Ancam Tablet: Complete Guide to Uses, Side Effects, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- High fever with severe muscle rigidity, confusion, or irregular pulse (possible neuroleptic malignant syndrome).
- Involuntary repetitive movements of the face, lips, tongue, or limbs (possible tardive dyskinesia).
- Severe muscle stiffness, tremors, or difficulty swallowing.
- Rash, swelling of face, lips, or throat, or difficulty breathing (severe allergic reaction).
- Unusual bruising or bleeding, sore throat, or fever (possible blood disorder).
- Yellowing of skin or eyes, dark urine, or severe abdominal pain (possible liver problem).
- Palpitations, fainting, or irregular heartbeat (possible cardiac arrhythmia).
- Seizures or loss of consciousness.
If experiencing severe symptoms, call emergency services immediately.
What is neocalm forte tablet used for?
This medicine is a combination of chlorpromazine (an antipsychotic) and trihexyphenidyl (an anticholinergic) used to treat psychotic disorders and to prevent or treat movement side effects caused by antipsychotic medications. It is available as a tablet and must be taken under medical supervision.
- Generic Name: Chlorpromazine (50mg) + Trihexyphenidyl (2mg)
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 neocalm forte tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरप्रोमाज़ीन और ट्राईहेक्सीफेनिडाइल का संयोजन है, जिसका उपयोग मानसिक विकारों जैसे सिज़ोफ्रेनिया और अन्य मनोविकारों के इलाज में किया जाता है। यह दवा मतिभ्रम, भ्रम और आंदोलन को कम करने में मदद करती है। साथ ही, यह एंटीसाइकोटिक दवाओं के कारण होने वाले मांसपेशियों में अकड़न, कंपन और अनैच्छिक हरकतों को रोकने या कम करने में भी प्रभावी है। इस दवा को डॉक्टर के निर्देशानुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुंह सूखना, धुंधली दृष्टि, कब्ज, पेशाब में रुकावट, चक्कर आना और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में मांसपेशियों में अकड़न, कंपन, निगलने में कठिनाई, अनैच्छिक हरकतें, तेज बुखार, भ्रम, अनियमित नाड़ी, त्वचा पर चकत्ते, सूजन, सांस लेने में कठिनाई, असामान्य रक्तस्राव, पीलिया और दौरे शामिल हो सकते हैं। यदि आपको कोई भी गंभीर लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से दवा की खुराक न बदलें और न ही अचानक बंद करें। शराब और अन्य नींद लाने वाली दवाओं का सेवन न करें। गाड़ी चलाने या मशीनरी चलाने से बचें जब तक कि आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। यदि आपको ग्लूकोमा, पेशाब में रुकावट, प्रोस्टेट की समस्या, लीवर या किडनी की बीमारी, हृदय रोग या पार्किंसन रोग है, तो अपने डॉक्टर को बताएं। नियमित जांच और फॉलो-अप जरूरी है।
💊 neocalm forte tablet Uses & Benefits
- [{"condition":"Schizophrenia and other psychotic disorders","description":"Chlorpromazine helps reduce hallucinations, delusions, and disorganized thinking.
- Trihexyphenidyl is added to prevent or treat extrapyramidal side effects caused by chlorpromazine.","evidence":"Well-established"},{"condition":"Drug-induced extrapyramidal symptoms","description":"Trihexyphenidyl effectively manages movement disorders such as tremors, rigidity, and dystonia that may occur with antipsychotic therapy.","evidence":"Well-established"},{"condition":"Acute mania","description":"Chlorpromazine may be used to control acute manic episodes in bipolar disorder, with trihexyphenidyl reducing movement side effects.","evidence":"Moderate"},{"condition":"Nausea and vomiting (severe)","description":"Chlorpromazine has antiemetic properties and may be used for severe nausea, though not a first-line choice.","evidence":"Limited"},{"condition":"Intractable hiccups","description":"Chlorpromazine is sometimes used for persistent hiccups that do not respond to other treatments.","evidence":"Limited"}]
Off-label uses: [{"condition":"Porphyria","description":"Chlorpromazine may be used off-label to treat acute intermittent porphyria attacks.","evidence":"Limited"},{"condition":"Tetanus","description":"Chlorpromazine has been used as an adjunct for muscle relaxation in tetanus.","evidence":"Limited"},{"condition":"Migraine headache","description":"Chlorpromazine is sometimes given intravenously for acute migraine in emergency settings, but this combination tablet is not intended for that use.","evidence":"Limited"}]
Primary treatment for: Schizophrenia and other psychotic disorders
Also treats: Drug-induced extrapyramidal symptoms, Acute mania, Severe nausea and vomiting, Intractable hiccups
📋 Drug Information
| Generic Name(s) | Chlorpromazine (50mg) + Trihexyphenidyl (2mg) |
| Brand Name | neocalm forte tablet |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture, or as indicated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Chlorpromazine blocks dopamine D2 receptors in the mesolimbic and mesocortical pathways, reducing psychotic symptoms. It also blocks serotonin, histamine, and alpha-adrenergic receptors, contributing to its sedative and autonomic effects. Trihexyphenidyl is a centrally acting anticholinergic that inhibits acetylcholine at muscarinic receptors, helping to restore the dopamine-acetylcholine balance in the basal ganglia, thereby reducing extrapyramidal symptoms.
Mechanism Steps
💡 How to Take neocalm forte tablet
Strength: Each tablet contains chlorpromazine 50 mg and trihexyphenidyl 2 mg.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, and renal and hepatic function. Typically, one tablet is taken one to three times daily, but the exact dose and frequency depend on the clinical response and tolerability. Do not adjust the dose without medical advice. The maximum daily dose should not exceed the limit prescribed by your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine, especially sedation, anticholinergic effects, and orthostatic hypotension. Lower initial doses and slower titration are recommended. Regular monitoring for falls, confusion, and cardiac effects is advised. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary based on creatinine clearance. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Chlorpromazine is extensively metabolized in the liver, and liver function should be monitored. Dose reduction may be required. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is determined by the prescribing clinician based on the patient's condition and response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of neocalm forte tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| MAOIs | Major | |
| Anticholinergics | Major | |
| QT-prolonging drugs | Major | |
| Levodopa | Major | |
| Antihypertensives | Moderate | |
| Metoclopramide | Moderate | |
| Lithium | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- CNS depressants (alcohol, benzodiazepines, opioids)
- Monoamine oxidase inhibitors (MAOIs)
- Anticholinergic drugs (e.g., atropine, benztropine, antihistamines)
- QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
- Levodopa
⚡ Moderate Interactions
- Antihypertensive drugs
- Metoclopramide
- Corticosteroids
- Lithium
- Tricyclic antidepressants
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Alcohol increases the sedative and CNS depressant effects of chlorpromazine, leading to excessive drowsiness, dizziness, impaired coordination, and increased risk of respiratory depression. It may also worsen extrapyramidal symptoms and increase the risk of hypotension.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to chlorpromazine, trihexyphenidyl, or any component of the formulation","Glaucoma (narrow-angle)","Urinary retention or prostatic hypertrophy","Severe liver disease","Severe kidney disease","Parkinson's disease (trihexyphenidyl may worsen some symptoms, but combination is used cautiously)","Myasthenia gravis","Severe cardiovascular disease","Blood dyscrasias","Coma or severe CNS depression","Breastfeeding"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until effects are known.","Avoid alcohol and other CNS depressants.","Use with caution in elderly patients due to increased risk of confusion, falls, and anticholinergic effects.","May cause orthostatic hypotension; rise slowly from sitting or lying position.","May lower seizure threshold; use with caution in patients with epilepsy.","May cause photosensitivity; use sunscreen and protective clothing.","Long-term use may cause tardive dyskinesia; monitor regularly.","May impair temperature regulation; avoid extreme heat or cold.","Do not stop abruptly; withdrawal may cause nausea, vomiting, insomnia, and relapse.","Inform your doctor if you have a history of glaucoma, prostate problems, or heart disease."]
🤱 Lactation Safety
Chlorpromazine is excreted in breast milk and may cause drowsiness, lethargy, or developmental effects in the nursing infant. Trihexyphenidyl may also pass into breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor. Consult your healthcare provider for guidance.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, coma, respiratory depression, hypotension, cardiac arrhythmias, and extrapyramidal symptoms. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs, ECG, and electrolytes. Manage hypotension with fluids and vasopressors if needed. For extrapyramidal symptoms, anticholinergic drugs may be used cautiously. For arrhythmias, appropriate antiarrhythmic therapy should be initiated.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you miss multiple doses, consult your doctor for guidance.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not change the dose or stop suddenly without consulting your doctor, as abrupt withdrawal can cause withdrawal symptoms or relapse. Avoid alcohol and other central nervous system depressants while taking this medicine, as they can increase drowsiness and dizziness. Use caution when driving or operating heavy machinery until you know how this medicine affects you. Inform your doctor if you have a history of glaucoma, prostate problems, urinary retention, liver disease, kidney disease, heart disease, or Parkinson's disease. Regular blood tests and eye examinations may be needed during long-term therapy. Keep all appointments with your healthcare provider. Store this medicine in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of sedation, confusion, falls, orthostatic hypotension, and anticholinergic effects. Lower doses are recommended, and regular monitoring for cognitive and motor function is advised. Chlorpromazine carries a boxed warning for increased mortality in elderly patients with dementia-related psychosis; use with caution.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both chlorpromazine and trihexyphenidyl may pose risks to the fetus. Your doctor will weigh the benefits and risks and may adjust or change your treatment plan.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and affect blood pressure and heart rate. Your doctor may advise temporary discontinuation or dose adjustment.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dry mouth, which can increase the risk of dental problems. It may also interact with local anesthetics or sedatives used during dental work. Maintain good oral hygiene and regular dental check-ups.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness, dizziness, and orthostatic hypotension, which can increase the risk of falls during exercise. Avoid strenuous exercise or activities requiring high coordination until you know how the medicine affects you. Light to moderate exercise is generally safe, but consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause significant drowsiness, dizziness, and blurred vision, which may impair your ability to drive, operate machinery, or perform tasks requiring alertness. It is advisable to avoid these activities until you know how the medicine affects you. Discuss with your employer if your job requires such tasks, and consider temporary adjustments. The sedative effects may diminish over time, but caution is always needed.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Abrupt discontinuation can cause withdrawal symptoms such as nausea, vomiting, insomnia, restlessness, and relapse of the underlying condition. Your doctor will gradually taper the dose if discontinuation is necessary. Seek immediate medical advice if you experience severe side effects.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of tardive dyskinesia, a potentially irreversible movement disorder. Regular monitoring with the Abnormal Involuntary Movement Scale (AIMS) is recommended. Other long-term effects may include weight gain, metabolic changes, and cardiac effects. Periodic blood tests, liver function tests, and eye examinations are advised. The dose should be reviewed regularly by your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medication for psychotic disorders and help manage symptoms.
Evidence: Well-establishedImproves treatment adherence and outcomes in schizophrenia.
Evidence: Well-establishedRegular exercise, healthy diet, and stress management can support overall well-being.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, consult your doctor before receiving any live vaccines while on immunosuppressive therapy. Routine vaccinations should be up to date.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the dosing schedule. Store it at room temperature and protect it from direct sunlight and moisture. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Sedative effects may begin within 30-60 minutes, but antipsychotic effects may take several days to weeks to fully manifest. Extrapyramidal symptom relief may occur within hours to days.
A: Yes, taking it with food or milk can reduce stomach upset.
A: Take it as soon as you remember if less than half the dosing interval has passed. Otherwise, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, you should never stop this medicine abruptly without consulting your doctor, as it can cause withdrawal symptoms or relapse.
A: No, alcohol should be strictly avoided as it increases sedation and the risk of respiratory depression.
🤔 Common Patient Concerns
🔄 Substitutes for neocalm forte tablet
View AllAlternative brands with exact same active ingredient:
-
normacalm forte 50 mg/2 mg/5 mg tabletMankind Pharma Ltd ₹3.66 2.4% CHEAPER
-
Shicalm Forte 50 mg/2 mg/5 mg TabletShine Pharmaceuticals Ltd ₹3.97 5.9% COSTLIER
-
manocalm forte 50 mg/2 mg/5 mg tabletOrchid Chemicals & Pharmaceuticals Ltd ₹4.36 16.3% COSTLIER
-
schizonil f 50 mg/2 mg/5 mg tabletD D Pharmaceuticals ₹6.00 60% COSTLIER
-
wipetri plus tabletNexus India ₹7.36 96.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is an antipsychotic combination, not a sleeping pill. It may cause drowsiness as a side effect, but it is used for psychiatric conditions. - Myth: You can stop taking this medicine once you feel better.
Fact: You should never stop this medicine abruptly without consulting your doctor, as it can cause withdrawal symptoms or relapse of the underlying condition. - Myth: This medicine is addictive.
Fact: This medicine is not addictive in the traditional sense, but it can cause dependence and withdrawal symptoms if stopped suddenly. It should be tapered under medical supervision. - Myth: This medicine can be taken with alcohol.
Fact: Alcohol should be strictly avoided while taking this medicine due to increased sedation and risk of respiratory depression.
🔄 Alternative Options
Generic Alternatives
- Chlorpromazine + Trihexyphenidyl (generic)
Brand Alternatives
- Ancam Tablet