Atrapure 50mg Injection (Atracurium): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath after receiving this medicine.
- Severe hypotension or dizziness.
- Signs of anaphylaxis such as rash, swelling of face or throat, or difficulty swallowing.
- Prolonged muscle weakness or paralysis beyond the expected duration.
- Seizures or unusual muscle twitching.
- Chest pain or irregular heartbeat.
If experiencing severe symptoms, call emergency services immediately.
What is atb 50mg injection used for?
This medicine is a non-depolarizing neuromuscular blocker used in hospitals to relax muscles during surgery, intubation, and mechanical ventilation. It is given intravenously by a healthcare professional and requires close monitoring.
- Generic Name: Atracurium besilate
- Manufacturer: Cachet Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 atb 50mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एट्राक्यूरियम बेसिलेट 50 मिलीग्राम इंजेक्शन के रूप में उपलब्ध है और इसका उपयोग अस्पतालों में सर्जरी के दौरान मांसपेशियों को शिथिल करने के लिए किया जाता है। यह एक नॉन-डिपोलराइजिंग न्यूरोमस्कुलर ब्लॉकर है जो नसों से मांसपेशियों तक संकेत पहुंचने को रोकता है। इसका उपयोग इंटुबेशन, मैकेनिकल वेंटिलेशन और कुछ डायग्नोस्टिक प्रक्रियाओं में भी किया जाता है। यह दवा केवल डॉक्टर या एनेस्थेसियोलॉजिस्ट द्वारा नस में दी जाती है और इसके प्रभाव की निरंतर निगरानी आवश्यक होती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में त्वचा पर लालिमा, हल्का रक्तचाप कम होना और हृदय गति में मामूली वृद्धि शामिल हैं। गंभीर दुष्प्रभावों में लंबे समय तक मांसपेशियों का पक्षाघात, सांस लेने में कठिनाई, एलर्जी प्रतिक्रिया, ब्रोंकोस्पाज्म और दौरे पड़ सकते हैं। यदि कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर को सूचित करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल में प्रशिक्षित डॉक्टर द्वारा ही दी जानी चाहिए। इससे पहले कि आपको यह दवा दी जाए, अपने डॉक्टर को अपनी सभी दवाओं, एलर्जी और चिकित्सीय स्थितियों के बारे में बताएं। गुर्दे या यकृत की बीमारी, मांसपेशियों के विकार या अस्थमा होने पर विशेष सावधानी बरतें। इस दवा के प्रभाव के पूरी तरह खत्म होने तक वाहन न चलाएं और मशीनरी न चलाएं। शराब का सेवन न करें क्योंकि इससे दुष्प्रभाव बढ़ सकते हैं।
💊 atb 50mg injection Uses & Benefits
[{"condition":"Surgical muscle relaxation","description":"Used to provide skeletal muscle relaxation during general anesthesia for surgical procedures, including abdominal, orthopedic, and cardiac surgeries.","evidence":"Well-established"},{"condition":"Endotracheal intubation","description":"Facilitates intubation by relaxing the vocal cords and surrounding muscles, allowing for safe placement of an endotracheal tube.","evidence":"Well-established"},{"condition":"Mechanical ventilation","description":"Used in intensive care units to facilitate mechanical ventilation in patients who require controlled muscle relaxation, such as those with acute respiratory distress syndrome.","evidence":"Well-established"},{"condition":"Diagnostic procedures","description":"May be used to provide muscle relaxation during certain diagnostic procedures like endoscopy or bronchoscopy, though less commonly.","evidence":"Limited"}]
Off-label uses: [{"condition":"Management of tetanus","description":"Sometimes used off-label to control muscle spasms in patients with tetanus, in conjunction with sedatives and other supportive care.","evidence":"Limited"},{"condition":"Treatment of severe muscle spasticity","description":"Rarely used off-label for severe muscle spasticity in conditions like multiple sclerosis or spinal cord injury, but only in specialized settings.","evidence":"Limited"}]
Primary treatment for: Surgical muscle relaxation
Also treats: Endotracheal intubation, Mechanical ventilation, Diagnostic procedures
📋 Drug Information
| Generic Name(s) | Atracurium besilate |
| Brand Name | Atracurium Besilate Injection |
| Manufacturer | Cachet Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Skeletal muscle relaxant- Peripherally acting |
| Route of Administration | Intravenous |
| Storage | Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Once removed from refrigeration, it should be used within a specified time as per manufacturer instructions. Keep out of reach of children. |
| Shelf Life | Refer to the manufacturer's packaging for the exact shelf life. Typically, the shelf life is 24 months from the date of manufacture when stored under recommended conditions. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a non-depolarizing neuromuscular blocker that acts by competitively binding to nicotinic acetylcholine receptors at the motor endplate of the neuromuscular junction. By occupying these receptors, it prevents acetylcholine from binding and triggering depolarization, thereby inhibiting muscle contraction. Unlike depolarizing agents, it does not cause initial muscle fasciculations. The blockade is reversible with acetylcholinesterase inhibitors such as neostigmine. This medicine also has a unique property of undergoing Hofmann elimination, a non-enzymatic degradation process that occurs at physiological pH and temperature, making its duration of action independent of liver and kidney function.
Mechanism Steps
💡 How to Take atb 50mg injection
Strength: Injection: 50 mg/5 mL (10 mg/mL) in a single-use vial.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, patient's age, weight, renal and hepatic function, and concurrent medications. For intubation, a common initial dose is 0.4 to 0.5 mg/kg intravenously, followed by maintenance doses of 0.08 to 0.1 mg/kg as needed. For prolonged procedures, continuous infusion may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Use in children should be based on clinical judgment and weight-based calculations, typically similar to adult dosing but with careful monitoring. |
| Elderly Dosage | Elderly patients may have altered sensitivity to neuromuscular blocking agents. Dose should be individualized by a qualified clinician based on renal and hepatic function, and concurrent medications. Monitoring is essential. |
| Renal Impairment | In patients with renal impairment, the parent drug's duration of action is not significantly prolonged due to Hofmann elimination. However, the metabolite laudanosine can accumulate and may cause seizures. Dose adjustment may be necessary, and monitoring is recommended. |
| Hepatic Impairment | Hepatic impairment does not significantly affect the pharmacokinetics of this medicine due to Hofmann elimination. No specific dose adjustment is typically required, but clinical monitoring is advised. |
| Maximum Daily Dose | Not established from the available information. Dosing is individualized and titrated to effect under medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of atb 50mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Magnesium sulfate | Major | |
| Isoflurane | Moderate | |
| Furosemide | Moderate | |
| Lidocaine | Moderate | |
| Corticosteroids | Minor | |
| Beta-blockers | Minor | |
| Phenytoin | Moderate | |
| Lithium | Moderate | |
| Procainamide | Moderate |
🚨 Major Interactions
- Aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
- Magnesium sulfate
- Other neuromuscular blocking agents
⚡ Moderate Interactions
- Inhalational anesthetics (e.g., isoflurane, sevoflurane)
- Local anesthetics (e.g., lidocaine)
- Diuretics (e.g., furosemide)
🍷 Alcohol Interaction
Alcohol may enhance the sedative and cardiovascular effects of this medicine. Patients should avoid alcohol before and after receiving this medicine, as it can increase the risk of hypotension and prolonged recovery.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to atracurium or any component of the formulation","Use in patients with neuromuscular disorders such as myasthenia gravis (unless absolutely necessary and with extreme caution)","Concurrent use with other neuromuscular blocking agents without proper monitoring"]
⚠️ Warnings & Precautions
["This medicine should only be administered by experienced healthcare professionals in a setting with immediate access to resuscitation equipment.","Use with caution in patients with severe electrolyte imbalances, as these can alter the effects of neuromuscular blockers.","Patients with renal impairment may be at risk of laudanosine accumulation and seizures; monitor closely.","This medicine can cause histamine release; use with caution in patients with asthma or cardiovascular disease.","Prolonged use in intensive care may lead to tolerance and critical illness polyneuropathy.","Reversal agents (e.g., neostigmine) should be available to counteract prolonged blockade.","This medicine does not provide anesthesia or analgesia; ensure adequate sedation and pain control."]
🤱 Lactation Safety
Not established from the available information. It is not known if this medicine passes into breast milk. Consult a doctor before use in breastfeeding women.
💊 Overdose Management
Overdose of this medicine results in prolonged neuromuscular blockade, leading to respiratory paralysis and apnea. Management includes immediate ventilatory support, continuous monitoring of neuromuscular function, and administration of acetylcholinesterase inhibitors such as neostigmine or edrophonium, along with an anticholinergic agent like atropine or glycopyrrolate to counteract bradycardia. In severe cases, sugammadex is not effective for atracurium. Supportive care in an intensive care unit is essential until full recovery.
⏰ Missed Dose
This medicine is administered by healthcare professionals in a controlled setting. Missed doses are not applicable as dosing is scheduled and monitored by the medical team.
Additional Safety Advice
This medicine must only be administered by a qualified anesthesiologist or critical care specialist in a hospital setting equipped with continuous monitoring and immediate access to resuscitation equipment. Patients should inform their doctor about all medications they are taking, especially antibiotics, magnesium salts, and other neuromuscular blocking agents, as these can enhance the effects of this medicine. It is crucial to disclose any history of neuromuscular disorders, kidney or liver disease, or allergic reactions to medications. This medicine should not be used during pregnancy unless clearly necessary, and it is not known if it passes into breast milk. Women who are breastfeeding should consult their doctor. After receiving this medicine, patients must be closely monitored until full muscle function returns. Driving or operating machinery is not permitted until the effects have completely worn off and the healthcare provider gives clearance. Alcohol should be avoided as it can increase the risk of adverse effects. Always ensure that the healthcare team is aware of any other medical conditions, such as asthma or heart disease, before this medicine is administered.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have increased sensitivity to neuromuscular blocking agents. Doses should be carefully titrated, and monitoring should be intensified.
🤰 Pregnancy Planning (TTC)
Not established from the available information. If you are planning pregnancy, discuss with your doctor before receiving this medicine.
🏥 Post-Surgery Considerations
After surgery, you will be monitored until the effects of this medicine wear off. You may experience temporary muscle weakness. Follow your surgeon's instructions for recovery.
🦷 Dental Procedures
This medicine is not typically used for dental procedures. If you are scheduled for dental work and have recently received this medicine, inform your dentist.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting until you have fully recovered from the effects of this medicine and anesthesia. Consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, and its effects can last for a few hours. You should not drive or operate machinery until fully recovered. Plan to have someone accompany you home after the procedure.
🛑 When to Stop This Medicine
This medicine is administered by healthcare professionals, and its use is stopped when the procedure is complete or when no longer needed. Do not attempt to stop or adjust the dose yourself.
📅 Long-Term Use Effects
Long-term effects are not well established for single-dose use. Prolonged use in intensive care may lead to tolerance, critical illness polyneuropathy, and prolonged muscle weakness. Monitoring of neuromuscular function and renal function is recommended during extended use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Cisatracurium, vecuronium, or rocuronium may be used as alternatives depending on the clinical scenario.
Evidence: Well-establishedIn some cases, regional anesthesia may be used instead of general anesthesia with muscle relaxants.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There are no known interactions with vaccines, but consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C.
❌ DON'T
Do not freeze.
✅ DO
Protect from light.
❌ DON'T
Do not use if the solution is discolored or contains particles.
✅ DO
Keep in original container.
❌ DON'T
Do not transfer to unmarked containers.
✈️ Traveling with This Medicine
This medicine is administered only in hospital settings and is not for outpatient use. Patients do not need to carry it during travel. However, if you have received this medicine recently, carry a copy of your hospital discharge summary and inform your travel companions about your recent anesthesia. Avoid driving or operating machinery until fully recovered. If traveling by air, ensure you have medical clearance if you experienced any complications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 to 2 minutes after intravenous administration, with maximum effect in 3 to 5 minutes.
A: You may feel a brief stinging sensation at the injection site, but this is usually minor and short-lived.
A: No, this medicine causes temporary muscle paralysis. You will not be able to move until the effects wear off, and you will be closely monitored.
A: Pediatric dosing is not established from available information. Consult a pediatrician for guidance.
🤔 Common Patient Concerns
🔄 Substitutes for atb 50mg injection
View AllAlternative brands with exact same active ingredient:
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artacil 50mg injectionNeon Laboratories Ltd ₹130.00 5.5% CHEAPER
-
arium 50mg injectionCelon Laboratories Ltd ₹215.23 56.5% COSTLIER
-
atrager 50mg injectionZydus Cadila ₹218.71 59.1% COSTLIER
-
acris 50mg injectionGland Pharma Limited ₹248.00 80.4% COSTLIER
-
atacurium 50mg injectionThemis Medicare Ltd ₹266.34 93.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Atracurium is a painkiller.
Fact: Atracurium is a muscle relaxant and does not provide pain relief or anesthesia. - Myth: Atracurium can be taken at home.
Fact: Atracurium is a hospital-only medicine given intravenously under strict supervision. - Myth: Atracurium is safe for everyone.
Fact: Atracurium has contraindications and must be used with caution in certain conditions.
🔄 Alternative Options
Generic Alternatives
- Atracurium besylate injection
Brand Alternatives
- Atrapure 50mg injection