caditrex 50mg injection

4.8 (16 reviews)

Methotrexate (50mg)

🏭 Cadila Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is caditrex 50mg injection used for?

AuraTrex 5mg Tablet (Methotrexate) is used to treat ANTI NEOPLASTICS. It contains Methotrexate (50mg), which Inhibits dihydrofolate reductase (DHFR), blocking tetrahydrofolate synthesis and. Always consult your doctor before use. Take as prescribed.

Generic Name: Methotrexate
Manufacturer: Cadila Pharmaceuticals Ltd
Form: Allopathy
Pregnancy Category: X
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 caditrex 50mg injection Uses & Benefits

Acute lymphoblastic leukemia, rheumatoid arthritis, psoriasis, ectopic pregnancy, osteosarcoma, non-Hodgkin lymphoma, breast cancer, head and neck cancer, lung cancer, bladder cancer, mycosis fungoides.

Off-label uses: Sarcoidosis, systemic lupus erythematosus, dermatomyositis, Crohn's disease, graft-versus-host disease, multiple sclerosis, vasculitis, uveitis, ectopic pregnancy (non-surgical management).

📋 Drug Information

Generic Name(s)	Methotrexate
Brand Name	AuraTrex 5mg Tablet
Manufacturer	Cadila Pharmaceuticals Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Antimetabolite- Methotrexate
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionOral absorption is dose-dependent; low doses (<25 mg) are well absorbed, while higher doses have variable absorption.

DistributionDistributes widely into body tissues, including third-space fluids (pleural effusions, ascites).

Protein BindingApproximately 50% bound to plasma proteins.

MetabolismHepatic metabolism to polyglutamated forms; also undergoes intracellular polyglutamation.

Half-LifeLow dose: 3-10 hours; high dose: 8-15 hours.

ExcretionPrimarily renal excretion via glomerular filtration and active tubular secretion.

BioavailabilityDose-dependent; low doses (≤25 mg) have ~60% bioavailability, higher doses have lower bioavailabilit

Onset of ActionVariable; antineoplastic effects may take weeks.

Peak Plasma Time1-2 hours after oral administration.

Duration of ActionVariable; prolonged due to intracellular polyglutamation.

How It Works

Inhibits dihydrofolate reductase (DHFR), blocking tetrahydrofolate synthesis and DNA synthesis.

Mechanism Steps

1Methotrexate enters cells via reduced folate carrier (RFC1).

2Intracellularly, it is polyglutamated by folylpolyglutamate synthetase (FPGS).

3Polyglutamated methotrexate inhibits dihydrofolate reductase (DHFR) with high affinity.

💡 How to Take caditrex 50mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of caditrex 50mg injection

✅ Common Side Effects

Nausea
Vomiting
Diarrhea
Stomatitis
Mucositis
Fatigue
Alopecia
Anorexia
Elevated liver enzymes
Leukopenia
Thrombocytopenia
Anemia

🚨 Serious Side Effects

Myelosuppression
Hepatotoxicity
Nephrotoxicity
Pulmonary fibrosis
Pneumonitis
Severe infections
Tumor lysis syndrome
Gastrointestinal perforation
Neurotoxicity (leukoencephalopathy)

⚠️ Rare Side Effects

Anaphylaxis
Stevens-Johnson syndrome
Toxic epidermal necrolysis
Lymphoma
Osteoporosis
Photosensitivity
Acute uric acid nephropathy
Pancreatitis
Pericarditis
Pleural effusion

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
NSAIDs	Major	Increased methotrexate toxicity (myelosuppression, nephrotoxicity)
Probenecid	Major	Decreased renal excretion, increased toxicity
Salicylates	Major	Displacement from protein binding, increased toxicity
Sulfonamides	Major	Additive antifolate effect
Phenytoin	Major	Decreased phenytoin levels
Retinoids	Major	Increased hepatotoxicity
Penicillins	Moderate	Decreased methotrexate clearance
Cephalosporins	Moderate	Decreased methotrexate clearance
Omeprazole	Moderate	Delayed methotrexate elimination
Theophylline	Moderate	Increased theophylline levels
Folic acid	Moderate	Reduced methotrexate efficacy
Antacids	Minor	Decreased absorption
Cholestyramine	Minor	Decreased absorption
Digoxin	Minor	Decreased digoxin levels

🚨 Major Interactions

NSAIDs
Probenecid
Salicylates
Sulfonamides
Phenytoin
Retinoids

⚡ Moderate Interactions

Penicillins
Cephalosporins
Omeprazole
Theophylline
Folic acid

ℹ️ Minor Interactions

Antacids
Cholestyramine
Digoxin

🍽️ Food Interactions

Food may delay absorption; high-fat meals reduce peak concentration.

🍷 Alcohol Interaction

Increased hepatotoxicity risk; avoid alcohol.

🛡️ Safety & Warnings

🚫 Contraindications

Pregnancy, breastfeeding, severe renal impairment, severe hepatic impairment, alcoholism, immunodeficiency syndromes, pre-existing blood dyscrasias.

📊 Monitoring Parameters

CBC with differential, liver function tests, renal function tests, methotrexate serum levels, chest X-ray, pulmonary function tests.

🤱 Lactation Safety

Contraindicated; excreted in breast milk.

💊 Overdose Management

Administer leucovorin (folinic acid) as soon as possible; hydration and alkalinization of urine; consider charcoal hemoperfusion.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

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🔄 Substitutes for caditrex 50mg injection

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Alternative brands with exact same active ingredient (Methotrexate (50mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.