bleocare 30mg injection - Bleomycin (30mg) medicine

bleocare 30mg injection

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🏭 Criticare Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 18, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 18, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is bleocare 30mg injection used for?

This medicine contains Bleomycin (30mg) and is used to treat ANTI NEOPLASTICS. Causes DNA strand breaks via free radical generation, inhibiting DNA synthesis and cell division.. Always consult your doctor before use.

  • Generic Name: Bleomycin
  • Manufacturer: Criticare Laboratories Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 bleocare 30mg injection Uses & Benefits

Hodgkin lymphoma, non-Hodgkin lymphoma, testicular cancer, squamous cell carcinoma of head and neck, cervical cancer, and malignant pleural effusion.

Off-label uses: Malignant effusions (pleurodesis), warts (intralesional), hemangiomas.

📋 Drug Information

Generic Name(s)Bleomycin
Brand NameBleomycin Sulphate Injection
ManufacturerCriticare Laboratories Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassAlkaloids-cytotoxic agents
Route of AdministrationIntravenous, intramuscular, subcutaneous, or intracavitary (pleural, peritoneal)
StorageStore at 2-8°C; protect from light.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionIntravenous or intramuscular administration; absorption is rapid and complete after IM injection.
DistributionWidely distributed; highest concentrations in skin, lungs, and lymph nodes; poor penetration into CNS.
Protein BindingApproximately 1% bound to plasma proteins.
MetabolismMetabolized primarily by hydrolase enzymes in various tissues, including liver and kidney.
Half-LifeBiphasic: initial half-life ~1.3 hours, terminal half-life ~9 hours (may be prolonged in renal impai
ExcretionRenal excretion; about 60-70% of dose excreted unchanged in urine.
BioavailabilityNot applicable (parenteral administration).
Onset of ActionRapid; within hours for antitumor effect.
Peak Plasma TimeImmediately after IV bolus; 30-60 minutes after IM injection.
Duration of ActionVariable; effects may persist for days to weeks.

How It Works

Causes DNA strand breaks via free radical generation, inhibiting DNA synthesis and cell division.

Mechanism Steps

1Bleomycin binds to DNA via intercalation and metal ion chelation.
2Forms a complex with Fe(II) and oxygen, generating reactive oxygen species (ROS).
3ROS cause single- and double-strand breaks in DNA.
4Inhibition of DNA synthesis and cell cycle arrest (G2 phase).
5Induction of apoptosis in cancer cells.

💡 How to Take bleocare 30mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of bleocare 30mg injection

✅ Common Side Effects

Fever
Chills
Nausea
Vomiting
Alopecia
Mucositis
Skin hyperpigmentation
Raynaud phenomenon

🚨 Serious Side Effects

Pulmonary fibrosis
Pneumonitis
Hypersensitivity reactions
Myelosuppression (rare)
Hepatic veno-occlusive disease

⚠️ Rare Side Effects

Cardiotoxicity
Nephrotoxicity
Seizures
Scleroderma-like skin changes

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Cisplatin Major Increased risk of pulmonary toxicity and renal impairment.
Methotrexate Major Increased risk of pulmonary toxicity.
Vinca alkaloids Major Increased risk of pulmonary toxicity.
Radiation therapy Major Enhanced radiation-induced pulmonary fibrosis.
Phenytoin Moderate Decreased phenytoin levels.
Digoxin Moderate Decreased digoxin absorption.
Warfarin Moderate Increased anticoagulant effect.
Acetaminophen Minor Possible decreased clearance of acetaminophen.
Cimetidine Minor Possible increased bleomycin toxicity.

🚨 Major Interactions

  • Cisplatin
  • Methotrexate
  • Vinca alkaloids
  • Radiation therapy

⚡ Moderate Interactions

  • Phenytoin
  • Digoxin
  • Warfarin

🍷 Alcohol Interaction

No specific interaction; but alcohol may exacerbate hepatotoxicity.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to bleomycin; severe pulmonary disease; pregnancy.

🤱 Lactation Safety

Contraindicated; excreted in breast milk.

💊 Overdose Management

Supportive care; no specific antidote; monitor pulmonary function.

⏰ Missed Dose

Administer as soon as remembered; do not double dose; consult physician.

🔄 Substitutes for bleocare 30mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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