What is arium 50mg injection used for?

This medicine is a non-depolarizing muscle relaxant used during surgery to relax muscles and help with intubation. It is given intravenously by a healthcare professional in a hospital setting.

Generic Name: Atracurium (50mg)
Manufacturer: Celon Laboratories Ltd
Form: Allopathy
Pregnancy Category: Consult doctor
Prescription Required: Yes

🇮🇳 arium 50mg injection के बारे में (Hindi Summary)

उपयोग: यह दवा एट्राक्यूरियम बेसिलेट 50 मिलीग्राम इंजेक्शन के रूप में उपलब्ध है और इसका उपयोग अस्पताल में सर्जरी के दौरान मांसपेशियों को शिथिल करने के लिए किया जाता है। यह एक नॉन-डिपोलराइजिंग न्यूरोमस्कुलर ब्लॉकर है जो नसों से मांसपेशियों तक संकेत पहुंचने को रोकता है, जिससे मांसपेशियां ढीली हो जाती हैं। इसका उपयोग इंटुबैशन (श्वास नली में ट्यूब डालना) और मशीन से सांस देने में भी किया जाता है। यह दवा केवल प्रशिक्षित डॉक्टर द्वारा अस्पताल में ही दी जाती है। मरीज को इस दवा के प्रभाव के दौरान वेंटिलेटर पर रखा जाता है। इस दवा से एलर्जी, अस्थमा, हृदय रोग, गुर्दे या यकृत की बीमारी वाले मरीजों को सावधानी बरतनी चाहिए। गर्भवती महिलाओं में इसका उपयोग केवल तभी किया जाता है जब स्पष्ट रूप से आवश्यक हो।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में निम्न रक्तचाप, दिल की धड़कन तेज होना, चेहरे पर लालिमा, और सांस की नली में ऐंठन शामिल हैं। गंभीर दुष्प्रभावों में एनाफिलेक्सिस (तीव्र एलर्जी), लंबे समय तक मांसपेशियों का पक्षाघात, और हृदय गति रुकना शामिल हो सकते हैं। कभी-कभी दौरे भी पड़ सकते हैं। अस्पताल में निगरानी के दौरान इनका प्रबंधन किया जाता है।

सुरक्षा सलाह: यह दवा केवल अस्पताल में योग्य डॉक्टर द्वारा ही दी जानी चाहिए। इस दवा को देने से पहले मरीज को अपनी सभी एलर्जी, दवाओं, और बीमारियों के बारे में बताना चाहिए। इस दवा के प्रभाव के दौरान मरीज को वेंटिलेटर पर रखा जाता है और लगातार निगरानी की जाती है। इस दवा को लेने के 24 घंटे तक वाहन चलाने या मशीनरी चलाने से बचें। गर्भवती और स्तनपान कराने वाली महिलाओं को इस दवा के बारे में अपने डॉक्टर से सलाह लेनी चाहिए।

💊 arium 50mg injection Uses & Benefits

[{"condition":"Surgical muscle relaxation","description":"Used to provide skeletal muscle relaxation during general anesthesia for various surgical procedures, including abdominal, orthopedic, and cardiac surgeries.","evidence":"Well-established"},{"condition":"Endotracheal intubation","description":"Facilitates intubation by relaxing the vocal cords and pharyngeal muscles.","evidence":"Well-established"},{"condition":"Mechanical ventilation in ICU","description":"Used to facilitate mechanical ventilation in critically ill patients who require prolonged muscle paralysis.","evidence":"Well-established"},{"condition":"Electroconvulsive therapy","description":"Used to prevent fractures and muscle injuries during electroconvulsive therapy by inducing muscle relaxation.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Treatment of tetanus","description":"Sometimes used off-label to control muscle spasms in severe tetanus.","evidence":"Limited"},{"condition":"Management of status epilepticus","description":"Rarely used off-label to reduce muscle activity during refractory status epilepticus.","evidence":"Limited"}]

Primary treatment for: Surgical procedures requiring muscle relaxation

Also treats: Mechanical ventilation, Electroconvulsive therapy, Endotracheal intubation

📋 Drug Information

Generic Name(s)	Atracurium (50mg)
Brand Name	arium 50mg injection
Manufacturer	Celon Laboratories Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	PAIN ANALGESICS
Action Class	Skeletal muscle relaxant- Peripherally acting
Route of Administration	Parenteral (intravenous)
Storage	Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Once removed from refrigeration, it should be used within 14 days.
Shelf Life	24 months from the date of manufacture.
WHO Guideline	Not established from the available information.
ICMR Guideline	Not established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1

Always administer this medicine in a setting with immediate access to intubation and ventilation equipment.

2

Monitor neuromuscular function using a peripheral nerve stimulator to avoid overdosing.

3

Be prepared to manage histamine-related effects such as hypotension and bronchospasm.

4

Use with caution in patients with cardiovascular disease or asthma.

5

Consider dose reduction in elderly patients and those with significant renal or hepatic impairment.

6

Ensure proper reversal with neostigmine or edrophonium at the end of the procedure.

7

Document the total dose and duration of administration, especially in ICU settings.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅

Muscle relaxation during surgery

This medicine is commonly used for this purpose.

Likely Use

❌

Pain

This medicine does not provide pain relief.

Not Primary

❌

Anxiety

This medicine does not treat anxiety.

Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is administered intravenously and therefore has 100% bioavailability. Absorption is not applicable as it is given directly into the bloodstream.

DistributionThis medicine is distributed throughout the extracellular fluid. It does not cross the blood-brain barrier significantly due to its quaternary ammonium structure. It may cross the placenta to a limited extent.

Protein BindingNot established from the available information.

MetabolismThis medicine undergoes non-enzymatic degradation in the plasma via Hofmann elimination, which is independent of liver and kidney function. It is also metabolized by non-specific plasma esterases.

Half-LifeThe elimination half-life is approximately 20-30 minutes.

ExcretionThis medicine and its metabolites are excreted primarily in the urine and bile.

Bioavailability100% (intravenous administration)

Onset of ActionThe onset of action is within 1-2 minutes after intravenous administration.

Peak Plasma TimePeak effect occurs within 2-3 minutes.

Duration of ActionThe duration of action is typically 20-35 minutes, but may be longer with higher doses or in patients with organ impairment.

How It Works

This medicine is a non-depolarizing neuromuscular blocker that competitively antagonizes acetylcholine at nicotinic receptors on the motor endplate of skeletal muscle. By binding to these receptors, it prevents depolarization and subsequent muscle contraction. This results in flaccid paralysis. The effect is reversible by increasing acetylcholine levels with acetylcholinesterase inhibitors.

Mechanism Steps

1

Competitive binding: This medicine competes with acetylcholine for binding sites on the nicotinic receptors at the motor endplate.

2

Blockade of depolarization: By occupying the receptors, it prevents acetylcholine from depolarizing the muscle membrane, thereby blocking nerve impulse transmission.

3

Muscle relaxation: The lack of depolarization leads to flaccid paralysis of skeletal muscles, which is essential for surgical procedures and intubation.

4

Reversal: The effect can be reversed by administering acetylcholinesterase inhibitors, which increase acetylcholine concentration and displace the blocker.

💡 How to Take arium 50mg injection

Strength: Injection: 50 mg/5 mL (10 mg/mL) in a single-use vial.

1This medicine is administered by a healthcare professional.

2It is given intravenously, either as a bolus or continuous infusion.

3The dose is determined by the anesthesiologist based on the patient's weight and response.

4Continuous monitoring of neuromuscular function is required during administration.

5The effect is reversed with neostigmine or edrophonium at the end of the procedure.

Dosage Information

Adult Dosage	The dosage of this medicine must be individualized by a qualified clinician based on the patient's condition, weight, and response. For intubation, a typical initial dose is 0.4 to 0.5 mg/kg intravenously. For maintenance, smaller doses of 0.08 to 0.1 mg/kg may be given as needed. Continuous infusion may be used in intensive care settings. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric Dosage	Pediatric dosing is not established from available information. Consult a pediatrician.
Elderly Dosage	Elderly patients may have increased sensitivity to the effects of this medicine. Dose reduction and careful monitoring are recommended.
Renal Impairment	No specific dose adjustment is required for renal impairment, as atracurium undergoes Hofmann elimination independent of renal function. However, metabolites may accumulate in severe renal failure; monitor closely.
Hepatic Impairment	No specific dose adjustment is required for hepatic impairment, but caution is advised due to potential altered metabolism.
Maximum Daily Dose	Not established from the available information. Dosing is individualized by the clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

No food interactions

Not applicable

This medicine is given intravenously in a hospital setting.

⏰ What to Do If You Miss a Dose

📌 This medicine is administered by healthcare professionals in a controlled setting.

→ Missed doses are not applicable.

💡 The dosing schedule is managed by the medical team.

⚠️ Side Effects of arium 50mg injection

✅ Common Side Effects

Hypotension (Common (10-20%))

Usually managed by the anesthesiologist with fluids or vasopressors.

Flushing (Common (5-10%))

Resolves spontaneously; no specific treatment needed.

Tachycardia (Common (5-10%))

Monitor heart rate; treat if symptomatic.

Bronchospasm (Uncommon (1-5%))

Administer bronchodilators if needed.

🚨 Serious Side Effects

Anaphylaxis (Rare (<0.1%))

Seek immediate medical attention; administer epinephrine, corticosteroids, and antihistamines as appropriate.

Prolonged paralysis (Rare (<0.1%))

Requires continued mechanical ventilation and monitoring until full recovery.

Severe bronchospasm (Rare (<0.1%))

Administer oxygen and bronchodilators; consider alternative muscle relaxants.

Cardiac arrest (Very rare (<0.01%))

Initiate cardiopulmonary resuscitation immediately.

⚠️ Rare Side Effects

Seizures

Report to the medical team; manage with anticonvulsants.

Critical illness polyneuropathy

May require prolonged rehabilitation; discuss with critical care team.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug	Severity	Effect
Aminoglycosides	Major
Magnesium sulfate	Major
Inhalational anesthetics	Major
Loop diuretics	Moderate
Calcium channel blockers	Moderate
Corticosteroids	Minor

🚨 Major Interactions

Aminoglycoside antibiotics
Magnesium sulfate
Inhalational anesthetics

⚡ Moderate Interactions

Loop diuretics
Calcium channel blockers

🍷 Alcohol Interaction

Alcohol may enhance the sedative and cardiovascular effects of this medicine. Patients should avoid alcohol for at least 24 hours after receiving this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to atracurium or any component of the formulation","Use in patients without facilities for intubation and artificial ventilation"]

⚠️ Warnings & Precautions

["Should be administered only by experienced clinicians.","May cause histamine release; use with caution in patients with asthma or cardiovascular disease.","Prolonged use in ICU may lead to muscle weakness and polyneuropathy.","Dose adjustment may be needed in elderly patients and those with renal or hepatic impairment.","Not recommended for use in neonates due to lack of safety data.","Should be used with caution in patients with neuromuscular disorders such as myasthenia gravis."]

🤱 Lactation Safety

It is not known whether this medicine is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be avoided for 24 hours after administration.

💊 Overdose Management

Overdose may cause prolonged muscle paralysis and respiratory depression. Management includes maintaining a patent airway, mechanical ventilation, and administration of acetylcholinesterase inhibitors such as neostigmine or edrophonium. Cardiovascular support may be required. There is no specific antidote for atracurium; treatment is supportive.

⏰ Missed Dose

This medicine is administered by healthcare professionals in a controlled setting. Missed doses are not applicable.

Additional Safety Advice

General Safety

This medicine must be administered only by qualified healthcare professionals in a hospital setting equipped with facilities for intubation, artificial ventilation, and oxygen therapy. Continuous monitoring of neuromuscular function, heart rate, blood pressure, and oxygen saturation is mandatory. Patients should inform their doctor about any allergies, especially to muscle relaxants, and about any history of asthma, heart disease, kidney or liver problems, or neuromuscular disorders such as myasthenia gravis. This medicine should be used with caution in elderly patients and in those with cardiovascular disease. It should not be used during pregnancy unless clearly necessary, and breastfeeding should be avoided for 24 hours after administration. Avoid driving or operating machinery for at least 24 hours after receiving this medicine. Do not take any other medications, including over-the-counter drugs, without consulting your doctor, as many drugs can interact with this medicine.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of this medicine. A reduced dose and careful monitoring are recommended. The risk of prolonged muscle weakness and cardiovascular effects is higher in this population.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, inform your doctor before receiving this medicine. It should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your healthcare provider.

🏥 Post-Surgery Considerations

After surgery, you will be monitored until the effects of this medicine wear off. You may experience some muscle weakness, which usually resolves within a few hours. Follow your surgeon's instructions for post-operative care.

🦷 Dental Procedures

This medicine is not typically used for dental procedures. However, if you have received this medicine for another procedure, inform your dentist about it, especially if you are scheduled for dental work within 24 hours.

💚 Lifestyle Tips for Better Results

🏃

Follow your doctor's instructions for recovery after surgery.

🥗

Engage in gentle physical therapy to regain muscle strength.

😴

Stay hydrated and maintain a balanced diet.

💧

Avoid alcohol for at least 24 hours after receiving this medicine.

🧘

Get plenty of rest to aid recovery.

🌞

Report any persistent muscle weakness to your doctor.

🏋️ Exercise Considerations

Avoid strenuous exercise or heavy lifting for at least 24-48 hours after receiving this medicine, as muscle weakness may persist. Consult your doctor before resuming your regular exercise routine.

🥗 Diet Recommendations

Eat a balanced diet rich in protein to support muscle recovery.

Stay well hydrated.

Avoid alcohol for 24 hours after administration.

💼 Impact on Daily Work & Life

This medicine is given in a hospital setting, and its effects usually wear off within a few hours. However, you should not drive or operate machinery for at least 24 hours after receiving this medicine. Plan to have someone drive you home after the procedure.

🛑 When to Stop This Medicine

This medicine is stopped by the healthcare professional once the surgical procedure is completed or when muscle relaxation is no longer needed. Do not attempt to stop or adjust the dose yourself.

📅 Long-Term Use Effects

Long-term use of this medicine, especially in intensive care settings, may lead to prolonged muscle weakness and critical illness polyneuropathy. Regular monitoring of neuromuscular function and early discontinuation when possible can reduce these risks. There is no evidence of long-term effects after short-term use during surgery.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cisatracurium

A similar muscle relaxant with fewer histamine-related side effects.

Evidence: Well-established

Vecuronium

Another non-depolarizing muscle relaxant with a longer duration of action.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, elective procedures should be scheduled at least 2 weeks after vaccination to avoid confusion between vaccine side effects and procedural complications.

📦 Storage Guide

✅ DO

Store refrigerated at 2°C to 8°C

❌ DON'T

Do not freeze

✅ DO

Protect from light

❌ DON'T

Do not use if solution is discolored or contains particles

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✈️ Traveling with This Medicine

This medicine is administered only in a hospital setting and is not for self-administration. Patients who have received this medicine should not travel alone immediately after the procedure. If you are traveling after a procedure that required this medicine, carry a copy of your prescription and medical records. Inform your travel companions about any allergies. Avoid driving or operating machinery for at least 24 hours. If you are traveling to a different time zone, no dose adjustments are needed as this medicine is given only under medical supervision.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 65-year-old man undergoing abdominal surgery

This patient received this medicine for muscle relaxation during surgery. The anesthesiologist monitored neuromuscular function closely and adjusted the dose. The surgery was successful, and the patient recovered without any complications. He was informed about the possibility of mild muscle weakness after surgery, which resolved within a few hours.

💡 Lesson: Proper monitoring and dose adjustment ensure safe use of this medicine during surgery.

👤 A 45-year-old woman in the ICU requiring mechanical ventilation

This patient was given this medicine as a continuous infusion to facilitate mechanical ventilation. The ICU team monitored her neuromuscular function daily and used the lowest effective dose. After 3 days, the infusion was stopped, and she was successfully weaned off the ventilator. She experienced some muscle weakness, which improved with physiotherapy.

💡 Lesson: Prolonged use of this medicine in ICU requires careful monitoring and early discontinuation to prevent muscle weakness.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within 1-2 minutes after intravenous administration.

Q: How long does the effect last?

A: The muscle relaxation typically lasts 20-35 minutes, but this can vary based on dose and individual factors.

Q: Will I be asleep during the procedure?

A: This medicine does not cause sleep. It is used along with anesthetics that keep you unconscious during surgery.

Q: Can I receive this medicine if I have kidney problems?

A: Yes, this medicine is often preferred in patients with kidney problems because its elimination is not dependent on kidney function. However, your doctor will monitor you closely.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

Can I take this medicine at home?
Will I be awake during the procedure?
How long will the muscle relaxation last?
Are there any long-term effects?
Can I drive after receiving this medicine?
Is it safe in kidney disease?

🔄 Substitutes for arium 50mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

Myth: Atracurium is a painkiller.
Fact: Atracurium is a muscle relaxant and does not provide pain relief or sedation.
Myth: Atracurium can be taken at home.
Fact: Atracurium must be administered only in a hospital setting with proper monitoring.

🔄 Alternative Options

Generic Alternatives

Atracurium besylate

Brand Alternatives

Tracrium
Atracurium besylate injection

📊 Comparison with Similar Medicines

[{"medicine":"Atracurium","onset":"1-2 min","duration":"20-35 min","histamine_release":"Yes","organ_independent":"Yes"},{"medicine":"Cisatracurium","onset":"2-3 min","duration":"30-40 min","histamine_release":"No","organ_independent":"Yes"},{"medicine":"Vecuronium","onset":"2-3 min","duration":"30-60 min","histamine_release":"No","organ_independent":"No"}]

Artacil 50mg Injection (Atracurium): Comprehensive Medicine Guide

When to Call Your Doctor IMMEDIATELY

What is arium 50mg injection used for?

🇮🇳 arium 50mg injection के बारे में (Hindi Summary)

💊 arium 50mg injection Uses & Benefits

📋 Drug Information

👨‍⚕️ Doctor's Practical Tips

🔍 Is This Medicine Right for Your Symptom?

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take arium 50mg injection

Dosage Information

Dosage Timeline

🍽️ Food Timing Guide

⏰ What to Do If You Miss a Dose

⚠️ Side Effects of arium 50mg injection

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

🍷 Alcohol Interaction

🔎 Check Your Other Medicines

🛡️ Safety & Warnings

🚫 Contraindications

⚠️ Warnings & Precautions

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

Additional Safety Advice

👴 Special Considerations for Elderly

💡 For Patients Above 65

🤰 Pregnancy Planning (TTC)

🏥 Post-Surgery Considerations

🦷 Dental Procedures

💚 Lifestyle Tips for Better Results

🏋️ Exercise Considerations

🥗 Diet Recommendations

💼 Impact on Daily Work & Life

🛑 When to Stop This Medicine

📅 Long-Term Use Effects

🌿 Non-Medicine Approaches

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

📦 Storage Guide

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✈️ Traveling with This Medicine

💰 Cost Analysis & Savings

👥 Real Patient Stories

💬 Questions Patients Often Ask

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

🔄 Substitutes for arium 50mg injection

🛑 Myths vs. Facts

🔄 Alternative Options

Generic Alternatives

Brand Alternatives

📊 Comparison with Similar Medicines

😊 Was this information helpful?

Browse Medicines A-Z

✍️ Write a Review

❓ Ask a Question

⚠️ Report an Issue