ulcevin-dsr 30mg/40mg capsule - Domperidone (30mg) + Rabeprazole (40mg) medicine

Allocid 40 DSR Capsule: Complete Medicine Guide

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🏭 Vinca Lifesciences 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe chest pain or difficulty breathing
  • Irregular or rapid heartbeat
  • Sudden swelling of face, lips, or throat
  • Severe abdominal pain or blood in vomit
  • Yellowing of skin or eyes
  • Uncontrollable muscle spasms or tremors
  • Severe diarrhea with fever

If experiencing severe symptoms, call emergency services immediately.

What is ulcevin-dsr 30mg/40mg capsule used for?

This medicine is a combination of Domperidone and Rabeprazole used to treat acid reflux, heartburn, and functional dyspepsia. It works by reducing stomach acid and improving gastric emptying. It is a prescription medicine and should be taken once daily before breakfast.

  • Generic Name: Domperidone (30mg) + Rabeprazole (40mg)
  • Manufacturer: Vinca Lifesciences
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ulcevin-dsr 30mg/40mg capsule के बारे में (Hindi Summary)

उपयोग: यह दवा डोम्पेरिडोन और रेबेप्राजोल का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, हार्टबर्न, और अपच के इलाज के लिए किया जाता है। यह पेट में एसिड का उत्पादन कम करती है और पेट खाली होने की प्रक्रिया को तेज करती है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सूखा मुँह, सिरदर्द, दस्त, पेट दर्द और जी मिचलाना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इसमें अनियमित दिल की धड़कन, स्तन में दर्द या सूजन, और मांसपेशियों में अकड़न हो सकती है। अगर आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे न चबाएं और न ही खोलें, पूरा कैप्सूल पानी के साथ निगलें। इसे सुबह नाश्ते से 30-60 मिनट पहले खाली पेट लें। इस दवा के साथ शराब न लें। अगर आपको चक्कर या नींद आती है तो वाहन न चलाएं। लंबे समय तक बिना डॉक्टर की सलाह के न लें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 ulcevin-dsr 30mg/40mg capsule Uses & Benefits

[{"condition":"Gastroesophageal reflux disease (GERD)","description":"Reduces acid reflux and heartburn by suppressing gastric acid secretion and improving gastric emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Helps relieve symptoms like bloating, early satiety, and upper abdominal discomfort by enhancing gastric motility and reducing acid.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with acid-related disorders","description":"Domperidone component helps control nausea and vomiting by blocking dopamine receptors in the brain.","evidence":"Moderate"},{"condition":"Peptic ulcer disease (adjunct)","description":"Used alongside other treatments to reduce acid and promote ulcer healing.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes prescribed off-label to improve gastric emptying in patients with diabetes.","evidence":"Limited"},{"condition":"Refractory nausea in palliative care","description":"Occasionally used off-label for nausea not responding to standard antiemetics.","evidence":"Limited"}]

Primary treatment for: Gastroesophageal reflux disease (GERD)

Also treats: Functional dyspepsia, Peptic ulcer disease, Nausea and vomiting

📋 Drug Information

Generic Name(s)Domperidone (30mg) + Rabeprazole (40mg)
Brand Nameulcevin-dsr 30mg/40mg capsule
ManufacturerVinca Lifesciences
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C. Protect from moisture and direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine on an empty stomach, at least 30 to 60 minutes before breakfast, for best results.
2
Swallow the capsule whole with water; do not crush or chew it.
3
Avoid alcohol and grapefruit juice while taking this medicine.
4
Do not drive or operate heavy machinery if you feel dizzy or drowsy.
5
Inform your doctor if you have heart, liver, or kidney problems before starting this medicine.
6
Do not take this medicine for longer than 8 weeks without a medical review.
7
Report any unusual muscle stiffness, tremors, or palpitations immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Heartburn
This medicine is commonly prescribed for this.
Likely Use
Acid regurgitation
This medicine helps reduce acid reflux.
Likely Use
Bloating
Domperidone component helps improve gastric emptying.
Likely Use
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRabeprazole is rapidly absorbed after oral administration, with peak plasma concentrations reached within 2 to 5 hours. Domperidone is also absorbed from the gastrointestinal tract, with peak levels occurring within 30 to 60 minutes. Food may slightly delay the absorption of Rabeprazole but does not significantly affect overall bioavailability.
DistributionRabeprazole is approximately 96% bound to plasma proteins and distributes widely into tissues, including the gastric mucosa. Domperidone is about 91-93% protein-bound and does not readily cross the blood-brain barrier, which limits central nervous system side effects.
Protein BindingRabeprazole is about 96% protein-bound. Domperidone is approximately 91-93% bound to plasma proteins.
MetabolismRabeprazole is extensively metabolized in the liver primarily by CYP2C19 and CYP3A4 enzymes. Domperidone undergoes rapid and extensive first-pass metabolism in the liver and intestinal wall via CYP3A4 and CYP1A2.
Half-LifeThe elimination half-life of Rabeprazole is approximately 1 to 2 hours. Domperidone has a terminal half-life of about 7 to 9 hours in healthy individuals.
ExcretionRabeprazole metabolites are excreted mainly in urine (about 90%) and feces (about 10%). Domperidone is excreted primarily in feces (about 66%) and urine (about 33%).
BioavailabilityThe oral bioavailability of Rabeprazole is approximately 52% due to first-pass metabolism. Domperidone has a bioavailability of about 13-17% because of extensive first-pass metabolism.
Onset of ActionRabeprazole begins to suppress acid secretion within 1 hour of oral administration, with maximum effect after 2 to 4 hours. Domperidone's prokinetic effect starts within 30 to 60 minutes.
Peak Plasma TimeRabeprazole reaches peak plasma concentration in about 2 to 5 hours. Domperidone peaks in about 30 to 60 minutes.
Duration of ActionRabeprazole's acid suppression lasts up to 24 hours, allowing once-daily dosing. Domperidone's prokinetic effect lasts approximately 6 to 8 hours, often requiring multiple daily doses.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Rabeprazole is a proton pump inhibitor that irreversibly blocks the hydrogen-potassium ATPase enzyme in gastric parietal cells, thereby reducing both basal and stimulated acid secretion. Domperidone is a peripheral dopamine D2 receptor antagonist that enhances gastric motility and accelerates gastric emptying without crossing the blood-brain barrier significantly. Together, they reduce acid exposure and improve stomach emptying, providing relief from reflux and dyspepsia symptoms.

Mechanism Steps

1
Rabeprazole absorption and activation: Rabeprazole is absorbed in the small intestine and accumulates in the acidic environment of gastric parietal cells, where it is converted to its active sulfenamide form.
2
Proton pump inhibition: The active form binds irreversibly to the H+/K+ ATPase enzyme, blocking the final step of acid secretion and reducing gastric acidity.
3
Domperidone dopamine receptor blockade: Domperidone blocks dopamine D2 receptors in the gastrointestinal tract and chemoreceptor trigger zone, enhancing gastric motility and reducing nausea.
4
Improved gastric emptying: Enhanced antral contractions and relaxed pyloric sphincter lead to faster stomach emptying, reducing reflux and bloating.
5
Combined symptomatic relief: The dual action reduces acid exposure and improves motility, providing relief from heartburn, regurgitation, and dyspepsia.

💡 How to Take ulcevin-dsr 30mg/40mg capsule

Strength: Capsule containing Domperidone 30 mg and Rabeprazole 40 mg.

1Take the capsule whole with a glass of water.
2Swallow it whole; do not crush, chew, or open the capsule.
3Take it on an empty stomach, at least 30 to 60 minutes before breakfast.
4If you forget, take it as soon as you remember unless it's almost time for the next dose.
5Do not take more than one capsule in 24 hours unless prescribed.

Dosage Information

Adult DosageThe usual adult dose is one capsule taken orally once daily on an empty stomach, at least 30 to 60 minutes before breakfast. However, the dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially cardiac arrhythmias and extrapyramidal symptoms. Dose adjustment may be needed based on renal and hepatic function. Use with caution and under medical supervision.
Renal ImpairmentDose adjustment may be required in patients with severe renal impairment. Domperidone is not recommended in moderate to severe renal impairment. Consult a doctor for individualized dosing.
Hepatic ImpairmentThis medicine is contraindicated in severe hepatic impairment. In mild to moderate hepatic impairment, dose reduction may be necessary. Consult a doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is one capsule (Domperidone 30 mg + Rabeprazole 40 mg) per day. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take on an empty stomach
Rabeprazole works best when taken before a meal.
Grapefruit juice
Avoid
May increase Domperidone levels and side effects.
Alcohol
Avoid
Increases stomach irritation and drowsiness.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ulcevin-dsr 30mg/40mg capsule

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent or severe.
Dry mouth (Common (5-10%))
Sip water frequently. Chew sugar-free gum if needed.
Diarrhea (Common (5-10%))
Stay hydrated. Consult doctor if diarrhea persists beyond 2 days.
Abdominal pain (Common (5-10%))
Take with food if not contraindicated. Report severe pain to doctor.
Nausea (Common (5-10%))
Take with a light meal. If nausea worsens, contact your doctor.

🚨 Serious Side Effects

Irregular heartbeat (QT prolongation) (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations, dizziness, or fainting.
Extrapyramidal symptoms (Rare (<0.1%))
Report muscle stiffness, tremors, or difficulty speaking to your doctor immediately.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Call emergency services if you develop rash, swelling of face or throat, or difficulty breathing.
Clostridium difficile-associated diarrhea (Rare (<0.1%))
Seek medical attention if you have severe, persistent diarrhea with fever or abdominal cramps.

⚠️ Rare Side Effects

Galactorrhea (breast milk secretion)
Consult your doctor if you notice unexpected breast discharge.
Gynecomastia (breast enlargement in men)
Report to your doctor; dose adjustment or alternative may be needed.
Hypomagnesemia
Regular blood tests may be needed if used long-term. Report muscle cramps or weakness.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Amiodarone Major
Warfarin Moderate
Methotrexate Moderate
Digoxin Moderate
Atazanavir Moderate
Antacids Minor
Sucralfate Minor
Clarithromycin Major
Haloperidol Major

🚨 Major Interactions

  • Ketoconazole, itraconazole, clarithromycin
  • Amiodarone, sotalol, quinidine
  • Methadone, haloperidol, chlorpromazine

⚡ Moderate Interactions

  • Warfarin
  • Methotrexate
  • Digoxin
  • Atazanavir, nelfinavir

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine. It can increase stomach acid production, worsen reflux symptoms, and enhance central nervous system side effects such as dizziness and drowsiness. Alcohol may also increase the risk of liver toxicity.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Domperidone, Rabeprazole, or any component of the formulation","Severe liver impairment","Known QT prolongation or family history of long QT syndrome","Concomitant use with QT-prolonging drugs or strong CYP3A4 inhibitors","Gastrointestinal obstruction, perforation, or bleeding","Prolactin-releasing pituitary tumor (prolactinoma)","Moderate to severe renal impairment (for Domperidone component)"]

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular disease or risk factors for QT prolongation.","Avoid in patients with electrolyte imbalances (hypokalemia, hypomagnesemia).","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Long-term use of Rabeprazole may increase risk of bone fractures, especially in elderly.","May mask symptoms of gastric malignancy; rule out malignancy before starting therapy.","Not recommended for children unless prescribed by a pediatrician.","Use with caution in elderly patients due to increased risk of side effects.","Do not use for longer than 8 weeks without medical review."]

🤱 Lactation Safety

Domperidone passes into breast milk and may cause side effects in the infant. Rabeprazole may also be excreted in breast milk. This medicine is not recommended during breastfeeding unless advised by a doctor. Consult your healthcare provider for alternative options.

💊 Overdose Management

Overdose may cause severe drowsiness, extrapyramidal symptoms, and cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1 hour of ingestion. Monitor ECG and vital signs.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or open the capsule; swallow it whole with water. It is best taken on an empty stomach, at least 30 to 60 minutes before breakfast, to allow Rabeprazole to work effectively. Avoid alcohol while taking this medicine, as it can worsen stomach irritation and increase drowsiness. Do not drive or operate heavy machinery if you feel dizzy or sleepy. Inform your doctor if you have liver problems, kidney disease, or a history of heart rhythm disorders. Do not take this medicine for longer than recommended without medical review. Keep out of reach of children. Store at room temperature away from moisture and direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of side effects such as cardiac arrhythmias, extrapyramidal symptoms, and bone fractures. Dose adjustment may be needed. Regular monitoring is advised.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed and prescribed by a doctor.

🏥 Post-Surgery Considerations

After surgery, use this medicine only if prescribed by your surgeon. It may affect gastric motility and acid secretion, which could impact recovery. Inform your surgeon about all medicines you take.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine. It may increase the risk of bleeding during dental procedures. Your dentist may advise temporary discontinuation or monitoring.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce pressure on the stomach.
🥗
Avoid lying down immediately after meals; wait at least 2-3 hours.
😴
Eat smaller, more frequent meals instead of large ones.
💧
Avoid trigger foods like spicy, fatty, or acidic foods.
🧘
Elevate the head of your bed while sleeping.
🌞
Quit smoking and limit alcohol consumption.

🏋️ Exercise Considerations

Moderate exercise is generally safe, but avoid vigorous exercise immediately after meals as it may worsen reflux. Listen to your body and stop if you feel dizzy or unwell.

🥗 Diet Recommendations

Include high-fiber foods like fruits and vegetables.
Avoid spicy, fatty, and fried foods.
Limit caffeine and carbonated drinks.
Stay well hydrated with water.
Eat smaller, more frequent meals.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. Usually, the course is for 4-8 weeks, after which your doctor will reassess.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to low magnesium levels, vitamin B12 deficiency, and an increased risk of bone fractures. Domperidone long-term use may cause breast tenderness or discharge. Regular monitoring of blood levels and clinical review is advised. Do not use for more than 8 weeks without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet changes, weight loss, and avoiding trigger foods can help manage GERD.

Evidence: Well-established
Other proton pump inhibitors

Pantoprazole or omeprazole may be used as alternatives.

Evidence: Well-established
H2 receptor blockers

Ranitidine or famotidine may be used for milder symptoms.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, long-term use of proton pump inhibitors may slightly reduce the effectiveness of some vaccines. Consult your doctor before any vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking it once daily before breakfast as per your new local time. Check customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old man with chronic acid reflux
He was prescribed this medicine for frequent heartburn and regurgitation. After taking it daily before breakfast for two weeks, his symptoms improved significantly. He also reduced his coffee intake and avoided late-night meals.
💡 Lesson: Taking the medicine as prescribed and making lifestyle changes can greatly improve GERD symptoms.
👤 A 60-year-old woman with functional dyspepsia
She experienced bloating and early satiety after meals. Her doctor prescribed this medicine. Within a month, her bloating decreased and she could eat normal meals. She was advised to continue for another month and then review.
💡 Lesson: This medicine can effectively relieve dyspepsia symptoms, but regular follow-up is important.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within 1-2 hours, but noticeable symptom relief may take a few days to a week.

Q: Can I take it with other medicines?

A: It can interact with several drugs. Always inform your doctor about all medicines you are taking.

Q: Is it safe during pregnancy?

A: Use only if prescribed by a doctor. It is not recommended unless clearly needed.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for ulcevin-dsr 30mg/40mg capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for immediate relief of heartburn.
    Fact: This medicine is not for immediate relief. It is a prescription medicine for chronic acid-related conditions and takes time to work.
  • Myth: You can stop taking this medicine as soon as you feel better.
    Fact: You should complete the prescribed course. Stopping early may cause symptoms to return. Consult your doctor before stopping.
  • Myth: This medicine is safe to take with any other medication.
    Fact: This medicine can interact with several drugs, including ketoconazole, warfarin, and methotrexate. Always inform your doctor about all medicines you take.

🔄 Alternative Options

Generic Alternatives

  • Domperidone + Rabeprazole combination capsules from other manufacturers

Brand Alternatives

  • Rabium-DSR
  • Dexrab-DSR
  • Rabeprazole + Domperidone capsules

📊 Comparison with Similar Medicines

[{"medicine":"Rabeprazole + Domperidone","composition":"Rabeprazole 40 mg + Domperidone 30 mg","onset":"1-2 hours","duration":"24 hours","notes":"This medicine"},{"medicine":"Pantoprazole + Domperidone","composition":"Pantoprazole 40 mg + Domperidone 30 mg","onset":"1-2 hours","duration":"24 hours","notes":"Similar efficacy"},{"medicine":"Omeprazole + Domperidone","composition":"Omeprazole 20 mg + Domperidone 30 mg","onset":"1-2 hours","duration":"24 hours","notes":"May have more drug interactions"}]

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