amphocil 50mg injection - Amphotericin B (50mg) medicine

amphocil 50mg injection

4.5 (17 reviews)
๐Ÿญ Criticare Laboratories Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 21, 2026
โš ๏ธ Hepatotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 21, 2026

What is amphocil 50mg injection used for?

Amfy V Vaginal Gel (Amphotericin B) is used to treat ANTI INFECTIVES. It contains Amphotericin B (50mg), which Binds to ergosterol in fungal cell membrane, forming pores leading to leakage of. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Amphotericin B
  • Manufacturer: Criticare Laboratories Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: B
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š amphocil 50mg injection Uses & Benefits

Vaginal candidiasis.

Off-label uses: Not commonly used off-label.

๐Ÿ“‹ Drug Information

Generic Name(s)Amphotericin B
Brand NameAmfy V Vaginal Gel
ManufacturerCriticare Laboratories Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassFungal cell membrane active agent
Route of AdministrationVaginal (topical).
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption after vaginal application; local action primarily.
DistributionNot significantly distributed systemically; remains localized in vaginal tissues.
Protein Binding>90% bound to plasma proteins (if absorbed).
MetabolismNot extensively metabolized; if absorbed, metabolized in liver.
Half-LifeApproximately 15 days (systemic); not applicable for local use.
ExcretionPrimarily fecal via bile; renal excretion minimal.
BioavailabilityNegligible systemic bioavailability after vaginal application.
Onset of ActionRapid; within hours of application.
Peak Plasma TimeNot applicable due to minimal absorption.
Duration of ActionSustained local effect for 24-48 hours.

How It Works

Binds to ergosterol in fungal cell membrane, forming pores leading to leakage of ions and cell death.

Mechanism Steps

1Amphotericin B binds to ergosterol in fungal cell membrane.
2Forms transmembrane pores (channels).
3Leakage of monovalent ions (K+, Na+) and small molecules.

๐Ÿ’ก How to Take amphocil 50mg injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of amphocil 50mg injection

โœ… Common Side Effects

  • Vaginal burning
  • Itching
  • Irritation

๐Ÿšจ Serious Side Effects

  • Severe allergic reaction (rare)

โš ๏ธ Rare Side Effects

  • Contact dermatitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Nephrotoxic drugs Major Increased risk of nephrotoxicity
Corticosteroids Major Hypokalemia
Digitalis glycosides Major Increased risk of digitalis toxicity due to hypokalemia
Antineoplastic agents Moderate Increased risk of renal toxicity
Diuretics Moderate Hypokalemia
Skeletal muscle relaxants Moderate Enhanced neuromuscular blockade
Flucytosine Minor Increased antifungal effect

๐Ÿšจ Major Interactions

  • Nephrotoxic drugs (e.g., aminoglycosides, cyclosporine)
  • Corticosteroids
  • Digitalis glycosides

โšก Moderate Interactions

  • Antineoplastic agents
  • Diuretics
  • Skeletal muscle relaxants

โ„น๏ธ Minor Interactions

  • Flucytosine

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

No known interaction.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to amphotericin B or any component.

๐Ÿ“Š Monitoring Parameters

Clinical response; local irritation.

๐Ÿคฑ Lactation Safety

Not absorbed systemically; considered safe during lactation.

๐Ÿ’Š Overdose Management

Overdose unlikely due to local application; symptomatic treatment if needed.

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for amphocil 50mg injection

View All

Alternative brands with exact same active ingredient (Amphotericin B (50mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

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