Folitrax 50 Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever, chills, or sore throat
- Unusual bleeding or bruising
- Shortness of breath or dry cough
- Yellowing of skin or eyes
- Decreased urine output
- Severe mouth sores or ulcers
- Blood in vomit or stool
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is methocip 50mg injection used for?
This medicine is a methotrexate injection used to treat certain cancers, severe rheumatoid arthritis, and psoriasis. It works by blocking cell division and suppressing the immune system. It is given by a healthcare professional and requires regular blood tests.
- Generic Name: Methotrexate (50mg)
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 methocip 50mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा मेथोट्रेक्सेट का इंजेक्शन है, जिसका उपयोग कुछ प्रकार के कैंसर, गंभीर रूमेटॉइड आर्थराइटिस और सोरायसिस के इलाज के लिए किया जाता है। यह शरीर में कोशिकाओं के विभाजन को रोककर और प्रतिरक्षा प्रणाली को दबाकर काम करती है। यह दवा डॉक्टर द्वारा इंजेक्शन के रूप में दी जाती है और इसके दौरान नियमित रक्त परीक्षण की आवश्यकता होती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, भूख न लगना, मुँह के छाले, थकान और बालों का पतला होना शामिल हैं। गंभीर दुष्प्रभावों में रक्त कोशिकाओं का कम होना, लीवर और किडनी की क्षति, और फेफड़ों में सूजन हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य डॉक्टर द्वारा ही दी जानी चाहिए। इलाज के दौरान शराब का सेवन पूरी तरह बंद कर दें। बिना डॉक्टर की सलाह के कोई भी दर्द निवारक दवा न लें। गर्भावस्था के दौरान इस दवा का उपयोग न करें। नियमित रक्त परीक्षण कराते रहें। बुखार, गले में खराश, असामान्य रक्तस्राव या सांस लेने में कठिनाई होने पर तुरंत डॉक्टर को बताएं।
💊 methocip 50mg injection Uses & Benefits
[{"condition":"Acute lymphoblastic leukemia","description":"Used as part of combination chemotherapy regimens to induce and maintain remission.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Used as a first-line DMARD to reduce joint inflammation and prevent joint damage.","evidence":"Well-established"},{"condition":"Psoriasis","description":"Used in severe cases to slow skin cell turnover and reduce plaques.","evidence":"Well-established"},{"condition":"Breast cancer","description":"Used in combination with other chemotherapy agents for treatment.","evidence":"Well-established"},{"condition":"Lung cancer","description":"Used in some chemotherapy regimens for non-small cell lung cancer.","evidence":"Well-established"},{"condition":"Ectopic pregnancy","description":"Used to terminate an early ectopic pregnancy in selected cases.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Crohn's disease","description":"Sometimes used to maintain remission in patients who cannot take other medicines.","evidence":"Limited"},{"condition":"Lupus","description":"May be used for severe skin and joint symptoms.","evidence":"Limited"}]
Primary treatment for: Rheumatoid arthritis
Also treats: Psoriasis, Acute lymphoblastic leukemia, Breast cancer, Lung cancer, Ectopic pregnancy
📋 Drug Information
| Generic Name(s) | Methotrexate (50mg) |
| Brand Name | methocip 50mg injection |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimetabolite- Methotrexate |
| Route of Administration | Parenteral (intramuscular, intravenous, or intrathecal) |
| Storage | Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Keep in the original carton until use. |
| Shelf Life | Refer to the product packaging for the expiration date. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the enzyme dihydrofolate reductase, which is needed to convert folic acid into its active form, tetrahydrofolate. Tetrahydrofolate is essential for the synthesis of DNA and RNA. By blocking this step, methotrexate prevents cells from dividing and growing. In cancer, this stops the rapid growth of tumor cells. In autoimmune diseases like rheumatoid arthritis, it reduces the activity of immune cells and decreases inflammation. It also increases levels of adenosine, which has anti-inflammatory effects.
Mechanism Steps
💡 How to Take methocip 50mg injection
Strength: Injection: 50 mg
Dosage Information
| Adult Dosage | The dose of this medicine varies widely depending on the condition being treated. For rheumatoid arthritis, a common dose is 7.5 to 20 mg once weekly, given as an intramuscular or intravenous injection. For psoriasis, similar weekly doses are used. For cancer, doses can range from 30 to 500 mg/m² or more, given in cycles. For ectopic pregnancy, a single dose of 50 mg/m² is often used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially bone marrow suppression and liver toxicity. Doses should be adjusted based on kidney and liver function. Close monitoring is required. |
| Renal Impairment | Dose reduction is required in patients with kidney impairment. In severe kidney disease, methotrexate is contraindicated. Consult a clinician for specific dose adjustments. |
| Hepatic Impairment | Dose reduction or avoidance is required in patients with liver impairment. Regular liver function tests are essential. Consult a clinician for specific dose adjustments. |
| Maximum Daily Dose | Not applicable as this medicine is not given daily. Maximum doses are determined by the specific protocol and indication. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of methocip 50mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| NSAIDs | Major | |
| Aspirin | Major | |
| Probenecid | Major | |
| Trimethoprim-sulfamethoxazole | Major | |
| Live vaccines | Major | |
| Corticosteroids | Moderate | |
| Phenytoin | Moderate | |
| Theophylline | Moderate | |
| Folic acid | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Aspirin
- Probenecid
- Trimethoprim-sulfamethoxazole
- Live vaccines
⚡ Moderate Interactions
- Corticosteroids
- Phenytoin
- Theophylline
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the risk of liver damage and can worsen methotrexate-induced liver toxicity. It may also increase the risk of stomach bleeding and ulcers.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy or planning to become pregnant","Breastfeeding","Severe liver disease","Severe kidney disease","Bone marrow suppression","Active infection","Hypersensitivity to methotrexate"]
⚠️ Warnings & Precautions
["This medicine should only be administered by a healthcare professional.","Regular blood tests are mandatory to monitor for toxicity.","Avoid alcohol completely during treatment.","Use effective contraception during and after treatment.","Do not receive live vaccines without doctor's approval.","Report any signs of infection, bleeding, or unusual fatigue immediately.","Avoid NSAIDs and aspirin unless specifically approved by your doctor.","Maintain good hydration to help prevent kidney damage."]
🤱 Lactation Safety
Methotrexate is excreted in breast milk and may harm a nursing infant. Breastfeeding is not recommended during treatment.
💊 Overdose Management
Overdose of methotrexate can cause severe bone marrow suppression, liver and kidney damage, and mucositis. Immediate medical attention is required. Treatment may include administration of leucovorin (folinic acid) to rescue normal cells, hydration, and supportive care. In severe cases, hemodialysis may be considered.
⏰ Missed Dose
This medicine is given by a healthcare professional, so missed doses are unlikely. If you miss an appointment for your injection, contact your doctor as soon as possible to reschedule. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a clinical setting. Regular blood tests to check liver, kidney, and bone marrow function are essential before and during treatment. Avoid alcohol completely while on this medicine, as it increases the risk of liver damage. Do not take over-the-counter medicines, especially pain relievers like ibuprofen or aspirin, without consulting your doctor, as they can interact and increase toxicity. Use effective contraception during treatment and for a period after, as this medicine can harm an unborn baby. Inform your doctor immediately if you experience fever, sore throat, unusual bleeding, or shortness of breath. Stay well hydrated and maintain good oral hygiene to reduce mouth sores. Do not receive any live vaccines while on this medicine without your doctor's approval.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of bone marrow suppression, liver toxicity, and kidney damage from this medicine. Doses should be adjusted based on kidney function, and monitoring should be more frequent. Falls and infections should be watched for closely.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated in pregnancy and can cause birth defects. Both men and women should use effective contraception during treatment and for at least 6 months after the last dose. If you are planning to become pregnant, consult your doctor to switch to a safer alternative before conception.
🏥 Post-Surgery Considerations
This medicine may impair wound healing and increase the risk of infection after surgery. Inform your surgeon that you are on this medicine. It may need to be temporarily stopped before and after surgery, as advised by your doctor.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it can increase the risk of bleeding and infection. You may need to stop the medicine temporarily before dental procedures. Your dentist may prescribe antibiotics or mouth rinses to prevent infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While on this medicine, you may experience fatigue or dizziness. Avoid strenuous exercise if you feel unwell. Low-impact exercises like walking, swimming, and yoga are generally safe and beneficial. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, nausea, or dizziness, which can affect your ability to drive or operate machinery. Avoid driving if you feel unwell. You may need to take time off work for injections and monitoring appointments. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping suddenly can cause a flare-up of your condition. Your doctor may stop treatment if you develop severe side effects, such as liver toxicity, bone marrow suppression, or pregnancy. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to liver damage, lung disease, and bone marrow suppression. Regular monitoring of liver and kidney function, and blood counts is essential. Patients on long-term therapy should have periodic liver biopsies if indicated. The risk of these effects increases with cumulative dose and duration of treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help improve joint function and reduce pain in rheumatoid arthritis.
Evidence: Well-establishedAlternative medicines like adalimumab or etanercept for rheumatoid arthritis if methotrexate is not effective.
Evidence: Well-establishedFor psoriasis, UV light therapy can be used alongside or instead of methotrexate.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided while on this medicine due to the risk of infection. Inactivated vaccines are generally safe, but their effectiveness may be reduced. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Keep out of reach of children
❌ DON'T
Do not store at room temperature for prolonged periods
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label clearly visible. Keep a copy of your prescription and a letter from your doctor explaining the medical need. Store the injection in a cool, refrigerated environment (2°C to 8°C) during travel; use an insulated bag with ice packs. Check airline regulations for carrying injectable medicines. If crossing time zones, consult your doctor about adjusting the timing of your dose. Always carry enough supply for the entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: For rheumatoid arthritis, it may take 3 to 6 weeks to see full benefits. For cancer, effects may be seen within days to weeks.
A: No, this medicine is contraindicated in pregnancy as it can harm the unborn baby. Use effective contraception during treatment.
A: Avoid alcohol, NSAIDs, aspirin, and live vaccines. Also avoid close contact with people who have infections.
🤔 Common Patient Concerns
🔄 Substitutes for methocip 50mg injection
View AllAlternative brands with exact same active ingredient:
-
methocip 50mg tabletCipla Ltd ₹15.62 68% CHEAPER
-
plastomet 50 injectionKhandelwal Laboratories Pvt Ltd ₹47.85 1.8% CHEAPER
-
hitrex 50mg injectionVhb Life Sciences Inc ₹50.48 3.5% COSTLIER
-
neotrexate injectionGlaxo SmithKline Pharmaceuticals Ltd ₹50.76 4.1% COSTLIER
-
methofast 50mg injectionNeon Laboratories Ltd ₹59.00 21% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Methotrexate is only for cancer.
Fact: Methotrexate is also used for autoimmune diseases like rheumatoid arthritis and psoriasis at lower doses. - Myth: You can stop methotrexate once you feel better.
Fact: Methotrexate should be continued as prescribed to maintain remission and prevent flare-ups. Stopping suddenly can worsen the condition. - Myth: Methotrexate is safe to take with alcohol.
Fact: Alcohol increases the risk of liver damage and should be avoided completely while on methotrexate.
🔄 Alternative Options
Generic Alternatives
- Methotrexate injection (generic)
Brand Alternatives
- Folitrax 50 injection