Arnim SP 100mg/15mg Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is cetolide plus 100mg/15mg tablet used for?
This medicine is a combination of nimesulide and serratiopeptidase used for short-term relief of inflammatory pain and swelling. It works by reducing pain and inflammation through different mechanisms. It should be taken with food and only as prescribed.
- Generic Name: Nimesulide + Serratiopeptidase
- Manufacturer: Roman Lifesciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cetolide plus 100mg/15mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड और सेरेशियोपेप्टिडेज़ का संयोजन है, जिसका उपयोग सूजन, दर्द और जलन को कम करने के लिए किया जाता है। यह मुख्य रूप से जोड़ों के दर्द, मांसपेशियों की चोट, दांतों के दर्द, और सर्जरी के बाद की सूजन में राहत के लिए दी जाती है। यह दवा दर्द और सूजन को कम करने में मदद करती है, लेकिन यह बीमारी का इलाज नहीं करती। इसे डॉक्टर की सलाह के अनुसार ही लें और भोजन के साथ लें ताकि पेट में जलन न हो। गर्भवती महिलाओं, स्तनपान कराने वाली माताओं, और गुर्दे या लीवर की बीमारी वाले मरीजों को इसका सेवन नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सीने में जलन, दस्त, चक्कर आना और हल्का सिरदर्द शामिल हैं। कुछ लोगों को त्वचा पर चकत्ते या खुजली हो सकती है। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, गंभीर एलर्जी, सांस लेने में कठिनाई, गुर्दे या लीवर की समस्या, और खून की बीमारियाँ शामिल हैं। यदि आपको काला मल, खून की उल्टी, तेज पेट दर्द, पेशाब कम आना, या त्वचा और आंखों का पीला पड़ना दिखे, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर भोजन के साथ लें ताकि पेट में जलन न हो। एक दिन में निर्धारित मात्रा से ज्यादा न लें और बिना सलाह के लंबे समय तक न लें। इस दवा के साथ शराब न पिएं क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ जाता है। बिना डॉक्टर की सलाह के अन्य दर्द निवारक दवाएं न लें। यदि आपको अल्सर, गुर्दे, लीवर या हृदय की समस्या है, तो डॉक्टर को बताएं। गर्भावस्था, स्तनपान या गर्भधारण की योजना बना रही महिलाएं बिना सलाह के इसका सेवन न करें। बच्चों से दूर रखें और ठंडी सूखी जगह पर रखें।
💊 cetolide plus 100mg/15mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, tendons, and joints due to strains, sprains, or injuries.","evidence":"Well-established for nimesulide component"},{"condition":"Post-operative inflammation and swelling","description":"Reduces swelling and pain after surgical procedures, including dental and orthopedic surgeries.","evidence":"Commonly used, evidence for serratiopeptidase is limited"},{"condition":"Dental pain and inflammation","description":"Used for relief of pain and swelling after dental extraction or in dental infections.","evidence":"Commonly prescribed in combination"},{"condition":"Osteoarthritis and rheumatoid arthritis","description":"Provides symptomatic relief of pain and stiffness in chronic inflammatory joint conditions.","evidence":"Nimesulide is effective; serratiopeptidase role is adjunctive"},{"condition":"Soft tissue injuries","description":"Helps reduce swelling and pain in conditions like tendinitis, bursitis, and sports injuries.","evidence":"Commonly used, limited high-quality evidence for combination"}]
Off-label uses: [{"condition":"Sinusitis","description":"Sometimes used to reduce inflammation and mucus thickness in sinus infections.","evidence":"Limited"},{"condition":"Bronchitis","description":"Occasionally prescribed to help thin mucus and reduce airway inflammation.","evidence":"Limited"}]
Primary treatment for: Inflammatory pain and swelling
Also treats: Osteoarthritis, Rheumatoid arthritis, Post-operative inflammation, Dental pain, Soft tissue injuries
📋 Drug Information
| Generic Name(s) | Nimesulide + Serratiopeptidase |
| Brand Name | Arnim SP 100mg/15mg Capsule |
| Manufacturer | Roman Lifesciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Proteolytic Enzyme |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins that cause pain, inflammation, and fever. Serratiopeptidase is a proteolytic enzyme that breaks down proteins involved in inflammation and edema, potentially reducing swelling and improving tissue repair. The combination aims to provide both rapid symptomatic relief and anti-inflammatory action.
Mechanism Steps
💡 How to Take cetolide plus 100mg/15mg tablet
Strength: Each capsule contains nimesulide 100 mg and serratiopeptidase 15 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one capsule taken orally one to two times daily, preferably after meals, or as directed by your physician. The exact dose and duration depend on the condition being treated, its severity, and your overall health. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. Do not use for more than 7-10 days without medical supervision. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are at higher risk of gastrointestinal, kidney, and liver side effects. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction or avoidance may be necessary. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | Avoid in severe liver disease. In mild to moderate liver impairment, use with caution and monitor liver function. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum recommended daily dose is 200 mg of nimesulide (two 100 mg doses) and 30 mg of serratiopeptidase (two 15 mg doses). Do not exceed this without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cetolide plus 100mg/15mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Aspirin | Major | |
| ACE inhibitors | Major | |
| Lithium | Moderate | |
| Methotrexate | Moderate | |
| SSRIs | Moderate | |
| Diuretics | Major | |
| Corticosteroids | Major | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Corticosteroids
- ACE inhibitors and ARBs
- Diuretics
⚡ Moderate Interactions
- Lithium
- Methotrexate
- SSRIs
- Antidiabetic drugs
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine because it significantly increases the risk of stomach bleeding, ulcers, and liver damage. It can also worsen dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to nimesulide, serratiopeptidase, or any component","Active peptic ulcer or history of recurrent ulcers","Severe kidney disease (eGFR
⚠️ Warnings & Precautions
["Take with food to reduce stomach irritation.","Avoid alcohol completely.","Do not use for more than 7-10 days without medical advice.","Use with caution in the elderly due to increased risk of side effects.","Inform your doctor if you have asthma, especially aspirin-sensitive asthma.","Stop immediately and seek medical help if you experience signs of allergic reaction.","Do not drive or operate machinery if you feel dizzy.","Monitor for signs of bleeding, especially if on blood thinners.","Avoid in patients with dehydration or volume depletion.","Use with caution in patients with hypertension or cardiovascular disease."]
🤱 Lactation Safety
Not recommended during breastfeeding because nimesulide may pass into breast milk and serratiopeptidase safety is unknown. Consult your doctor for alternatives.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, abdominal pain, drowsiness, and gastrointestinal bleeding. There is no specific antidote. Treatment is supportive and symptomatic. Seek immediate medical attention or contact a poison control center. Do not induce vomiting unless advised by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually with food to minimize stomach upset. Do not take more than the recommended dose or for longer than advised. Avoid alcohol while taking this medicine because it increases the risk of stomach bleeding. Do not take other NSAIDs or pain relievers without consulting your doctor. If you have a history of ulcers, kidney disease, liver disease, or heart problems, inform your doctor before starting this medicine. Do not use this medicine if you are pregnant, planning pregnancy, or breastfeeding without medical advice. Keep out of reach of children. Store at room temperature away from moisture and direct sunlight. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose; do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. Avoid concurrent use of other NSAIDs or blood thinners.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended if you are planning pregnancy or are pregnant. Nimesulide may affect ovulation and is contraindicated in the third trimester. Consult your doctor for safe alternatives before trying to conceive.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to reduce pain and swelling. Take it exactly as directed by your surgeon. Inform your surgeon if you have a history of ulcers, bleeding disorders, or kidney problems. Do not use for prolonged periods without medical supervision.
🦷 Dental Procedures
This medicine is often prescribed after dental procedures like extractions or implants to reduce pain and swelling. Take it with food and follow your dentist's instructions. Avoid alcohol and other NSAIDs. If you experience excessive bleeding or severe pain, contact your dentist immediately.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you have pain or swelling. Gentle stretching and low-impact activities are generally safe. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects such as stomach bleeding, allergic reactions, or yellowing of eyes. Do not stop abruptly if you are on a prescribed course without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney impairment, liver injury, and cardiovascular events. It is generally recommended for short-term use only. Regular monitoring of liver and kidney function may be needed if prolonged use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help reduce localized swelling and pain.
Evidence: Commonly usedAlternative for localized pain with fewer systemic side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue your regular dosing schedule but consult your doctor if adjustments are needed. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it with food. Maximum effect may take a few hours.
A: No, it should be taken with food to reduce the risk of stomach upset and bleeding.
A: Do not take other NSAIDs or painkillers without consulting your doctor, as it may increase the risk of side effects.
A: It is not recommended during pregnancy, especially in the third trimester. Consult your doctor for safer alternatives.
🤔 Common Patient Concerns
🔄 Substitutes for cetolide plus 100mg/15mg tablet
View AllAlternative brands with exact same active ingredient:
-
nisul s tabletIntas Pharmaceuticals Ltd ₹8.75 86.3% CHEAPER
-
lupicit n 100mg/15mg tabletLupin Ltd ₹9.38 85.3% CHEAPER
-
nimodase tabletCure Quick Pharmaceuticals ₹24.97 60.9% CHEAPER
-
nid s tabletApostle Remedies ₹30.94 51.6% CHEAPER
-
Scornim S 100 mg/15 mg CapsuleScortis Lab Pvt Ltd ₹36.00 43.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: It is specifically for inflammatory pain and should not be used for all pain types without medical advice. - Myth: It is safe to take this medicine for months.
Fact: Prolonged use increases the risk of liver, kidney, and gastrointestinal problems. It is usually for short-term use. - Myth: This medicine is safe during pregnancy.
Fact: It is not recommended during pregnancy, especially in the third trimester, due to potential risks to the baby.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Serratiopeptidase combination generics
Brand Alternatives
- Nise SP
- Nimucet SP
- Nimulid SP
- Nimesulide Serratiopeptidase capsules