Ampholip 100mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Decreased urine output or swelling in legs
- Severe chest pain or difficulty breathing
- Irregular heartbeat or palpitations
- Swelling of face, lips, or throat
- Severe abdominal pain or vomiting blood
- Yellowing of skin or eyes
- Confusion or extreme fatigue
If experiencing severe symptoms, call emergency services immediately.
What is amphocil 100mg injection used for?
Ampholip 100mg injection contains Amphotericin B, an antifungal medicine used to treat serious fungal infections. It works by breaking down the fungal cell membrane. It is given intravenously in a hospital setting under medical supervision.
- Generic Name: Amphotericin B (100mg)
- Manufacturer: Criticare Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amphocil 100mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एम्फोटेरिसिन बी का इंजेक्शन है, जिसका उपयोग गंभीर फंगल संक्रमणों के इलाज के लिए किया जाता है। यह अस्पताल में डॉक्टर की देखरेख में नस के माध्यम से दी जाती है। यह एस्परजिलोसिस, क्रिप्टोकोकल मेनिनजाइटिस, म्यूकोरमाइकोसिस और विसरल लीशमैनियासिस जैसी बीमारियों में प्रभावी है। यह फंगस की कोशिका की दीवार को तोड़कर उसे नष्ट कर देती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में बुखार, ठंड लगना, मतली, उल्टी, सिरदर्द और इंजेक्शन की जगह पर दर्द शामिल हैं। गुर्दे की समस्या और पोटैशियम की कमी भी हो सकती है। गंभीर दुष्प्रभावों में गुर्दे की क्षति, हृदय की धड़कन में गड़बड़ी और एलर्जी प्रतिक्रिया शामिल हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा दी जानी चाहिए। इसे घर पर स्वयं न लगाएं। इलाज के दौरान गुर्दे की कार्यप्रणाली और इलेक्ट्रोलाइट्स की नियमित जांच होती रहनी चाहिए। पर्याप्त पानी पिएं। शराब से बचें। बुखार, ठंड लगना या सांस लेने में तकलीफ हो तो तुरंत डॉक्टर को बताएं।
💊 amphocil 100mg injection Uses & Benefits
[{"condition":"Invasive aspergillosis","description":"Used as a primary or alternative therapy for serious Aspergillus infections, especially in immunocompromised patients.","evidence":"Well-established"},{"condition":"Cryptococcal meningitis","description":"Used in combination with other antifungals for treating cryptococcal meningitis, particularly in HIV-infected individuals.","evidence":"Well-established"},{"condition":"Mucormycosis","description":"A first-line treatment for mucormycosis, a severe fungal infection often seen in people with uncontrolled diabetes.","evidence":"Well-established"},{"condition":"Visceral leishmaniasis","description":"Used as an alternative treatment for visceral leishmaniasis (kala-azar) in certain regions.","evidence":"Well-established"},{"condition":"Candidiasis (severe invasive)","description":"Reserved for severe invasive Candida infections that are resistant to other antifungals or in patients who cannot tolerate them.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Fungal keratitis","description":"Sometimes compounded into topical eye drops for fungal corneal infections, though this is not a standard approved use.","evidence":"Limited"},{"condition":"Fungal peritonitis","description":"Occasionally used intraperitoneally in patients on peritoneal dialysis with fungal peritonitis.","evidence":"Limited"}]
Primary treatment for: Invasive fungal infections
Also treats: Aspergillosis, Cryptococcosis, Mucormycosis, Visceral leishmaniasis, Severe candidiasis
📋 Drug Information
| Generic Name(s) | Amphotericin B (100mg) |
| Brand Name | amphocil 100mg injection |
| Manufacturer | Criticare Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Fungal cell membrane active agent |
| Route of Administration | Intravenous (IV) infusion. This medicine is given by a healthcare professional in a hospital or clinic setting |
| Storage | Store the unopened vial in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Once reconstituted, the solution should be used immediately or stored as directed by the pharmacist. Discard any unused portion. |
| Shelf Life | The shelf life of the unopened vial is typically 24 months from the date of manufacture. Check the expiry date on the vial. Once reconstituted, use within the time specified by the manufacturer, usually within 24 hours if refrigerated. |
| WHO Guideline | Amphotericin B is included in WHO essential medicines list for treating serious fungal infections. Specific recommendations vary by condition and region. |
| ICMR Guideline | ICMR guidelines recommend Amphotericin B for management of mucormycosis and other invasive fungal infections in appropriate clinical settings. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Amphotericin B binds to ergosterol, a key sterol in the fungal cell membrane. This binding forms pores or channels that increase membrane permeability, causing leakage of potassium, magnesium, and other essential intracellular components. The resulting osmotic imbalance and loss of cellular function lead to fungal cell death. Because human cell membranes contain cholesterol instead of ergosterol, Amphotericin B has some selectivity for fungal cells, but it can still cause toxicity in human cells, especially in the kidneys.
Mechanism Steps
💡 How to Take amphocil 100mg injection
Strength: 100 mg lyophilized powder for injection, to be reconstituted before use.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the type and severity of the fungal infection, the patient's kidney function, and other factors. For invasive fungal infections, a typical adult dose may range from 0.5 to 1.5 mg/kg per day, given as a slow intravenous infusion over 2 to 6 hours. For some infections, a higher dose or a different schedule may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Doses are individualized based on weight and clinical condition. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially kidney damage. Kidney function should be monitored closely, and the dose may need to be adjusted by a qualified clinician. |
| Renal Impairment | In patients with kidney impairment, the dose may need to be reduced or the dosing interval extended. Kidney function should be monitored closely, and the dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is established for liver impairment. Use with caution and monitor liver function. |
| Maximum Daily Dose | The maximum daily dose is individualized by a qualified clinician. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amphocil 100mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | |
| Vancomycin | Major | |
| NSAIDs | Major | |
| Digoxin | Major | |
| Corticosteroids | Major | |
| Flucytosine | Moderate | |
| Fluconazole | Moderate | |
| Neuromuscular blockers | Major | |
| Antihistamines | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Nephrotoxic drugs (e.g., aminoglycosides, vancomycin, NSAIDs)
- Digoxin
- Corticosteroids
- Neuromuscular blocking agents
⚡ Moderate Interactions
- Flucytosine
- Azole antifungals (e.g., fluconazole)
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine because it can increase the risk of liver problems and stomach upset.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Amphotericin B or any component of the formulation","Severe kidney disease (relative contraindication; use with caution)","Concurrent use with other nephrotoxic drugs (relative contraindication)"]
⚠️ Warnings & Precautions
["This medicine can cause serious kidney damage. Monitor renal function closely.","Severe allergic reactions, including anaphylaxis, can occur. Have emergency equipment ready during infusion.","Electrolyte imbalances, especially low potassium and magnesium, are common. Monitor and replace as needed.","Use with caution in patients with heart disease or those taking drugs that affect heart rhythm.","Do not use if the solution is cloudy or contains particles.","Pregnancy: Use only if clearly needed. Consult your doctor.","Lactation: Not known if safe. Consult your doctor."]
🤱 Lactation Safety
It is not known whether Amphotericin B passes into breast milk. Because of the potential for serious side effects in a nursing infant, breastfeeding should be discontinued during treatment, or the mother should consult her doctor.
💊 Overdose Management
Overdose can cause severe kidney damage, electrolyte imbalances, and cardiac arrest. Treatment is supportive and symptomatic. There is no specific antidote. Hemodialysis does not effectively remove Amphotericin B. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
This medicine is given by a healthcare professional. If you miss an appointment for your dose, contact your doctor or clinic as soon as possible to reschedule. Do not try to self-administer a double dose.
Additional Safety Advice
This medicine must be given by a healthcare professional in a monitored setting. Do not attempt to self-administer this injection. Your doctor will check your kidney function, electrolyte levels, and blood counts before and during treatment. Tell your doctor if you have kidney disease, heart disease, or are taking other medicines that can affect the kidneys. Stay well hydrated unless your doctor tells you otherwise. Avoid alcohol during treatment because it can worsen liver and stomach side effects. Report any fever, chills, or unusual tiredness to your nurse or doctor right away.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney damage and electrolyte imbalances. Close monitoring and dose adjustments are often needed.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor. This medicine should be used during pregnancy only if clearly needed. Effective contraception is recommended during treatment.
🏥 Post-Surgery Considerations
If you have surgery while on this medicine, inform your surgeon and anesthesiologist. Monitoring of kidney function and electrolytes is important during the perioperative period.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. No specific precautions are established, but good oral hygiene is important.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during treatment as you may feel weak or dizzy. Light activity is fine if you feel up to it. Consult your doctor before starting any exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take time off work for hospital visits and recovery. Fatigue and infusion reactions can affect your daily activities. Arrange for help with transportation and daily tasks during treatment.
🛑 When to Stop This Medicine
Do not stop this medicine without your doctor's advice. Your doctor will decide when to stop based on your response and test results. Stopping early may allow the infection to return.
📅 Long-Term Use Effects
Long-term use can lead to kidney damage, electrolyte imbalances, and rarely, hearing loss. Regular monitoring of kidney function, electrolytes, and blood counts is essential. Your doctor will adjust the dose or switch to a less toxic formulation if needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A less nephrotoxic formulation of Amphotericin B.
Evidence: Well-establishedOral antifungals like fluconazole or voriconazole for less severe infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, live vaccines should be avoided during treatment due to weakened immunity. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store in refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store at room temperature for long periods
✈️ Traveling with This Medicine
This medicine is given in a hospital setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed by your pharmacist. Inform your doctor if you plan to travel to areas where fungal infections are common.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement may be seen within days to weeks, depending on the infection. Your doctor will monitor your progress.
A: You may feel dizzy or tired after the infusion. It is best to arrange for someone else to drive you home.
A: Avoid alcohol and other medicines that can harm the kidneys. Always inform your doctor about all medicines you take.
🤔 Common Patient Concerns
🔄 Substitutes for amphocil 100mg injection
View AllAlternative brands with exact same active ingredient:
-
amphomul 100mg injectionBharat Serums & Vaccines Ltd ₹8,500.00 22.7% CHEAPER
-
ampholip 100mg injectionBharat Serums & Vaccines Ltd ₹10,734.29 2.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Amphotericin B is safe for everyone.
Fact: It can cause serious kidney problems and should only be used under medical supervision. - Myth: You can take Amphotericin B orally.
Fact: It is not effective orally for systemic infections and must be given intravenously. - Myth: Amphotericin B is a painkiller.
Fact: It is an antifungal medicine, not a painkiller.
🔄 Alternative Options
Generic Alternatives
- Amphotericin B injection (generic)
Brand Alternatives
- Ampholip 100mg injection