ativan 1mg tablet - Lorazepam (1mg) medicine

ativan 1mg tablet

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Lorazepam (1mg)
🏭 Pfizer Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
🤰 Pregnancy Category D 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

What is ativan 1mg tablet used for?

This medicine contains Lorazepam (1mg) and is used to treat RESPIRATORY. Enhances the inhibitory effect of GABA by binding to benzodiazepine receptors on GABA-A receptors, i. Always consult your doctor before use.

  • Generic Name: Lorazepam
  • Manufacturer: Pfizer Ltd
  • Form: Allopathy
  • Pregnancy Category: Category D
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 ativan 1mg tablet Uses & Benefits

Anxiety disorders, Insomnia (short-term), Preoperative sedation, Status epilepticus (IV), Alcohol withdrawal syndrome

Off-label uses: Chemotherapy-induced nausea and vomiting, Catatonia, Rapid eye movement sleep behavior disorder

📋 Drug Information

Generic Name(s)Lorazepam
Brand NameAtivan
ManufacturerPfizer Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassBenzodiazepines
Route of AdministrationOral, intravenous, intramuscular
StorageStore at room temperature (20-25°C) away from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; peak plasma concentrations occur within 2 hours.
DistributionWidely distributed throughout the body; crosses the blood-brain barrier and placenta.
Protein BindingApproximately 85% bound to plasma proteins.
MetabolismPrimarily metabolized in the liver via glucuronidation to inactive metabolites.
Half-LifeApproximately 12-18 hours.
ExcretionExcreted mainly in urine as glucuronide conjugates; less than 1% excreted unchanged.
BioavailabilityOral bioavailability is about 90%.
Onset of Action30-60 minutes after oral administration.
Peak Plasma Time2 hours.
Duration of Action6-8 hours.

How It Works

Enhances the inhibitory effect of GABA by binding to benzodiazepine receptors on GABA-A receptors, increasing chloride ion influx and hyperpolarizing neurons.

Mechanism Steps

1Binds to benzodiazepine site on GABA-A receptor
2Increases affinity of GABA for its binding site
3Enhances chloride ion channel opening frequency
4Increases chloride ion influx
5Hyperpolarizes postsynaptic neuron
6Reduces neuronal excitability
7Produces anxiolytic, sedative, and anticonvulsant effects

💡 How to Take ativan 1mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of ativan 1mg tablet

✅ Common Side Effects

Drowsiness
Dizziness
Ataxia
Weakness
Blurred vision
Sedation

🚨 Serious Side Effects

Respiratory depression
Paradoxical reactions (e.g., agitation, aggression)
Physical dependence and withdrawal
Seizures (with abrupt discontinuation)
Anterograde amnesia

⚠️ Rare Side Effects

Blood dyscrasias (e.g., agranulocytosis)
Jaundice
Allergic reactions
Hypotension
Urinary retention

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect

🚨 Major Interactions

  • Opioid analgesics
  • Other CNS depressants (e.g., barbiturates, alcohol)
  • Sodium oxybate

⚡ Moderate Interactions

  • Antipsychotics
  • Antidepressants (e.g., SSRIs, MAOIs)
  • Antiepileptics (e.g., valproate)
  • Antihistamines

🍷 Alcohol Interaction

Avoid alcohol; additive CNS depression and increased risk of sedation, respiratory depression, and impaired psychomotor function.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to lorazepam or any benzodiazepine, Acute narrow-angle glaucoma, Severe respiratory insufficiency, Myasthenia gravis, Sleep apnea syndrome, Severe hepatic impairment

🤱 Lactation Safety

Lorazepam is excreted in breast milk; use with caution and monitor infant for sedation and feeding d

💊 Overdose Management

Supportive care; consider flumazenil (benzodiazepine antagonist) but monitor for seizures and arrhythmias.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

🔄 Substitutes for ativan 1mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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