avokuf d syrup - Chlorpheniramine Maleate (2mg) + Dextromethorphan Hydrobromide (10mg) medicine

Avokuf D Syrup - Uses, Price, Side Effects

4.8 (4 reviews)
๐Ÿญ Avonic Life Sciences ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 23, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 23, 2026

What is avokuf d syrup used for?

Avokuf D Syrup is a combination medicine used to relieve cough and cold symptoms. It contains Chlorpheniramine Maleate (an antihistamine that reduces sneezing and runny nose) and Dextromethorphan Hydrobromide (a cough suppressant that works on the brain to reduce the urge to cough). It is typically taken twice daily, morning and evening.

  • Generic Name: Chlorpheniramine Maleate + Dextromethorphan Hydrobromide
  • Manufacturer: Avonic Life Sciences
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š avokuf d syrup Uses & Benefits

Allergic rhinitis, cough due to cold or allergies

Off-label uses: Urticaria, pruritus, motion sickness (chlorpheniramine); neuropathic pain (dextromethorphan)

๐Ÿ“‹ Drug Information

Generic Name(s)Chlorpheniramine Maleate + Dextromethorphan Hydrobromide
Brand NameAlex Junior Syrup
ManufacturerAvonic Life Sciences
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntihistamine + Antitussive
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally
DistributionDistributed throughout body; crosses blood-brain barrier
Protein BindingChlorpheniramine: ~72%; Dextromethorphan: ~60-70%
MetabolismHepatic via CYP2D6 (dextromethorphan) and other pathways
Half-LifeChlorpheniramine: 14-25 hours; Dextromethorphan: 3-6 hours
ExcretionRenal (urine) as metabolites
BioavailabilityChlorpheniramine: ~25-50%; Dextromethorphan: ~11%
Onset of ActionChlorpheniramine: 30-60 min; Dextromethorphan: 15-30 min
Peak Plasma TimeChlorpheniramine: 2-6 hours; Dextromethorphan: 2-2.5 hours
Duration of ActionChlorpheniramine: 4-6 hours; Dextromethorphan: 4-6 hours

How It Works

Chlorpheniramine: H1-receptor antagonist; Dextromethorphan: NMDA receptor antagonist and sigma-1 agonist

Mechanism Steps

1Chlorpheniramine competitively blocks H1 receptors, preventing histamine-mediated effects
2Dextromethorphan acts as a non-competitive NMDA receptor antagonist, reducing cough reflex
3Dextromethorphan also binds to sigma-1 receptors, contributing to antitussive effect

๐Ÿ’ก How to Take avokuf d syrup

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of avokuf d syrup

โœ… Common Side Effects

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Nausea

๐Ÿšจ Serious Side Effects

  • Respiratory depression
  • Serotonin syndrome
  • Seizures
  • QT prolongation

โš ๏ธ Rare Side Effects

  • Hypotension
  • Allergic reactions
  • Urinary retention
  • Blurred vision

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
MAOIs Major Hypertensive crisis
CNS Depressants Moderate Increased sedation
Alcohol Moderate Enhanced CNS depression

๐Ÿšจ Major Interactions

  • MAOIs
  • CYP2D6 inhibitors
  • CNS depressants

โšก Moderate Interactions

  • Anticholinergics
  • SSRIs
  • SNRIs

โ„น๏ธ Minor Interactions

  • Alcohol
  • Caffeine

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase dextromethorphan levels

๐Ÿท Alcohol Interaction

Increased CNS depression

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Low
Heart
Low
Pregnancy
Category C

๐Ÿšซ Contraindications

Hypersensitivity, MAOI use within 14 days, asthma attack, severe hypertension

๐Ÿ“Š Monitoring Parameters

CNS depression, respiratory rate, blood pressure, heart rate

๐Ÿคฑ Lactation Safety

Use with caution; may pass into breast milk

๐Ÿ’Š Overdose Management

Gastric lavage, activated charcoal, supportive care; naloxone may reverse dextromethorphan effects

โฐ Missed Dose

Take as soon as remembered; skip if near next dose; do not double

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

๐Ÿ”— View Profile

โญ User Reviews

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

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