Avokold Syrup: Complete Medicine Guide for Cold and Allergy Relief
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, tongue, or throat
- Severe drowsiness, confusion, or fainting
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain or vomiting blood
- Blood in stool or black, tarry stools
- Irregular heartbeat or palpitations
- Seizures or convulsions
- Decreased urine output or inability to urinate
If experiencing severe symptoms, call emergency services immediately.
What is avokold syrup used for?
This medicine is a combination syrup containing chlorpheniramine maleate (an antihistamine) and paracetamol (a pain and fever reducer). It is used to relieve symptoms of common cold and allergies such as runny nose, sneezing, watery eyes, and mild fever or body ache. It is usually taken every 4 to 6 hours as needed, but do not exceed 6 doses in 24 hours. It may cause drowsiness, so avoid driving. Do not use in children under 2 years without medical advice.
- Generic Name: Chlorpheniramine Maleate + Paracetamol
- Manufacturer: Avonic Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 avokold syrup के बारे में (Hindi Summary)
उपयोग: यह दवा आम सर्दी, एलर्जी और नाक बहने, छींक आने, आंखों में पानी आने, हल्के बुखार और शरीर दर्द के इलाज के लिए इस्तेमाल की जाती है। इसमें क्लोरफेनिरामाइन मेलिएट और पैरासिटामोल होते हैं। यह दवा लक्षणों को कम करती है, बीमारी का इलाज नहीं करती।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना, धुंधली दृष्टि और पेट खराब होना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, लीवर की समस्या या खून की बीमारी हो सकती है। अगर कोई भी दुष्प्रभाव लंबे समय तक रहे तो डॉक्टर से सलाह लें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। ज्यादा मात्रा में न लें क्योंकि इससे लीवर को नुकसान हो सकता है। इस दवा के साथ शराब न पिएं। गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। अगर आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। बच्चों को 2 साल से कम उम्र में यह दवा न दें।
💊 avokold syrup Uses & Benefits
[{"condition":"Common cold","description":"Provides symptomatic relief from runny nose, sneezing, watery eyes, and mild fever or body ache associated with the common cold.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Reduces sneezing, nasal itching, rhinorrhea, and associated headache or malaise due to allergic rhinitis.","evidence":"Well-established"},{"condition":"Allergic conjunctivitis","description":"Helps relieve itchy, watery eyes and associated discomfort in allergic conjunctivitis.","evidence":"Moderate"},{"condition":"Urticaria","description":"May provide relief from itching and rash in mild urticaria, though paracetamol does not treat the rash itself.","evidence":"Limited"}]
Off-label uses: [{"condition":"Insomnia due to allergic symptoms","description":"Sometimes used off-label for its sedating effect to help sleep in patients with allergic symptoms, but this is not a recommended primary use.","evidence":"Limited"}]
Primary treatment for: Common cold and allergic rhinitis
Also treats: Allergic conjunctivitis, Urticaria, Sinusitis, Pharyngitis
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate + Paracetamol |
| Brand Name | Alex P Syrup |
| Manufacturer | Avonic Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Antihistamine + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the bottle tightly closed. Do not refrigerate unless specified on the label. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as stated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors on effector cells, thereby preventing histamine-mediated symptoms such as sneezing, itching, and increased vascular permeability. It also has anticholinergic properties that contribute to dry mouth and sedation. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which leads to reduction of fever and pain. The exact mechanism of paracetamol is not fully established, but it is believed to involve inhibition of cyclooxygenase enzymes in the brain and spinal cord, and possibly activation of descending serotonergic pathways.
Mechanism Steps
💡 How to Take avokold syrup
Strength: Each 5 mL of syrup contains chlorpheniramine maleate 0.5 mg and paracetamol 125 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 mL (2 teaspoons) every 4 to 6 hours as needed for symptoms, not to exceed 6 doses in 24 hours. However, the exact dose and frequency depend on the indication, severity of symptoms, and individual patient factors. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Use the measuring cup or spoon provided with the product for accurate dosing. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. This medicine is contraindicated in children under 2 years of age due to the risk of severe respiratory depression. For children 2 years and older, dosing should be based on weight and clinical condition, and must be determined by a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the effects of chlorpheniramine, including sedation, confusion, and anticholinergic effects such as dry mouth, constipation, and urinary retention. The dose may need to be reduced or the medicine used with caution. Paracetamol clearance may be slightly reduced. Dose must be individualized by a qualified clinician based on renal and hepatic function. Regular monitoring for side effects is recommended. |
| Renal Impairment | Use with caution in patients with renal impairment. Chlorpheniramine is primarily excreted by the kidneys, and its half-life may be prolonged in renal failure. Paracetamol metabolites may accumulate. Dose adjustment may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Paracetamol is metabolized by the liver, and the risk of hepatotoxicity is increased in patients with liver disease. Chlorpheniramine is also metabolized by the liver. Dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose of this medicine for adults is 60 mL (12 teaspoons) in 24 hours, providing 1500 mg of paracetamol and 6 mg of chlorpheniramine maleate. Do not exceed this dose. For children, the maximum daily dose must be determined by a pediatrician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of avokold syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Alcohol | Major | |
| Warfarin | Major | |
| Benzodiazepines | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Carbamazepine | Moderate | |
| Cimetidine | Moderate | |
| Antihypertensives | Minor | |
| Diuretics | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Alcohol and other CNS depressants (e.g., benzodiazepines, opioids, sedatives)
- Warfarin
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants, some antipsychotics)
- Enzyme inducers (e.g., carbamazepine, phenytoin, rifampicin)
- Enzyme inhibitors (e.g., cimetidine, ketoconazole)
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine. Alcohol increases the sedative effects of chlorpheniramine, leading to excessive drowsiness and impaired coordination. Additionally, chronic alcohol use can induce liver enzymes, increasing the risk of paracetamol-induced hepatotoxicity even at therapeutic doses. Acute alcohol ingestion may also increase the toxic metabolite of paracetamol. Therefore, it is unsafe to consume alcohol during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to chlorpheniramine, paracetamol, or any component of the formulation","Severe liver disease or active liver disease","Use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOI","Narrow-angle glaucoma","Urinary retention due to prostatic hypertrophy or other causes","Severe cardiovascular disease","Children under 2 years of age (due to risk of severe respiratory depression)"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not exceed the recommended dose; high doses of paracetamol can cause liver damage.","Avoid alcohol while taking this medicine.","Use with caution in elderly patients due to increased risk of confusion, sedation, and anticholinergic effects.","Use with caution in patients with asthma, glaucoma, or difficulty urinating.","Consult a doctor before use if pregnant or breastfeeding.","Do not use for more than 7 days without medical advice.","Keep out of reach of children.","If symptoms persist or worsen, consult a doctor.","This medicine may impair your ability to perform tasks requiring alertness."]
🤱 Lactation Safety
Chlorpheniramine is excreted in breast milk and may cause drowsiness or irritability in the nursing infant. Paracetamol is also excreted in breast milk in small amounts and is generally considered safe. However, due to the sedating effects of chlorpheniramine, this medicine should be used with caution during breastfeeding. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose of this medicine can be serious, primarily due to the paracetamol component, which can cause severe liver damage. Symptoms of paracetamol overdose may include nausea, vomiting, abdominal pain, and sweating, followed by liver failure. Chlorpheniramine overdose can cause severe drowsiness, confusion, seizures, and anticholinergic effects. If overdose is suspected, seek immediate emergency medical attention, even if you feel well. Treatment may include activated charcoal, N-acetylcysteine (for paracetamol toxicity), and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose because the paracetamol component can harm the liver in high doses. Avoid alcohol while taking this medicine as it can increase drowsiness and the risk of liver problems. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have liver or kidney disease, glaucoma, difficulty urinating, asthma, or if you are pregnant or breastfeeding. Do not use this medicine for more than a few days without medical advice. Keep out of reach of children. Store at room temperature away from direct sunlight and moisture.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the sedative and anticholinergic effects of chlorpheniramine, such as confusion, dry mouth, constipation, and urinary retention. They may also have reduced liver and kidney function, increasing the risk of paracetamol toxicity. Use with caution, consider dose reduction, and monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Paracetamol is generally considered safe during pregnancy when used at recommended doses for short periods. Chlorpheniramine should be used with caution, especially in the first trimester. Discuss the risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
After surgery, use this medicine with caution. Chlorpheniramine may increase sedation and interfere with recovery. Paracetamol is often used for post-operative pain, but the combination should be used only if prescribed by your surgeon. Inform your surgeon about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. The sedative effect may interact with anesthetics or sedatives used during dental work. Paracetamol may be used for dental pain, but the combination should be used as directed by your dentist.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness, which can impair your ability to exercise safely. Avoid strenuous exercise or activities that require balance and coordination until you know how the medicine affects you. If you exercise, do so in a safe environment and stay hydrated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, which may affect your ability to work, drive, or operate machinery. It is advisable to avoid driving or engaging in hazardous activities until you know how the medicine affects you. If your work requires alertness, discuss with your doctor about alternative non-sedating options. The sedative effect may also impact your productivity, so plan your tasks accordingly.
🛑 When to Stop This Medicine
Stop taking this medicine if your symptoms resolve or after the recommended duration (usually not more than 7 days) unless advised otherwise by your doctor. If you experience any serious side effects, stop immediately and seek medical attention. Do not stop abruptly if you have been taking it for a long time without consulting your doctor, as withdrawal symptoms may occur.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of chlorpheniramine can lead to tolerance, dependence, and increased risk of side effects such as cognitive impairment, especially in the elderly. Chronic high-dose paracetamol use can increase the risk of liver and kidney damage. If symptoms persist beyond 7 days, consult a doctor to determine the underlying cause and appropriate treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps relieve nasal congestion and runny nose without medication.
Evidence: Well-establishedCan ease nasal congestion and soothe irritated airways.
Evidence: ModerateFor allergic conjunctivitis, topical eye drops may be used instead of systemic antihistamines.
Evidence: Well-establishedFor allergies without fever, second-generation antihistamines like cetirizine or loratadine may be preferred to avoid drowsiness.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, it is generally advisable to postpone vaccination until you recover, as fever may be a sign of infection. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container with cap tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or doctor's note, especially for international travel. Store it in a cool, dry place away from direct sunlight. If traveling across time zones, continue taking the medicine as needed for symptoms, but do not exceed the maximum daily dose. Check customs regulations for carrying medicines in your destination country. Keep it in your carry-on luggage if you need it during the flight.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts to relieve symptoms within 30 to 60 minutes after taking a dose.
A: Adults can take 10 mL every 4 to 6 hours as needed, but do not exceed 6 doses in 24 hours.
A: It can be taken with or without food, but taking it with food may reduce stomach upset.
A: It is not recommended for children under 2 years. For older children, consult a pediatrician for appropriate dosing.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Inform your doctor about all other medicines you are taking, especially MAOIs, warfarin, and other CNS depressants, as interactions may occur.
🤔 Common Patient Concerns
🔄 Substitutes for avokold syrup
View AllAlternative brands with exact same active ingredient:
-
unicold syrupUniBiotics Pharmaceutical ₹32.81 27.1% CHEAPER
-
Stencold Oral SuspensionStensa Life Sciences ₹34.69 22.9% CHEAPER
-
kunim cold syrupStenkem Molecules Pvt Ltd ₹42.19 6.2% CHEAPER
-
zecold kid oral suspensionMedivista Lifesciences Pvt. Ltd. ₹43.13 4.2% CHEAPER
-
antidoz-kid oral suspensionMedisoft Pharma ₹45.00 SAME PRICE
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection. The common cold usually resolves on its own. - Myth: It is safe to take extra doses for faster relief.
Fact: Taking more than the recommended dose can cause serious liver damage due to paracetamol. Always follow the dosing instructions. - Myth: This medicine is safe for children of all ages.
Fact: It is not recommended for children under 2 years due to the risk of severe respiratory depression. Consult a pediatrician for appropriate use. - Myth: You can drink alcohol while taking this medicine.
Fact: Alcohol should be avoided as it increases drowsiness and the risk of liver damage.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine maleate + Paracetamol syrup (various manufacturers)
Brand Alternatives
- Avokold Syrup (this medicine)
- Other brands containing chlorpheniramine and paracetamol