avoid alcohol and recreational drugs.
😴
Get regular sleep and maintain a consistent routine.
💧
Stay hydrated and eat a balanced diet rich in fiber.
🧘
Use sunscreen and protective clothing when outdoors.
🌞
Practice stress-reduction techniques like deep breathing or meditation.
🚭
Engage in regular low-impact exercise as tolerated.

🏋️ Exercise Considerations

This medicine can cause drowsiness and dizziness, which may affect your ability to exercise safely. Avoid activities that require alertness, such as heavy lifting or high-intensity workouts, until you know how it affects you. Stay hydrated and rise slowly to prevent dizziness.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits, vegetables, and whole grains.
Limit caffeine and sugary drinks.
Avoid alcohol.
Include fiber-rich foods to prevent constipation.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness, dizziness, and blurred vision, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. Avoid these activities until you know how it affects you. It may also cause weight gain and metabolic changes, which can impact overall health. Discuss any work-related concerns with your doctor.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Abrupt discontinuation can cause withdrawal symptoms such as nausea, vomiting, insomnia, and agitation, and may lead to relapse of the underlying condition. Your doctor will gradually taper the dose if discontinuation is necessary.

📅 Long-Term Use Effects

Long-term use of chlorpromazine may lead to tardive dyskinesia, a potentially irreversible movement disorder. It can also cause weight gain, metabolic changes, and eye changes. Regular monitoring of weight, blood sugar, lipids, and eye exams is recommended. Periodic blood tests and ECG may be needed. The dose should be reviewed regularly to ensure it is the lowest effective amount.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cognitive behavioral therapy (CBT)

Can complement medicine for schizophrenia and bipolar disorder.

Evidence: Well-established
Family therapy

Helps support patients and families in managing mental illness.

Evidence: Well-established
Lifestyle modifications

Regular exercise, healthy diet, and sleep hygiene can improve overall well-being.

Evidence: Emerging

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. However, consult your doctor before receiving any vaccine while taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep out of reach of children

❌ DON'T

Do not use after expiry date

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the timing of doses. Check local customs regulations for controlled substances before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with schizophrenia
He was started on chlorpromazine 50 mg twice daily for hallucinations and delusions. After a few weeks, his symptoms improved significantly, but he experienced drowsiness and dry mouth. His doctor adjusted the dose and advised him to take it at bedtime. He now manages his symptoms well with regular follow-up.
💡 Lesson: Dose adjustment and timing can help manage side effects while maintaining effectiveness.
👤 A 60-year-old woman with severe nausea and vomiting
She was prescribed chlorpromazine 25 mg three times daily for nausea unresponsive to other treatments. Her nausea resolved within a day, but she felt dizzy when standing up. Her doctor advised her to rise slowly and stay hydrated. She completed the short course without further issues.
💡 Lesson: Chlorpromazine can effectively treat severe nausea, but monitoring for low blood pressure is important, especially in older adults.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Sedation and antipsychotic effects may begin within 30-60 minutes, but full therapeutic effects may take several days to weeks.

Q: Can I stop taking this medicine if I feel better?

A: No, do not stop suddenly. Always consult your doctor before stopping, as withdrawal symptoms and relapse can occur.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Q: Is it safe to drink alcohol while taking this medicine?

A: No, avoid alcohol as it can increase drowsiness, dizziness, and low blood pressure.

Q: Can I take this medicine during pregnancy?

A: Consult your doctor. Use only if clearly needed and under medical supervision. Human data are limited.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Will it cause weight gain?
  • Is it safe during pregnancy?

🔄 Substitutes for chlorpro 50mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Chlorpromazine is only for severe mental illness.
    Fact: It is also used for severe nausea and vomiting, and for intractable hiccups.
  • Myth: You can stop taking chlorpromazine once you feel better.
    Fact: Stopping suddenly can cause withdrawal symptoms and relapse. Always taper under medical supervision.
  • Myth: Chlorpromazine is addictive.
    Fact: It is not addictive in the traditional sense, but it can cause dependence and withdrawal symptoms if stopped abruptly.

🔄 Alternative Options

Generic Alternatives

  • Chlorpromazine 50 mg tablet (generic)

Brand Alternatives

  • Chlorpromazine 50 mg tablet (various manufacturers)

📊 Comparison with Similar Medicines

[{"medicine":"Chlorpromazine","class":"Typical antipsychotic","main_use":"Schizophrenia, bipolar mania","sedation":"High","extrapyramidal_symptoms":"Moderate","weight_gain":"Moderate"},{"medicine":"Haloperidol","class":"Typical antipsychotic","main_use":"Schizophrenia, agitation","sedation":"Low","extrapyramidal_symptoms":"High","weight_gain":"Low"},{"medicine":"Olanzapine","class":"Atypical antipsychotic","main_use":"Schizophrenia, bipolar disorder","sedation":"Moderate","extrapyramidal_symptoms":"Low","weight_gain":"High"}]

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