bortirel 3.5mg injection - Uses, Price, Side Effects & Substitutes
What is bortirel 3.5mg injection used for?
Borziv (Bortezomib) is used to treat ANTI NEOPLASTICS. It contains Bortezomib (3.5mg), which Reversible inhibition of the 26S proteasome, disrupting protein degradation and . Always consult your doctor before use. Take as prescribed.
- Generic Name: Bortezomib
- Manufacturer: Reliance Life Sciences
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
π bortirel 3.5mg injection Uses & Benefits
Multiple myeloma (first-line and relapsed), mantle cell lymphoma.
Off-label uses: WaldenstrΓΆm macroglobulinemia, amyloidosis, T-cell lymphoma.
π Drug Information
| Generic Name(s) | Bortezomib |
| Brand Name | Borziv |
| Manufacturer | Reliance Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Proteasome inhibitor |
| Route of Administration | Intravenous or subcutaneous injection. |
| Storage | Store at 2-8Β°C (refrigerated); protect from light. |
| Shelf Life | As per manufacturer |
π¬ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Reversible inhibition of the 26S proteasome, disrupting protein degradation and leading to cell cycle arrest and apoptosis in cancer cells.
Mechanism Steps
π‘ How to Take bortirel 3.5mg injection
Follow your doctor's prescription exactly.
β οΈ Side Effects of bortirel 3.5mg injection
β Common Side Effects
- Nausea
- Diarrhea
- Fatigue
- Thrombocytopenia
- Peripheral neuropathy
π¨ Serious Side Effects
- Cardiotoxicity
- Hepatotoxicity
- Tumor lysis syndrome
- Posterior reversible encephalopathy syndrome (PRES)
β οΈ Rare Side Effects
- Interstitial lung disease
- Progressive multifocal leukoencephalopathy (PML)
- Severe hypotension
Consult your doctor if you experience any unusual symptoms.
π¬ Drug Interactions
| β οΈ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased bortezomib exposure |
| Rifampin | Major | Decreased bortezomib efficacy |
| Warfarin | Major | Increased INR and bleeding risk |
π¨ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP3A4 inducers (e.g., rifampin)
- Warfarin
β‘ Moderate Interactions
- Antihypertensives
- Oral hypoglycemics
- Cisplatin
βΉοΈ Minor Interactions
- Grapefruit juice
- St. John's Wort
π½οΈ Food Interactions
No significant food interactions; avoid grapefruit juice.
π· Alcohol Interaction
Alcohol may increase risk of hepatotoxicity; avoid excessive consumption.
π‘οΈ Safety & Warnings
π« Contraindications
Hypersensitivity to bortezomib, boron, or mannitol; severe hepatic impairment.
π Monitoring Parameters
Complete blood count, liver function tests, renal function, peripheral neuropathy assessment.
π€± Lactation Safety
Not recommended; discontinue breastfeeding during treatment.
π Overdose Management
No specific antidote; supportive care and monitoring of vital signs.
β° Missed Dose
If a dose is missed, do not double the dose; resume next scheduled dose.
π¨ββοΈ Reviewed by Expert
π Substitutes for bortirel 3.5mg injection
View AllAlternative brands with exact same active ingredient (Bortezomib (3.5mg)):
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bortenat 3.5mg injectionNatco Pharma Ltd βΉ3,881.00 12.5% COSTLIER
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borzomed 3.5mg injectionMedicamen Biotech Ltd βΉ5,737.50 66.4% COSTLIER
-
borviz 3.5 injectionIntas Pharmaceuticals Ltd βΉ5,855.05 69.8% COSTLIER
-
Norvelzo 3.5mg InjectionTaj Pharma India Ltd βΉ15,455.00 348.1% COSTLIER
-
bortero 3.5mg injectionHetero Drugs Ltd βΉ15,937.50 362.1% COSTLIER
-
onbort 3.5mg injectionNeon Laboratories Ltd βΉ16,537.50 379.5% COSTLIER
-
velcade 3.5mg injectionJanssen Pharmaceuticals βΉ50,953.13 1377.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.