arorab hd 30mg/40mg capsule sr - Domperidone (30mg) + Rabeprazole (40mg) medicine

arorab hd 30mg/40mg capsule sr

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🏭 Aareen Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

What is arorab hd 30mg/40mg capsule sr used for?

This medicine contains Domperidone (30mg) + Rabeprazole (40mg) and is used to treat GASTRO INTESTINAL. Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tra. Always consult your doctor before use.

  • Generic Name: Domperidone + Rabeprazole
  • Manufacturer: Aareen Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 arorab hd 30mg/40mg capsule sr Uses & Benefits

Gastroesophageal reflux disease (GERD), dyspepsia, gastroparesis, nausea and vomiting.

Off-label uses: Diabetic gastroparesis, cyclic vomiting syndrome, migraine-associated nausea.

📋 Drug Information

Generic Name(s)Domperidone + Rabeprazole
Brand NameAcera-D Capsule SR
ManufacturerAareen Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassProkinetic agent + Proton pump inhibitor
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDomperidone: Rapidly absorbed after oral administration; Rabeprazole: Well absorbed, peak plasma concentration at 2-4 hours.
DistributionDomperidone: Widely distributed, crosses blood-brain barrier minimally; Rabeprazole: Volume of distribution ~0.3 L/kg.
Protein BindingDomperidone: 91-93%; Rabeprazole: 96%.
MetabolismDomperidone: Hepatic via CYP3A4; Rabeprazole: Hepatic via CYP2C19 and CYP3A4.
Half-LifeDomperidone: 7-9 hours; Rabeprazole: 1-2 hours.
ExcretionDomperidone: Urine (31%) and feces (66%); Rabeprazole: Urine (90%) as metabolites.
BioavailabilityDomperidone: 13-17%; Rabeprazole: 52%.
Onset of ActionDomperidone: 30-60 minutes; Rabeprazole: 1-2 hours.
Peak Plasma TimeDomperidone: 1-2 hours; Rabeprazole: 2-4 hours.
Duration of ActionDomperidone: 4-6 hours; Rabeprazole: Up to 24 hours.

How It Works

Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, enhancing gastric motility and emptying. Rabeprazole: Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells, reducing gastric acid secretion.

Mechanism Steps

1Domperidone blocks dopamine D2 receptors in the chemoreceptor trigger zone and GI tract.
2This increases lower esophageal sphincter pressure and enhances gastric motility.
3Rabeprazole accumulates in the acidic environment of gastric parietal cells.
4It binds irreversibly to the H+/K+ ATPase enzyme, inhibiting proton transport.
5This leads to a sustained reduction in gastric acid secretion.

💡 How to Take arorab hd 30mg/40mg capsule sr

Follow your doctor's prescription exactly.

⚠️ Side Effects of arorab hd 30mg/40mg capsule sr

✅ Common Side Effects

Headache
Diarrhea
Constipation
Abdominal pain
Nausea
Dry mouth

🚨 Serious Side Effects

QT prolongation
Ventricular arrhythmias
Torsades de pointes
Gynecomastia
Galactorrhea
Liver injury

⚠️ Rare Side Effects

Extrapyramidal symptoms
Hyperprolactinemia
Interstitial nephritis
Clostridium difficile infection

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major Increased risk of QT prolongation and arrhythmias
Warfarin Moderate Increased INR and bleeding risk
Digoxin Moderate Increased digoxin levels
Antacids Minor Reduced absorption of rabeprazole

🚨 Major Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
  • CYP2C19 inhibitors (e.g., fluconazole)
  • QT-prolonging drugs (e.g., amiodarone, moxifloxacin)

⚡ Moderate Interactions

  • Antacids
  • Sucralfate
  • Digoxin
  • Methotrexate

🍷 Alcohol Interaction

Alcohol may worsen gastrointestinal irritation and reduce drug efficacy.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to domperidone or rabeprazole; gastrointestinal hemorrhage, obstruction, or perforation; prolactinoma; concomitant use with QT-prolonging drugs or strong CYP3A4 inhibitors.

🤱 Lactation Safety

Domperidone: Excreted in breast milk, may cause adverse effects; Rabeprazole: Excreted in breast mil

💊 Overdose Management

Symptomatic and supportive treatment; gastric lavage; monitoring of ECG for QT prolongation.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

🔄 Substitutes for arorab hd 30mg/40mg capsule sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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